Led by researchers from the University of Newcastle and Swinburne University of Technology in Australia, the study determined the optimum dosage of resveratrol needed to aid in improving vasodilator responses – that is, the widening of blood vessels – in the brain for patients with Type 2 diabetes mellitus. In particular, people who have Type 2 diabetes are known to have endothelial dysfunction and sub-clinical cognitive impairment.
The study built on the research team's previous foray into the subject, wherein they demonstrated that resveratrol is known to improve blood vessel function in the blood circulatory system. The research team hypothesized that resveratrol would also enhance cerebral circulation.
The study involved 36 individuals with Type 2 diabetes, with ages ranging from 40 to 80 years. The participants each received a single dose of synthetic trans-resveratrol in 75 mg, 150 mg, 300 mg, or placebo at weekly intervals. The research team used a Transcranial Doppler ultrasound to examine the participants' cerebral vasodilator responsiveness to a hypercapnic stimulus, such as breathing carbogen gas for three minutes, both before and 45 minutes after the resveratrol or placebo treatment. They measured the participants' cerebral vasodilator responsiveness in the left and right middle cerebral arteries.
The study results revealed that each resveratrol dose was effective in enhancing cerebral vasodilator responsiveness in people who are prone to have endothelial dysfunction and sub-clinical cognitive impairment, in comparison with the placebo. The greatest response was seen in the 75 mg dose of resveratrol, which is the lowest dosage among the treatments.
Resveratrol, a compound found in plants, acts as an antioxidant. It is found in different plants and plant products, such as grapes, red wine, grape juice, peanuts, cocoa, and berries such as blueberries, bilberries, and cranberries. In grapes, the compound is only found in the skins, and the concentrations of resveratrol in grape skins differ with the grape cultivar, its geographic origin, and exposure to fungal infection. Resveratrol is also available in supplements. (Related: Resveratrol is "Nature's Medicine" for Cancer, Heart Disease and Much More.)
Listed below are the other health benefits that resveratrol can provide.
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