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Why double-blind drug trials are a science FRAUD: The more toxic the side effects, the more patients believe the drugs are 'working'


Clinical trials

(NaturalNews) When it comes to antidepressants and many other drugs, double-blind drug trials are a complete fraud. Here's why: "Double-blind" means that one group gets a placebo while another group gets the real drug, but neither group knows what they're actually getting. This is supposed to sort out the placebo effects (which are real but discarded by scientists who don't believe in "mind-body medicine") from the "real" drug effects (which are considered legitimate because they are caused by chemicals) and provide proof that the drug in question works better than placebo.

There's only one problem with all that: The patients realize they have the "real" drug when they start experiencing horrific side effects!

Once patients start to suffer from side effects, they get excited about realizing they have the "real" treatment and not the placebo. From this realization, their mind creates a powerful new placebo effect from the deeply implanted belief that only chemical drugs can "balance brain chemistry" -- a claim driven into their heads by incessant drug advertising on television as well as by miracle promises from their drug-dealing doctor.

Thus, the more toxic the side effects, the more the patient generates her own placebo response that makes the drug look better than mere placebo.

Those patients who suffer no side effects, meanwhile, decide they're not on the "real" drug, and they mentally shut down any possibility of the drug actually working. This is a "negative placebo" effect.

It sounds bizarre, but it's the truth: Patients in America now believe that drugs don't work unless they generate toxic side effects. This belief system drives their mind-body reactions in drug trials, causing a gross distortion of drug trial data in so-called "double-blind" clinical trials, making it appear as if the more toxic drugs work better than they actually do.

The beliefs of patients strongly impact "double-blind" clinical trials, rendering them scientifically invalid

This phenomenon is explained in delightful detail by my favorite science writer, Rupert Sheldrake, in his extraordinary book Science Set Free (a highly recommended read). In this book, Sheldrake explains: (bolding added)

In scientific and medical research, as in everyday life, our beliefs, desires and expectations can influence, often subconsciously, how we observe and interpret things...

In medicine, patients’ expectations also influence the results, and double-blind procedures are used to guard against the expectations of both subjects and investigators. For example, in a typical double-blind clinical trial of a drug, some patients, selected at random, are given tablets of the drug being tested and others are given similar-looking placebo tablets, pharmacologically inert. The purpose of these trials is to find out if the new drug works better than the placebo...

The largest placebo responses tend to occur in trials in which both patients and physicians believe a powerful new treatment is being tested. The blank pills work because the patients who take them and the doctors who administer them think that they might contain the new wonder drug. If the trial is not blind, and the patients and doctors know who has been given the real drug and who has the placebo, the placebo response is greatly reduced. Neither the patients nor the doctors expect the placebo to have much effect, and it doesn’t. This can be a serious problem even in double-blind trials. If the real drug has noticeable side effects, both the patients and the doctors can find out who is receiving the placebo and the real drug, and as a result the placebo is less effective, which makes the real drug more effective relative to the placebo. This may seem like a tiresome technical detail, but it has huge economic consequences.

For example, in several clinical trials, the antidepressant drug Prozac had slightly more effect than the placebo, and was licensed for use, resulting in annual revenues to the manufacturers of more than $12 billion. But was it really better than a placebo? Perhaps not. Although the trials were double-blind, Prozac has some well-known side effects, such as nausea and insomnia. Both patients and clinicians might have realized who had received the Prozac and who the placebo by noticing these side effects, or their absence. This is called “breaking the blind.”

Once some people realized they were receiving the real drug and others realized they were getting the placebo, the placebo would have become less effective, and hence Prozac would have seemed more effective by comparison. In a study in which doctors and patients were asked to say whether they had received the real drug or the placebo, 80 percent of the patients and 87 percent of the doctors were right, as opposed to the 50 percent that would be expected by random guessing.

However, in several other clinical trials, Prozac was no better than the placebo. One reason could be that in these trials the patients had less experience with antidepressants and were less able to recognize the side effects. However, the drug company, Eli Lilly, did not publish the results of unsuccessful trials, which were revealed only because an independently minded researcher, Irving Kirsch, managed to obtain the data using the US Freedom of Information Act. He found that when all the data were taken into account, not just the positive results published by the manufacturers, Prozac and several other antidepressants turned out to be no more effective than placebos, or than a herbal remedy, St. John’s wort, which is far cheaper. Ironically, the suppression of the data showing that Prozac was no better than a placebo probably helped to increase its effectiveness as a prescription drug, because doctors and patients had more belief in it, thus enhancing the placebo response.


The bottom line? Don't believe Big Pharma's "double-blind" placebo controlled drug trials. They all produce false results due to the influence of the patient's programming and beliefs.

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About the author:Mike Adams (aka the "Health Ranger") is a best selling author (#1 best selling science book on Amazon.com) and a globally recognized scientific researcher in clean foods. He serves as the founding editor of NaturalNews.com and the lab science director of an internationally accredited (ISO 17025) analytical laboratory known as CWC Labs. There, he was awarded a Certificate of Excellence for achieving extremely high accuracy in the analysis of toxic elements in unknown water samples using ICP-MS instrumentation. Adams is also highly proficient in running liquid chromatography, ion chromatography and mass spectrometry time-of-flight analytical instrumentation.

Adams is a person of color whose ancestors include Africans and Native American Indians. He's also of Native American heritage, which he credits as inspiring his "Health Ranger" passion for protecting life and nature against the destruction caused by chemicals, heavy metals and other forms of pollution.

Adams is the founder and publisher of the open source science journal Natural Science Journal, the author of numerous peer-reviewed science papers published by the journal, and the author of the world's first book that published ICP-MS heavy metals analysis results for foods, dietary supplements, pet food, spices and fast food. The book is entitled Food Forensics and is published by BenBella Books.

In his laboratory research, Adams has made numerous food safety breakthroughs such as revealing rice protein products imported from Asia to be contaminated with toxic heavy metals like lead, cadmium and tungsten. Adams was the first food science researcher to document high levels of tungsten in superfoods. He also discovered over 11 ppm lead in imported mangosteen powder, and led an industry-wide voluntary agreement to limit heavy metals in rice protein products.

In addition to his lab work, Adams is also the (non-paid) executive director of the non-profit Consumer Wellness Center (CWC), an organization that redirects 100% of its donations receipts to grant programs that teach children and women how to grow their own food or vastly improve their nutrition. Through the non-profit CWC, Adams also launched Nutrition Rescue, a program that donates essential vitamins to people in need. Click here to see some of the CWC success stories.

With a background in science and software technology, Adams is the original founder of the email newsletter technology company known as Arial Software. Using his technical experience combined with his love for natural health, Adams developed and deployed the content management system currently driving NaturalNews.com. He also engineered the high-level statistical algorithms that power SCIENCE.naturalnews.com, a massive research resource featuring over 10 million scientific studies.

Adams is well known for his incredibly popular consumer activism video blowing the lid on fake blueberries used throughout the food supply. He has also exposed "strange fibers" found in Chicken McNuggets, fake academic credentials of so-called health "gurus," dangerous "detox" products imported as battery acid and sold for oral consumption, fake acai berry scams, the California raw milk raids, the vaccine research fraud revealed by industry whistleblowers and many other topics.

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