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Depression may Cause Heart Disease and Related Death

Saturday, March 28, 2009 by: Reuben Chow
Tags: depression, health news, Natural News

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(NewsTarget) Previous research has already suggested that there a two-directional link between depression and health conditions of the heart. A recent study published in the Journal of the American College of Cardiology has added to the body of evidence, having found that being depressed could increase the likelihood that a person gets hit or killed by heart disease.

Details of Study

The study team, comprising members from the Columbia University Medical Center in New York, University of California, Berkeley, Harvard Medical School in Boston, as well as the Harvard School of Public Health in Boston, had followed 63,469 women who were part of the Nurses' Health Study; the study subjects were free from cardiovascular disease at the start of the exercise.

Questionnaires were used in 1992, 1996 and 2000 to obtain information on symptoms of depression, while data on antidepressant use was collected in 1996 and 2000. Outcomes looked at were sudden cardiac death, fatal coronary heart disease, and nonfatal myocardial infarction.

Findings of Study

The Mental Health Index (MHI-5) was used to assess the women's symptoms in 1992, and the scale predicted that 7.9% of them had clinical depression. The researchers also found that symptoms of depression were associated with events of coronary heart disease. After controlling for other risk factors for the condition, it was found that those with such symptoms had 49% higher risk of fatal coronary heart disease.

In post-1996 models, the study team used a proxy variable for clinical depression, which consisted of severe depressive symptoms and / or the use of antidepressants, and they found that depressed women had 133% higher risk of sudden cardiac death. This risk could be mainly attributed to the relationship between the use of antidepressants and sudden cardiac death (234% higher risk).

The latter finding is somewhat of a surprise. There are two main possibilities for it - that the use of antidepressants was indicative of women who suffered the worst bouts of depression, which would make sense, or that antidepressants could themselves be contributing to heart problems, which would be bad news. This is especially since antidepressants already have a number of other known side effects. More research into this area will be needed.

William Whang, MD, the leader of the study, said that his team's findings add to growing research which shows depression as an independent risk factor for cardiovascular disease, on top of already well-established ones like smoking, hypertension and unhealthy cholesterol levels. And, in fact, the Nurses' Health Study, which covered mainly white females, may understate the risk. "If anything, the impact in African-American women is probably greater," he said. According to him, future research should check out whether proper treatment of depression would lower the risk of negative heart outcomes.

Other Research

The same applies to males too, according to a study recently presented at the American Psychosomatic Society's annual meeting. In that study, information on over 1,200 male twins who had been in the US military during the Vietnam War was used. The men were surveyed on various health issues, including depression, in 1992 and then again in 2005. The researchers found that men who were depressed in 1992 had twice the risk of getting heart disease in the following years, as compared to those who did not suffer from the condition.

Jeffrey F Scherrer, PhD, a research assistant professor of psychiatry at the Washington University School of Medicine and the St. Louis Veterans Affairs Medical Center, summed up his team's research when he said: "Based on our findings, we can say that after adjusting for other risk factors, depression remains a significant predictor of heart disease."

The Depression-Heart Disease Link

After suffering a serious ailment like a heart attack or a stroke, it is easy to slump into a period of depression. This is especially so if the patient is required to make certain drastic changes to his lifestyle and dietary habits. No more smoking, drinking, or eating their favorite foods, for example. Some may even suffer from loss of vital bodily functions, due to partial or full paralysis. Under such circumstances, it is natural to feel down.

But how does depression affect heart health? In the first study, it had been discovered that women who had worse symptoms of depression had a higher likelihood of also having other risk factors for heart disease. In addition, emotional stressors such as depression could cause elevated resting heart rates, making the heart work harder.

Further, depressed persons are more likely to neglect their own health and wellbeing. This may include not eating properly, failing to exercise, and not resting well.

And we cannot rule out the possibility of a vicious cycle taking place, whereby heart disease patients fall into depressive states and then become more likely to suffer worsening heart outcomes. It is thus very important that the depression-heart health link be taken seriously.

Indeed, the American Heart Association had recently made the recommendation that persons who suffer from heart disease undergo regular checks for depression. This is something which you and your loved ones should take note of, and heart patients should be carefully observed for any possible symptoms of depression.


Whang W et al. Depression and Risk of Sudden Cardiac Death and Coronary Heart Disease in Women. Journal of the American College of Cardiology 2009;53:950-958.

More evidence that depression is hard on the heart (http://www.newsweek.com/id/188508)

Depression Increases Risk For Heart Disease More Than Genetics Or Environment (http://www.sciencedaily.com/releases/2009/03...)

About the author

Reuben Chow has a keen interest in natural health and healing as well as personal growth. His website, All 4 Natural Health, offers a basic guide on natural health information. It details simple, effective and natural ways, such as the use of nutrition, various herbs, herb remedies, supplements and other natural remedies, to deal with various health conditions as well as to attain good health. His other websites also cover topics such as depression help, omega 3 fatty acids, as well as cancer research and information.

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