Subscribe (free)
About NaturalNews
Contact Us
Write for NaturalNews
Media Info
Advertising Info
US military

Off-label use of blood clotting prescription drug may be killing U.S. soldiers, military doctors say

Monday, November 20, 2006 by: Ben Kage
Tags: US military, off-label prescribing, blood transfusions

Most Viewed Articles

(NewsTarget) Denmark-based company Novo Nordisk's Recombinant Activated Factor VII was originally designed to coagulate blood and treat rare forms of hemophilia, but reports say that it is being used on critically wounded U.S. troops deployed to Iraq, despite being linked to clots resulting in strokes, heart attacks and death in other patients.

In December, the FDA issued a warning against giving Factor VII to patients who did not have the rare hemophilia -- which affects fewer than 3,000 Americans -- because of the dangerous side effects. FDA scientists also released a January study that blamed 43 blood-clot-related deaths on Factor VII.

The Army medical command, however, considers the drug a medical breakthrough in treating deadly bleeding on the front lines. More than 1,000 patients in Iraq have been treated with the drug.

"When it works, it's amazing," said Col. John B. Holcomb, an Army trauma surgeon and commander of the Army's Institute of Surgical Research. "It's one of the most useful new tools we have."

Military doctors have reported that soldiers who are in need of 10 or more units of blood have between a 25 and 50 percent chance of dying, and Factor VII has proven itself useful in such situations.

"I've seen it with my own eyes," said Lt. Col. Jeffrey Bailey, an Air Force trauma surgeon and senior physician at the American military hospital in Balad, Iraq. "Patients who are hemorrhaging to death, they get the drug and it stops. Factor VII saves their lives."

However, some doctors still stand in opposition of the off-label use of Factor VII.

"It's a completely irresponsible and inappropriate use of a very, very dangerous drug," said blood-clotting and blood-thinning medication specialist Dr. Jawed Fareed, who is director of the hemostasis and thrombosis research program at Loyola University in Chicago.

Some doctors in German and U.S. military hospitals have reported unusual, sometimes fatal, blood clots in soldiers who have been evacuated from Iraq, resulting in unexplained strokes, heart attacks and blood clots in the lungs. A number of doctors fear Factor VII is responsible. The problem is that finding the exact cause of a blood clot is often impossible, which makes it hard to identify any direct relation between clots and Factor VII.

"It's really not a question of an absolute safety level, but rather a ratio of benefit to risk that has to be established," said Dr. Michael Shalmi, vice president of biopharmaceuticals for Novo Nordisk.

Holcomb said he supported the off-label use of the drug because, "We're making decisions, in the middle of a war, with the best information we have available to us."


Join the Health Ranger's FREE email newsletter
Get breaking news alerts on GMOs, fluoride, superfoods, natural cures and more...
Your privacy is protected. Unsubscribe at any time. | Learn more...

comments powered by Disqus

Science News & Studies
Medicine News and Information
Food News & Studies
Health News & Studies
Herbs News & Information
Pollution News & Studies
Cancer News & Studies
Climate News & Studies
Survival News & Information
Gear News & Information
News covering technology, stocks, hackers, and more

Get alerted on heavy metals and pesticide test results for foods and supplements

Natural News is about to begin releasing lab test results for off-the-shelf food, supplement and pet food products, covering heavy metals, nutritive minerals, pesticides and herbicides. These details will be released exclusively to Natural News email newsletter subscribers (FREE) and will NOT be publicly posted on the website. To be alerted, join our free email newsletter now, and watch for lab test results in the weeks ahead.

Enter your email address below to subscribe to our email announcement list (but don't use gmail). Your privacy is protected and you can unsubscribe at any time. If you don't join our email list, you may never see our valuable content again via Facebook, Google or YouTube. CENSORSHIP has now reached EXTREME levels across the 'net. The truth is being suffocated. Subscribe now if you want to escape the delusional bubble of false reality being pushed by Google and Facebook.

Once you click subscribe, we will send you an email asking you to confirm your free subscription.