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TCM herbal formula yang he hua yan decoction found to prevent mammary tumorigenesis

07/17/2019 // Evangelyn Rodriguez // Views

Tags: alternative medicine, angiogenesis, anticancer, apoptosis, breast cancer, breast cancer mortality, cancer cures, cancer prevention, cancer solutions, cancer treatment, chemopreventive, Chinese herbal formula, disease treatments, goodcancer, goodhealth, goodmedicine, goodscience, herbal medicine, Herbs, longevity, natural cures, natural medicine, oxidative stress, prevention, research, TCM, traditional Chinese medicine, tumor prevention, yang he hua yuan decoction

Researchers from Shandong University of Traditional Chinese Medicine investigated the mechanism-based chemopreventive potential of a Chinese herbal formula called yang he hua yuan (YHHY) decoction using a 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary carcinogenesis model. The results of their study appeared in the journal BMC Complementary and Alternative Medicine.

• The development of safe and effective chemopreventive agents is an effective strategy in reducing the morbidity and mortality of breast cancer.
• To examine the anticancer potential of YHHY decoction, the researchers orally administered the medicine (10 mg/mL) to female rats once a day one week before and four weeks after DMBA treatment.
• They monitored the development of mammary tumor every day. They defined the length of time before a palpable tumor was noticed as tumor-free survival time.
• They used high-performance liquid chromatography (HPLC) to identify major chemical compositions of the YHHY decoction.
• They performed bioinformatics data mining and experimental analyses to demonstrate the underlying mechanism of action of YHHY decoction.
• The researchers reported that DMBA-treated rats that received YHHY treatment exhibited a significant delay and, in some animals, prevention of tumor occurrence without obvious toxicity.
• YHHY treatment also suppressed oncogenic myc activation significantly in the DMBA-induced rats.
• The researchers identified eight major chemical compounds present in the decoction that interfered with multiple tumorigenic pathways simultaneously in the mammary tumors. The compounds did the following:

  • Induced tumor apoptosis
  • Up-regulated pro-apoptotic protein Bax
  • Down-regulated anti-apoptotic protein Bcl-2
  • Suppressed abnormal cell proliferation and the MAPK/ERK, PI3K/AKT signaling
  • Blocked neo-angiogenesis and the VEGF/KDR signaling
  • Inhibited oxidative stress in the mammary tumors

Based on these results, the researchers concluded that the many components and multi-targeting properties of YHHY decoction support its use as a potent chemopreventive drug against breast cancer.

Read the full study at this link.

Journal Reference:

Li J, Liu X, Chen H, Sun Z, Chen H, Wang L, Sun X, Li X. MULTI-TARGETING CHEMOPREVENTION OF CHINESE HERB FORMULA YANGHE HUAYAN DECOCTION ON EXPERIMENTALLY INDUCED MAMMARY TUMORIGENESIS. BMC Complementary and Alternative Medicine. 13 February 2019;19(1). DOI: 10.1186/s12906-019-2456-1

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