zinc

Zinc deficiency worsens sepsis, causes 'catastrophic malfunctioning' of immune system, increases inflammation


Most Viewed Articles
Popular on Facebook
The five biggest lies about Ebola being pushed by government and mass media
Why does the CDC own a patent on Ebola 'invention?'
White House admits staging fake vaccination operation to gather DNA from the public
Ultraviolet light robot kills Ebola in two minutes; why doesn't every hospital have one of these?
EXCLUSIVE: Natural News tests flu vaccine for heavy metals, finds 25,000 times higher mercury level than EPA limit for water
Truvia sweetener a powerful pesticide; scientists shocked as fruit flies die in less than a week from eating GMO-derived erythritol
Irrefutable proof we are all being sprayed with poison: 571 tons of toxic lead 'chemtrailed' into America's skies every year
Tetanus vaccines found spiked with sterilization chemical to carry out race-based genocide against Africans
Russia taking McDonald's to court, threatens countrywide shutdown
Oregon man serving prison sentence for collecting rainwater on his own property
The best way to help your body protect itself against Ebola (or any virus or bacteria)
Global warming data FAKED by government to fit climate change fictions
Senator who attacked Doctor Oz over dietary supplements received over $146,000 in campaign contributions from Big Pharma mega-retailer and Monsanto
Healthy 12-year-old girl dies shortly after receiving HPV vaccine
Ebola outbreak may already be uncontrollable; Monsanto invests in Ebola treatment drug company as pandemic spreads
HOAX confirmed: Michelle Obama 'GMOs for children' campaign a parody of modern agricultural politics
Ben & Jerry's switches to non-GMO, Fair Trade ice cream ingredients
W.H.O. contradicts CDC, admits Ebola can spread via coughing, sneezing and by touching contaminated surfaces

Delicious
(NaturalNews) Zinc appears to play a key role in modulating the body's response to severe infection, and deficiency may increase susceptibility to a lethal immune reaction, according to a study conducted by researchers from Ohio State University and published in the journal PLOS ONE.

"When the body detects an infection, zinc is recruited to help produce immune response proteins, and then it's used to stop their production," lead author Daren Knoell, PharmD, PhD, said. "But zinc deficiency during sepsis appears to cause a catastrophic malfunctioning of the system, resulting in a magnified and prolonged inflammatory response."

The study was funded by the National Heart, Lung, and Blood Institute and received biostatistics support from the Ohio State Center for Clinical and Translational Science.

Zinc prevents immune over-reaction

Sepsis is a body-wide inflammatory reaction in response to a severe infection and is one of the main causes of death in intensive care units in the United States. One-fifth of all cases result in death, because the overload of inflammatory chemicals produced by the immune system eventually causes organ failure.

Prior research by the same team found that, when zinc-deficient mice developed sepsis, they were three times more likely to die than non-deficient mice with the same condition. They also found that, when zinc-deficient mice received zinc supplements, their sepsis survival rate improved.

In another study, the researchers discovered that zinc helps regulate the activity of an immune protein called IKK-beta, part of the NF-kappaB immune-regulating pathway. In the presence of more zinc, the pathway successfully lowers levels of inflammation and cell damage.

The new study expands upon this work.

"This research builds upon our past findings and further demonstrates that our immune system requires zinc to achieve a balanced and effective defense against overwhelming infection," Knoell said. "This new evidence provides further incentive to determine the extent to which zinc may be useful to prevent or treat sepsis, particularly in patients that may be zinc deficient."

Can zinc prevent Alzheimer's, heart disease?

In the new study, the researchers performed a genome-wide microarray analysis on DNA taken from the lung tissue of zinc-deficient mice with sepsis. They had to examine the entire genome because zinc plays so many roles in the body -- interacting with as many as 10,000 separate proteins -- and its specific effects can therefore be hard to pinpoint through larger-scale observation.

The researchers found that, when mice were suffering from sepsis, zinc deficiency caused changes in several different pathways, particularly the JAK-STAT3 pathway, which regulates the production of the inflammatory protein serum amyloid A (SAA). These changes prevented the body from being able to deactivate its inflammatory response, eventually leading to the destruction of healthy cells.

"Without zinc present in sufficient quantities, the JAK-STAT pathway keeps giving the genes the 'on' signal, and continues production of this inflammatory protein," Knoell said. "When we add zinc back into the equation, it stops JAK-STAT, SAA production and the acute response activity."

Knoell noted that SAA has also been linked with other inflammatory diseases, including cardiovascular and Alzheimer's disease.

"These findings not only provide some evidence for why zinc-based cold remedies may work, but also provide hints of how a zinc imbalance might also play a role in chronic diseases connected with inflammation," he said.

Unfortunately, doctors cannot prevent sepsis simply by supplementing deficient patients after they become sick. Instead, it is important that people get enough zinc in their diet and avoid deficiency in the first place.

"During illness, the body diverts zinc from the blood to the organs, so a deficiency is hard to detect, particularly in people who are already sick," Knoell said. "Without a way to better define the deficiency, we aren't able to define the ideal patient or a therapeutic dose of zinc."

Sources for this article include:

http://www.newswise.com

http://www.plosone.org

http://science.naturalnews.com

Join over four million monthly readers. Your privacy is protected. Unsubscribe at any time.
comments powered by Disqus
Take Action: Support NaturalNews.com by linking back to this article from your website

Permalink to this article:

Embed article link: (copy HTML code below):

Reprinting this article:
Non-commercial use OK, cite NaturalNews.com with clickable link.

Follow Natural News on Facebook, Twitter, Google Plus, and Pinterest

Colloidal Silver

Advertise with NaturalNews...

Support NaturalNews Sponsors:

Advertise with NaturalNews...

GET SHOW DETAILS
+ a FREE GIFT

Sign up for the FREE Natural News Email Newsletter

Receive breaking news on GMOs, vaccines, fluoride, radiation protection, natural cures, food safety alerts and interviews with the world's top experts on natural health and more.

Join over 7 million monthly readers of NaturalNews.com, the internet's No. 1 natural health news site. (Source: Alexa.com)

Your email address *

Please enter the code you see above*

No Thanks

Already have it and love it!

Natural News supports and helps fund these organizations:

* Required. Once you click submit, we will send you an email asking you to confirm your free registration. Your privacy is assured and your information is kept confidential. You may unsubscribe at anytime.