Did AstraZeneca fake clinical trial data for its ovarian cancer drug?

Most Viewed Articles
Popular on Facebook
BACK INTO THE CLOSET: Why U.S. reporters are not allowed to write about rainbow events in nations where being gay is still condemned
Depopulation test run? 75% of children who received vaccines in Mexican town now dead or hospitalized
A family destroyed: Six-month-old dies after clinic injects baby with 13 vaccines at once without mother's informed consent
Biologist explains how marijuana causes tumor cells to commit suicide
INVESTIGATION: Three days before Dr. Bradstreet was found dead in a river, U.S. govt. agents raided his research facility to seize a breakthrough cancer treatment called GcMAF
BOMBSHELL: China and America already at war: Tianjin explosion carried out by Pentagon space weapon in retaliation for Yuan currency devaluation... Military helicopters now patrolling Beijing
Companies begin planting microchips under employees' skin
BAM! Chipotle goes 100% non-GMO; flatly rejecting the biotech industry and its toxic food ingredients
ECONOMIC SLAVERY FOR ALL: While we were distracted with the Confederate flag flap, Congress quietly forfeited our entire economic future via fast-track trade authority
NJ cops bust teenagers shoveling snow without a permit
McDonald's in global profit free fall as people everywhere increasingly reject chemically-altered toxic fast food
March Against Monsanto explodes globally... World citizens stage massive protests across 38 countries, 428 cities... mainstream media pretends it never happened
Italian court rules mercury and aluminum in vaccines cause autism: US media continues total blackout of medical truth
SCOTUS same-sex marriage decision may have just legalized the concealed carry of loaded firearms across all 50 states, nullifying gun laws everywhere
Orthorexia Nervosa - New mental disorder aimed at people who insist on eating a clean diet
Vicious attack on Dr. Oz actually waged by biotech mafia; plot to destroy Oz launched after episode on glyphosate toxicity went viral
Nearly every mass shooting in the last 20 years shares one surprising thing? and it's not guns
Holistic cancer treatment pioneer Dr. Nicholas Gonzalez dies suddenly; patients mourn the loss of a compassionate, innovative doctor who helped thousands heal from cancer
(NaturalNews) AstraZeneca has come out making bold claims about their new experimental ovarian cancer drug called olaparib. In clinical trials, the drug company shows that their new drug enables an 83 percent reduction in the risk of ovarian cancer progression.

According to a review by officials from the US Food and Drug Administration, this 83 percent statistic most likely couldn't be reproduced.

"AstraZeneca has put up some pretty lofty expectations," said Damien Conover, an analyst at Morningstar.

The drug is designed to be a maintenance therapy for recurring ovarian cancer that has only partially responded to platinum-based chemotherapy. Could the drug's efficacy rate even be proven since it's used as a secondary, follow-up drug to chemotherapy? How can the success of these two therapies be differentiated?

For that matter, how can the efficacy of the platinum-based chemotherapy and/or the new drug be measured if it's the person's immune system that is overcoming the cancer? Drug companies can't market patients' own immune systems.

In the end, could it be that the two treatment methods are actually diverting energy away from immune system empowerment and cellular energy production?

Meanwhile, olaparib awaits FDA approval. The future of this multi-billion-dollar cash cow hinges on the decision of FDA staff. An FDA staff report, recently published on the agency's website, is preparing discussion with outside experts who will weigh the benefits versus the risks of the new drug. The FDA's decision usually hinges on the advice of these expert panels. If it is approved, olaparib is already set to be sold under the brand name Lynparza.

Clinical tests are vague, making general correlations that cannot be proven

The new drug intervenes in the body by blocking poly(ADP-ribose) polymerase (PARP) activity. This enzyme plays an important role in cell repair.

According to the clinical trials, ovarian cancer patients witnessed median improvement of seven months for progression-free survival. This test basically just measures the amount of time a patient lives without the cancer showing any signs of progression. The test does not show whether the drug is mitigating the cancer progression but does show a general correlation (that cannot be effectively proven or consistently replicated).

Measuring quality-of-life factors like energy levels and strength recovery are not included in this clinical test either. Likewise, the drug's ability to prevent other health problems and future cancers is not included in the test. To make matters worse, olaparib boasts a new set of side effects for the body to handle along with the cancer -- nausea, fatigue, abdominal pain, vomiting, diarrhea and anemia.

Drug has potential to mislead women into taking it as a "preventive" measure

The drug was designed for women who test positive for BRCA gene mutations. There are about 2,000 of these cases every year in the United States. Under this premise, pharmaceutical advertisement may lure doctors and scare patients into "preventing" ovarian cancer in women who test positive for BRCA gene mutation predisposition. If they have these genes, then they may be coerced or scared into lifetime "preventive" doses of the new ovarian cancer drug. The drug could be marketed according to its clinical trials that show an 83 percent reduction in the risk of disease progression. The method of marketing might sell over quite well, victimizing those who don't question authority, fooling women into using pills for cancer prevention.

FDA questions "the reliability of the estimation of treatment effect"

What the FDA is concerned about is how AstraZeneca conducted its data analysis. The FDA review said there is some uncertainty about the validity of the results, showing how AstraZeneca collected some of the data using archived blood samples. The FDA review formally questioned "the reliability of the estimation of treatment effect."

The review went on to say that the data suggests that most patients may experience some progression-free survival, but that benefit came from a control arm that performed unusually poorly. The review said that there was no difference between the two treatment arms and their overall survival rate.

Sources for this article include:

Follow real-time breaking news headlines on
AstraZeneca at
Join over four million monthly readers. Your privacy is protected. Unsubscribe at any time.
comments powered by Disqus
Take Action: Support by linking back to this article from your website

Permalink to this article:

Embed article link: (copy HTML code below):

Reprinting this article:
Non-commercial use OK, cite with clickable link.

Follow Natural News on Facebook, Twitter, Google Plus, and Pinterest

Colloidal Silver

Advertise with NaturalNews...

Support NaturalNews Sponsors:

Advertise with NaturalNews...


Sign up for the FREE Natural News Email Newsletter

Receive breaking news on GMOs, vaccines, fluoride, radiation protection, natural cures, food safety alerts and interviews with the world's top experts on natural health and more.

Join over 7 million monthly readers of, the internet's No. 1 natural health news site. (Source:

Your email address *

Please enter the code you see above*

No Thanks

Already have it and love it!

Natural News supports and helps fund these organizations:

* Required. Once you click submit, we will send you an email asking you to confirm your free registration. Your privacy is assured and your information is kept confidential. You may unsubscribe at anytime.