immune response

Individual organs capable of independent immune response, study suggests

Wednesday, December 19, 2012 by: David Gutierrez, staff writer
Tags: organs, immune response, infectious disease

eTrust Pro Certified

Most Viewed Articles
Popular on Facebook
White House admits staging fake vaccination operation to gather DNA from the public
EXCLUSIVE: Natural News tests flu vaccine for heavy metals, finds 25,000 times higher mercury level than EPA limit for water
Irrefutable proof we are all being sprayed with poison: 571 tons of toxic lead 'chemtrailed' into America's skies every year
Truvia sweetener a powerful pesticide; scientists shocked as fruit flies die in less than a week from eating GMO-derived erythritol
Russia taking McDonald's to court, threatens countrywide shutdown
Why does the CDC own a patent on Ebola 'invention?'
Senator who attacked Doctor Oz over dietary supplements received over $146,000 in campaign contributions from Big Pharma mega-retailer and Monsanto
Global warming data FAKED by government to fit climate change fictions
Oregon man serving prison sentence for collecting rainwater on his own property
HOAX confirmed: Michelle Obama 'GMOs for children' campaign a parody of modern agricultural politics
Ebola outbreak may already be uncontrollable; Monsanto invests in Ebola treatment drug company as pandemic spreads
Ben & Jerry's switches to non-GMO, Fair Trade ice cream ingredients
Diet soda, aspartame linked to premature deaths in women
Elliot Rodger, like nearly all young killers, was taking psychiatric drugs (Xanax)
Right to farm being stripped from Americans: Michigan to criminalize small family farms with chickens, goats, honey bees and more
BREAKING: CDC whistleblower confesses to MMR vaccine research fraud in historic public statement
Monsanto's seed imperialism halted in Canada thanks to massive protests
5 powerful antibiotics that don't require a prescription
Delicious
(NaturalNews) Individual organs may possess innate, individual immune systems separate from the body's larger immune system, suggests a study conducted by researchers from The Rockefeller University, Harvard Medical School and the Memorial Sloan-Kettering Cancer Institute.

To date, models of the immune system have focused on actors such as white blood cells, which are produced by blood marrow and circulate through the body and circulate through the body searching out and destroying infectious agents and other health threats. But the new study found that the brain is capable of mounting a response to destroy certain viruses without involving white blood cells, or any other component of what is typically thought of as the "immune system."

The study came out of prior research by scientists at The Rockefeller University into children with a disease called Herpes simplex encephalitis, a potentially fatal brain infection caused by the herpes virus HSV-1. The researchers had previously determined that these children possess a genetic defect leading to faulty function of the immune system agent known as toll-like receptor 3 (TLR3).

TLR3 function as both a pathogen detector and an immune trigger. After detecting an infection, the receptor causes surrounding cells to release proteins called interferons, which hamper the pathogen's ability to reproduce.

But the researchers found that the mutation in children with Herpes simplex encephalitis did not appear to affect TLR3's effect on white blood cells, which has been the most well-studied.

"One interesting thing about these patients is that they didn't have any of the other, more common herpes symptoms," Zhang said. "They didn't have an infection on their skin or their mouths, just in their brains. We therefore hypothesized that the TLR3 response must be specifically responsible for keeping the herpes virus from infecting the brain and not necessary in other parts of the body."

Intrinsic immunity

To test their idea, the researchers induced stem cells made from the tissue of patients with Herpes simplex encephalitis to develop into central nervous cells. They then exposed these cells to HSV-1 and to a synthetic RNA mimicking a byproduct of the virus' reproduction. The researchers then measured levels of interferons, concluding that levels were indeed lower than they should be - suggesting a faulty FLR3 response. But when the same virus and synthetic RNA were mixed with the patients' blood cells, interferon levels (and thus, presumably, TLR3 activity) were normal.

This implies that the brain cells themselves must be able to produce TLR3 and interferons in order fight off infection, without help from the wider immune system.

"This is evidence of an intrinsic immunity, a newly-discovered function of the immune system," Zhang said. "It's likely that other organs also have their own specific tools for fighting infection."

The researchers are now planning a study to examine whether brain cells also exhibit signs of intrinsic immunity to types of viruses other than herpes. They are also planning a pilot study to see if Herpes simplex encephalitis can be treated directly using interferons, thereby bypassing the faulty TLR3 gene.

Sources:

http://www.sciencedaily.com/releases/2012/12/121210221259.htm

Join over four million monthly readers. Your privacy is protected. Unsubscribe at any time.
comments powered by Disqus
Take Action: Support NaturalNews.com by linking back to this article from your website

Permalink to this article:

Embed article link: (copy HTML code below):

Reprinting this article:
Non-commercial use OK, cite NaturalNews.com with clickable link.

Follow Natural News on Facebook, Twitter, Google Plus, and Pinterest

Colloidal Silver

Advertise with NaturalNews...

Support NaturalNews Sponsors:

Advertise with NaturalNews...

GET SHOW DETAILS
+ a FREE GIFT

Sign up for the FREE Natural News Email Newsletter

Receive breaking news on GMOs, vaccines, fluoride, radiation protection, natural cures, food safety alerts and interviews with the world's top experts on natural health and more.

Join over 7 million monthly readers of NaturalNews.com, the internet's No. 1 natural health news site. (Source: Alexa.com)

Your email address *

Please enter the code you see above*

No Thanks

Already have it and love it!

Natural News supports and helps fund these organizations:

* Required. Once you click submit, we will send you an email asking you to confirm your free registration. Your privacy is assured and your information is kept confidential. You may unsubscribe at anytime.