Vitamin D

Chemotherapy drugs are linked to severe vitamin D deficiency

Wednesday, October 24, 2012 by: Ethan Evers
Tags: chemotherapy drugs, vitamin D, deficiency

eTrust Pro Certified

Most Viewed Articles
Popular on Facebook
BACK INTO THE CLOSET: Why U.S. reporters are not allowed to write about rainbow events in nations where being gay is still condemned
Depopulation test run? 75% of children who received vaccines in Mexican town now dead or hospitalized
A family destroyed: Six-month-old dies after clinic injects baby with 13 vaccines at once without mother's informed consent
Biologist explains how marijuana causes tumor cells to commit suicide
INVESTIGATION: Three days before Dr. Bradstreet was found dead in a river, U.S. govt. agents raided his research facility to seize a breakthrough cancer treatment called GcMAF
Companies begin planting microchips under employees' skin
BAM! Chipotle goes 100% non-GMO; flatly rejecting the biotech industry and its toxic food ingredients
ECONOMIC SLAVERY FOR ALL: While we were distracted with the Confederate flag flap, Congress quietly forfeited our entire economic future via fast-track trade authority
NJ cops bust teenagers shoveling snow without a permit
Chemotherapy kills cancer patients faster than no treatment at all
McDonald's in global profit free fall as people everywhere increasingly reject chemically-altered toxic fast food
March Against Monsanto explodes globally... World citizens stage massive protests across 38 countries, 428 cities... mainstream media pretends it never happened
Italian court rules mercury and aluminum in vaccines cause autism: US media continues total blackout of medical truth
SCOTUS same-sex marriage decision may have just legalized the concealed carry of loaded firearms across all 50 states, nullifying gun laws everywhere
Orthorexia Nervosa - New mental disorder aimed at people who insist on eating a clean diet
Vicious attack on Dr. Oz actually waged by biotech mafia; plot to destroy Oz launched after episode on glyphosate toxicity went viral
Nearly every mass shooting in the last 20 years shares one surprising thing? and it's not guns
Holistic cancer treatment pioneer Dr. Nicholas Gonzalez dies suddenly; patients mourn the loss of a compassionate, innovative doctor who helped thousands heal from cancer
Delicious
(NaturalNews) Vitamin D is critically important for cancer patients in surviving their disease longer. Now, researchers have discovered that several chemotherapy drugs used to treat cancer may also cause severe vitamin D deficiency in patients. More disturbing is that attempts to give such patients supplemental vitamin D have met with mixed results, unless very high doses are applied. If these surprise findings are more widely applicable, they could provide new explanations for the extremely negative side effects of chemotherapy drugs.

Chemotherapy lowers vitamin D in colon cancer patients

It is well established that cancer patients have lower levels of vitamin D than the general public, but the relationship between vitamin D status and severity (stage) of cancer among patients remains unclear. It was exactly this link that oncologists at the Roswell Park Cancer Institute were researching when they unexpectedly discovered that the strongest risk factor for severe vitamin D deficiency was the use of chemotherapy drugs. Patients taking chemo (any of the three regimens being used) were 400 percent more likely to show severely depressed levels of the vitamin (less than 15 ng/ml) compared to those not on chemo (multivariate analysis of 315 patients). This is problematic, as one recent study showed that colon cancer patients with the lowest levels of vitamin D had a significantly greater risk of death compared to those with higher levels (hazard ratio equals 1.92, lowest to highest quartile).

Vitamin D lowering effect also confirmed in breast cancer patients

Not long after the results from the Roswell Park Cancer Institute were published, French researchers announced similar findings, but this time for breast cancer patients. Before treatment, 79.5 percent of their patients were insufficient for vitamin D (levels below 30 ng/ml), but 97.4 percent were insufficient after treatment (with neoadjuvant chemotherapy). Chemotherapy had caused the patients' median vitamin D level to drop from 21.3 ng/ml to 14.7 ng/ml. As with colon cancer, lower vitamin D levels among breast cancer patients are correlated with reduced survival.

How can vitamin D levels be maintained during chemotherapy?

Research on maintaining vitamin D levels during chemotherapy treatment is still in early stages. Doctors at the Roswell Park Cancer Institute tested 2000 IU/day of supplemental vitamin D given to their colon cancer patients in a randomized trial. The average level of vitamin D for all patients at the start of the trial was 17.5 ng/ml. After six months of supplementation, this rose to a healthy 37.5 ng/ml for non-chemotherapy patients, but to only 29 ng/ml for patients on chemo, which is still insufficient. A similar trial was run with breast cancer patients, using low dose (1000 IU/day) or high dose (50,000 IU once per week). Patients started the trial with an average of 27.5 ng/ml. On the low dose, patients' levels increased by only 9.4 ng/ml. However, the high dose increased patients' vitamin D by 24.3 ng/ml, which brought their levels into a healthy range. These trials confirmed that chemotherapy may reduce a patient's ability to utilize supplemental vitamin D, requiring them to take much higher doses than normal to achieve sufficiency.

The mechanisms by which chemotherapy drugs lower vitamin D in cancer patients remain unclear, but could include decreased absorption via subclinical mucositis or increased metabolism of vitamin D via the activation of enzymes such as CYP3A4. Until further research is completed, there is a risk that most (if not all) chemotherapy drugs may depress patients' vitamin D levels. Cancer patients taking these drugs should therefore consider monitoring their vitamin D status throughout the treatment period as well as aggressive supplementation to maintain adequate levels which are associated with a better prognosis.

Sources for this article include:

http://www.ncbi.nlm.nih.gov/pubmed/22928063
http://www.ncbi.nlm.nih.gov/pubmed/18830610
http://www.ncbi.nlm.nih.gov/pubmed/22562178
http://www.ncbi.nlm.nih.gov/pubmed/22493367
http://www.ncbi.nlm.nih.gov/pubmed?term=21384167

About the author:
Ethan Evers is author of the award-winning medical thriller "The Eden Prescription," in which cutting-edge researchers perfect an effective, all-natural treatment for cancer, only to be hunted down by pharmaceutical interests which will stop at nothing to protect their $80 billion cancer drug cash machine. The Eden Prescription is based on the latest science and draws on real historical events stretching back to the beginning of the "War on Cancer." Ethan has a PhD in Applied Science.

The Eden Prescription is available on amazon: www.amazon.com/Eden-Prescription-cancer-what...
Follow Ethan on Facebook for the latest breakthroughs and news on natural medicine for cancer: www.facebook.com/pages/The-Eden-Prescription...
For more information: www.edenprescription.com




Follow real-time breaking news headlines on
Chemotherapy drugs at FETCH.news
Join over four million monthly readers. Your privacy is protected. Unsubscribe at any time.
comments powered by Disqus
Take Action: Support NaturalNews.com by linking back to this article from your website

Permalink to this article:

Embed article link: (copy HTML code below):

Reprinting this article:
Non-commercial use OK, cite NaturalNews.com with clickable link.

Follow Natural News on Facebook, Twitter, Google Plus, and Pinterest

Colloidal Silver

Advertise with NaturalNews...

Support NaturalNews Sponsors:

Advertise with NaturalNews...

GET SHOW DETAILS
+ a FREE GIFT

Sign up for the FREE Natural News Email Newsletter

Receive breaking news on GMOs, vaccines, fluoride, radiation protection, natural cures, food safety alerts and interviews with the world's top experts on natural health and more.

Join over 7 million monthly readers of NaturalNews.com, the internet's No. 1 natural health news site. (Source: Alexa.com)

Your email address *

Please enter the code you see above*

No Thanks

Already have it and love it!

Natural News supports and helps fund these organizations:

* Required. Once you click submit, we will send you an email asking you to confirm your free registration. Your privacy is assured and your information is kept confidential. You may unsubscribe at anytime.