GMO

Scientific studies conclude GMO feed causes organ disruption in animals

Wednesday, October 05, 2011 by: Jeffrey M. Smith
Tags: GMO, animal feed, health news

eTrust Pro Certified

Delicious Pin It
(NaturalNews) A new paper reviewing data from 19 animal studies shows that consuming genetically modified (GM) corn or soybeans leads to significant organ disruptions in rats and mice, particularly in livers and kidneys (http://www.enveurope.com/content/23/1/10). "Other organs may be affected too, such as the heart and spleen, or blood cells," stated the paper. In fact some of the animals fed genetically modified organisms had altered body weights, which is "a very good predictor of side effects in various organs."

The GM soybean and corn varieties used in the feeding trials "constitute 83% of the commercialized GMOs" that are currently consumed by billions of people. While the findings may have serious ramifications for the human population, the authors demonstrate how a multitude of GMO-related health problems could easily pass undetected through the superficial and largely incompetent safety assessments that are used around the world.

The researchers, lead by French Professor Gilles-Eric Seralini, found that nearly 1 out of every 10 measured parameters in the studies, including blood and urine biochemistry, organ weights, and microscopic analyses, were significantly disrupted in the animals fed GMOs. The kidneys of males fared the worst, with 43.5% of all the changes. The liver of females followed, with 30.8%. The report, published in Environmental Sciences Europe on March 1, 2011, confirms that "several convergent data appear to indicate liver and kidney problems as end points of GMO diet effects." The authors point out that livers and kidneys "are the major reactive organs" in cases of chronic food toxicity.

Feed'em longer!

One of the most glaring faults in the current regulatory regime is the short duration of animals feeding studies. The industry limits trials to 90 days at most, with some less than a month. Only two studies reviewed in this new publication were over 90 days -- both were non-industry research.

Short studies could easily miss many serious effects of GMOs. It is well established that some pesticides and drugs, for example, can create effects that are passed on through generations, only showing up decades later. IN the case of the drug DES (diethylstilbestrol), "induced female genital cancers among other problems in the second generation." The authors urge regulators to require long-term multi-generational studies, to "provide evidence of carcinogenic, developmental, hormonal, neural, and reproductive potential dysfunctions, as it does for pesticides or drugs."

Pesticide Plants

Nearly all GM crops are described as "pesticide plants." They either tolerate doses of weed killer, such as Roundup, or produce an insecticide called Bt-toxin. In both cases, the added toxin -- weedkiller or bug killer -- is found inside the corn or soybeans we consume.

When regulators evaluate the toxic effects of pesticides, they typically require studies using three types of animals, with at least one feeding trial lasting 2 years or more. One third or more of the side effects produced by these toxins will show up only in the longer study -- not the shorter ones. But for no good reason, regulators ignore the lessons learned from pesticides and waive the GM crops-containing-pesticides onto the market with a single species tested for just 90 days. The authors affirm that "it is impossible, within only 13 weeks, to conclude about the kind of pathology that could be induced by pesticide GMOs and whether it is a major pathology or a minor one. It is therefore necessary to prolong the tests."

GMO approvals also ignore the new understanding that toxins don't always follow a linear dose-response. Sometimes a smaller amount of toxins have greater impact than larger doses. Approvals also overlook the fact that mixtures can be far more dangerous than single chemicals acting alone. Roundup residues, for example, have been "shown to be toxic for human placental, embryonic, and umbilical cord cells," whereas Roundup's active ingredient glyphosate does not on its own provoke the same degree of damage. One reason for this is that the chemicals in Roundup "stabilize glyphosate and allow its penetration into cells."

Furthermore, toxins may generate new substances (metabolites) "either in the GM plant or in the animals fed with it." Current assessments completely ignore the potential danger from these new components in our diets, such as the "new metabolites" in GMOs engineered to withstand Roundup. The authors warn, "We consider this as a major oversight in the present regulations."

"It's not the same stuff that farmers spray"

Regulators claim that the Bt-toxin produced inside GM corn is safe. They say that the Bt gene comes from soil bacteria Bacillus thuringiensis (Bt), which has been safely applied as a spray-on insecticide by farmers in the past. But the authors insist that "the argument about 'safe use history' of the wild Bt protein . . . Cannot, on a sound scientific basis, be used for direct authorizations of . . . GM corns," without conducting proper long-term animal feeding studies.

In order to justify their claim that the wild Bt-toxin is safe, the authors state that it must first be separately tested on animals and humans and then authorized individually for food or feed, which it has not. And even if the wild variety had been confirmed as safe, the GM versions are so different, they must require their own independent studies. The paper states:

"The Bt toxins in GMOs are new and modified, truncated, or chimerical in order to change their activities/solubility in comparison to wild Bt. For instance, there is at least a 40% difference between the toxin in Bt176 [corn] and its wild counterpart."

Even though the isolated Bt-toxin from GM corn has not been tested on animals, rodent studies on corn containing the toxin do show problems. Male rats fed Monsanto's MON863 corn, for example, had smaller kidneys with more focal inflammation and other "disrupted biochemical markers typical of kidney filtration or function problems."

Stop with the dumb excuses

If statistically significant problems show up in their studies, biotech company researchers often attempt to explain away the adverse findings. But the authors of this review paper describe their excuses as unscientific, obsolete, or unjustified.

When male and female animals have different results, for example, biotech advocates claim that this couldn't possibly be related to the feed. Since both genders eat the same amount, they argue, both would have to show the same reaction in all of their organs, etc. And if the group of animals fed with less of the GMO feed exhibit more severe reactions than the group fed the larger amount, advocates claim that this discrepancy also means that the GMOs could not be the cause, since there must always be a linear dose relationship.

The authors of this paper, however, point out that effects found in a GMO animal feeding study "cannot be disregarded on the rationale that it is not linear to the dose (or dose-related) or not comparable in genders. This would not be scientifically acceptable." In fact, most "pathological and endocrine effects in environmental health are not directly proportional to the dose, and they have a differential threshold of sensitivity in both sexes. This is, for instance, the case with carcinogenesis and endocrine disruption."

What's the culprit, pesticide or plant?

The shortcomings of the feeding studies make it impossible to determine whether a particular problem is due to the added pesticide, such as Roundup residues or Bt-toxin, or due to the genetic changes in the modified plants' DNA.

Mice fed Roundup Ready soybeans, for example, showed numerous changes indicating increased metabolic rates in the liver (i.e. irregular hepatocyte nuclei, more nuclear pores, numerous small fibrillar centers, and abundant dense fibrillar components). Since studies on Roundup herbicide also show changes in the liver cells of mice and humans, the Roundup residues within the soybeans may be a significant contributing factor to the metabolic changes.

Similarly, rats fed Roundup Ready corn showed indications that their kidneys leaked. Such an effect "is well correlated with the effects of glyphosate-based herbicides (like Roundup) observed on embryonic kidney cells." Thus, the rats' kidney problems may also be caused by the Roundup that is accumulated within Roundup Ready corn kernels.

In addition to the herbicide, the Bt-toxin insecticide produced inside GM corn might also cause disorders. The authors state, "The insecticide produced by MON810 [corn] could also induce liver reactions, like many other pesticides." Studies do confirm significant liver changes in rats fed Bt corn.

On the other hand, "unintended effects of the genetic modification itself cannot be excluded" as the possible cause of these very same health problems. The process of gene insertion followed by cloning plant cells (tissue culture) can cause massive collateral damage in the plant's DNA with potentially harmful side-effects. In MON810 corn, for example, the insertion "caused a complex recombination event, leading to the synthesis of new RNA products encoding unknown proteins." The authors warn that "genetic modifications can induce global changes" in the DNA, RNA, proteins, and the numerous natural products (metabolites), but the faulty safety assessments are not designed to adequately identify these changes or their health impacts.

Population at risk

In addition to the shortcomings mentioned above, the paper shows how GMO feeding trials are "based on ancient paradigms" with "serious conceptual and methodological flaws," employ statistical methods that obscure the findings, add irrelevant control groups that confuse and confound the analysis, and rely on numerous assumptions that either remain untested or have already proved false.

Unlike drug approvals, biotech companies do not conduct human studies. They would therefore fail to identify both general human health reactions, and the potentially more serious ones endured by sub-populations. "If some consumers suffer from stomach problems or ulcers," for example, the paper states, "the new toxins will possibly act differently; the digestion in children could be affected too." The paper recommends the implementation of post market monitoring, which, among other things, "should be linked with the possibility of detecting allergenicity reactions to GMOs in routine medicine."

But even if authorities wanted to conduct epidemiological studies on GMOs, the authors acknowledge that they "are not feasible in America, since there is no organized traceability of GMOs anywhere on the continent." Not only is labeling of GMOs urgently needed to allow such studies to proceed, the study says:

"The traceability of products from animals fed on GMOs is also crucial. The reason for this is because they can develop chronic diseases which are not utterly known today…. Labeling animals fed on GMOs is therefore necessary because some pesticide residues linked to GMOs could pass into the food chain."

They also point out that "even if pesticides residues or DNA fragments are not toxic nor transmitted by themselves" nevertheless, "nobody would want to eat disabled or physiologically modified animals after long-term GMOs ingestion."

"New experiments," they concluded, "should be systematically performed to protect the health of billions of people that could consume directly or indirectly these transformed products."

In the meantime, for those not willing to wait for the new studies, we recommend consulting the Non-GMO Shopping Guide at www.NonGMOShoppingGuide.com

Jeffrey M. Smith is the author of Seeds of Deception (http://www.seedsofdeception.com/Public/Home/...), the world's bestselling book on GMOs. He is also the author of Genetic Roulette (http://www.geneticroulette.com), and the Executive Director of the Institute for Responsible Technology (http://www.responsibletechnology.org). The Institute's Non-GMO Shopping Guide website (http://www.nongmoshoppingguide.com), iPhone app ShopNoGMO, and pocket guide, help people navigate to healthier non-GMO foods. Join the Institute's Non-GMO Tipping Point Network (http://action.responsibletechnology.org/p/sa...) to connect with others in your area, to bring the truth about GMOs to your friends and community.

Get breaking news alerts on GMOs, fluoride, superfoods, natural cures and more...
Join over four million monthly readers. Email privacy 100% protected. Unsubscribe at any time.


Have comments on this article? Post them here:

comments powered by Disqus

Take Action: Support NaturalNews.com

Email this article to a friend

Permalink to this article:

Reprinting this article: Non-commercial use OK, cite NaturalNews.com with clickable link.

Embed article link: (copy HTML code below):
Most Popular
Today | Week | Month | Year

See all Top Headlines...



GET SHOW DETAILS
+ a FREE GIFT

Now Available at ShopNaturalNews.com

O3 Essentials OraJuvenate™
A powerful, cleansing dental cream for maximum oral/dental health.
New Cancer Solutions
Over 3 hours of content covering today’s best cancer tests, how to kill cancer cells and the best diets and exercise routines.
Freeze-Dried 100% Organic Whole Corn
Our freeze-drying method preserves taste, texture and nutrients better than any other food preservation method ever invented.
Fenix TK35 Flashlight
Tough, waterproof, extremely bright and it’s touted to throw an 800+ lumen beam more than 1,000 feet into the night.
Inca Treasure Smoothie Pack
This pack of our four most popular superfoods from South America is the perfect combo pack for smoothie lovers.
Pink Himalayan Salt
This salt delivers significant levels of magnesium, zinc and selenium, with trace levels of dozens of other elements.
Pinhole Glasses - Aviator Style
Pinhole glasses are becoming famous for helping people improve their vision without the risks of laser surgery.
Oxy-Rich Facial Serum
O3 Essentials Jojoba Oxy-Rich Facial Serum is cellular nourishment for your skin. Helps smooth fine lines while enhancing tissue elasticity.
Freeze-Dried 100% Blackberry Halves
Our freeze-dried blackberry halves are grown in Serbia under strict organic standards.

Also on NaturalNews:

Health Ranger Videos
Activist music
CounterThink Cartoons
Food documentaries
FREE Special Reports
Podcasts
Colloidal Silver

Advertise with NaturalNews...

Support NaturalNews Sponsors:

Advertise with NaturalNews...

Most Popular Stories

Flu shot kills 19-year-old, but vaccine industry still has total immunity against lawsuits
Here's a nutty fact: Eating more tree nuts lowers the risk of all-cause death by up to 20 percent
Six important facts you're not being told about lost Malaysia Airlines Flight 370
Malaysia Airlines Flight 370 now clearly a government cover-up: All evidence contradicts official story
10 other companies that use the same Subway yoga mat chemical in their buns
BLM fracking racket exposed! Armed siege and cattle theft from Bundy ranch really about fracking leases
High-dose vitamin C injections shown to annihilate cancer
U.S. treating meat with ammonia, bleach and antibiotics to kill the '24-hour sickness'
USDA to allow U.S. to be overrun with contaminated chicken from China
Vaccine fraud exposed: Measles and mumps making a huge comeback because vaccines are designed to fail, say Merck virologists
Battle for humanity nearly lost: global food supply deliberately engineered to end life, not nourish it
Diet soda, aspartame linked to premature deaths in women

25 Amazing Facts About Food

This FREE downloadable report unveils a collection of astonishing and little-known facts about the food we eat very day. Click here to read it now...

 

Resveratrol and its Effects on Human Health and Longevity - Myth or Miracle.

Unlock the secrets of cellular health with the "miracle" nutrient Resveratrol Click here to read it now...

 

Nutrition Can Save America

FREE online report shows how we can save America through a nutrition health care revolution. "Eating healthy is patriotic!" Click here to read it now...

The Healing Power of Sunlight and Vitamin D

In this exclusive interview, Dr. Michael Holick reveals fascinating facts on how vitamin D is created and used in the human body to ward off chronic diseases like cancer, osteoporosis, mental disorders and more. Click here to read it now...

Vaccines: Get the Full Story

The International Medical Council on Vaccination has released, exclusively through NaturalNews.com, a groundbreaking document containing the signatures of physicians, brain surgeons and professors, all of which have signed on to a document stating that vaccines pose a significant risk of harm to the health of children. Click here to read it now...

Health Ranger Storable Organics

GMO-free, chemical-free foods and superfoods for long-term storage and preparedness. See selection at www.StorableOrganics.com



Recommended Resources On:

Natural News trends
Health Ranger news
Natural News GMOs
Mike Adams tracker
Natural News photos
Natural News Global
Natural News in focus
Natural News connect
Natural News shocking stories
Natural News radar
GMOs
Quackwatch
Vaccines
Health freedom
Dr. Paul Offit

This site is part of the Natural News Network © 2014 All Rights Reserved. Privacy | Terms All content posted on this site is commentary or opinion and is protected under Free Speech. Truth Publishing International, LTD. is not responsible for content written by contributing authors. The information on this site is provided for educational and entertainment purposes only. It is not intended as a substitute for professional advice of any kind. Truth Publishing assumes no responsibility for the use or misuse of this material. Your use of this website indicates your agreement to these terms and those published here. All trademarks, registered trademarks and servicemarks mentioned on this site are the property of their respective owners.

eTrust Pro Certified Android app on Google Play

Sign up for the FREE Natural News Email Newsletter

Receive breaking news on GMOs, vaccines, fluoride, radiation protection, natural cures, food safety alerts and interviews with the world's top experts on natural health and more.

Join over 7 million monthly readers of NaturalNews.com, the internet's No. 1 natural health news site. (Source: Alexa.com)

Your email address *

Please enter the code you see above*

No Thanks

Already have it and love it!

Natural News supports and helps fund these organizations:

* Required. Once you click submit, we will send you an email asking you to confirm your free registration. Your privacy is assured and your information is kept confidential. You may unsubscribe at anytime.