cancer

Breast Cancer Discovery: Vitamin A Derivative Normalizes Cell Growth

Sunday, August 23, 2009 by: S. L. Baker, features writer
Tags: vitamin A, health news, Natural News

eTrust Pro Certified

Delicious Pin It
(NaturalNews) What if a substance was found that normalizes out-of-control cell growth? The result could be a way to treat and prevent cancer. And a new study offers hope that discovery may have already been made. Scientists from the University of Chicago have just published groundbreaking research in the journal Cell which concludes a powerful compound exists that can restore a healthy balance to cell processes. It's not a new chemotherapy agent or drug but one derived from nature -- retinoic acid, a derivative of vitamin A.

According to the American Cancer Society, estrogen fuels the growth of two out of three breast cancers. The female hormone can spur on cancer by altering the expression of certain genes, resulting in breast cells that become malignant and proliferate. The University of Chicago study found that retinoic acid can also alter these same estrogen-sensitive genes. But instead of causing cells to grow without restraint, a hallmark of cancer, retinoic acid restored normal balance to the cells and inhibited their growth.

"This work reveals important insights on the interplay between vitamin A and estrogen action," said Myles Brown, MD, professor of medicine at Harvard Medical School and the Dana Farber Cancer Institute, in a statement to the media. "These insights will hopefully lead to new approaches for the prevention and treatment of the most common form of breast cancer."

Retinoic acid has already demonstrated cancer fighting effects in previous studies and it is currently used to treat a rare form of leukemia. In addition, earlier research has associated retinoic acid with the halting of breast cancer cell proliferation.

For the new study, Kevin White, PhD, professor of human genetics and director of the Institute for Genomics and System Biology at the University of Chicago, and colleagues focused on documenting cell receptors for the vitamin A derivative. They used a process dubbed ChIP-chip analysis that combines chromatin immunoprecipitation (ChIP), which locates where the retinoic acid receptors are bound to the genome, with micro-array gene-chip analysis, which measures the expression levels of specific genes.

This merging of techniques allowed the scientists to map out the complete genetic effects of retinoic acid and its receptors in a cell line provided by patients who had estrogen-fueled breast cancers. The results showed that 39 percent of the genomic regions bound by the estrogen receptor known as alpha overlapped with the estrogen receptors bound by retinoic acid.

What's more, they discovered that estrogen and retinoic acids receptors often competed to activate or repress many of the same genes. For example, estrogen increased expression of the same 139 genes that retinoic repressed and retinoic acid activated 185 genes that estrogen repressed. For approximately140 genes, estrogen and retinoic acid had the same effect.

So what does all this mean? As the scientists explained in their press statement, they now have evidence that estrogen and retinoic acid carry on a kind of "cross talk". So, although they can have opposite effects, certain estrogen and retinoic acid receptors on cells activate each other and normalize each other. That provides what the researchers call "an additional level of control for achieving a balanced regulation of expression."

The study also uncovered another way retinoic acid could help fight breast cancer. Some of the genes that are expressed in malignant breast tumors don't have estrogen receptors so anti-estrogen drugs can't be used as therapies. That makes so-called double or triple negative breast cancers extremely difficult to treat and, subsequently, they carry poor prognoses. However, in the new study, the researchers found these forms of cancerous cells did respond positively to the vitamin A derivative.

The new study may have produced a new way to help predict long-term survival for breast cancer patients, too. When the researchers compared the effects of retinoic acid on tissues from 295 breast cancer patients with the results from the scientists' initial study using a typical breast cancer cell line, they discovered that the more strongly a tumor responded to retinoic acid, the greater the chances of long-term survival and a lack of relapse.

"Understanding all the components of this process could be used against breast cancer in three ways," said Dr. White, in the media statement. "It suggests new ways to think about preventing the disease in those at high risk. It offers molecular tools that could provide a more precise diagnosis and predict outcomes. It could also be used to enhance current therapies, making existing drugs, such as tamoxifen, that selectively block estrogen's effects even more powerful, or even to develop new anti-cancer drugs."

As reported earlier in Natural News (http://www.naturalnews.com/025495_cancer_Vit...), researchers are also studying vitamin D to see what role it may play in fighting breast cancer. It appears to help protect against breast cancer by keeping normal cell growth in check.

For more information:
http://www.cancer.org/docroot/CRI/content/CR...
http://www.cancer.gov/cancertopics/understan...

Get breaking news alerts on GMOs, fluoride, superfoods, natural cures and more...
Join over four million monthly readers. Email privacy 100% protected. Unsubscribe at any time.


Have comments on this article? Post them here:

comments powered by Disqus

Take Action: Support NaturalNews.com

Email this article to a friend

Permalink to this article:

Reprinting this article: Non-commercial use OK, cite NaturalNews.com with clickable link.

Embed article link: (copy HTML code below):
Most Popular
Today | Week | Month | Year

See all Top Headlines...



GET SHOW DETAILS
+ a FREE GIFT

Now Available at ShopNaturalNews.com

O3 Essentials OraJuvenate™
A powerful, cleansing dental cream for maximum oral/dental health.
New Cancer Solutions
Over 3 hours of content covering today’s best cancer tests, how to kill cancer cells and the best diets and exercise routines.
Freeze-Dried 100% Organic Whole Corn
Our freeze-drying method preserves taste, texture and nutrients better than any other food preservation method ever invented.
Fenix TK35 Flashlight
Tough, waterproof, extremely bright and it’s touted to throw an 800+ lumen beam more than 1,000 feet into the night.
Inca Treasure Smoothie Pack
This pack of our four most popular superfoods from South America is the perfect combo pack for smoothie lovers.
Pink Himalayan Salt
This salt delivers significant levels of magnesium, zinc and selenium, with trace levels of dozens of other elements.
Pinhole Glasses - Aviator Style
Pinhole glasses are becoming famous for helping people improve their vision without the risks of laser surgery.
Oxy-Rich Facial Serum
O3 Essentials Jojoba Oxy-Rich Facial Serum is cellular nourishment for your skin. Helps smooth fine lines while enhancing tissue elasticity.
Freeze-Dried 100% Blackberry Halves
Our freeze-dried blackberry halves are grown in Serbia under strict organic standards.

Also on NaturalNews:

Health Ranger Videos
Activist music
CounterThink Cartoons
Food documentaries
FREE Special Reports
Podcasts
Colloidal Silver

Advertise with NaturalNews...

Support NaturalNews Sponsors:

Advertise with NaturalNews...

Most Popular Stories

Flu shot kills 19-year-old, but vaccine industry still has total immunity against lawsuits
Here's a nutty fact: Eating more tree nuts lowers the risk of all-cause death by up to 20 percent
Six important facts you're not being told about lost Malaysia Airlines Flight 370
Malaysia Airlines Flight 370 now clearly a government cover-up: All evidence contradicts official story
10 other companies that use the same Subway yoga mat chemical in their buns
BLM fracking racket exposed! Armed siege and cattle theft from Bundy ranch really about fracking leases
High-dose vitamin C injections shown to annihilate cancer
U.S. treating meat with ammonia, bleach and antibiotics to kill the '24-hour sickness'
USDA to allow U.S. to be overrun with contaminated chicken from China
Vaccine fraud exposed: Measles and mumps making a huge comeback because vaccines are designed to fail, say Merck virologists
Battle for humanity nearly lost: global food supply deliberately engineered to end life, not nourish it
Diet soda, aspartame linked to premature deaths in women

25 Amazing Facts About Food

This FREE downloadable report unveils a collection of astonishing and little-known facts about the food we eat very day. Click here to read it now...

 

Resveratrol and its Effects on Human Health and Longevity - Myth or Miracle.

Unlock the secrets of cellular health with the "miracle" nutrient Resveratrol Click here to read it now...

 

Nutrition Can Save America

FREE online report shows how we can save America through a nutrition health care revolution. "Eating healthy is patriotic!" Click here to read it now...

The Healing Power of Sunlight and Vitamin D

In this exclusive interview, Dr. Michael Holick reveals fascinating facts on how vitamin D is created and used in the human body to ward off chronic diseases like cancer, osteoporosis, mental disorders and more. Click here to read it now...

Vaccines: Get the Full Story

The International Medical Council on Vaccination has released, exclusively through NaturalNews.com, a groundbreaking document containing the signatures of physicians, brain surgeons and professors, all of which have signed on to a document stating that vaccines pose a significant risk of harm to the health of children. Click here to read it now...

Health Ranger Storable Organics

GMO-free, chemical-free foods and superfoods for long-term storage and preparedness. See selection at www.StorableOrganics.com



Recommended Resources On:

Natural News trends
Health Ranger news
Natural News GMOs
Mike Adams tracker
Natural News photos
Natural News Global
Natural News in focus
Natural News connect
Natural News shocking stories
Natural News radar
GMOs
Quackwatch
Vaccines
Health freedom
Dr. Paul Offit

This site is part of the Natural News Network © 2014 All Rights Reserved. Privacy | Terms All content posted on this site is commentary or opinion and is protected under Free Speech. Truth Publishing International, LTD. is not responsible for content written by contributing authors. The information on this site is provided for educational and entertainment purposes only. It is not intended as a substitute for professional advice of any kind. Truth Publishing assumes no responsibility for the use or misuse of this material. Your use of this website indicates your agreement to these terms and those published here. All trademarks, registered trademarks and servicemarks mentioned on this site are the property of their respective owners.

eTrust Pro Certified Android app on Google Play

Sign up for the FREE Natural News Email Newsletter

Receive breaking news on GMOs, vaccines, fluoride, radiation protection, natural cures, food safety alerts and interviews with the world's top experts on natural health and more.

Join over 7 million monthly readers of NaturalNews.com, the internet's No. 1 natural health news site. (Source: Alexa.com)

Your email address *

Please enter the code you see above*

No Thanks

Already have it and love it!

Natural News supports and helps fund these organizations:

* Required. Once you click submit, we will send you an email asking you to confirm your free registration. Your privacy is assured and your information is kept confidential. You may unsubscribe at anytime.