Linnea Launches an Industry First: HMRlignan(TM) – the Richest Source of Plant Lignans and Direct Enterolactone Precursor (press release)

Friday, August 26, 2005
by Mike Adams, the Health Ranger
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Linnea SA announced today the launch of an innovative lignan compound, HMRlignan™, a patented product developed in Finland by Hormos Medical Corporation, and manufactured and marketed worldwide under license by Linnea, Switzerland. Linnea SA is a specialist manufacturer of botanical extracts and phytochemicals for the pharmaceutical, dietary supplement and cosmetic industries.

HMRlignan™ is a breakthrough, in lignan research representing years of research to achieve an efficient dose response in lignan pharmacology to encouraging the body’s natural production of enterolactone as a direct precursor. Enterolactone is the human metabolite of plant lignans normally present in low concentrations as part of a healthy diet. Lignans were once common in the diet in grains and whole foods but nowadays are often removed from foods by over processing and mass production of foods. Epidemiological evidence relates low plasma enterolactone levels with increased risks of the development of cardiovascular disease and hormonally regulated cancers, especially breast cancer and prostate cancer.

There has been a steady growth of interest in the health benefits of lignans, such as flax, driven by the increasing pool of scientific knowledge in this area including compelling evidence from population studies and pharmacological research. Lignans are a major growth area in consumer interest and also a significant area sales growth in the dietary supplement industry.

“HMRlignan™ is a true dietary supplement offering a standardized and efficient method of replacing lost lignans in the diet,” said Michael Granville, President of Linnea SA. “We saw HMRlignan™ as a way of building on the health benefits of lignans by providing an ingredient that overcame the problems of dosing lignans such as flax lignans. HMRlignan™, a new generation low-dose, highly bioavailable lignan supplement, provides a more digestible alternative.”

Derived from the Norway spruce (Picea abies), HMRlignan™ will give formulators significant advantage in price, dosage and bioavailability compared with other lignan sources. As HMRlignan™ is not in a food matrix, it is characterized by a superior and proven pharmacokinetic and bioavailability. Other lignans, such as flax, are glycosides or diglycosides - bound to sugar molecules that must first be cleaved in the body before they can be metabolized into the target molecule enterolactone. HMRlignan™ is a pure lignan in the aglycone form (not bound to sugars) and upon arrival in a healthy intestinal tract, is more efficiently transformed into enterolactone – HMRlignan™ is the first direct enterolactone precursor dietary supplement. Once ingested, HMRlignan™ travels to the intestine, where a healthy environment of beneficial bacteria immediately go to work to transform it into enterolactone, the desired compound that is protective in human health.

Finland is a center of excellence for the study of phytoestrogens and it was researchers at the University of Helsinki who made the link between the research chemistry and the potential human health benefits of the wood derived lignan 7-hydroxymatairesinol (HMRlignan™) and its metabolism to the protective weak phyto-hormone and lower incidences of breast and prostate cancers and cardiovascular disease. This led to the partnership between Hormos Medical Corporation of Turku, Finland, and Linnea, Switzerland, and the success in bringing HMRlignan™ from the academic arena to the consumer.

Lignans have a soft phyto-hormonal activity. As HMRlignan™ converts directly into enterolactone, it is the enterolactone that binds weakly to estrogen receptors. Says Lauri Kangas, Ph.D., Senior Scientific Advisor at Hormos Medical Corporation, “diet selection and over-processing of foods has reduced daily lignan intake in U.S. women below established levels to maintain a protective soft phyto-hormonal activity and this is reflected in increased risks of major disease related to women’s health – breast cancer, cardiovascular disease, osteoporosis and menopausal symptoms.”

In addition, HMRlignan™ is also a natural source in antioxidants, comparable to that of vitamin E, adding further protective benefit. Its ability to assist the body in directly producing higher levels of enterolactone coupled with the antioxidant activity make it an attractive compound for gender-specific formulas geared to post-menopausal women and middle-aged men and formulas targeted for cardiovascular health.

Studies have demonstrated that a mere 10 to 30 mg daily of HMRlignan™ in a single dosage is sufficient to elevate blood enterolactone to a protective level. “Compare one easy-to-swallow tablet or capsule to heaps of flax powder or spoonfuls of flax oil, or even handfuls of sesame seeds – every day,” Granville added. “And, by saving on dosage, manufacturers also realize great economic advantage.”

As a novel lignan source, the developers undertook extensive safety testing according to pharmaceutical GCP (Good Clinical Practice). In May 2004, New Dietary Ingredient (NDI) clearance from the FDA was obtained for the ingredient, allowing HMRlignan™, containing dietary supplements, to be marketed in the United States.

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Linnea Launches an Industry First: HMRlignan(TM) – the Richest Source of Plant Lignans and Direct Enterolactone Precursor (press release)

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About the author:Mike Adams (aka the "Health Ranger") is the founding editor of, the internet's No. 1 natural health news website, now reaching 7 million unique readers a month.

In late 2013, Adams launched the Natural News Forensic Food Lab, where he conducts atomic spectroscopy research into food contaminants using high-end ICP-MS instrumentation. With this research, Adams has made numerous food safety breakthroughs such as revealing rice protein products imported from Asia to be contaminated with toxic heavy metals like lead, cadmium and tungsten. Adams was the first food science researcher to document high levels of tungsten in superfoods. He also discovered over 11 ppm lead in imported mangosteen powder, and led an industry-wide voluntary agreement to limit heavy metals in rice protein products to low levels by July 1, 2015.

In addition to his lab work, Adams is also the (non-paid) executive director of the non-profit Consumer Wellness Center (CWC), an organization that redirects 100% of its donations receipts to grant programs that teach children and women how to grow their own food or vastly improve their nutrition. Click here to see some of the CWC success stories.

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Adams is well known for his incredibly popular consumer activism video blowing the lid on fake blueberries used throughout the food supply. He has also exposed "strange fibers" found in Chicken McNuggets, fake academic credentials of so-called health "gurus," dangerous "detox" products imported as battery acid and sold for oral consumption, fake acai berry scams, the California raw milk raids, the vaccine research fraud revealed by industry whistleblowers and many other topics.

Adams has also helped defend the rights of home gardeners and protect the medical freedom rights of parents. Adams is widely recognized to have made a remarkable global impact on issues like GMOs, vaccines, nutrition therapies, human consciousness.

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