Originally published November 27 2005
Children of type 2 diabetics are at risk of defective insulin, study says
by Mike Adams, the Health Ranger, NaturalNews Editor
The Journal of Clinical Investigation has published a study from Yale that demonstrates the children of type 2 diabetics have reduced mitochondrial function, which can lead to defective insulin action in the body.
In a paper appearing online on November 10 in advance of print publication of the December issue of the Journal of Clinical Investigation, Gerald Shulman and colleagues from Yale University take muscle biopsies from these offspring and show that they have reduced mitochondrial content as assessed by electron microscopy.
The subjects also have lower insulin-stimulated muscle glucose uptake and increased lipid content in muscle cells.
However in contrast to two recent studies, the authors did not find any alterations in PGC-1a or PGC-1b or other downstream regulators of mitochondrial gene expression.
These results provide new insights into the earliest defects that may be responsible for the pathogenesis of type 2 diabetes.
Moreover, reduced mitochondrial content could result in reduced mitochondrial function, which predisposes the offspring of type, 2 diabetic parents to muscle cell lipid accumulation, which then leads to defective insulin signaling and action.
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