Originally published November 7 2005
Buffalo researchers discover link between fatty liver and hypertension
by Mike Adams, the Health Ranger, NaturalNews Editor
Researchers at the University at Buffalo have found that a fatty liver can put you at increased risk of hypertension, revamping earlier theories that linked hypertension with alcohol consumption.
The study, conducted by researchers at the University at Buffalo, appears in the current issue (November 2005) of the journal Hypertension.
"Our findings extend previous work, and indicate that the association of the liver enzyme GGT with hypertension risk is strongly affected by variation in weight and, above all, body fat distribution," said lead author Saverio Stranges, Ph.D., assistant professor of social and preventive medicine in the UB School of Public Health and Health Professions.
"Specifically, we found that GGT was a significant predictor of hypertension only among overweight participants with increased central body fat.
"If we consider that fatty liver is the most common cause of liver injury in the United States, these findings may have both important clinical and public health implications," said Stranges.
Alcohol consumption initially was thought to be the link between liver enzymes and high blood pressure for several reasons: Alcoholism is a known risk factor for hypertension; the liver enzyme GGT is a marker for alcohol consumption, and GGT also has been associated with hypertension.
In addition, chronic liver disease, in which GGT levels can be increased, often is associated with heavy alcohol consumption or actual alcoholism.
However, this study showed that the accumulation of fat in the liver, or "fatty liver" (in this case non-alcoholic fatty liver) in study participants with increased central body fat may be the important underlying mechanism linking GGT and hypertension.
A number of measures were taken at baseline, including GGT, blood pressure, weight, abdominal height and size of waistline.
Stranges said these findings suggest that fatty liver should be considered part of the metabolic syndrome, a cluster of conditions physicians use to help assess a patient's risk for cardiovascular disease.
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