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Originally published October 17 2005

Canadian research suggests cannabis acts as an antidepressant

by Mike Adams, the Health Ranger, NaturalNews Editor

Researchers from Canada's University of Saskatchewan have found that chemical compounds in marijuana help to regenerate nerve cells.



The Journal of Clinical Investigation study showed rats given a cannabinoid were less anxious and less depressed. But UK experts warned other conflicting research had linked cannabis, and other cannabinoids, to an increased risk of depression and anxiety. The hippocampus has been shown to generate new nerve cells throughout a person's or an animal's life, but this ability is reduced if cells are engineered to lack a cannabinoid receptor protein called CB-1. In the Canadian study, rats given the cannabinoid were also found to be less anxious, and more willing to eat food in new environments - a change which would normally frighten them. However, research has previously linked use of the drug cannabis to long-term damage to mental health, and to increase the risk of mental illness in those who are already genetically susceptible. In addition, short-term high doses of cannabinoids had also been shown to produce anxiety-like effects in rats and depression-like effects in mice. The Canadian team said: "These complicated effects of high and low doses of acute and chronic exposure to cannabinoids may explain the seemingly conflicting results observed in clinical studies regarding the effects of cannabinoid on anxiety and depression." Professor Robin Murray, of the Institute of Psychiatry, questioned whether the anti-anxiety and antidepressant effects seen in the animals would be replicated in humans. Paul Corry, Director of campaigns and communication at Rethink said: "Cannabinoids are an exciting new area for medical research, but it is important to recognise that there are over 60 active ingredients in cannabis - synthetic cannabinoid may be showing evidence of nerve regeneration. "For most people with severe mental illness, raw cannabis remains a risky substance. "All medical research needs to be checked before it would make a difference to the hundreds of thousands of people living with severe mental illness in the UK."


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