Originally published February 23 2005
Seroquel makes dementia symptoms worse in Alzheimer’s patients, study finds
by Mike Adams, the Health Ranger, NaturalNews Editor
An antipsychotic drug prescribed for almost half of all Alzheimer’s patients in Britain can actually worsen symptoms of the disease, according to a study conducted by the Institute of Psychiatry. Seroquel was designed to treat aggression and dementia in schizophrenics, but has been heavily prescribed for Alzheimer’s patients after other drugs were found to increase the risk of stroke and pulled off the market.
An antipsychotic drug frequently given to Alzheimer's patients actually worsens their illness, researchers say.
Patients given AstraZeneca Seroquel had a marked deterioration of memory and other higher brain functions compared to those on placebo, according to Professor Clive Ballard of the Institute of Psychiatry and colleagues.
AstraZeneca, Europe's third largest drugmaker, disputed the findings.
Drugs such as Seroquel, which was originally developed to tackle schizophrenia, are increasingly used to treat the personality changes and aggression often associated with Alzheimer's disease.
They are not approved by regulators for dementia but are often prescribed by doctors on an "off-label" basis for patients who develop serious behavioural problems.
In one form or another, antipsychotics are used in up to 45 percent of British nursing homes, experts estimate.
"It's a big potential threat to patient health," Ballard told Reuters on Friday.
There have been concerns that the two most commonly used antipyschotics, Eli Lilly and Co's Zyprexa and Johnson & Johnson's Risperdal, may increase the risk of stroke -- something British healthcare regulators warned about last year.
His team studied 93 patients with dementia in the northeast of England over six months and found those taking Seroquel experienced a doubling in cognitive decline compared with patients given a dummy pill.
Those taking another antipyschotic in the trial, Novartis AG's Exelon, showed no worsening of their illness -- but no improvement above the placebo group.
Seroquel -- sales of which jumped 33 percent last year to $2 billion (1.1 billion pounds) -- is a key revenue driver for Europe's third largest drugmaker, especially following a series of setbacks with newer drugs.
The company has been investigating expanding Seroquel's use into Alzheimer's, following tests suggesting it reduced agitation in dementia patients without risk of cerebrovascular problems.
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