Ray D. Strand See book keywords and concepts | Also, the fact that the Finnish Study used dl-alpha-tocopherol, synthetic vitamin e, concerns me. Other studies have shown this synthetic vitamin e to cause problems rather than reduce them.31 Instead, most studies reported in the medical literature use d-alpha-tocopherol, which is a natural vitamin E.
I have already shared my concern that most studies are done with just one or two antioxidants, with researchers looking for the "magic bullet. | Dr. Steve Blake See book keywords and concepts | Natural vitamin E in supplements is designated by a d as in d-alpha-tocopherol. synthetic vitamin e is designated with a dl as in dl-alpha-tocopherol. The newer and more accurate designations differentiate between R for natural and S for synthetic. As seen in Figure 5-7, the synthetic forms are different from the natural forms. There are eight possible isomers: RRR (natural), SRR, SSR, SRS, SSS, RSR, RRS, and RSS. synthetic vitamin e is a mix of eight isomers, of which only one is natural. Half of the synthetic forms (SRR, SSR, SRS, and SSS) do not function as vitamin E in the body at all. | Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D. See book keywords and concepts | However, other recent double-blind trials have found either limited benefit,117 or no benefit at all from supplementation with synthetic vitamin e.118 One of the negative trials used 400 IU of natural vitamin E119—a similar amount and form to previous successful trials. In attempting to make sense of these inconsistent findings the following is clear: less than 400 IU of synthetic vitamin e, even when taken for years, does not protect against heart disease. Whether 400 to 800 IU of natural vitamin E is or is not protective remains unclear. | Jack Challem See book keywords and concepts | To distinguish natural from synthetic vitamin e, you have to read the fine print on the label: "d-alpha . . ." refers to natural, and "dl-alpha ..." refers to synthetic vitamin e. These two molecules are different. The natural form is absorbed twice as well in blood and tissues compared with the synthetic form, so do not buy synthetic vitamin e or any product where the source is ambiguous. | Dr. Steve Blake See book keywords and concepts | Natural alpha-tocopherol is RRR alpha-tocopherol
Position 8 = R Position 4 = R
Position 2 = R
One of the forms of synthetic vitamin E: SRR alpha-tocopherol
H3C
Position 2 = S
Position 4 = R
Position 8 = R Figure 5-7 Natural and synthetic alpha-tocopherol.
VITAMIN E POTENCY
There are two ways of stating the potency of vitamin E, in International Units (IU) and in milligrams (mg). The acetate form of synthetic alpha-tocopherol was arbitrarily chosen to have one IU per mg. Natural RRR-alpha-tocopherol has a biological activity of at least 1.49 IU per mg. | | There are eight possible isomers: RRR (natural), SRR, SSR, SRS, SSS, RSR, RRS, and RSS. synthetic vitamin e is a mix of eight isomers, of which only one is natural. Half of the synthetic forms (SRR, SSR, SRS, and SSS) do not function as vitamin E in the body at all.
The correct, current way to describe natural alpha-tocopherol is RRR-alpha-tocopherol. When vitamin E is synthesized, all eight isomers are made and the result is called "racemic," as in all-rac-alpha-tocopherol. This synthetic mix is the most common form used in medical studies. | Ray D. Strand See book keywords and concepts | Other studies have shown this synthetic vitamin e to cause problems rather than reduce them.31 Instead, most studies reported in the medical literature use d-alpha-tocopherol, which is a natural vitamin E.
I have already shared my concern that most studies are done with just one or two antioxidants, with researchers looking for the "magic bullet." But an understanding of oxidative stress and how it can damage the body forces us to realize that a one- or two-nutrient approach is like trying to bring down a locomotive with a rifle. | Mike Adams, the Health Ranger See article keywords and concepts | Every single study over the past two decades that has sought to discredit Vitamin E, for example, focused on using synthetic vitamin e in order to show harm. It is curious that no researcher from the world of conventional medicine will ever test the natural, full-spectrum vitamins, nutrients and phytochemicals that appear in nature. You know why? Because they would discover a universe of natural medicine that makes patented prescription drugs obsolete.
A second way to fake a vitamin meta-data study is to simply cherry-pick the results you want to include in your meta-data analysis. | Thomson Healthcare, Inc. See book keywords and concepts | Several forms of vitamin E exist: Alpha-tocopherol (Farrell & Roberts, 1994); d-alpha tocopherol (also termed RRR-alpha tocopherol) is an unesterified natural product derived from soybean oil; d-alpha tocopheryl (acetate or succinate) is an esterified form of the natural product; dl-alpha tocopheryl (acetate or succinate) is an esterified form of synthetic vitamin e (also termed all-rac-alpha tocopherol). Mixed tocopherols is a mixture of unesterified natural isomers including alpha, beta, delta, and gamma tocopherol. | Elaine Magee See book keywords and concepts | Natural E is more likely to contribute E compounds other than alpha-tocopherol, such as gamma-tocopherol, and when equivalent amounts are compared, synthetic vitamin e is half as effective as natural. Some experts suggest not exceeding 200 IU of all-natural, mixed-tocopherol vitamin E. No study has found doses this low to be harmful.
12 Smart Ways to Get Your Three Bs!
After looking at "B Vitamins: How Much Do I Need Each Day?", your head is probably swimming with a veritable banquet of assorted food sources but no idea of how to put them together into a meal or dish. No worries. | Mike Adams, the Health Ranger See article keywords and concepts | Avoid synthetic vitamin e supplements, as they have been shown to actually harm health. Only consume natural vitamin E from a reputable source such as the Life Extension Foundation (www.LEF.org)
Vitamin A promotes proper repair and maintenance of the skin, and deficiencies can result in a dry, flaky complexion. Topical vitamin A treatments are often used to treat acne and other skin ailments. Foods high in vitamin A include liver, chili peppers, dandelion, carrots, apricots, collard greens, kale, sweet potatoes, spinach, and cantaloupe. | Phyllis A. Balch, CNC See book keywords and concepts | Also, natural sources of vitamin E are better than synthetic vitamin e because natural vitamin E is more available for use by the body than the synthetic form. synthetic vitamin e is only 67 percent as active as the natural form. Read labels closely. The natural form of vitamin E is listed as d-alpha-tocopherol, rrr-alpha-to-copherol, d-alpha-tocopherol acetate or d-alpha-tocopherol succinate. The synthetic form is listed as dl-alpha-tocopherol or all-rac alpha-tocopherol (watch out for the / after the d). | Gary Null See book keywords and concepts | If you still believe that natural and synthetic vitamin e are the same creature, try comparing the two under a microscope. Both are composed of the same hydrogen, carbon, and oxygen atoms. But the molecules of natural vitamin E are of different shapes, while those of synthetic vitamin e are of exactly the same shape and dimension.
The difference is this: nature's own vitamin E contains variety, like nature itself. synthetic vitamin e looks machine-made, which it is. Nature's design, as in so many other cases, is a hard one on which to improve. | Mike Adams, the Health Ranger See article keywords and concepts | Naturally, I'm taking natural vitamin E supplements and not synthetic vitamin e.
Most medical research projects don't actually study healthy people. They give synthetic vitamin e and other chemicals to heavily diseased people who are typically suffering from advanced-stage cardiovascular disorders, and then they take the results from those distorted studies and announce to the whole world that "vitamin E will kill you! | Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D. See book keywords and concepts | In attempting to make sense of these apparently inconsistent findings, the following is clear: less than 400 IU of synthetic vitamin e, even when taken for years, does not protect against heart disease. Whethet 400 to 800 IU of natural vitamin E is, or is not, protective remains unclear.
Vitamin E also plays some role in the body's ability to process glucose. Some, but not all, trials suggest that vitamin E supplementation may eventually prove to be helpful in the prevention and treatment of diabetes (page 152). | Phyllis A. Balch, CNC See book keywords and concepts | Some vitamin manufacturers have been known to mix 10 percent natural and 90 percent synthetic vitamin e, then label the product natural. Your responsibility is to check the label and make sure it says 100 percent potency or 200 percent natural vitamin E.
If you cannot absorb fat, there is a special water-soluble form of vitamin E available from various suppliers.
What about the "esterified" vitamin E, otherwise known as tocopherol phosphate? This is a relatively new product that is being sold as vitamin E. | Mike Adams, the Health Ranger See article keywords and concepts | In fact, this synthetic vitamin e has the opposite molecular structure of natural vitamin E. Yet researchers, scientists and journalists in the mainstream press continue to call this synthetic chemical "vitamin E" and thereby are scaring potentially millions of people away from taking nutritional supplements that are very beneficial to their health.
Most of the debate on this issue, in fact, has been about the dosage of vitamin E that would be considered safe for public consumption. There has been no discussion about the difference between natural vitamin E and synthetic vitamin e. | Phyllis A. Balch, CNC See book keywords and concepts | Synthetic vitamin E is only 67 percent as active as the natural form. Read labels closely. The natural form of vitamin E is listed as d-alpha-tocopherol, rrr-alpha-to-copherol, d-alpha-tocopherol acetate or d-alpha-tocopherol succinate. The synthetic form is listed as dl-alpha-tocopherol or all-rac alpha-tocopherol (watch out for the / after the d). The synthetic form costs only about half as much as the natural form, but it has significantly less activity, or potency. | Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D. See book keywords and concepts | Natural vitamin E may be as much as twice as bioavailable as synthetic vitamin e, not 1.36 times as is generally accepted.17 Many doctors advise people to use only the natural, the "d" form, of vitamin E.
After the "d" or "dl" designation, often the Greek letter "alpha" appears, which also describes the structure. Synthetic "dl" vitamin E is found only in the alpha form—as in "dl-alpha tocopherol." Natural vitamin E may be found either as alpha—as in "d-alpha tocopherol"—or in combination with beta, gamma, and delta, labeled "mixed"—as in mixed natural tocopherols. | | The National Academy of Sciences has established the daily tolerable upper intake level for adults to be 1,000 mg of vitamin E, which is equivalent to 1,500 IU of natural vitamin E or 1,100 IU of synthetic vitamin e.24
In a double-blind study of healthy elderly people, supplementation with 200 IU of vitamin E per day for 15 months had no effect in the incidence of respiratory infections, but increased the severity of those infections that did occur.25 For elderly individuals, the risks and benefits of taking this vitamin should be assessed with the help of a doctor or nutritionist. | Mike Adams, the Health Ranger See article keywords and concepts | Some vitamin E haters rounded up a bunch of people dying from advanced stage heart disease, then they gave them synthetic vitamin e (i.e. a non-natural chemical) in very low doses. When the people started dying off from their heart disease, the researchers put the blame squarely on vitamin E. Hence the bizarre news headlines in late 2004 proclaiming, "Vitamin E will kill you!" It's all nonsense. The people were dying of heart disease in the first place, and the statistics were not adequately adjusted to take expected mortality rates into account. | Mike Adams, the Health Ranger See article keywords and concepts | They can use synthetic vitamin e, they can disqualify anyone who is healthy, or they can do tests on people who are about to die. These are all things that have happened.
Barron: Yes. Many things are done to discredit alternative health. There's one other big thing that I think is worth mentioning. Invariably, alternative health works best when people do it as part of a protocol. Rarely are people told to just take one herb, like echinacea. It's usually part of a formula just like I'm recommending, along with the antipathogens. | Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D. See book keywords and concepts | In a double-blind trial, supplementation with 200 IU of synthetic vitamin e (page 609) pet day was found to reduce several risk factors for kidney stone formation in people with elevated levels of urinary oxalate.89
Are there any side effects or interactions?
Refer to the individual supplement for information about any side effects or interactions.
Herbs that may be helpful
Two trials from Thailand reported that eating pumpkin seeds (page 733) reduces urinary risk factors for forming kidney stones. | James F. Balch, M.D. and Mark Stengler, N.D. See book keywords and concepts | E has been shown to have significantly greater bioavailability than synthetic vitamin e. Make sure to look for natural forms of vitamin E, listed as d-alpha-tocopherol, as opposed to synthetic, which is listed as dl-alpha-tocopherol.
Vitamin D (Vitamin D2-Ergocalciferol, Vitamin D3-Cholecacliferol)
D2—derived from plant sources
D3—derived from animal sources
Function: It promotes calcium and phosphorous absorption from intestines, increases calcium deposition into bones, mobilizes calcium and phosphorous from bones. It prevents certain cancers and is required for proper thyroid function. | Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D. See book keywords and concepts | In attempting to make sense of these inconsistent findings the following is clear: less than 400 IU of synthetic vitamin e, even when taken for years, does not protect against heart disease. Whether 400 to 800 IU of natural vitamin E is or is not protective remains unclear.
In one study, intravenous injections of N-acetyl cysteine (page 562) (NAC) decreased the amount of tissue damage in people who had suffered a heart attack.120 Whether oral NAC would have the same effect is unknown. | Jack Challem See book keywords and concepts | The natural form is absorbed twice as well in blood and tissues compared with the synthetic form, so do not buy synthetic vitamin e or any product where the source is ambiguous.
Good choices are d-alpha tocopheryl acetate, d-alpha tocopheryl suecinate, d-alpha tocopherol with other mixed natural tocopherols, which would include a little beta and gamma tocopherol, or a mix of natural vitamin E tocopherols and tocotrienols. The mixed tocopherols most closely resemble how the vitamin occurs in nature, and at least gamma tocopherol may provide additional anti-inflammatory properties. | Gary Null See book keywords and concepts | But the molecules of natural vitamin E are of different shapes, while those of synthetic vitamin e are of exactly the same shape and dimension.
The difference is this: nature's own vitamin E contains variety, like nature itself. synthetic vitamin e looks machine-made, which it is. Nature's design, as in so many other cases, is a hard one on which to improve. If you had to choose between a vegetable grown in earth and one grown in a factory, which would you choose? The answer is obvious. Why cheat yourself when choosing a vitamin supplement? | Jack Challem See book keywords and concepts | E. These two molecules are different. The natural form is absorbed twice as well in blood and tissues compared with the synthetic form, so do not buy synthetic vitamin e or any product where the source is ambiguous.
Good choices are d-alpha tocopheryl acetate, d-alpha tocopheryl suecinate, d-alpha tocopherol with other mixed natural tocopherols, which would include a little beta and gamma tocopherol, or a mix of natural vitamin E tocopherols and tocotrienols. | Mike Adams, the Health Ranger See article keywords and concepts | They give synthetic vitamin e and other chemicals to heavily diseased people who are typically suffering from advanced-stage cardiovascular disorders, and then they take the results from those distorted studies and announce to the whole world that "vitamin E will kill you!" Maybe synthetic chemicals will kill people who are already approaching death, but that doesn't say anything about the health benefits of macadamia nuts, cashews, peanuts or other natural sources of vitamin E. | Patrick Holford See book keywords and concepts | Natural d-alpha tocopherol succinate is 36 percent more potent than the synthetic vitamin e called dl-alpha tocopherol (in this case the "1" dictates the chemical difference). So natural vitamin E, usually derived from wheat germ or soybean oil, is better.
However, synthetic vitamin C (ascorbic acid) has the same biological potency as the natural substance, according to Dr. Linus Pauling, although advanced scientific techniques have shown visible differences between the two. No one has yet shown that natural vitamin C is more potent or more beneficial to take. |
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