Bottom Line Health
See book keywords and concepts | | Broccoli and tomatoes: Broccoli contains sulforaphane; tomatoes contain lycopene. Eaten together, they maximize each other's ability to fight cancer.
Soy and tea (black or green): A diet high in soy and tea can lower the risk of prostate and breast cancers.
Selenium and sulforaphane: When combined, these can have a significant effect on the genes that control cancer development. Selenium can be found in poultry, tuna, eggs and sunflower seeds. sulforaphane can be found in broccoli, cabbage and watercress.
Andrew L. |
Ann M. Coulston and Carol J. Boushey
See book keywords and concepts |  Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects. Exp. Biol. Med. 232, 227-234.
265. Gamet-Payrastre, L., Li, P., Lumeau, S., et al. (2000). sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. Cancer Res. 60, 1426-1433.
266. Jackson, S. J., Singletary, K. W., and Venema, RC. (2007). sulforaphane suppresses angiogenesis and disrupts endothelial mitotic progression and microtubule polymerization. Vase. Pharmacol. 46, 77-84.
267. Hosono, T., Fukao, T., Ogihara, J. |
Elaine Magee
See book keywords and concepts |  Laboratory studies show that sulforaphane may also block an enzyme that triggers inflammation and joint pain. This is great news for those who suffer from arthritis or give their bones and joints a beating by running on hard surfaces or playing contact sports. Prolonged pressure on the joints can suppress the function of helpful phase two enzymes, but sulforaphane may regenerate and reenergize these wonderful enzymes. Your knees and elbows will thank you for eating broccoli! |
Ann M. Coulston and Carol J. Boushey
See book keywords and concepts | | Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. Cancer Res. 60, 1426-1433.
266. Jackson, S. J., Singletary, K. W., and Venema, RC. (2007). sulforaphane suppresses angiogenesis and disrupts endothelial mitotic progression and microtubule polymerization. Vase. Pharmacol. 46, 77-84.
267. Hosono, T., Fukao, T., Ogihara, J., et al. (2005). Diallyl trisulfide suppresses the proliferation and induces apoptosis of human colon cancer cells through oxidative modification of beta-tubulin. J. Biol. Chem. 280, 41487-41493.
268. |
Elaine Magee
See book keywords and concepts | | Researchers theorize that sulforaphane, which is abundant in broccoli, may combat heart disease and perhaps stomach ulcers by inhibiting the presence of Helicobacter pylori (H. pylori) infection. Broccoli does indeed contain two phytochemicals thought to help eye health, lutein and zeaxanthin, and fend off macular degeneration (an age-related eye disease).
Broccoli may help reduce inflammation and joint pain. Laboratory studies show that sulforaphane may also block an enzyme that triggers inflammation and joint pain. |
Bottom Line Health
See book keywords and concepts | | Selenium and sulforaphane: When combined, these can have a significant effect on the genes that control cancer development. Selenium can be found in poultry, tuna, eggs and sunflower seeds. sulforaphane can be found in broccoli, cabbage and watercress.
Andrew L. Rubman, ND, medical director, Southbury Clinic for Traditional Medicines, Southbury, CT.
Relax! We Debunk the 7 Biggest Cancer Myths
Gregory Pennock, MD, medical director, clinical research, M.D. Anderson Cancer Center, Orlando, FL. www. mdandersonorlando. org. |
David W. Grotto, RD, LDN
See book keywords and concepts |  Cauliflower contains a phytochemical called sulforaphane, which helps the liver produce enzymes that block cancer-causing chemicals from damaging the body.
Home Remedies
Biotin, a water-soluble vitamin found in cauliflower, has been shown to control dandruff. Biotin also helps thicken nails and reduce splitting and cracking. Munching of crunchy foods such as cauliflower before bed may help stop jaw-clenching while sleeping.
Throw Me a Lifesaver! |
Bottom Line Health
See book keywords and concepts | | Selenium can be found in poultry, tuna, eggs and sunflower seeds. sulforaphane can be found in broccoli, cabbage and watercress.
Andrew L. Rubman, ND, medical director, Southbury Clinic for Traditional Medicines, Southbury, CT.
Relax! We Debunk the 7 Biggest Cancer Myths
Gregory Pennock, MD, medical director, clinical research, M.D. Anderson Cancer Center, Orlando, FL. www. mdandersonorlando. org.
Despite all of the medical information in the media, many people are still misinformed about the realities of cancer. These misconceptions can prevent people from getting appropriate treatment. |
by Michael Murray, N.D. and Joseph Pizzorno, N.D.
See book keywords and concepts | | Compounds in broccoli known as glucosinolates, specifically indole-3-carbinol and sulforaphane, increase the excretion of the form of estrogen (2-hydroxyestrone) linked to breast cancer.
Sulforaphane was first identified in broccoli sprouts grown in plastic laboratory dishes by scientists at the Johns Hopkins University School of Medicine in Baltimore, Maryland. |
David W. Grotto, RD, LDN
See book keywords and concepts | | Myzak MC, Hardin K, Wang R, Dashwood RH, Ho E. sulforaphane inhibits his-tone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells. Carcinogenesis. 2006 Apr;27(4):811-819.
Tadi K, Chang Y, Ashok B, Chen Y, Moscatello A, Schaefer SD, Schantz SP, Policastro AJ, Geliebter J, Tiwari RK. 3,3'-Diindolylmethane, a cruciferous vegetable derived synthetic anti-proliferative compound in thyroid disease. Biochem Biophys Res Commun. 2005 Nov 25;337(3):1019-1025.
Takai M, Suido H, Tanaka T, Kotani M, Fujita A, Takeuchi A, Makino T, Sumikawa K, Origasa H, Tsuji K, Nakashima M. | | ULCERS: sulforaphane in broccoli may prevent the growth of H. pylori bacteria, often attributed to causing stomach ulcers and other ailments. Even strains of bacteria that have been found resistant to antibiotics were effectively reduced in the presence of broccoli.
Tips on Using Broccoli
SELECTION AND STORAGE:
• Look for firm stalks and compact heads that are dark green in color.
• Place unwashed broccoli in an open bag in the refrigerator or in the crisper drawer.
• For best taste, use the broccoli within one to two days of buying. |
John J. Ratey, MD
See book keywords and concepts |  For example, in broccoli, there's a chemical called sulforaphane, and it clearly activates stress response pathways in cells that upregulate antioxidant enzymes. Broccoli has antioxidants, but at the level you could get from your diet, they're not going to function as antioxidants."
Just as with the nuclear shipyard workers, a mild toxin generates an adaptive stress response that bolsters cells. It's the same process generated by dietary restriction and exercise. |
Patrick Holford
See book keywords and concepts |  Originally, it was discovered to reduce risk of stomach cancer and stomach ulcers, but now we know this is mainly because sulforaphane is one of nature's best antibacterial compounds. As many as half of all stomach ulcers are triggered by infection with the Helicobacter pylori bacterium. sulforaphane kills off this unpleasant bacterium, helping to keep your digestive tract healthy. sulforaphane also lessens the incidence of breast cancer in animals.
Zeanxanthin: This is an antioxidant that gives corn its yellow color. It is also found in spinach, cabbage, broccoli, and peas. |
The Editors of FC&A
See book keywords and concepts | | But they may not be able to escape from broccoli sprouts and their powerful disease-fighter, sulforaphane. In test-tube studies, this natural plant compound wiped out the toughest H. pylori.
"We showed that Helicobacter pylori strains resistant to multiple antibiotics were killed by sulforaphane in-vitro," reports Johns Hopkins researcher Jed W. Fahey. The substance also protects your stomach in other ways. "It boosts the body's own protective enzymes," he explains, "which could have both cancer preventive and antioxidant benefits. |
David W. Grotto, RD, LDN
See book keywords and concepts | | Cabbage, especially raw sauerkraut (cooking cabbage appears to reduce these helpful plant chemicals), is rich in the anti-cancer compounds indole-3-carbinole (I3C), isothiocyanates (a type of beneficial compound found in Brassica vegetables), and sulforaphane. These compounds help activate and stabilize the body's antioxidant and detoxification mechanisms, which, in turn, eliminate cancer-producing substances. Cabbage intake has been linked to a lower incidence of colon, lung, cervical, and breast cancer. |
Donald R. Yance, j r.,C.N., M.H., A.H.G., with Arlene Valentine
See book keywords and concepts |  Another component in broccoli, called sulforaphane, also appears to block tumor formation in animals and presumably in humans as well. Organically grown broccoli produces a much greater amount of sulforaphane than the commercially grown variety. sulforaphane is a potent inducer of phase II cellular enzyme activity, which is known to deactivate cancer-causing agents through detoxification.8 Broccoli sprouts, which taste something like alfalfa sprouts, contain up to one hundred times more sulforaphane than does broccoli itself. |
Devra Davis
See book keywords and concepts |  In Baltimore, Paul Talalay has come up with a specially designed form of broccoli-based sprouts rich in sulforaphane that looks like it can convert bad cells back to good ones. In New York, teams are finding that young patients with a precancerous condition of the larynx called laryngeal papilloma, which normally requires repeated operations to remove small growths on the voice box, don't need surgery after drinking enriched cabbage juice. |
David W. Grotto, RD, LDN
See book keywords and concepts | | Scientists discovered that a handful of three-day-old broccoli sprouts contained as much as twenty to fifty times as much sulforaphane glucosinolate as 114 pounds of regular broccoli!
Home Remedies
Getting vitamin C from fresh foods in the treatment of sinus infections is a plus, and broccoli, rich in C, along with other foods (like berries and citrus fruits), is eaten to both treat and prevent sinus problems. Used as a base of various juice blends, broccoli has long been advocated for relieving symptoms of herpes outbreaks. Now some scientists believe they may have found out why. |
Jonny Bowden, Ph.D., C.N.S.
See book keywords and concepts |  Broccoli: Contains two classes of anticancer phytonutrients: isothiocyanates and glucosinolates. The sulforaphane in broccoli activates detoxifying enzymes in the body, preventing the formation of cancer-forming substances. Eat it raw or lightly steam it. Boiling causes it to lose vitamin C and other nutrients. The sprouts contain thirty to fifty times the concentration of nutrients found in the mature broccoli plant.
3. Blueberries: One of nature's antiaging superstars. They contain a mega supply of antioxidants known as anthocyanins, as well as fiber and vitamins. | | Other members of the brassica family include cabbage, broccoli, Brussels sprouts, and kale, and all are loaded with cancer-fighting substances like indoles, isothiocyanates, and sulforaphane. One of the key dietary recommendations of the American Cancer Society is to include these cruciferous vegetables in your diet on a regular basis.
So mustard seeds come from veggie royalty. Other members of the same plant family include horseradish (see page 43) and cress. | | Broccoli sprouts: No food is higher in sulforaphane than these. Great on salads or in wraps. If you are short on these tiny powerhouses, eat cruciferous vegetables (broccoli, cauliflower, cabbage).
6. Spinach (and other dark green leafies):
Packed with nutrients, especially folate, without a slug of carbs.
7. Tomatoes: Full of potassium and lycopene and so versatile you can serve them at any meal.
8. Pomegranate: Powerful antioxidant, and delicious to boot.
9. Celery root: All the benefits of potatoes, used in much the same way, but without the starch load.
10. | | According to research from the Department of Urology at Stanford University published in Cancer Epidemiology Biomarkers and Prevention, sulforaphane is the most potent inducer of phase-2 enzymes of any phytochemical known to date.
A Nutritional Powerhouse
Even apart from its demonstrated cancer-fighting ability, broccoli is a nutritional powerhouse. | | According to research from the Department of Urology at Stanford University published in Cancel- Epidemiology Biomarkers and Prevention, sulforaphane is the most potent inducer of phase-2 enzymes of any phytochemical known to date. And in a review article from the 11th Annual Research Conference on Diet, Nutrition, and Cancer from the American Institute for Cancer Research, the authors stated that "isothiocyanates are well-known protectors against carcinogenesis. | | Like its relatives (broccoli, Brussels sprouts, cabbage), kohlrabi contains important phytochemicals such as cancer-fighting indoles, sulforaphane, and isothiocynates. It's also a good source of vitamin C (83 mg per cup) and an excellent source of potassium (472 mg). And for a measly 36 calories per cup, you get a whopping 5 g of fiber.
In case someone ever asks you, Hamburg Township in Michigan has christened itself the "Kohlrabi Capital of the World." No, I'm not making this up. At one time, back in the 1980s, they had a kohlrabi festival that actually drew 600 people. |
James F. Balch, M.D. and Mark Stengler, N.D.
See book keywords and concepts |  Sulforaphane
Description: sulforaphane is a phytonutrient found in broccoli sprouts and other cruciferous vegetables. It has potent antioxidant effects, supports healthy detoxification, and improves estrogen balance.
Indications: Cancer prevention
Detoxification Precautions: There are no known side effects. Dosage: Take 400 mg daily.
Taurine
Description: Taurine is an amino acid-like substance that is an important part of bile for fat absorption. It is also essential for the development of the nervous system and for heart function. |
Joseph E. Mario
See book keywords and concepts |  Broccoli contains Glucoraphanin precursing sulforaphane that stimulates body phase-2 enzymes neutralizing chemical- and dimethylbenzanthracene-caused tumors. Eating 2 pounds broccoli per week cut colon cancer risk in half, but 3-day broccoli sprouts provide 20-50 times more sulforaphane. Reduced mammary tumors in tests 60%.
•BRUSSELS SPROUTS A Crucifer plant with many small cabbage-like clusters on an upright stalk.
•CABBAGE (Brassica oleracea capitata) Colewort ancestor. |
Phyllis A. Balch, CNC
See book keywords and concepts |  You'll find sulforaphane in brassica vegetables such as broccoli, spinach, cabbage, cauliflower, Brussels sprouts, kale, collard greens, bok choi, and kohlrabi. Sul-foraphane also positively interacts with selenium, a mineral that vegetables absorb through the soil. Because it can be hard to know how much selenium is present in store-bought vegetables, taking a supplement along with foods high in sulforaphane may be the best way to use this synergy to your advantage.
Many supplements are now available in liquid form. This delivery system has its advantages and disadvantages. |
by Michael Murray, N.D. and Joseph Pizzorno, N.D.
See book keywords and concepts | | Because the concentration of sulforaphane is much higher in broccoli sprouts than in mature broccoli, the same reduction in risk theoretically might be had with a weekly intake of just a little over an ounce of sprouts.
Sulforaphane may also be proven to be effective in helping the body get rid of Helicobacter pylori. This bacterium is responsible for most peptic ulcers and also increases a person's risk of getting gastric cancer three- to sixfold. It is also a causative factor in a wide range of other stomach disorders, including gastritis, esophagitis, and acid indigestion. |
Bryan Hanson, PhD
See book keywords and concepts |  One example is sulforaphane, an isothiocyanate derived from a glucosinolate in broccoli and broccoli sprouts (Figure 4.25, part b). This compound activates certain ena
HO
HO
Myrosinase
Allyl isothiocyanate (other products not shown)
0 b
S
11
N=C = S
Sulforaphane
FIGURE 4.25. Glucoslnolates. a: reaction to form an isothiocyanate; b: another isothiocyanate. zymes that are able to detoxify toxic molecules, and it also induces cell death. These two modes of action make it a powerful cancer-protective agent. |
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ABOUT THE CREATOR OF NATURALPEDIA: Mike Adams, the creator of this NaturalNews Naturalpedia, is the editor of NaturalNews.com, the internet's top natural health news site, creator of the Honest Food Guide (www.HonestFoodGuide.org), a free downloadable consumer food guide based on natural health principles, author of Grocery Warning, The 7 Laws of Nutrition, Natural Health Solutions, and many other books available at www.TruthPublishing.com, creator of the earth-friendly EcoLEDs company (www.EcoLEDs.com) that manufactures energy-efficient LED lighting products, founder of Arial Software (www.ArialSoftware.com), a permission e-mail technology company, creator of the CounterThink Cartoon series (www.NaturalNews.com/index-cartoons.html) and author of over 1,500 articles, interviews, special reports and reference guides available at www.NaturalNews.com. Adams' personal philosophy and health statistics are available at www.HealthRanger.org.
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