Joan Liebmann-Smith, Ph. D., and Jacqueline Nardi Egan
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 You may, in fact, have the classic sign of extreme sound sensitivity, medically known as hyperacusis, a rare condition affecting about one in 50,000 people. Extreme sound sensitivity is sometimes a harbinger of tinnitus. (See Ringing in Your Ears, above.) Ironically, people with impaired hearing sometimes become supersensitive to certain sounds.
Noise sensitivity can be a reaction to the artificial sweetener aspartame as well as some antibiotics, analgesics, and allergy medicines. It can also signal magnesium deficiency. |
Jonny Bowden, Ph.D., C.N.S.
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 Studies Examine the Use of Vinegar in Treating Diabetes
In the above-mentioned study published in Diabetes Care, apple cider vinegar significantly improved insulin sensitivity in insulin-resistant subjects. (The vinegar also improved insulin sensitivity somewhat in diabetics, but the results didn't quite reach statistical significance.) The authors stated that "vinegar may possess physiological effects similar to ... metformin." (Metformin, the generic name for Glucophage, is a drug typically given to diabetics and prediabetics to increase insulin sensitivity. |
David Winston, RH(AHG), and Steven Maimes
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 Safety Issues: In large doses this herb has been shown to cause sensitivity to sunlight in cows and in a few cases in people as well. Some people have suggested using hypericum oil as a sunscreen. This is a bad idea because it can increase sun sensitivity and cause severe sunburn.
Herb/Drug Interactions: St. John's wort is well-known for enhancing liver detoxification, which reduces blood levels of many medications. Do not take St. |
Joan Liebmann-Smith, Ph. D., and Jacqueline Nardi Egan
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| Noise sensitivity can be a reaction to the artificial sweetener aspartame as well as some antibiotics, analgesics, and allergy medicines. It can also signal magnesium deficiency. And finding normal noises annoying
SIGN OF THE TIMES
Beethoven not only started losing his hearing when he was 27 (apparently from otosclerosis) but also suffered from hypersensitivity to noise and tinnitus. By the time he was 50, he was totally deaf. Yet he continued to compose until his death a few years later. can be a sign of head injuries and whiplash, as well as depression and posttraumatic stress syndrome. |
| Medically known as hyper-osmia, smell sensitivity is usually a benign, albeit annoying, sign. However, if you have this condition, mildly unpleasant smells can make you nauseated. But pleasant smells come in stronger, too. For example, a person with hyperosmia can often detect the scent of a woman's perfume long after she's left a room.
Supersensitivity to smell is often thought to be a psychosomatic condition and a sign of neurosis. But don't be so quick to run off to a shrink. It can be a sign of pregnancy. |
Gabriel Cousens
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 Symptoms of nerve damage include numbness, tingling, increased sensitivity to touch, insensitivity to pain and temperature, and loss of coordination. The excess sugar also damages blood vessels that carry the oxygen and nutrients to the nerves. People with Syndrome X are more likely to develop obstruction to the arteries and therefore increased or decreased blood flow to the extremities, which creates increased rates of amputations. Up to 70 percent of people with Syndrome X have some form of nerve damage. It is even worse in smokers. |
Greg Critser
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 For the last decade, CP450 and its numerous subsystems have become the intense focus of academic pharmacologists because science has been able to identify the main genetic traits that lead to varying degrees of CP450 sensitivity. Some genes lead to increased sensitivity to some drugs; some genes lead to decreased sensitivity. |
Paula Begoun and Bryan Barron
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 Cardamom and vetiver are problematic ingredients for someone dealing with skin sensitivity, and may cause sensitivity in otherwise normal skin. That makes this a tough recommendation though it's not a terrible product.
AVEDA BOTANICAL KINETICS PRODUCTS
© $$$ Botanical Kinetics Purifying Creme Cleanser ($17for 5 ounces) would be a much better lotion-style cleanser without the witch hazel extract, but the emollient ingredients keep it from being a significant problem for the normal to dry skin types this cleanser is best for. |
Benjamin H. Natelson, M.D.
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 The symptoms included eye, nose, or throat irritation; dry cough; dry or itchy skin; dizziness and nausea; difficulty concentrating; fatigue; and sensitivity to odors. Usually the symptoms went away when the individual left the environment, but in some cases the symptoms persisted and would be made substantially worse by exposure to strong odorants, such as detergents, perfumes, newsprint, and insecticides. Patients with these complaints were said to have multiple chemical sensitivity. |
| This group genotyped 202 healthy women, looking specifically for different forms of a gene related to pain sensitivity called COMT; prior to this work, interest in this gene was mostly focused on the fact that its primary action was to produce the hormone adrenaline. Importantly, the researchers found that specific forms of the gene predicted increased sensitivity to painful stimuli. Over the three years of the study, fifteen women developed temporomandibular joint disorder (TMD); of these, half had the genotype for increased pain. |
Jonny Bowden, Ph.D., C.N.S.
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| The vinegar also improved insulin sensitivity somewhat in diabetics, but the results didn't quite reach statistical significance.) The authors stated that "vinegar may possess physiological effects similar to ... metformin." (Metformin, the generic name for Glucophage, is a drug typically given to diabetics and prediabetics to increase insulin sensitivity.) Since insulin resistance is a feature of metabolic syndrome and often precedes diabetes, anything that makes the cells more sensitive to insulin and helps control blood sugar bears looking into. |
Paula Begoun and Bryan Barron
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| Cardamom and vetiver are problematic ingredients for someone dealing with skin sensitivity, and may cause sensitivity in otherwise normal skin. That makes this a tough recommendation though it's not a terrible product.
AVEDA BOTANICAL KINETICS PRODUCTS
© $$$ Botanical Kinetics Purifying Creme Cleanser ($17for 5 ounces) would be a much better lotion-style cleanser without the witch hazel extract, but the emollient ingredients keep it from being a significant problem for the normal to dry skin types this cleanser is best for. |
Gabriel Cousens
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Lean Obese T2D
Insulin sensitivity in the lean, obese, and type 2 diabetic (T2D) groups before and after 3 months of exercise. Insulin sensitivity Is expressed as the ratio of the amount of glucose metabolized to the prevailing plasma insulin levels {M (mg - kgSM-1 ?min-1 )/l (uU/ml) x 100} during the lost 30 min of the eugiycemk clamp, ?Glucose uptake is significantly lower {? < 0.05) in the caffeine trial {black bar) compared with the placebo trial (white bar), independent of group and exercise training.
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Jack Challem
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 Neuropathy is a general term that refers to nerve damage, which may be characterized by extreme sensitivity to pain or numbness. Alpha-lipoic acid is the number-one choice for treating neuropathy. Try 200 mg three times daily. In addition, gamma-linolenic acid, part of a family of essential dietary fats, can also help with diabetes-related nerve damage. Try 100 mg twice daily in combination with alpha-lipoic acid.
• Eye disease. Diabetes increases the risk of developing virtually all serious eye diseases. Inadequate intake of vitamin A, which is characterized by night blindness (i.e. |
Mark Lynas
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 Even if we assume a relatively low climate sensitivity, we will by then have a less reassuring 75 per cent chance of meeting the two-degree goal. These are not odds that many people would accept for anything other than a very low-stakes game of poker - they are certainly not good odds when one is gambling the planet.
Still, I repeat: we don't have much choice. It is hardly politically realistic to demand that greenhouse gas emissions come down by 60 per cent or so within the next decade, as would be required to stabilise atmospheric C02 concentrations below 400 ppm. |
| So either the fossil data about past temperatures and C02 levels is wrong, or the models are underestimating climate sensitivity. They can't both be right.
Climate models, by their very nature, are part of a reductionist scientific enterprise, picking apart the different bits of the climate system and trying to understand and describe them individually using physical equations. Put all these equations together, the logic goes, representing everything from clouds to sea ice, and you get your model. But the whole of a complex and interacting system is not necessarily just a sum of all the parts. |
| One of the biggest hurdles to calculating climate sensitivity is the phenomenon of 'global dimming'. It has long been known that sulphate aerosols - released during the combustion of fossil fuels, and an important contributor to acid rain - have a short-term cooling effect on the climate, temporarily shielding us from the full effects of greenhouse warming by cutting off some of the Sun's rays. |
| On the other hand, if climate sensitivity is high, then even drastically curtailing emissions may not save us from rapid increases in temperature.
Climate models, because they are designed by different teams with slightly different parameters, come up with slightly different figures for this crucial number. |
| The second 'known unknown' is a genuinely scientific one: what academics call 'climate sensitivity'. (I should note that neither of these uncertainties affects the scenarios portrayed in previous chapters of this book, which refer to the impacts of actual temperature rises - independently of the emissions scenarios that generate them. I am raising them here in order to lay the groundwork for answering the crucial question posed by this book so far: which emissions paths will lead to which temperature outcomes? |
John J. Ratey, MD
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 He asked if he could stop taking it, and I told him that over time, if he got into the exercise and maybe CBT, he should be able to lower his anxiety sensitivity. Eventually, I said, my guess was that he'd be able to reduce his medication and maybe eliminate it altogether. But nobody really knows whether exercise can entirely replace medication. Our brains are just too complex.
A lot of people who are treated for panic disorder can go on to have a completely different kind of life. The farther they get from their last panic episode, the less likely they are to have another panic episode. |
Stacy Malkan
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 While the drug initially improved the sensitivity, the redness problem kept getting worse. She kept using more skin products to try to cover up the problem — cleansers, toners, scrubs and defoliators along with her usual four hair products and full-face makeup. "It became a vicious cycle where my skin was ruddy and uneven looking and so I used more makeup to cover up the irritation that the products were causing. |
Greg Critser
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| Some genes lead to increased sensitivity to some drugs; some genes lead to decreased sensitivity. The next logical step is to take these insights from the lab and expand them from generalizations about various populations (for example, Latinos' CP450 genes make them bad metabolizers of alcohol) to more specific tests for individual and group susceptibility to liver poisoning. And to do that, a growing cadre of scientists say, drug companies should invest heavily in drug-gene identification. |
Jack Challem
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| It turned out that Edward had an allergylike sensitivity to wheat and tomatoes, foods that he ate in one form or another at nearly every meal. Eliminating these foods greatly reduced his snoring and sleep apnea. Both he and his wife began to cut back on high-carb foods and eat more lean protein and vegetables. Dietary changes are often more successful when a spouse also follows them. The couple also stopped snacking in front of the television. As Edward's weight dropped over the next six months, his snoring and sleep apnea diminished. |
Hyla Cass, M.D.
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 Even moderate exercise (such as brisk walking) enhances insulin sensitivity, as does resistance training with weights.
DRUGS FOR DIABETES AND THE NUTRIENTS THEY DEPLETE
If you have a diagnosis of diabetes or insulin resistance, also known as "prediabetes," borderline diabetes, metabolic syndrome, or Syndrome X, you should not head right for the pharmacy. It's been proven over and over that you can reverse this condition yourself, with the right diet, plus exercise. Speak to your doctor, and enroll him or her as your partner here. |
| Given insulin's risks, your medical team will try to make the most of the insulin your body can make, and will try to increase your cells' sensitivity to it, before prescribing it.
Even if you require insulin therapy, don't give up on weight loss, a healthful diet, supplements, and exercise. These measures are every bit as important to your health as they are to the person who is prediabetic, and you are much less likely to develop the devastating complications of diabetes. Don't believe for a minute that "it's OK to cheat, I'll just increase my insulin. |
| Actions: Metformin increases insulin sensitivity, encouraging cells to let sugars in when insulin is present; and it reduces the amount of glucose (simple sugars) absorbed into the body from food. Overall, it enhances the action of insulin and reduces blood sugar. It causes less weight gain and fewer episodes of hypoglycemia (low blood sugar) than any other medicine discussed in this chapter. It also has been found to protect against diabetic complications (neuropathy, retinopathy, kidney damage), and to lengthen lifespan in overweight people with type 2 diabetes. |
Mark Lynas
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| Each downloaded model had tiny differences from the next, and by examining thousands of results the researchers hoped to get a cluster of 'best estimates' for climate sensitivity. They made international headlines in the process: while most of the home-run model results came in at the standard 3°C or so, a fair few showed climate sensitivities as high as an incredible 11°C. As the project coordinator Dave Frame told reporters: 'The possibility of such high responses has profound implications. |
Donna Jackson Nakazawa
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 But when the intestinal flora lacks sufficient good bacteria from a healthy whole-foods diet, or when we consume foods that can produce an allergic sensitivity in some people—as do many chemicals, artificial preservatives, and dyes— inflammation develops in the lining of the intestine. That inflammation breaks these seals, the gaps widen, and, in what is referred to as "leaky gut syndrome," antigens leak out. Those antigens can rev up the immune system. |
John J. Ratey, MD
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| Some people also have anxiety sensitivity, which complicates any form of the disorder. Your heart rate or breathing might increase for an unrelated reason, and when you sense this physical arousal, that awareness alone can trigger a state of anxiety or panic. You lose control because you feel like you're going to lose control. If you begin to fear the fear—whether it's mental or physical—anxiety can quickly spiral out of control.
Amy is a textbook case of generalized anxiety disorder, with shades of panic disorder and social anxiety disorder. |
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