Frederic Vagnini, M.D. and Barry Fox, Ph.D. See book keywords and concepts | Pseudoephedrine plus ibuprofen may be given to relieve some of the symptoms of a cold. pseudoephedrine is a decongestant that helps improve breathing by constricting the blood vessels in the mucosa of the respiratory tract and relaxing the bronchial (breathing) tubes. These two actions allow air to flow in and out more freely. Ibuprofen helps reduce inflammation and relieve pain.
Possible Side Effects
Pseudoephedrine's side effects include rapid heartbeat, irregular heartbeat, weakness, and tremor. Ibuprofen's side effects include headache, fluid retention, rash, and kidney failure. | Bottom Line Health See book keywords and concepts | | Do not use pseudoephedrine if you have taken an MAO inhibitor (a type of antidepressant) within the last two weeks—the combination can cause dangerously high blood pressure.
Consult a doctor if you have hypertension, an overactive thyroid gland or difficulty urinating due to an enlarged prostate gland—pseudoephedrine can aggravate these conditions. DEXTROMETHORPHAN
An antitussive that relieves a dry (nonproductive) cough caused by a cold or flu.
Popular brands: Benylin Cough Suppressant, Robitussin DM Cough Syrup, Sucrets 8-Hour Cough Suppressant, Vicks 44 Cough Relief. | | Some OTC products, such as Advil Cold and Sinus Caplets and Tylenol Sinus Daytime, contain pseudoephedrine along with other active ingredients.
Dangers: Increased blood pressure.. .rapid heart beat.. .insomnia.
What to do: Avoid caffeinated beverages because they can increase restlessness and insomnia. Do not use pseudoephedrine if you have taken an MAO inhibitor (a type of antidepressant) within the last two weeks—the combination can cause dangerously high blood pressure. | Thomson Healthcare, Inc. See book keywords and concepts | Renal excretion of pseudoephedrine. Clin Pharmacol Ther; 28:690-694. 1980.
Capwell RR. Ephedrine-induced mania from an herbal diet supplement. Am J Psychiatry; 152:647. 1995.
Cho S, Hong T, Jin GB et al. The combination therapy of ephedra herb and loxoprofen caused gastric lesions in mice. Am J Chin Ato/;30(4):571-7. 2002.
Chua SS & Benrimoj SI. Non-prescription sympathomimetic agents and hypertension. Med Toxicol Adverse Drug Exp; 3:387-417. 1988.
Cuthbert MF, Greenberg MP & Morley SW. Cough and cold remedies: a potential danger to patients on monoamine oxidase inhibitors. BMJ; 1:404-406. | Joe Graedon, M.S. and Teresa Graedon, Ph.D. See book keywords and concepts | Too many people used pseudoephedrine to make the illegal drug methamphetamine, so states and the federal government cracked down on easy access.
The research demonstrating that pseudoephedrine is quite effective in relieving allergy symptoms has forced us to reevaluate this old and inexpensive vasoconstrictor. It works by shrinking blood vessels in the nose. Perhaps that's why so many drug companies now add this OTC ingredient to their antihistamines. | Frederic Vagnini, M.D. and Barry Fox, Ph.D. See book keywords and concepts | PSEUDOEPHEDRINE PLUS IBUPROFEN (soo-doe-e-FED-rin, eye-byoo-PRO-fen)
Brand Names: Advil Cold & Sinus Caplets, Dimetapp Sinus Caplets, Dristan Sinus Caplets, Motrin IB Sinus, Sine-Aid IB
About pseudoephedrine plus Ibuprofen
Being cold does not give you a cold, and having a cold does not make you cold: The common cold has litde to do with cold temperatures.
Colds are caused by viruses, and the rhinovirus is the usual suspect. This virus leaves an infected body via the nasal secretions, typically by hitching a ride on the individual's hands, which pass it the next victim's hands. | Bottom Line Health See book keywords and concepts | | Examples: Sudafed and Nyquil both have pseudoephedrine.. .Benadryl and Tylenol PM have diphenhydramine.
Always check the labels. When in doubt, consult a pharmacist.
•Measuring liquid medications incorrectly. Tableware is not for measuring medications. The most accurate measuring devices are oral dosage syringes, calibrated medicine droppers and similar products. Some pharmacies distribute them free.
•Not shaking suspensions before each use. Certain medicines are mixed with—but not dissolved in—liquids, so the medicine particles settle to the bottom. | Marshall Editions See book keywords and concepts | Medications used for this type of incontinence are pseudoephedrine q and imipramine. Sometimes estrogen treatment can be helpful in post-menopausal women with stress incontinence. Natural bioidentical estrogen can be given for this purpose as opposed to the more risky synthetic variety. If these methods fail, surgery, known as cystourethropexy, which raises the neck of the bladder so that urine can not leak out, can be performed.
To treat overflow incontinence: One medication used is bethanechol. | | Decongestants: pseudoephedrine is an effective decongestant but should not be used by people with hypertension or anxiety.
Antihistamines: To treat sneezing due to allergies, take an antihistamine such as Benadryl™ at bedtime and Claritin™ during the day to suppress the sneezing. Quercetin is a natural supplement that also treats sneezing caused by allergies; take 1 g twice a day.
TRADITIONAL CHINESE MEDICINE
Herbs: If sneezing persists, try some tea formulas that are convenient and effective for reducing this condition. If you have an allergic reaction to any herb, stop drinking the tea. | Michael T. Murray, N.D. See book keywords and concepts | Pseudoephedrine
Pseudoephedrine relaxes bronchial muscle like ephedrine, but exerts weaker effects on the heart and central nervous system. pseudoephedrine is often recommended in preference to ephedrine in the treatment of chronic asthma, as it has fewer side effects.3
Pseudoephedrine has also demonstrated a significant antiinflammatory effect in various experimental models.45 Other ephedra alkaloids, including ephedrine, also exhibit antiinflammatory activity, but at much lower potency. | Thomson Healthcare, Inc. See book keywords and concepts | Coadministration of indirect-acting sympathomimetics such as pseudoephedrine and phenylpropanolamine with MAOIs has resulted in severe hypertension (Smookler & Bermudez, 1982) and one case has been reported of severe agitation, tachycardia, hypotension, and fever with concomitant use of ephedrine and a MAOI (Dawson et al, 1995). Patients who take MAOIs with Ma Huang may be predisposed to hypertensive crisis and other symptoms consistent with excessive sympathomimetic amine activity. Other potential reactions include cardiac arrhythmias, chest pain, hyperpyrexia, and death. | | It produces vasoconstriction, cardiac stimulation, acute increases in blood pressure, tachycardia, mydriasis, insomnia, vertigo, headache, and nervousness. pseudoephedrine enhances beta-2-agonist activity including bronchodilation, but also has alpha-agonist activity that helps with nasal constriction (White et al, 1997).
Clinical trials demonstrated efficacy of Ma Huang or ephedrine in the treatment of asthma and obesity; the primary current applications of Ma Huang are in the treatment of asthma and hay fever, the common cold, and as a weight loss aid. | | Sodium Bicarbonate and other Antacids: The renal elimination of ephedrine and pseudoephedrine are urinary pH-depen-dent. By increasing the urinary pH above 7.5 the renal elimination of either drug may decrease by more than 50%. If the urine remains alkaline for more than 1 to 2 days increased ephedrine toxicity may be observed (Brater et al, 1980). Concurrent use may result in ephedrine toxicity (hypertension, tachycardia). Clinical Management: Monitor for possible ephedrine toxicity (eg, hypertension and tachycardia) and decrease the dose as needed. | | These include ephedrine, phenylpropanolamine, pseudoephedrine, phenmetrazine, and phentermine (high doses). Their recent use should be ruled out when test results are positive. Clinical Management: When screening for amphetamines using the EMIT assay, recent use of ephedrine should be ruled out when test results are positive. overdosage
Life-threatening poisonings are seen with very high dosages of the drug (over 100 g, lethal dosage with oral administration corresponding to approximately 1 to 2 g L-ephedrine). | Brigitte Mars, A.H.G. See book keywords and concepts | Synthetic ephedrine and pseudoephedrine are currently found in pharmaceuticals including Contac, Sinutab, Sudafed, Actifed, and Robitussin PE.
Topically, the resin from the ephedra shrub can be applied to cuts to promote healing.
Edible Uses
The red berries on the plant are the only parts considered edible.
Other Uses
Guards of Genghis Khan's army used ephedra to help them stay awake (they would be beheaded if caught dozing!). Taoist monks use ephedra to sharpen awareness. The herb also has been smoked as an aphrodisiac. | Thomson Healthcare, Inc. See book keywords and concepts | Clinical Management: Concomitant use of Ma Huang and pseudoephedrine should be avoided, as it may lead to excessive adrenergic stimulation, which may increase blood pressure, heart rate, and the risk of cardiac arrhythmia.
Reserpine: Concomitant ephedrine and reserpine therapy has been reported to result in a decrease in the effectiveness of ephedrine due to the depletion of norepinephrine by reserpine
(Hansten & Horn, 1990). Patients receiving reserpine may have a diminished response to ephedrine.
Secale alkaloid derivatives or oxytocin: Development of high blood pressure. | Joe Graedon, M.S. and Teresa Graedon, Ph.D. See book keywords and concepts | The research demonstrating that pseudoephedrine is quite effective in relieving allergy symptoms has forced us to reevaluate this old and inexpensive vasoconstrictor. It works by shrinking blood vessels in the nose. Perhaps that's why so many drug companies now add this OTC ingredient to their antihistamines. Whenever you see a D appended to the name of an allergy medicine, you can pretty much assume that there is a decongestant on board, and frequently it is pseudoephedrine. It is found in Allegra-D, Claritin-D, Clarinex-D, Zyrtec-D, and other similar formulations.
• • •
Q. | Joseph E. Mario See book keywords and concepts | A desert herb shrub, jointed grass of the Horsetail family rich in Silica; source for Ephedrine (Ma Huang), pseudoephedrine (a vasoconstrictor, dries up mucous), Norpseudoephedrine (Amer.), 8 more alkaloids, and nine other active ingredients, Central Nervous System stimulants related to Adrenalin, substitute for Cortisone. For headaches, stuffed up ears, sinuses, colds, fevers, Ephedrine bronchodilates, for lung mucous, and asthma (with Fritillaria Roy lei and Armeniaca Amara). | Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D. See book keywords and concepts | The oral decongestant pseudoephedrine (Sudafed) may help relieve nasal congestion, while antihistamines such as diphenhydramine (Benadryl), brompheniramine (Dimetapp), chlorpheniramine (Chlor-Trimeton), and loratadine (Claritin) might help dry excess mucous and reduce sneezing. Cromolyn sodium (Nasalcrom) is used as a nose spray to prevent hayfever symptoms.
Prescription antihistamines are often prescribed for relief of hay fever symptoms. These include cetirizine (Zyrtec), desloratadine (Clarinex), and fexofenadine (Allegra). | James A. Duke, Ph.D. See book keywords and concepts | Doctors sometimes prescribe decongestants containing pseudoephedrine as a treatment for urge incontinence. pseudoephedrine makes the urethral muscles clamp down, which helps prevent involuntary urine flow. (As mentioned above, decongestants can aggravate overflow incontinence.)
If I had urge incontinence, I'd rather go with the original source of pseudoephedrine: Chinese ephedra (ma huang). Unfortunately, the FDA is considering restricting access to Chinese ephedra because of a handful of deaths—many involving people who took huge doses to experience amphetamine-like intoxication. | Heather Boon, BScPhm, PhD and Michael Smith, BPharm, MRPharmS, ND See book keywords and concepts | Administration of ephedrine results in direct bronchodilation.12 pseudoephedrine appears to work in a similar manner but is generally considered less potent than ephedrine.4
Localized anti-inflammatory properties have been demonstrated for both ephedrine and pseudoephedrine in a number of animal models.13
RESPIRATORY SYSTEM ACTIVITY
As mentioned above, ephedrine has bronchodilating properties, causing prolonged relaxation of smooth muscles upon oral administration. | Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D. See book keywords and concepts | Medical treatments
Over the counter drugs include antihistamines such as diphenhydramine (Benadryl), loratadine (Claritin), and chlorpheniramine (Chlor-Trimeton), as well as the decongestant pseudoephedrine (Sudafed). Topical nasal decongestants such as Oxymetazoline (Afrin) and Phenylephrine (Neo-Synephrine) may be used for a few days without harmful side effects. Saline-based nasal sprays such as Ocean, Ayr, and Dristan Saline Spray may be used to soothe inflamed tissue due to allergies. The nasal solution cromolyn sodium (Nasalcrom) may be used to prevent future allergy attacks. | H. Winter Griffith, M.D. See book keywords and concepts | Pseudoephedrine
Increased pseudoephedrine effect.
Salicylates*
Increased salicylate effect.
Tetracyclines
Decreased tetracycline effect.
Ticlopidine
Decreased ticlopidine effect.
ISW POSSIBLE INTERACTION l*AJI WITH OTHER SUBSTANCES
INTERACTS WITH
COMBINED EFFECT
Alcohol:
Decreased antacid effect.
Beverages:
Milk.
May cause bone discomfort.
Cocaine:
No proven problems.
Foods:
Decreased antacid effect. Wait 1 hour after eating.
Marijuana:
Decreased antacid effect.
Tobacco:
Decreased antacid effect. | American Medical Publishing See book keywords and concepts | | The Ephedras have been shown to contain various chemical stimulants, including the alkaloids ephedrine, pseudoephedrine and norpseudoephedrine, as well as various tannins and related chemicals. The concentrations of these alkaloids depends upon the particular species of Ephedra used. Ephedrine and pseudoephedrine are amphetamine-like chemicals used in OTC and prescription drags. Many of these stimulants have known serious side effects.
Ma huang is sold in products for weight control, as well as in products that boost energy levels. | Heather Boon, BScPhm, PhD and Michael Smith, BPharm, MRPharmS, ND See book keywords and concepts | It should also be noted that products containing ephedrine or pseudoephedrine are prohibited by a number of sporting authorities.36
Most of the evidence purported to support the use of ma huang for the indications described above comes from work carried out using ephedrine or pseudoephedrine alone and not the herb ma huang. While a substantial amount of historical and empirical evidence exists regarding this herb's medicinal usefulness, it is primarily restricted to the treatment of asthma, bronchitis and conditions of the upper respiratory tract. | Mike Adams See book keywords and concepts | Thanks to its active alkaloids ephedrine and pseudoephedrine, Ephedra has proven itself extremely useful in treating a number of conditions, including asthma and hay fever. In Chinese medicine, Ephedra is also used—always in conjunction with other supporting herbs—as a tool to regulate water circulation, relieve edema, stop coughing, disperse coldness and dampness from areas of the body, as well as other holistic purposes (Chinese medicine never uses one chemical to treat one condition; herbs are always used synergistically to support the body's own healing systems and processes). | Joe Graedon, M.S. and Teresa Graedon, Ph.D. See book keywords and concepts | So can many antidepressants, such as Effexor (venlafaxine), Prozac (fluoxetine), Wellbutrin (bupropion), Zoloft (sertraline), and others, and allergy medicines that contain decongestants such as phenylephrine and pseudoephedrine.
The list of drugs that can cause sleeplessness is so long that we cannot possibly include it in its entirety here. If you suspect that your medication may be interfering with restful sleep, discuss this issue with your pharmacist and your physician. There may be alternatives.
Forgo the Nightcap
And don't forget alcohol. | Joseph E. Mario See book keywords and concepts | Health Concerns' Nasal Tabs with Ephedrine and pseudoephedrine source Ma
Huang, and its balancers Magnolia, Pueria/Kudzu, Rhubarb, Coix, Gypsum,
Cinnamon, Peony, Ginger, Licorice*, Cnidium, Jujube, and Platycodon. Sinus Clear with Chinese Ephedra, Fenugreek seed, Eucalyptus leaf, Laurel Leaf,
Grindelia herb, and Goldenseal root. Transpacific Health Products" Bee TungteawithFlos Magnolia, Silerroot, Licorice root (rids mucous, opens sinuses). Nasal Vaporizer with Oils of Eucalyptus, Camphor, Wintergreen, Peppermint, Pine needle, Rosemary, Sage, Olive, Lanolin and Beeswax. | Phyllis A. Balch, CNC See book keywords and concepts | Caffeine consumption, jet lag, and the use of certain drugs, including many antidepressants, the antiseizure medication pheny-toin (Dilantin), most appetite suppressants, beta-blockers (medications used for high blood pressure and heart ailments), the decongestant pseudoephedrine (found in many cold and allergy remedies), and thyroid hormone replacement drugs can also lead to insomnia.
A lack of the nutrients calcium and magnesium can cause you to wake up after a few hours and not be able to return to sleep. | | A decongestant such as pseudoephedrine (found in Sudafed and other products) may also be helpful, but remember, these medications are dehydrating (and so is the lack of humidity in an airplane cabin). If you use them, be sure to drink plenty of water and juice during the flight, and skip the cocktail and coffee, as alcohol and caffeine also are dehydrating.
Q Always wear ear protection (disposable plugs or an earphone-style headset) when using loud appliances such as power tools or lawn mowers; and when you know you will be exposed to sudden loud noises, such as when shooting a gun. |
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