Dr. Steven R. Gundry
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 Both factors increase the level of oxidative stress on the system, just as smoking does to humans. (In simple terms, oxidation is caused by free radicals that "rust" your body, much as metal degrades when exposed to oxygen.) Ultraathletes also exhibit high levels of oxidative stress.15 If your autopilot detects heightened oxidative stress, it perceives you as an unsuccessful animal, harboring genes that are not worth passing on. |
Mike Adams, the Health Ranger
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 Chemotherapy agents basically kill cancer cells through inducing an oxidative stress. So the idea is that if you take an antioxidant, it would undo that oxidative stress, thereby protecting the cancer cells. And that's the simple logic of it, but when you actually go and look at the studies and see what's happening in the body and apply this, you find that antioxidants protect the healthy cells from this oxidative stress and not the cancer cells from the oxidative stress. So we still have a lot of room for growth in that area. |
Gary Null and Amy McDonald
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 Addictions_
Effects of Melatonin on oxidative stress and Spatial Memory Impairment Induced by Acute Ethanol Treatment in Rats. Gonenc S; Uysal N; et al. Physiological Research, 2005, 54(3):341-348.
The researchers determined that melatonin influences ethanol-induced oxidative stress and spatial memory impairment.
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Review Article: Nutritional Therapy in Alcoholic Liver Disease. Stickel F; Hoehn B; et al. Alimentary Pharmacology & Therapeutics, 2003 August 15, 18(4):357-373. |
Dr. Steve Blake
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 This attack is known as oxidative stress. When the "attacked" molecule loses its electron, it can become a free radical itself, beginning a chain reaction that can continue. If this chain reaction continues, it can disrupt a living cell.
Free radicals occur normally during metabolism. Also, the body's immune system purposefully creates them to neutralize viruses and bacteria. Other sources of free radicals and other oxidative stresses include environmental factors such as pollution, hard radiation, cigarette smoke, and certain pesticides. |
Mike Adams, the Health Ranger
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| So the idea is that if you take an antioxidant, it would undo that oxidative stress, thereby protecting the cancer cells. And that's the simple logic of it, but when you actually go and look at the studies and see what's happening in the body and apply this, you find that antioxidants protect the healthy cells from this oxidative stress and not the cancer cells from the oxidative stress. So we still have a lot of room for growth in that area. The bottom line is dollars and cents, and this is what troubles them. |
Dr. Steven R. Gundry
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| Ultraathletes also exhibit high levels of oxidative stress.15 If your autopilot detects heightened oxidative stress, it perceives you as an unsuccessful animal, harboring genes that are not worth passing on. Killer genes are being activated in smokers and marathoners as well as folks who live on foods full of refined grains, sugar, and trans fats and deficient in micronutrients. |
Herbert Ross, DC with Keri Brenner, L.Ac.
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 This is called oxidative stress. The oxidative stress profile assesses the degree of free radical damage in the body and measures the body's levels of glutathione, an amino acid complex central to detoxification.
Diagnosing Candidiasis
Candidiasis causes systemic illnesses that produce a wide variety of symptoms. This makes candidiasis difficult to accurately diagnose, since it shares symptoms with so many other conditions. One clue that candidiasis may be an issue is if symptoms are chronic rather than acute or sudden. |
Jonny Bowden, Ph.D., C.N.S.
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 Since both cardiovascular disease and cancer are thought to be highly related to what's called "oxidative stress" (the damage done to cells and DNA by oxidation), the ability to fight off the destructive effects of that oxidation is a major weapon in the healing power of any food. Apples have that antioxidant power in spades. In fact, apples have the second highest level of antioxidant activity of any other commonly consumed fruit in the United States (beaten out only by cranberries). |
| Polyphenols, like other antioxidants, help protect cells from the normal, but damaging, physiological process known as "oxidative stress." Although oxygen is vital to life, it's also incorporated into reactive substances called free radicals. These can damage the cells in our body, and they have been implicated in the slow chain reaction of damage leading to heart disease and cancer. Many studies have demonstrated the anticancer properties of polyphenols. They can stop the damage that free radicals do to cells, neutralize enzymes essential for tumor growth, and deactivate cancer promoters. |
| A second study, published recently in Nutrition, Metabolism and Cardiovascular Disease, indicated that the consumption of pistachio nuts decreased oxidative stress and improved both total cholesterol and HDL ("good") cholesterol in healthy volunteers. (There was a trend toward reducing triglycerides and LDL ["bad"] cholesterol, but this didn't reach statistical significance.) The ratio of total cholesterol to HDL, reported to be one of the most specific risk factors for cardiovascular disease, fell by 21 percent in the pistachio-eating group. |
Ray D. Strand
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 Excessive fat intake at meals is known to induce oxidative stress, especially when adequate amounts of antioxidants are missing in that meal. We must decrease saturated-fat intake, making certain we consume at least seven servings of fruits and vegetables and more than thirty-five grams of fiber each day. (I know you have heard all this before; but less than 9 percent of the population follows this advice!)11
4. Be Aware of Other Carcinogens. |
Thomson Healthcare, Inc.
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 Smokeless tobacco, oxidative stress, apoptosis, and antioxidants in human oral keratinocytes. Free Radic Biol Med; 26(7-8):992-1000. 1999.
Banerjee B & Bagchi D. Beneficial effects of a novel IH636 Grape Seed proanthocyanidin extract in the treatment of chronic pancreatitis. Digestion; 63(3):203-206. 2001.
Baruch. the effects of Endotelon in postoperative edema. Results of a double-blind study versus placebo in 32 female patients. Ann Chir Plast Estfie?;29(4):393-395. 1984.
Bavaresco L; Fregoni C; Cantu E; Trevisan M. Stilbene compounds: from the grapevine to wine. |
Ray D. Strand
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| Lungs and Air Pollution
When you consider the major causes of oxidative stress in the body, the most serious and the most potent causes enter the body through the respiratory tract. This begins with the nasal passageways and ends with the very thin-lined alveoli of the lung. The air that we breathe today is filled with ozone, nitrogen oxides, fuel emissions, and secondary cigarette smoke. In short: breathe in, cough out.
I will never forget my long journey to San Diego to start my internship at Mercy Hospital. I stopped along the way to see friends in Azusa. |
Jonny Bowden, Ph.D., C.N.S.
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| Another study in the Journal of Medicinal Food examined nine different fruits and fruit juices and reported that eight of them—including kiwi— exhibited significant ability to reduce oxidative stress (damage from free radicals) in human plasma. This ability of kiwi to protect against cellular damage was confirmed in yet another study in Carcinogenesis that was even more promising: In the Carcinogenesis study, not only did the kiwifruit limit the amount of oxidative damage to DNA, but it also stimulated cellular repair of the damage that did occur! |
| And inflammation and oxidative stress are involved in virtually every major killer disease: Alzheimer's, Parkinson's, diabetes, and heart disease, not to mention "run-of-the-mill" conditions of aging like arthritis. These compounds by themselves would be enough to land blueberries on anyone's list of superfoods. But the blueberries do even more. They actually help neurons in the brain communicate with one another more effectively.
BLUEBERRIES KEEP YOUR MEMORY SHARP
"Old neurons are kind of like old married couples," Joseph says. "They don't talk to each other so much any more. |
Ray D. Strand
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| Antioxidants Help Good Cells
It is common knowledge that almost all of the harmful side effects of chemo- and radiation therapy to normal cells are the result of the increased oxidative stress these treatments create inside the body. What is not common knowledge, however, is that when a patient takes high doses of antioxidant supplements, he improves the defense system of normal cells since they take up these antioxidants normally. This creates a true win-win situation. |
| If we have enough antioxidants available, oxidative stress does not occur and the DNA of the nucleus is safe from initial damage. Imagine again the metaphor of the fireplace. When a screen is in place, cinders cannot pop out onto the carpet.
Chemoprevention also aims to reverse the damage that has already occurred to the cell. As you learned in Chapter 4, the body has the amazing ability to heal itself (remember the MASH unit). Let us now carefully consider a strategy for fighting off cancer in three planned phases of chemoprevention, and the effects each has on the body. |
Thomson Healthcare, Inc.
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| Ginkgo biloba extract (EGb 761) pretreatment limits free radial-induced oxidative stress in patients undergoing coronary bypass surgery. Cardiovasc Drugs Ther; L 1(2): 121-131. 1997.
Pincemail J, Dupuis M, Nasr C et al. Superoxide anion scavenging effect and superoxide dismutase activity of Ginkgo biloba extract. Experiment; 45(8):708-712. 1989.
Pittler M & Ernst E. Ginkgo biloba extract for the treatment of intermittent claudication: A meta-analysis of randomized trials. Am J Med; 108:276-281. 2000.
Porsolt RD, Roux S & Drieu K. |
Ray D. Strand
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| It seems logical that if oxidative stress is indeed the cause of cancer, antioxidants used to bring free radicals back into balance would lower the risk of cancer. This logic proves true. Cancer research specialist Dr. Gladys Block followed this precise logic while reviewing 172 epidemiological studies from around the world on diet and cancer. Dr. Block discovered a universal and consistent finding: those individuals who had the highest intake of fruits and vegetables (the main source of antioxidants) showed a significantly decreased risk of developing almost every kind of cancer. |
| Chemoprevention Phase III: Empowering the Body's Repair System
In Phase I and Phase II of chemoprevention, we were primarily concerned with decreasing the amount of oxidative stress the body has to handle and providing adequate antioxidants to prevent such stress to the DNA of the cell. In Phase III we will focus on the body's amazing repair system when coupled with adequate nutrients enabling the cell to repair significant damage that has already occurred.
Precancerous lesions or growths offer us a unique insight into the use of antioxidants in chemoprevention. |
Elaine Magee
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 Resveratrol reduces oxidative stress. A polyphenol found in grapes, resver-atrol belongs to another subclass of antioxidant phytochemicals called phyto-alexin. Plants that produce resveratrol do so in response to stress, so this phytochemical serves as a natural antibiotic for the plant. In humans, its protective effects may contribute to the Mediterranean paradox—the protective effect of red wine drinking on cardiovascular health.
Isoflavones fight cancer. |
Paula Begoun and Bryan Barron
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 Using a product that adds to the body's oxidative stress load won't do a thing to create younger-looking skin.
However, the good news is that there is nothing in this outrageously expensive product that can increase skin's oxygen consumption. It's a terribly boring concoction of water, glycerin, almond protein, plasticizer, skin-identical ingredients, silicone, plant oil, film-forming agent, and fragrance. |
J. Douglas Bremner
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 VITAMINS
There is some connection between oxidative stress and heart disease, and the known role of vitamins C and E as antioxidants. However a large body of research, including large studies of tens of thousands of patients, has shown that vitamins do not prevent heart disease.31 In fact, they may actually have the opposite effect. In one large study, male physicians given beta-carotene (the precursor of vitamin A) showed no differences in rates of heart disease compared to those given a placebo. |
Mike Adams, the Health Ranger
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 Protects the body from oxidative stress.
Prevents kidney stones and protects the body from oxalates in coffee and tea.
Alkalizes the body, helping to balance overly acidic dietary habits.
Cures ulcers, IBS, Crohn's disease and other digestive disorders.
Reduces high blood pressure natural, by treating the cause, not just the symptoms.
Nourishes the body with minerals, vitamins, enzymes and glyconutrients.
Accelerates healing from physical burns and radiation burns.
Replaces dozens of first aid products, makes bandages and antibacterial sprays obsolete. |
Dr. Steven R. Gundry
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| If your autopilot detects heightened oxidative stress, it perceives you as an unsuccessful animal, harboring genes that are not worth passing on. Killer genes are being activated in smokers and marathoners as well as folks who live on foods full of refined grains, sugar, and trans fats and deficient in micronutrients. Most patients hospitalized with heart disease or diabetes show a similar nutritional profile: they're overfed but undernourished, with remarkably low levels of quality protein and vitamins and minerals revealed in their blood work. |
Russell L. Blaylock, M.D.
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 A recent study, in which one hundred Parkinson's patients were compared to two hundred matched controls, found that Parkinson's patients had a genetic defect that altered their ability to form conjugating enzymes, a vital method of cellular detoxification,98 and a condition that would make them more susceptible to oxidative stress in the part of the brain causing the disease. Mercury, by increasing free-radical generation (oxidative stress) and poisoning the antioxidant network, would greatly magnify the effects of this inherited weakness. |
Mike Adams, the Health Ranger
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| And that's the simple logic of it, but when you actually go and look at the studies and see what's happening in the body and apply this, you find that antioxidants protect the healthy cells from this oxidative stress and not the cancer cells from the oxidative stress. So we still have a lot of room for growth in that area. The bottom line is dollars and cents, and this is what troubles them. It is threatening every time a study comes out saying more and more people are spending more and more money on alternative practitioners. |
Tom Bohager
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 It is defined as an imbalance between pro-oxidants and antioxidants, with the former prevailing. oxidative stress is thought to contribute to the aging process.
Compounds that prevent free-radical damage are known as antioxidants. The body produces antioxidant enzymes, including catalase, glutathione peroxidase, and super oxide dismutase (SOD). These enzymes prevent damage caused by certain types of free radicals. |
Elaine Magee
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| The latter trio best improved cholesterol profiles and helped protect against inflammation and oxidative stress to the point that lower doses of the supplements could be given.
How could these three seemingly different supplements demonstrate such powerful effects in the body? First of all, they aren't the strange bedfellows you might think. Niacin is very effective at decreasing triglycerides and LDL cholesterol and raising HDL cholesterol. Fish oil with omega-3s makes cholesterol particles larger and less likely to stick to artery walls and has been shown to decrease triglycerides, too. |
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