Mike Adams, the Health Ranger
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 In this article, I will be discussing the PYY3-36 Appetite Control nasal spray made by a company called Nastech. This is an upcoming prescription drug product still in Phase II testing that could someday offer tremendous potential to help people lose weight. But it's not all smooth sailing yet; there are some potential dangers and pitfalls along the way. Those will be discussed here as well.
The first thing to realize about this Nastech product is that it's not really a prescription drug at all, in my view. |
| What about the PYY3-36 nasal spray? Is it a good drug?
Well, that depends on how you use it. And unfortunately, the way it is likely to be used by most Americans is as a replacement for making healthy lifestyle changes. And again, this is unfortunate, and it's no fault of the drug itself. It is a cultural issue and an issue of personal discipline and personal responsibility. A lot of people will say, "This is great! I can just take this drug, inhale it three times a day, and I will automatically lose weight. |
| This is the promise of the Nastech PYY3-36 nasal spray, and it is potentially a very promising treatment for obesity (and would even help those with diabetes as well). In fact, this could potentially become a huge success as a prescription drug. It could be a blockbuster seller.
But now let's look at some of the problems this product could bring to the forefront if it becomes a huge success. The first problem, as far as I see it, is that the Nastech company has chosen to partner up with Merck as its marketing and distribution partner. |
Thomson Healthcare, Inc.
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 Side effects reported with nasal spray formulations include nasal irritation, decreased sense of smell, and headache. Taking androstenedione could increase serum testosterone levels and result in a positive testosterone assay (Cummings et al 1998). dosage
Mode of Administration: oral, sublingual, intranasal
How Supplied: Capsules, tablets, sublingual tablets, and nasal spray
Daily Dosage: For muscle gain, most manufacturers recommend a maximum of 100 mg per day, taken with water on an empty stomach, 30 minutes prjor to physical activity; a few advocate using higher doses. |
Craig Pepin-Donat
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 Major Twice-A-Day 12 Hour nasal spray (Lot #K4496, Exp 10/06) by Propharma was recalled because the lot was contaminated with Burkholderia cepacia bacteria. According to the alert, the lot was distributed to wholesalers, pharmacies, hospitals and retailers nationwide. Use of this contaminated product could cause serious or potentially life-threatening infections in patients with compromised immune systems.
On March 22, 2004, the FDA put the entire class of antidepres-
Drug Recalls: Real-life Examples sant drugs listed here on warning. |
Thomson Healthcare, Inc.
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| For maintenance of normal testosterone levels in women, the usual dose is 25 mg of nasal spray (1 spray) per day, no more than 5 days per week.
Storage: Store at room temperature, away from heat, moisture, and direct light. literature
Ballantyne CS, Phillips SM, MacDonald JR et al: The acute effects of androstenedione supplements in healthy young males. Can J Appl Physiol; 25(l):68-78. Feb 2000
Bizeau, Hazel (abstract): Experimental biology 99. Washington, DC USA. April 17-21, 1999. Abstracts, Part I. FASEB J; Mar 12;13(4):Al-646. |
Marshall Editions
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 Clear your sinus passages: Peppermint oil, Afrin™ nasal spray and steam inhalation can all reduce inflammation and encourage mucus to drain from your sinuses.
Antibiotics: Amoxicillin, Septra™, erythromycin, or ceftin can be used to treat sinusitis. If there is no improvement after one week, try a more potent antibiotic such as augmentin or levofloxin. Antibiotics should be used for at least 14 days. A four- to eight-week course is sometimes prescribed in chronic cases.
Warning: A complication of sinusitis called periorbital cellulitis requires immediate medical attention. |
Bottom Line Health
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| THE NEXT STEP
Weiner and his team say they hope to begin small-scale testing of the Alzheimer's nasal spray vaccine in people following talks with the US Food and Drug Administration (FDA). They note that the human trial process will take time, so a nasal Alzheimer's vaccine is, at best, several years away from clinical use.
Weiner notes that although there are a number of different research projects currently exploring the possibility of reducing beta-amyloid buildup in the brain, none has yet been shown to work in people. |
Mike Adams, the Health Ranger
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 I suspect that the much-hyped PYY3-36 nasal spray, produced by a company called NasTech, might offer another realistic appetite suppressant solution. But that product is only in trials right now, and it won't even be available on the market for several years. It's also a drug, meaning you'd need a prescription, which makes it a lot more difficult to get than hoodia gordonii. So don't put any short-term hopes on the PYY nasal spray. Right now, hoodia gordonii is probably the best thing going. |
H. Winter Griffith, M.D.
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 BRAND NAMES
Chlorohist-LA Inspire
Neo-Synephrine II Long Acting nasal spray Adult Strength
Neo-Synephrine II Long Acting Nose Drops Adult Strength
Otrivin Decongestant Nose Drops
Otrivin Nasal Drops
Otrivin nasal spray Otrivin Pediatric
Decongestant Nose
Drops Otrivin Pediatric
Nasal Drops Otrivin Pediatric
Nasal Spray Otrivin with M-D
Pump
BASIC INFORMATION
Habit forming? No Prescription needed? No Available as generic? Yes Drug class: Sympathomimetic
Relieves congestion of nose, sinuses and throat from allergies and infections. a? |
Mike Adams, the Health Ranger
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 This product was a nasal spray, which would be more in accordance with the thought that there is some homeopathic element to it. Maybe that is not the exact word to describe it, but if the body just gets a sense of a little bit of it, it says, "Whoopee! Now we can go into business."
Dr. Frank spoke about this at length. He knew that the RNA was not going in, but he knew the results he was getting. He was saying that same thing. Sometimes you can get a few percent in across the gut. It is like chondroitin sulfate. People said, "No, you never get any in. |
Brigitte Mars, A.H.G.
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 It can be prepared as a compress to treat eye inflam-matino or mastitis, as a gargle to treat throat infection, as a nasal spray to treat sinus infection, or as a tea used as a douche or sitz bath to treat Candida, chlamydia, leukorrhea, and trichomonas.
Usnea, though sometimes used as a tea, is more effective as a tincture. In a wilderness situation where tea or tincture is unavailable, usnea can simply be chewed and swallowed.
Edible Uses
Usnea is edible, though it is so bitter that it would be considered for consumption only in emergencies. |
Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D.
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 However, in another double-blind o study, zinc nasal spray was no more effective than a n placebo; in both groups the median duration of symp- _j toms was seven days.15 The beneficial effect of zinc 3" nasal sprays should be weighed against a potentially se- o rious side effect. At least ten cases have been reported of people with previously normal sense of smell who experienced severe or complete loss of smell function after using intranasal zinc gluconate. In some cases the loss of smell was long-lasting or permanent. |
Brigitte Mars, A.H.G.
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| Topically, yerba mansa can be prepared as a wash to treat wounds; a salve or compress to help heal fungal infections and sores; a mouthwash or gargle to soothe and treat receding and inflamed gums as well as sore throat; a nasal spray to remedy hay fever; a snuff to treat nasal polyps; a powder to treat athlete's foot; a bath herb to relieve arthritis and sore muscles; a sitz bath to treat Bartholin gland cysts and anal fissures; and a douche to treat yeast infection.
Edible Uses
The root is edible raw or cooked. The seeds can be dried, ground, and used in place of grain to make cereal. |
Mark Sircus
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 The FluMist vaccine is a live virus vaccine that is given as a nasal spray. The virus can be shed from the nasal passages of a vaccinated individual for up to 21 days after vaccination. The package insert for the FluMist vaccine clearly states, "Due to the possible transmission of vaccine virus, FluMist recipients should avoid being in close (for example, within the same household) contact with immune-compromised individuals for three weeks following vaccination. |
Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D.
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| A double-blind trial showed a 74% reduction in 3 symptom duration in people using a zinc nasal spray 3 four times daily, compared with the 42 to 53% reduc- ? tion reported in trials using zinc gluconate or zinc ac- ^ etate lozenges.14 The average duration of symptoms q after the beginning of treatment was 2.3 days in the ^ people receiving zinc, compared with 9.0 days in those ^ receiving placebo. However, in another double-blind o study, zinc nasal spray was no more effective than a n placebo; in both groups the median duration of symp- _j toms was seven days. |
James F. Balch, M.D. and Mark Stengler, N.D.
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 Super Prescription #6 Grapefruit seed extract
This is available as a nasal spray for sinusitis. Use the spray four times daily for acute sinusitis and twice daily for chronic sinusitis.
Super Prescription #7 Collodial silver
Use it as a nasal spray, or dilute it in a saline solution. Use the spray four times daily for acute sinusitis and twice daily for chronic sinusitis.
General Recommendations
Vitamin C has anti-allergy and immune-enhancing effects. Take 1,000 mg four times daily. Note: Reduce the dosage if diarrhea occurs.
Bioflavonoids are helpful for people with allergies. |
Andreas Moritz
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 Like so many other live virus vaccines, the nasal spray flu vaccine called FluMist contains MSG in the form of monosodium glutamate. Monosodium glutamate is described as a "mutagen and reproductive effector" by the Centers for Disease Control in their Registry of Toxic Effects of Chemical Substances.
More and more personal care products that are labeled "organic" actually contain free glutamic acid (MSG). Soon soaps, shampoos, and other body care products will have glutamate surfactants in them, as well as products that contain hydrolyzed proteins. |
Dr. Steve Blake
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 With pernicious anemia, Vitamin B12 must be injected or absorbed through membranes directly into the bloodstream via a nasal spray or absorbed from under the tongue.
It may take several years to develop deficiency symptoms as vitamin B |2 is efficiently recycled. Whether the deficiency is from poor absorption or from a diet low in animal products, onset of symptoms is typically slow.
Folate cannot be properly utilized if vitamin B12 is low or absent. This is because vitamin B]2 is needed to convert methyl folate to its active form. |
Marshall Editions
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| Grapefruit seed extract can be used in a nasal spray four times a day.
TIP: USE A HUMIDIFIER
Use a cool-mist humidifier. Moist air can help clear the mucus in your nasal passages. Also try resting a towel or washcloth that has been wrung out with hot water over your face for a few minutes. It can stimulate blood circulation, loosen mucus, and relieve pain.
HOMEOPATHY
Any of the following homeopathic remedies can help ease the pain of recently developed bouts of sinusitis and encourage the condition to resolve itself speedily. |
Ann M. Coulston and Carol J. Boushey
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 A randomized trial of nasal spray salmon calcitonin in postmenopausal women with established osteoporosis: The Prevent Recurrence of Osteoporotic Fractures Study. PROOF Study Group. Am. J. Med. 109, 267-276.
78. Neer, R. M., Arnaud, C. D., Zanchetta, J. R., Prince, R., Gaich, G. A., Reginster, J. Y., Hodsman, A. B., Eriksen, E. F., Ish-Shalom, S., Genant, H. K., Wang, O., and Mitlak,
B. H. (2001). Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N. Engl. J. Med. 344, 1434-1441.
79. Heaney, R. P. (2007). |
| Although calcitonin can be given by subcutaneous injection, most patients take the drug as a nasal spray (Miacalcin). In approved doses, calcitonin is a relatively weak antiresorptive drug with efficacy characteristics that are less pronounced than those of the other approved antiresorptive agents. f. Strontium Ranelate
Strontium has recently received approval in Europe and Asia for treatment of osteoporosis. It becomes incorporated directly into the bone mineral, which creates an artifactual increase in BMD. |
Marshall Editions
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| If the congestion is severe a steroid nasal spray is sometimes needed. A steam humidifier may also be helpful in relieving congestion.
O O
CO m CO
Allergy medications: If the congestion is caused by allergies, an antihistamine such as Claritin® or Allegra® can be used.
TRADITIONAL CHINESE MEDICINE
Herbs: The herbs used in the following formula are available from Chinese pharmacies or online. |
| In this case, a nasal spray containing desmopressin, which is available from a doctor, may help.
CONSULT A DOCTOR IF:
TREATMENT GOAL
• A child still wets the bed after the age of six
• A child suddenly starts wetting the bed
• A child's urine has a strong smell, or it hurts when he or she urinates
• A child starts to have accidents during the day
Do not make bed wetting a big issue. Encouragement is often the most helpful way to deal with the problem. |
Bottom Line Health
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| REPPED: Simple Nasal Vaccine May Slow Alzheimer's
Researchers think they are close to devising a deceptively simple way to prevent the progression of Alzheimer's disease— nasal spray vaccine. The vaccine, which so far has only been tested on mice, is a combination of two medications— Protollin and glatiramer acetate (Copaxone), which has already been approved to treat other conditions, including multiple sclerosis (MS).
The spray targets the abnormal buildup of beta-amyloid plaque in the brain. |
Charles Barber
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 Elizabeth Taylor acknowledged a steady diet of Valium and Jack Daniel's, and Tammy Faye Bakker, televangelist Jim Bakker's wife, admitted her addiction to Valium, which she took— very inventively, I might add—by means of a nasal spray solution. In response to such revelations, the U.S. Senate conducted hearings on tranquilizer addiction in 1979.20 And as quickly as Valium rose, it fell. Sales plummeted in the early 1980s. Valium is now the forty-first most prescribed generic drug in America. |
Marshall Editions
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| A syringe can also be used, as can a nasal spray.
Supplements: Take 1,000 mg of quercetin (eucalyptus flavonoid) three times a day. Take 500 mg-1 g of vitamin C a day, and add zinc and vitamins A and E to your diet. Take 4 g of EPA DHA (an omega-3 fat) fish oil a day in a 3:2 ratio.
Medication: Topical nasal steroids such as Flonase®, oral antihistamines, topical azelastine, or cromolyn sodium in combination with mucolytics (guaifenesin) and decongestants are usually prescribed. Although they do mask symptoms, they do not alleviate the actual cause. |
| A syringe can also be used as can a nasal spray.
Supplements: Take 1,000 mg of quercetin (eucalyptus flavonoid) three times a day. Take 500 mg -1 g of vitamin C a day, and add zinc and vitamins A and E to your diet. Take 4 g of EPA DHA (an omega-3 fat) fish oil a day in a 3:2 ratio.
Diet: Eliminating dairy products from your diet usually decreases the symptoms of the allergic reaction. Other common allergens are spices, yeast products, and gluten. |
Mike Adams, the Health Ranger
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 Maybe we will see a revolutionary approach to fat loss at some point in the future (perhaps the PYY appetite control nasal spray, for example), but chances are that medical researchers will continue to be baffled by the human body's multiple, redundant calorie accumulation mechanisms that have so far made it impossible to develop a safe, effective fat loss wonder drug. |
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