Gary Null and Amy McDonald See book keywords and concepts | Some have suggested that autism is just being better diagnosed today versus ten years ago and that many cases of mental retardation are now being coded as autism. This would also assume that the experts diagnosing autism before did not know what they were doing. This is NOT TRUE. Autism is the only disorder rising dramatically—mental retardation, Down's syndrome, and cystic fibrosis remain relatively the same.
GIRLS VS. BOYS: Autism often strikes boys more often than girls—roughly four times more common in boys. Statistics being 1 in every 166 children that makes it 1 in every 41 males. | Ann M. Coulston and Carol J. Boushey See book keywords and concepts | In addition to obesity, the Prader-Willi syndrome is characterized by hypotonic musculature, mental retardation, hypogonadism, short stature, and small hands and feet (for review, see [52, 53]). Aberrant behavior, including hyperphagia and aggressive food seeking, makes management of these patients difficult.
The better known of the autosomal recessive Mendelian obesity syndromes are the Bardet-Biedl syndromes (BBS1-BBS8) and the Alstrom syndrome (ALMS 1). | | The eight Bardet-Biedl syndromes are associated with variants in genes on eight separate chromosomes but are all characterized by mental retardation, pigmentary retinopathy, Polydactyly, obesity, and hypogonadism. It is, therefore, apparent that mutation in at least eight separate genes can result in the same phenotype. The gene coding for BBS2 may predispose males carrying only one copy of the gene to obesity and may explain approximately 3% of severely overweight males [54]. Of interest, BBS2 parents of both sexes were significantly taller than U.S. individuals of comparable age [54]. | | In addition to obesity, Alstrom syndrome (causative gene ALMS1) is characterized by retinitis pigmentosa leading to blindness, insulin resistance, diabetes, and deafness, but it does not involve mental retardation or Polydactyly (for review, see [55]). Onset of obesity is usually between 2 and 10 years of age and can range from mild to severe.
VIII. EVIDENCE FROM LINKAGE STUDIES OF OBESITY PHENOTYPES
A. Mapping of Loci in Animals
Animal models have been very important in the dissection of complex traits [56]. | | Polydactyly, and mental retardation as well as by cytogenetic assays. Thus, one should rule out these diagnoses by phenotype determination and by absence of characteristic chromosomal abnormalities.
B. Implications of Obesity Genes for Obesity Treatment
Patients with monogenic obesity will probably be more difficult to treat than those with polygenic obesity, because individuals with monogenic obesity will likely have strong food-seeking behavior and may have physiological resistance to fat loss. | Thomson Healthcare, Inc. See book keywords and concepts | In a study of 100 pediatric patients (ages 3 months to 21 years) with chronic sleep disorders, 54% were visually impaired and 85% had multiple neurodevelopmental disabilities (including visual loss, deafness, blindness, mental retardation, cerebral palsy, epilepsy, chromosomal abnormalities, head injuries, degenerative central nervous system disorders, autism, and brain tumors). Of the 15 patients not having the above conditions, diagnoses were attention deficit hyperactive disorder, anxiety, bowel disorders, and nocturnal seizures. Treatment with oral melatonin doses of 2. | Tori Hudson, N.D. See book keywords and concepts | FAS is caused by in utero alcohol-induced damages and results in mental retardation. Infants born with FAS have facial abnormalities and slow growth. They show impairment in their intellectual development and have difficulties in learning, memory, problem solving, and attention span. They can also experience mental health problems and difficulties with social behaviors.120 It is estimated that the prevalence of FAS in the United States ranges between 0.3 to 2.2 per 1,000 live births. Much higher rates can occur in some communities. | | Taurine is biosynthesized from methionine or from cysteine during the metabolic process, and disturbances in enzymatic reactions that take place in this process can lead to mental retardation. Vegetarian mothers who consume no meat products during their pregnancy, and therefore have a low-taurine diet, as well as others on a protein-, methionine-, or vitamin Bf—deficient diet might be at particular risk. | Dr. Abram Hoffer, MD, FRCP (C) and Dr. Harold D. Foster, PhD See book keywords and concepts | Individuals with a defective form of this enzyme develop very high blood and urine homocysteine levels that can cause a variety of symptoms, including mental retardation, vascular and skeletal problems, and optic lens dislocation. It has been found that roughly one half of cystathionine |3-synthase deficient patients respond well to very high doses of vitamin B-6, the coenzyme for cystathionine (3-synthase, which can lower their homocysteine and serine concentrations to normal levels. | Michael Friedman, ND See book keywords and concepts | WHO figures), usually considered due to simple iodine deficiency, presenting as goiter (at least 200 million), complex mental retardation from fetal and neonate iodine deficiency (iodine deficiency causes more mental retardation worldwide than all other causes combined) , and physical deformities (at least 20 million). Low dietary iodine is also associated with increased rates and risk for breast, endometrial, and ovarian cancer; the cause is probably gonadotropin stimulation with a resulting hyperestrogenic state characterized by relatively high production of estrogen and estradiol. | Ann M. Coulston and Carol J. Boushey See book keywords and concepts | Fetal Alcohol Syndrome Fetal alcohol syndrome (FAS) or, as proposed by the American Academy of Pediatrics (AAP), alcohol-related neurodevelopmental disorder (ARND) and alcohol-related birth defects (ARBD) is defined by pre- and postnatal growth disturbances, dysmorphic facial features, and mental retardation; behavioral abnormalities are common, as are motor problems, facial anomalies, and cardiac defects [34]. FAS represents an example of a developmental disability where prenatal nutrition likely plays a major role in the etiology. This is due to (1) the dietary energy provided by alcohol (7. | Dr. Edward F. Group III, DC, ND, DACBN See book keywords and concepts | | Aspartame has been investigated as a possible cause of brain tumors, mental retardation, birth defects, epilepsy, Parkinsons Disease, Fibromyalgia, and Diabetes, yet the FDA (that once sought to have Aspartame removed from the market) has done nothing to regulate this toxic artificial sweetener!
Did You Know?
After being inside the body for 20 minutes, Aspartame begins breaking down from its original compound into methanol, formaldehyde (a Class-A carcinogen used to embalm corpses) and formic acid (ant venom). | Tori Hudson, N.D. See book keywords and concepts | Three or four beers or glasses of wine a day can cause any one or more of the following defects: mental retardation, hyperactivity, a heart murmur, facial deformity such as a small head, or low-set ears.123
Cigarettes
The sad news is that more than 20 percent of women in the United States smoke. The numbers are similar in other developed countries and only slightly lower in developing countries. Unfortunately, many of these women also smoke during pregnancy—about 11 percent. | Dr. Edward F. Group III, DC, ND, DACBN See book keywords and concepts | | A pregnant woman who is infected with toxoplasmosis can pass the disease to her unborn child who may then develop a central nervous system disorder, spleen or liver enlargement, heart or eye damage, or even mental retardation.
Based on a simple review of available data, over 47 million people living in the U.S.A. may host the Toxoplasma parasite.122 Healthy individuals with uncompromised immune systems often show no symptoms, but those with weakened immune systems can suffer greatly from this parasite. | Jonny Bowden, Ph.D., C.N.S. See book keywords and concepts | Iodine deficiency is the leading cause of mental retardation, producing typical reductions in IQ often to fifteen points.
Interestingly, selenium deficiency can exacerbate the effects of iodine deficiency.
It's okay to supplement with iodine if you are taking thyroid medication like Synthroid or Armour thyroid.
Natural Prescription for Thyroid Support
Foods: Make sure to include foods in the diet such as seafood, iodized salt, sea vegetables such as kelp, and dairy products, all of which are high in iodine. | | For example, iodine deficiency has been called "the world's major cause of preventable mental retardation" by the International Council for the Control of Iodine Deficiency Disorders. Most notably, in 2000, the American Journal of Clinical Nutrition published a study that examined 196 iodine-deficient children in Northern Benin. The children were separated into two groups—those whose iodine status was improved after iodized salt was added to the community and those whose status did not change. | Andreas Moritz See book keywords and concepts | If pregnant women consume large quantities of diet sodas to avoid weight gain, their placenta may accumulate methyl alcohol, causing mental retardation in the fetus. They also risk maternal malnutrition because of the gastrointestinal problems and diarrhea associated with sweeteners.
Other sweeteners besides aspartame have similar effects. Added to soft drinks, they are now even linked with testicular damage and other key areas of the body. | | Depression, anorexia, low birth weight, slow growth, mental retardation, and amenorrhea are associated with deficiencies of zinc and, with the exception of amenorrhea, iron.
• Excess fiber consumption affects the onset of menstruation, retards uterine growth and, is associated with menstrual dysfunction.
Because of phytates, Dr. David Southgate, considered the world's leading authority on the effects of fiber, concludes that infants, children, young adolescents and pregnant women whose mineral needs are greater should avoid excessive consumption of fiber. | | Dietary intake of vitamin D has led to kidney calcification and severe mental retardation in their offspring. Children born to mothers, who take extra vitamin D in their diet, may develop a certain type of congenital heart disease called supravalvular aortic stenosis and show extreme deformations of facial bones.
Taking vitamin D supplements can also contribute to arteriosclerosis and even be fatal. In 1991, several Americans died from vitamin D in cow's milk. The supplement was added during the production process, but the measurement was faulty. | | Many babies born to cocaine-using mothers are born with severe mental retardation and are vulnerable to tuberculosis and lung diseases. The major experimental drugs are so poisonous that regular use can result in dementia, serious bacterial infections, and total destruction of the immune system. The drugs certainly possess a much higher probability of impairing immune functions so typical to AIDS than a simple, inactive virus.
2. Antibiotics
Most of the patients suffering from AIDS also have a long history of taking antibiotics. | Dr. Steve Blake See book keywords and concepts | Stunted growth, mental retardation, and cretinism can affect the children of pregnant women with inadequate iodine intake. Pregnant and breastfeeding women can ensure adequate iodine by taking a daily prenatal supplement providing 150 meg of iodine.
Pregnant women sometimes suffer from water retention. Lowering sodium amounts in the diet to recommended levels may help reduce swelling.
To ensure optimal health for both the baby and the mother, these vitamins and minerals need to be maintained at their ideal levels. | | Cretinism is a state of stunted growth and extreme mental retardation, resulting in intelligence quotients as low as 20. Pregnant and breastfeeding women can ensure adequate iodine by taking a daily prenatal supplement providing 150 meg of iodine.
Brain Damage from Iodine Deficiency
Iodine deficiency is the most common cause of preventable brain damage in the world. Diets that do not include seaweed, fish, iodized salt, or other iodized food have been found to contain very little iodine. Iodine deficiency disorders affect three-quarters of a billion people worldwide. | Gerald E. Markle and Frances B. McCrea See book keywords and concepts | Children born with metabolic disorders, "who once suffered irreversible mental retardation, now usually retain cognitive function as a result of routine newborn screening and treatment."15
These successes are noteworthy. They seem to reveal the value of routine physical examinations of supposedly healthy patients. Yet a few pages after lauding the exam's achievements, the 1989 Guide found "inadequate evidence to evaluate effectiveness or to determine the optimal frequency of a preventive service. | Michael Friedman, ND See book keywords and concepts | WHO figures), usually considered due to simple iodine deficiency, presenting as goiter (at least 200 million), complex mental retardation from fetal and neonate iodine deficiency (iodine deficiency causes more mental retardation worldwide than all other causes combined) , and physical deformities (at least 20 million). Low dietary iodine is also associated with increased rates and risk for breast, endometrial, and ovarian cancer; the cause is probably gonadotropin stimulation with a resulting hyperestrogenic state characterized by relatively high production of estrogen and estradiol. | Gary Null and Amy McDonald See book keywords and concepts | RESULTS: Phase one showed significantly increased risks for autism, speech disorders, mental retardation, personality disorders, and thinking abnormalities reported to VAERS following thimerosal-containing DTaP vaccines in comparison to thimerosal-free DTaP vaccines. Phase two showed significant associations between cumulative exposures to thimerosal and the following types of NDs: unspecified developmental delay, tics, attention deficit disorder (ADD), language delay, speech delay, and neurodevelopmental delays in general. | | In recent years, chemical exposure has increasingly been linked to a variety of "subclinical" mental health symptoms (behavior changes, cognitive decline) as well as neurodevelopmental disorders, such as autism, attention deficit disorder (ADD), and mental retardation.
"The human brain is a precious and vulnerable organ," says Philippe Grand-jean, adjunct professor at Harvard School of Public Health and the study's lead author. "And because optimal brain function depends on the integrity of the organ, even limited damage may have serious consequences.... | Peter J. Whitehouse and Daniel George See book keywords and concepts | In children, arsenic poisoning can lead to mental retardation, emotional disturbances, and in some cases death, while ingestion of arsenic-contaminated water has long been recognized to cause peripheral neuropathy in adults?
damage to the nerves of the peripheral nervous system.40 Although the specific relationship between arsenic and dementia is unknown, it goes without saying that researchers should inquire further into its role in neurodegeneration, and that regulatory action should protect developing brains against the ravages of this industrial chemical. | | Methylmercury
Evidence for the neurotoxicity of methylmercury became evident in the mid-twentieth century when researchers observed a rash of spasticity, blindness, and mental retardation in infants born to mothers who had consumed fish from contaminated waters.38 The U.S. National Academy of Sciences has recently concluded that there is strong evidence for fetal neurotoxicity of methylmercury, even at minimal exposures,39 and there are efforts worldwide to restrict mercury flux into the environment. | Connie Bennett, C.H.H.C. with Stephen T. Sinatra, M.D. See book keywords and concepts | Moreover, hypoglycemia has been called the "Great Imitator" because its strange, startling symptoms—some experts list as many as 125 of them—can mimic a frightening array of diseases and conditions, including bipolar disorder, schizophrenia, neurosis, migraines, Parkinson's syndrome, chronic bronchial asthma, paroxysmal tachycardia (rapid heartbeat), rheumatoid arthritis, cerebral arteriosclerosis (hardening of the brain's arteries), menopause, mental retardation, alcoholism, hyperactive disorder, and senility. | Gary Null and Amy McDonald See book keywords and concepts | The NDs examined included autism, mental retardation, and speech disorders. Statistical trend analysis was employed to evaluate the effects of removal of Thimerosal on the proportion of NDs reported to VAERS. RESULTS: There was a peak in the proportion of ND reports received by VAERS in 2001-2002 and in the proportion of ND reports by date of vaccine administration in 1998. There were significant reductions in the proportion of NDs reported to VAERS as Thimerosal was begun to be removed from childhood vaccines in the US from mid-1999 onwards. |
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