Lupeol

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PDR for Herbal Medicines, Fourth Edition Thomson Healthcare, Inc. See book keywords and concepts

Sterols: beta-sitosterol, campesterol, lupeol Volatile oil: chief components are alpha-pinene (25%), alpha-humulene (10%), beta-pinene (8%), beta-caryophyllene (8%) camphene (7%), camphor (6%), EFFECTS No information is available. Habitat: The plant is widespread in Europe, temperate Asia and North America. indications and usage Unproven Uses: Muira-Puama is used internally for diarrhea, loss of appetite, and for the prevention of sexual disorders. The herb is also used externally for the prevention of sexual disorders.

The Healing Power of Rainforest Herbs: A Guide to Understanding and Using Herbal Medicinals Leslie Taylor, ND See book keywords and concepts

Early researchers discovered that the root and bark were rich in fatty acids and fatty acid esters (the main one being behenic acid), essential oils (including beta-caryophyllene and alpha-humulene), plant sterols, triterpenes (including lupeol), and a new alkaloid—which they named muirapuamine.7 Scientists resumed researching the plant's constituents and pharmacological properties in the late 1960s and continued into the late 1980s.8-14 These studies indicated that the active constituents also included free long-chain fatty acids, sesquiterpenes, monoterpenes, and novel alkaloids.

PDR for Herbal Medicines, Fourth Edition Thomson Healthcare, Inc. See book keywords and concepts

Flavonoids (0.3 to 0.8%): including isorhamnetin and quercetin glycosides Hydroxycoumarins: including scopoletin, umbelliferone, es-culetin Carotinoids: chief components lutein, zeaxanthine Volatile oil (0.2%): chief components alpha-cadinol, T-cadi-nol, fatty acids Water-soluble polysaccharides (15%): rhamnoarabinogalac-tans, arabinogalactans Polyynes COMPOUNDS: MARIGOLD HERB Triterpene saponins Flavonoids Carotinoids Volatile oil EFFECTS: MARIGOLD HERB The astringent and granulation-promoting effect may be attributable to the essential oil, saponins, and the amaroid loliolid.

Anti-Aging Manual: The Encyclopedia of Natural Health Joseph E. Mario See book keywords and concepts

Free and esterified steroliccompoundsofBeta-Sitosterol,Stigmasterol,Campestrol,Cycloartenol, lupeol, Lupenone, and 24-methyl Cycloartenol. Along with Carotenoids; and polysaccharides Glucose, Mannose, Galactose, Arabinose, Rhamnose, and Glucuronic acid. South American Cactus(Opuntiaficusindica)flowers"powderridsprostate problems. Prickly Pear cactus counters prostate enlargement. Panax Ginseng increases Testosterone levels, and decreases enlarged prostate weight.

Beta-Sitosterol, Stigmasterol, Campesterol, Cycloartenol, lupeol, Lupenone, 24-methy 1 Cycloartenol, and glucosides. Extract has 25-35% free fatty acids; 63% of the oil are unsaturated fatty acids Oleic, Laurie (CI2), Myristic (CI4), Palmitic, Linoleic, Caprinic, Stearic, Capric (C8), Caprylic (C10), Caproic, and Linolenic acid; 22% saturated fats; 7% ethyl esters; alcohols Phytol,Farnesol,Geranylgeraniol,and Polyphenols; tannins, sugars, and enzyme Lipase that breaks down fats, for obesity. Dose ofthe 85-95% fatty acid extract is 160 mg.

Prescription for Nutritional Healing, 4th Edition: A Practical A-to-Z Reference to Drug-Free Remedies Using Vitamins, Minerals, Herbs & Food Supplements Phyllis A. Balch, CNC See book keywords and concepts

Chanca piedra Entire Phytochemicals: Limonene, lupeol, (Phyllanthus plant. methyl salicylate, quercetin, quercitrin, niruri) rutin, saponins. Fights inflammation and bacterial and viral infection. Acts as a diuretic. Useful for kidney stones, gallstones, colds, flu, digestion, asthma, bronchitis, diarrhea, pain relief, fever, sexually transmitted diseases, and muscle spasms. A rainforest herb whose name means "stone crusher." Also known as seed-on-the-leaf. Chaparral Leaves.

Phytochemicals: Beta-sitosterol, campesterol, coumarin, lupeol. Helps relieve pain, acts as a mild laxative and detoxifier, and supports the heart. Has a general tonic effect and balances sex hormones. Beneficial in treating nervous system disorders, impotence, depression, stress, rheumatism, hair loss, asthma, and menopausal and menstrual problems. An alcohol-based extract is believed to be the best form of this rainforest herb, as the active constituents are neither water soluble nor broken down in the digestive process. Mullein Leaves.

Phytochemicals: Alpha-amyrin, ascle- Reduces inflammation of the pleural Also called butterfly piadin, beta-amyrin, isorhamnetin, kaempferol, lupeol, quercetin, rutin, viburnitol. membranes of the lungs, enhances secretion of healthy lung fluids, and stimulates the lymphatic system. Has antispasmodic properties. Induces sweating and aids expectoration. Beneficial for pleurisy, pneumonia, bronchitis, flu, and coughs. weed. Primrose Seed oil.

The Healing Power of Rainforest Herbs: A Guide to Understanding and Using Herbal Medicinals Leslie Taylor, ND See book keywords and concepts

The olacoides variety is usually preferred, as it has a higher content of lupeol (one of the plant's active phytochemicals). A completely different species of Brazilian tree, Liriosma ovata, also goes by the common name of muira puama (and is often sold in commerce as such); however, it is a completely different tree with a different phytochemical makeup.1 TRIBAL AND HERBAL MEDICINE USES Muira puama is called "potency wood" because it is a highly regarded male sexual stimulant with a reputation as a powerful aphrodisiac in Brazil.

Fundamentals of Pharmacognosy and Phytotherapy Dr. Michael Heinrich, Joanne Barnes, Simon Gibbons and Elizabeth M. Williamson See book keywords and concepts

Constituents Marigold flowers contain saponins based on oleanolic acid, including calendasaponins A, B, C and D, and triterpene pentacyclic alcohols such as faradol, arnidiol, erythrodiol, calenduladiol, heliantriols Al, BO, Bl and B2, taraxasterol, lupeol and ursatriol. Among the other groups of natural products considered to be relevant for the pharmacological effects are flavonoids, including hyperoside and rutin; sesquiterpene and ionone glycosides such as officinosides A, B, C and D, loliolide and arvoside A; a volatile oil and polysaccharides PS-I, -II and -III; and chlorogenic acid.

Constituents likely to be important include: the fatty acids capric, caprylic, lauric, oleic, myristoleic, palmitic, linoleic and linolenic acids; the monoacyl glycerides 1-monolaurin and 1-monomyristicin; phytos-terols such as (3-sitosterol, campesterol, stigmasterol, lupeol and cycloartenol (Fig. 18.3). Long-chain alcohols (farnesol, phytol and polyprenolic alcohols) and flavonoids are present, as well as immunostimulant, high-molecular-weight polysaccharides containing galactose, arabinose, mannose, rhamnose and glucuronic acid.

Indian Herbal Remedies: Rational Western Therapy, Ayurvedic and Other Traditional Usage, Botany C. P. Khare See book keywords and concepts

From bark lupeol and betulinic acid were isolated. Ethanolic extract of the bark showed potent anti-inflammatory and analgesic properties (CCRAS). The fruit, the ethanolic extracts of stem bark, exhibited antiamoebic activity against Entamoeba histolytica. Fruits possess antibiotic and antibacterial activities against E. coli, and Ran-ikhet disease virus. The plant extract exhibited IFM-like activity against RDV.

Medical Herbalism: The Science Principles and Practices Of Herbal Medicine David Hoffman, FNIMH, AHG See book keywords and concepts

Interestingly, research has revealed that certain constituents, such as the triterpene saponin lupeol, have potential value in the prevention and treatment of oxalate-based stones.27 Only a few plants contain sufficient amounts of sodium and potassium oxalate to be considered toxic. Moreover, ruminants that consume these plants develop increasing levels of tolerance to oxalate. An oxalate-degrading anaerobic microorganism has been isolated from pure culture of rumen bacteria.

Antioxaluric and anticalciuric activity of lupeol derivatives. Indian Journal of Pharmacology 1995; 27:265-68. 28. Vulto AG, DeSmet PAGM. Drugs used in non-orthodox medicine. In: Dukes MNG, ed. Meylers Side Effects of Drugs, 11th edition. Amsterdam: Elsevier, 1988. 29. Ritschel WA, Brady ME, Tan HSI, et al. Pharmacokinetics of coumarin and its 7-hydroxymetabo-lites upon intravenous and peroral administration of coumarin in man. European Journal of Clinical Pharmacology 1977; 12:457-61. 30. Reilley O. Anticoagulant, antithrombotic, and thrombolytic drugs. In: Goodman LS, Gilman A, eds.

The Natural Medicine Guide to the 50 Most Common Medicinal Herbs Heather Boon, BScPhm, PhD and Michael Smith, BPharm, MRPharmS, ND See book keywords and concepts

Relevant Research Preventative and Therapeutic Uses CONSTITUENTS 2 5 8 10 þ terpenoids: lupeol, taraxerol, taraxasterol, faradiol, saponins, volatile oil component, campesterol, stigmasterol. þ flavonoids: rutinoside, rutin, isoquercetin, narcissin, neohesperoside. þ polysaccharides: rhamnoarabinogalactan, arabinogalactans. þ miscellaneous: bitter priniciple called loiliolide (calendin), carotenoid pigments (beta carotene, lycopene, violaxanthin). ANTI-INFLAMMATORY EFFECTS Calendula has been reported to have anti-inflammatory properties.

Herbal Drugs and Phytopharmaceuticals: A Handbook for Practice on a Scientific Basis Josef A. Brinckmann and Michael P. Lindenmaier See book keywords and concepts

Also present are flavonoids, particularly luteolin-7-O-diglucoronide [3, 4] and the diglucuro-nides of apigenin and acacetin [2, 5, 6], among others, as well as about 2% sta-chyose, small amounts of /3-sitosterol, ursolic acid, lupeol and traces of essential oil. Indications: Despite several pharmacological studies of constituents of European verbena herb, the use of the drug occurs primarily in folk medicine, as a diuretic, galactagogue, and antirheumatic. Its efficacy in these areas has not been sufficiendy substantiated.

Prescription for Nutritional Healing, 4th Edition: A Practical A-to-Z Reference to Drug-Free Remedies Using Vitamins, Minerals, Herbs & Food Supplements Phyllis A. Balch, CNC See book keywords and concepts

Nutrients: Calcium, essential fatty acids, vitamins A, B1( B2, B3, and C. Combats free radicals and inflammation. Relieves coughs and congestion. Builds the blood, cleanses the system, eases constipation. Enhances immune system function. Increases perspiration, lowers fever, soothes the respiratory tract, and stimulates circulation. Effective against flu viruses. The flowers are used to soothe skin irritations. Also called black elder, black elderberry, European elder. Caution: Should not be used during pregnancy. The stems of this plant should be avoided.

Prescription for Herbal Healing: An Easy-to-Use A-Z Reference to Hundreds of Common Disorders and Their Herbal Remedies Phyllis A. Balch, CNC See book keywords and concepts

This effect is probably due to the herb's content of lupeol, a chemical that deactivates enzymes needed to manufacture inflammation-inducing leukotrienes. • Kidney stones. Ayurvedic medicine has used varuna bark to treat kidney stones for over 3,000 years. Scientific research has confirmed that varuna deactivates the enzyme glycolate oxidase. This reduces the body's production of oxalates, which combine with calcium to form kidney stones. One of the other chemical components of varuna, lupeol, reduces the levels of various laboratory markers of kidney damage.

Indian Herbal Remedies: Rational Western Therapy, Ayurvedic and Other Traditional Usage, Botany C. P. Khare See book keywords and concepts

Lithotriptic activity of the drug is being attributed to lupeol. The drug also exhibits anti-inflammatory activity. The alcoholic extract of the stem exhibited antibacterial property against E. coli in vitro. The root extract proved antibacterial against Gram-positive and Gram-negative bacteria. Clinical studies indicate that the drug increases bladder tone and inhibits the formation of bladder stone, encourages the removal of stones in the urine. (CCRAS.

Active principles and pharmacology The seeds gave a glucoside—blepharin—and a saponin which on hydrolysis gave lupeol. The alcoholic extract of the seeds exhibited anti-inflammatory and diuretic activity in rats after 100 mg/kg p.o. CCRAS reported aphrodiasic property and also suggested drug's use in gout, arthritis and metabolic disorders. The seeds show deobstruent properties. This indicated their use in strangury. The root was found beneficial in urinary discharges and dysmenorrhoea.

Active principles and pharmacology The bark contains (+)-catechin, epicatechin, kaempherol, fistacacidin, leucocyanidin, leucopel-argonidin trimer, rhein glycoside, hexacosanol, lupeol and beta-sitosterol. The pulp from the crushed ripe pods is found rich in protein (19.94 %) and carbohydrates (26.3 %). They contain sennosides A and B, rhein and its glucoside, barbaloin, aloin, formic acid, butyric acid, their ethyl esters and oxalic acids. Presence of pectin, tannin, maltose, glucose, fructose, sucrose and a small quantity of volatile oil is also reported.

Active principles and pharmacology Fruits yielded beta-amyrin and its acetate lupeol and cucurbitacin B. Aerial parts gave hepta-cosane, cephalandrol, tritriacontane, beta-sitosterol, alkaloids cephalandrines A and B. The plant was screened for its hypoglycaemic activity in the Central Research Institute of Siddha Medicine, Trivendrum. The juice, decoction of leaves and stem of Coccinia indica and decoction of fruit in 20 ml/kg showed significant hypoglycaemic response in fasting rabbits. The fruits were found to be more potent. The root did not show hypoglycaemic activity.

The seed contains the triterpene alcohols, euphol, tirucallol, cycloartanol, taraxeol, alpha-and beta-amyrin, butyrospermol, cycloartenol, lupeol, 24-mefhylene cycloartanol and multiflore-nol. Cucurbita-5, 24-dienol is isolated from the leaves, stem, pericarp and roots. Use in Western herbal The pumpkin seeds are taken principally as a safe de-worming agent. The seeds of Cucurbita spp., Cucurbita pepo, Cucurbita maxima, Cucurbita moschata, according to Tyler, possess similar properties and enjoy a considerable reputation as teniafuges.

The Natural Medicine Guide to the 50 Most Common Medicinal Herbs Heather Boon, BScPhm, PhD and Michael Smith, BPharm, MRPharmS, ND See book keywords and concepts

Another study found direct anti-inflammatory activity which could be attributed to known sterols isolated from aloe vera gel (e.g., lupeol, campesterol). In this study, aloe vera gel also appeared to block hydrocortisone's inhibitory effects on wound healing.74 Another research team demonstrated that constituents of an aqueous gel-extract of aloe vera inhibited the release of reactive oxygen species by human PMNs, reducing the harmful effects of this release at the site of inflammation.

The Clinician's Handbook of Natural Healing Gary Null, Ph.D. See book keywords and concepts

LOPHENOL Seed lupeol Plant LUTEIN Fruit LUTEIN-5,6-EPOXIDE Fruit LUTEIN-EPOXIDE Fruit LYCOPENE Fruit 1—20 ppm LYCOPERSICONOL Root LYCOPERSICONOLIDE Root 6.7 ppm LYCOPHYLL Fruit LYCOXANTHIN Fruit LYSINE Fruit 20—5,455 ppm MAGNESIUM Fruit 70—6,000 ppm MAGNESIUM Leaf 4,300 ppm MALIC ACID Fruit MANGANESE Fruit 0.6—100 ppm MERCURY Fruit 0.001—0.

Healing with Plants in the American and Mexican West Margarita Artschwager Kay See book keywords and concepts

The aerial parts contain lupeol, valnerol, and numerous sesquiterpenes, diterpenes, and triterpenes. Sesquiterpenes, sulfur compounds, and diterpenes have been found in the root. Zexmenia species contain sesquiterpene lactones and saponins, which are toxic. No information on biological activity is given in napralert. ¦ Zomia (Fabaceae) SNAKEWEED Zornia diphylla (L.) Pers. koi vasogadi (vibora yerba), Tepehuan; yerba de la vibora, Spanish Zornia reticulata Sm. yerba de la vibora, Mountain Pima, Tarahumara Zornia spp. yerba de la vibora Zornia 1. Used for colds and stomachache. 2.

Principles and Practice of Phytotherapy: Modern Herbal Medicine Simon Mills and Kerry Bone See book keywords and concepts

Antiurolithiatic and diuretic activity of lupeol, the active constituent isolated from Crataeva nurvala (Buch. Ham). Proceedings of the 24th Indian Pharmacological Society Conference, Ahmedabad, Gujarat, India, 1991; A10 65. Varalakshmi P, Latha E, Shamila Y et al. Effect of Crataeva nurvala on the biochemistry of the small intestinal tract of normal and stone-forming rats, [ourna] of Ethnopharmacology 1991; 31(1): 67-73 66. McKay DW, Seviour JP, Comerford A et al. Herbal tea: an alternative to regular tea for those who form calcium oxalate stones.

Research has demonstrated a range of activity on urinary structures, including improved performance in clinical studies of benign prostatic hyperplasia611 and with urinary stones61-62 and in reducing oxalate stone formation,63 with the steroid lupeol being a possible active constituent.64 A pharmacological study found that Crataeva influenced small intestinal Na, K-ATPase which in turn influenced the transport of minerals.65 This is a reminder that oxalate problems may well originate from the digestive tract (see above).

The Clinician's Handbook of Natural Healing Gary Null, Ph.D. See book keywords and concepts

LOPHENOL Seed lupeol Seed LUTEIN Fruit LYSINE Fruit 380—5,183 ppm MAGNESIUM Fruit 118—2,340 ppm MALONIC-ACID Fruit MALONIC-ACID Leaf MANGANESE Fruit 0.7—39 ppm MARGARIC-ACID Fruit MERCURY Fruit 0.001—0.001 ppm METHIONINE Fruit 100—1,364 ppm MOLYBDENUM Fruit 0—15 ppm MYRCENE Fruit MYRISTIC-ACID Fruit 10—136 ppm N-Q3- METHYLTETRADECYL)ACET AMIDE Fruit 300—400 ppm N-HEXANAL Fruit N-METHYL-ANILINE Fruit 13.1 ppm N-NITROSO-DIMETHYLAMINE Fruit N-NITROSO-PYRROLIDINE Fruit N-PENTYLAMINE Fruit 3 ppm N-PROPYLAMINE Fruit 2.3 ppm NEOXANTHIN Fruit NIACIN Fruit 4—172 ppm NICKEL Fruit 0.05—5.

LUPEOL Root LUTEIN Root LUTEOLIN Plant LUTEOLIN-4'-0-BETA-D-DIGLUCOSIDE Seed LUTEOLIN-4'-0-BETA-GLUCOSIDE Seed LUTEOLIN-7-0-(6"-0-MALONYL)-BETA- D-DIGLUCOSIDE Plant LUTEOLIN-7-O-BETA-D-DIGLUCOSIDE Seed LUTEOLIN-7-O-BETA-GLUCOSIDE Root 100 ppm LUTEOLIN-7-O-BETA-GLUCURONIDE Plant LUTEOLIN-7-O-BETA-RUTINOSIDE Seed LYCOPENE Root 80—140 ppm LYSINE Root 400—3,275 ppm MAGNESIUM Root 100—1,980 ppm MALIC-ACID Root MALTOSE Root MALVIDIN-3,5-DIGLUCOSIDE Root MANGANESE Root 1—62 ppm MANNOSE Root MERCURY Root 0.001—0.

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