Bill Sardi See book keywords and concepts | Pharmacological Therapy 63: 265, 1994]
Cancer researchers intentionally caused kidney tumors in rats with the use of iron and then divided the rats into two groups, one group receiving only adequate amounts of vitamin E and another group receiving supplemental vitamin E. Among the rats that received low levels of vitamin E, 44 percent develop kidney tumors while among the rats receiving supplemental vitamin E only 5 percent developed tumors. This study suggests iron is a carcinogen and vitamin E is an antidote. | | The incidence of kidney tumors was two to four times higher with an estrogen + iron regimen than when estrogen was given with an iron-poor diet. No tumors were observed in animals treated with low or high-iron diets Estrogen is needed to loosen the iron to promote tumors, circulating levels of iron are not meaningful because most iron in the blood circulation is bound to proteins and will not promote cancer growth. Circulating levels of iron are much higher in animals given a high-iron diet plus estrogen. | | Among the rats that received low levels of vitamin E, 44 percent develop kidney tumors while among the rats receiving supplemental vitamin E only 5 percent developed tumors. This study suggests iron is a carcinogen and vitamin E is an antidote. [Cancer Research 57: 2410, 1997]
_ \ j
Iron, occupation and cancer
People who work with metals, particularly individuals who may inhale airborne iron particles, have been found to be more prone to develop cancer and other diseases. | | The incidence of kidney tumors is two to four times higher with an estrogen + iron regimen than when estrogen is given with an iron-poor diet. No tumors were observed in animals treated with low or high-iron diets. Circulating levels of iron are much higher in animals given a high-iron diet plus estrogen. [Carcinogenesis 19: 1285-90, 1998] Of particular interest is the fact that breast cancer cells exhibit 5 to 15 times more receptors for iron deposition (transferrin receptors) than normal cells. Iron-carrying proteins like transferrin are growth factors for breast tumors. | Russell L. Blaylock, M.D. See book keywords and concepts | For example, methylmercury and mercury chloride have been shown to cause kidney tumors in male mice. Studies of those exposed occupationally, such as chloralkali and nuclear weapons workers, dentists, and dental technicians, indicate that exposure to low levels of mercury may increase the risk of lung, kidney, and brain tumors.™ Better studies on these groups of high-risk individuals need to be done. No one has specifically examined the relationship between dental amalgams and brain tumors, but there is suggestive evidence that they are related. | Joseph E. Mario See book keywords and concepts | Alpha-Interferon boosts cell Immunity, inhibits viralRNA, helps hepatitis-B and C, hairy cell leukemia, Kaposi's sarcoma, and may counter myelogenous leukemia, lymphoma, colon and kidney tumors, bladder cancer, and melanomas.
DHEA, Adrenal hormone countering Alzheimer's and Parkinson diseases, diabetes, inhibits tumors, and HIV.
Isoprinosin Anti-viral that enhances B-Cells, T-cells, and Interleukin-2; counters bacteria, colds, flu, radiation, and parasites. | Committee on Diet, Nutrition, and Cancer, Assembly of Life Sciences National Research Council See book keywords and concepts | Circumstantial evidence that it may play a role in kidney tumors in the Balkans, but no epidemiological studies have been conducted.
Might be involved in cervical cancer in South Africa (Martin and Keen, 1978); however, no epidemiological studies have been conducted.
Circumstantial evidence that it may be involved in esophageal cancer in China and South Africa; however, no epidemiological studies have been conducted.
No data available.
Oral administration to mice Induced liver and kidney tumors (Kanisawa and Suzuki, 1978).
Oral administration not carcinogenic to rats (Becci et_ al. | H. Winter Griffith, M.D. See book keywords and concepts | Gold has been shown to cause kidney tumors and kidney cancer in animals given excessive doses.
• May interfere with the accuracy of some medical tests.
POSSIBLE INTERACTION WITH OTHER DRUGS
GENERIC NAME OR DRUG CLASS
COMBINED EFFECT
Bone marrow depressants*
Increased risk of toxicity of both drugs.
Hepatotoxics*
Increased risk of toxicity of both drugs.
Nephrotoxics*
Increased risk of toxicity of both drugs.
Penicillamine
Increased likelihood of kidney damage.
Phenytoin
Increased phenytoin blood levels: Phenytoin dosage may require adjustment. | Earl L. Mindell, RPh, PhD with Virginia Hopkins, MA See book keywords and concepts | | Acarbose can impair kidney function and has caused cancerous kidney tumors in rats. It can cause hypoglycemia, or low blood sugar levels, so if you're taking it, be sure to have a readily available source of dextrose on hand to counteract hypoglycemia.
A CAUTION! Think Twice About Taking This Drug If...
• You have kidney problems of any kind.
• You have serious intestinal problems.
• You are exposed to stress such as fever, trauma, infection, or surgery.
What Are the Interactions with Other Drugs? | The Life Extension Editorial Staff See book keywords and concepts | Of 18 kidney tumors treated, 13 (72%) showed no x-ray evidence of residual tumors immediately following treatment. One patient remains cancer-free 2 years following treatment. In a related NIH study involving adrenal gland tumors, 7 of 11 tumors (64%) showed no active disease following RFA. Though the remaining 36% of patients had evidence of residual tumors on follow-up imaging, all patients treated had x-ray confirmation that most of the targeted tumor was killed by treatment (Healthlink 2000).
Dr. Steven Curley (University of Texas M.D. | Ruth Winter See book keywords and concepts | The FAO-WHO Expert Committee on Food Additives said in 1993 that new data about potassium bromate showed long-term toxicity and carcinogenicity including kidney tumors, tumors of the lining of the stomach, and thyroid tumors in rats and slightly increased kidney tumors in hamsters. On the basis of the new safety data and the new data on residual bromate in bread, the Committee concluded the use of potassium bromate, as a flour treatment agent was not appropriate. The previous acceptable level of treatment of flours for bread-making was therefore withdrawn. | Committee on Diet, Nutrition, and Cancer, Assembly of Life Sciences National Research Council See book keywords and concepts | Oral administration to mice Induced liver and kidney tumors (Kanisawa and Suzuki, 1978).
Oral administration not carcinogenic to rats (Becci et_ al., in press), but carcinogenic to B6C3F mice (National Cancer Institute, in press).
Intragastric administration of L-Djq dose to rats induced cancer of digestive tract and brain (Schoental et al., 1979).
Subcutaneous injection produced sarcomas in rats (Dickens and Jones, 1965). Chronic administration per os to rats was not carcinogenic (Becci et al., 1981).
Not mutagenic : (Wehner e^t al.
Negative in Ami et al., 1978), in B_. | Samuel S. Epstein, M.D. See book keywords and concepts | Over the last decade, a plethora of new studies have identified a wide range of additional carcinogenic products and processes inducing cancers in a wide range of organs, particularly lung, brain, bladder, and kidney tumors and multiple myeloma. e*-17>5658
2. Based on exposure data, NIOSH59 has estimated that approximately 11 million workers are exposed to occupational carcinogens. Surveillance of these workers by the NCI and NIOSH is minimal, at best.
3. | Committee on Diet, Nutrition, and Cancer, Assembly of Life Sciences National Research Council See book keywords and concepts | Histopathological analysis of kidney tumors in rats induced by chemical carcinogens. Gann 62:4 35-444.
Jacobs, M. M., T. S. Matney, and A. C. Griffin. 1977. Inhibitory effects of selenium on the mutagenicity of 2-acetyl-aminofluorene (AAF) and AAF derivatives. Cancer Lett. 2:319-322.
Jansson, B., G. B. Seibert, and J. F. Speer. 1975. Gastrointestinal cancer: Its geographic distribution and correlation to breast cancer. Cancer 36:2373-2384.
Jansson, B., M. M. Jacobs, and A. C. Griffin. 1978. Gastrointestinal cancer: Epidemiology and experimental studies. Adv. Exp. Med. Biol. 91:305-322. | Ruth Winter See book keywords and concepts | For D and L limonene, the Committee the principal toxicological finding was that rf-limonene worsens spontaneously occurring nerve damage in mature male rats with subsequent occurrence of kidney tumors. The Committee concluded that "the postulated mechanism for d-limonene-induced neuropathy and renal tumors in the male rat was probably not relevant to humans." The ADI (see) was established based upon the significant decreases in the body weight gain associated with the administration of rf-limonene to male and female rats and mice and female rabbits. | Committee on Comparative Toxicity of Naturally Occurring Carcinogens See book keywords and concepts | Perchloroethylene-induced rat kidney tumors: An investigation of the mechanisms involved and their relevance to humans. Toxicol.
Appl. Pharmacol. 103:77-89. Green, S., J.D. Tugwood, and I. Issemann. 1992. The molecular mechanism of peroxisome proliferator action: A model for species differences and mechanistic risk assessment. Toxicol. Lett.
64/65:131-139.
Greenfield, R.E., L.B. Ellwein, and S.M. Cohen. 1984. A general probabilistic model of carcinogenesis: Analysis of experimental urinary bladder cancer. Carcinogenesis 5:437-445.
Gribble, G.W. 1992. | | Nature, classification and nomenclature of kidney tumors induced in the rat by dimethylnitrosamine. J. Nat. Cancer Inst. 42:643.
Roberts, A.B., and M.B. Sporn. 1992. Mechanistic interrelationships between two superfamilies: The steroid/retinoid receptors and transforming growth factor-beta. Cancer Surv. 14:205-220.
Rodricks, J.V., and A.E. Pohland. 1981. Food Hazards of Natural
Origin Pp. 181-237 in Food Safety, H.R. Roberts, ed. New York: Wiley.
Ross, R.K., J.M. Yuan, M.C. Yu, G.N. Wogan, G.S. Qian, J.T. Tu, J.D. Groopman, Y.T. Gao, and B.E. Henderson. 1992. | | Substance
Degree of Evidence for Carcinogenicity"
Human Animal
Overall Evaluation of Carcinogenicity'
Nature of Supporting Evidence*
Extent of Natural Occurrence in Foods
References'
Constitutive Naturally Occurring Carcinogens t^aneic aciq
ND
2B [56, 1993]
Forestomach tumors in male mice, male and female rats; kidney tumors in female mice, male rats, clastogenic, mutagenic
Occurs widely in plants as esters of hydroxyacids, such as quinic (e.g. | Ralph W. Moss, Ph.D. See book keywords and concepts | Shogen was studying the effects of such embryos on kidney tumors in frogs as well as on tumor cells of other species, including humans. Results were promising. In 1981, she founded the Alfacell company to develop such substances for the market. Onconase (formerly called P30 Protein) is the most advanced of the young company's products.
In 1984, the company developed an unpurified extract of leopard frog embryos. It was found to exert unique effects on cell lines. Toxicity studies showed that it did not cause organ damage in rats or dogs. | | Joachim Liehr from the University of Texas at Galveston reported that vitamin C inhibits the incidence of kidney tumors induced by female sex hormones. But pre-treatment of hamsters with vitamin C protected them against the effects of DES (a cancer-causing synthetic hormone) injections. Dr. M.E. Poydock of the Mercyhurst College Cancer Research Center, Eire, PA, told of a patient who showed a significant reduction in tumor after just three injections of vitamin C and B12 (29-31).
Dr. | Patrick Quillin, PhD,RD,CNS See book keywords and concepts | Vitamin C reduced the incidence and severity of kidney tumors in animals exposed to the hormones estradiol or diethylstilbestrol. 137 Through a wide variety of mechanisms, vitamin C is a potent inhibitor of cancer.138
2) Augmenting medical therapy. C may be able to enhance the toxicity of chemo and radiation against the cancer cells while protecting the patient from possible harm. C was able to enhance the effectiveness of a drug (misonidazole) that improves outcome in radiation treatment of cancer. | Donald R. Yance, j r.,C.N., M.H., A.H.G., with Arlene Valentine See book keywords and concepts | Vitamin C has also been shown to inhibit the development of estrogen-induced kidney tumors in hamsters. Large doses of vitamin C reduced the severity and incidence of mammary tumors in RIII mice and ultraviolet light-induced skin tumors in hairless mice. Isomers and metabolites of vitamin C may also have therapeutic benefit in different cancer sites in experimental models.23
Vitamin C ascorbate, in conjunction with other nutrients such as zinc, vitamin B12, and other cancer-inhibiting agents, has a synergistic antitumor effect. | Earl L. Mindell, R.Ph., Ph.D. See book keywords and concepts | Acarbose can impair kidney function and has caused cancerous kidney tumors in rats. It can cause hypoglycemia or low blood sugar levels, so if you're taking it, be sure to have a readily available source of dextrose on hand to counteract hypoglycemia.
Caution! Think Twice about Taking This Type of Drug If . . .
• You have kidney problems of any kind.
• You have serious intestinal problems.
• You are exposed to stress such as fever, trauma, infection or surgery.
What Are the Interactions with Other Drugs? |
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