Steven V. Joyal
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 One of the first signs of kidney damage is the presence in the urine of a protein called albumin, which can be detected through an analysis of a urine sample (a urinalysis). If this early stage of kidney damage (called microalbuminuria, the presence of small amounts of albumin in the urine) is not detected or treated, the kidneys will increasingly lose their ability to function, and levels of a substance called creatinine will increase in the blood. Creatinine is an indicator of the kidneys' filtering ability. A creatinine level greater than 1. |
Jeffrey M. Smith
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 Barnase is toxic to human cells and causes kidney damage in rats.
3. Although the GM plants were designed to produce the toxin in a non-food portion of the plant, some of the toxin is likely produced in all parts of the plant.
Pollen-sterilizing barnase in GM crops may cause kidney damage
As part of the process of breeding hybrid corn, Aventis (now Bayer CropScience) developed male-sterile corn (MS6) that is incapable of producing viable pollen—it will not out-cross or self-pollinate.* This was accomplished by inserting a gene from a bacterium that creates the enzyme barnase. |
Bottom Line Health
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| Substituting soy for animal protein lowers the glomerular filtration rate, a measure of kidney stress, and may slow kidney damage.
STUDIES NEEDED
Soy may be helpful for the following conditions, but research so far is inconclusive...
•Osteoporosis. Soy has been promoted for bone strength on the mistaken premise that Asian women have less incidence of osteoporosis than American women. Not true. While their rate of hip fractures is lower than in the US, the Japanese have twice the rate of vertebral fractures. |
Joerg Gruenwald, Ph.D.
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 The intake of acutely toxic doses leads to vomiting, gastroenteritis, spasms, severe kidney damage and eventually to death by kidney failure. The chronic intake of low dosages in laboratory animals led to the development of tumors. Because of the genotoxic and cancerogenic effects of the aristolochic acids, the drug is not to be administered even in small dosages.
DOSAGE
Mode of Administration: Birthwort is used as a tincture in an ethanol solution. No further information is available.
LITERATURE
Che CT et al, (1984) J Nat Prod 47(2):331. |
| OVERDOSAGE
TANACETI AETHEROLEUM
Symptoms of poisoning include vomiting, abdominal pain, gastroenteritis, severe reddening of the face, mydriasis, fixed pupil, tonic-clonic spasms, cardiac arrhythmias, uterine bleeding, kidney damage and liver damage. Death occurs after 1 to 3.5 hours. The lethal dosage is approximately 15-30 gm. The treatment for poisonings can only proceed symptomatically.
DOSAGE
TANACETI FLOS ET HERBA
Daily Dosage: Administration in allopathic dosages is to be avoided. |
Shannon Brownlee
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 The less a diabetic's blood sugar fluctuates, the more slowly he will develop the downstream effects of the disease, including heart disease, kidney damage, and blindness.) But if the patient was in a capitated plan, he might be told not to come back for months.
At the same time that managed care began to abandon capitation and loosen some of its restrictions, patients seemed to become even more demanding. They had seen the stories about patients who were refused needed care. |
Thomson Healthcare, Inc.
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| In addition, Khat preparations have been associated with ulcers in the digestive tract and liver and kidney damage. When the drug is used over periods of years, it can lead to personality disorders. dosage
Mode of Administration: Available as whole herb and powdered drug
Storage: Can be kept for several months deep-frozen literature
Al-Ahdal MN, McGarry TJ, Hannan MA Cytotoxicity of Khat (Catha edulis) extract on cultured mammalian cells: effects on macromolecule biosynthesis. |
| Ergot is now contraindicated for all therapeutic use, but especially in the presence of peripheral blood flow disorders such as Raynaud's disease, Thrombangitis obliterans, severe arteriosclerotic vascular changes, liver function disorders, severe coronary insufficiency, kidney damage, pregnancy, nursing, infectious diseases, sepsis, hypertonia, and severe hypotonia. precautions and adverse reactions
No health hazards are known in conjunction with the proper administration of designated therapeutic dosages, but therapeutic use is not recommended because of the many side effects. |
| After feeding sheep and cattle a total of 2 to 3 kg of Cotton seed press cakes over a period of 3 to 4 weeks, they exhibited gastroenteritis, kidney damage with hematuria, and icterus. Death occurred 24 to 48 hours after first appearance of symptoms. Eye damage (Cotton-seed blindness) was also noted. dosage
COTTON OIL
Preparation: Emulsion 10 to 15%: sterilization is carried out at 150° C for 1 hour.
Daily Dosage: Emulsion 40%: 60 ml p.o. in a single dose. literature
Bicchi C, Joulain D. Review / Headspace-Gas-Chromatographic Analysis of Medicinal and Aromatic Plants and Flowers. |
| Coughing, dyspnea, laryngospasms, kidney damage, visual disorders, head and muscle pain, and central paralyses are side effects following intake of the oil. It is severely irritating in local application. |
| High doses of the drug (or the herb) administered over extended periods can cause chronic gastritis, kidney damage, liver damage, and neurotoxic effects. The treatment for poisonings proceeds symptomatically. dosage
Mode of Administration: Preparations of Cayenne are exclusively fpr external indications in antirheumatic ointments and plasters.
How Supplied:
Capsules-400 mg, 445 mg, 450 mg, 455 mg, 500 mg Cream-0.25% capsaicin, 0.75% capsaicin Liquid Extract
Preparation: A liquid extract is prepared by percolating 100 g drug with 60 g ethanol. |
Elaine Magee
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 Because they are already at an increased risk of bloodflow problems, people dealing with both diabetes and high blood pressure also face kidney damage and numerous other vascular diseases. As further evidence of the link between these two diseases, high blood pressure
SYNERGY IN ACTIO
ALMONDS
Nuts in general contain a combination of various cholesterol-lowering plant food components. Here's the fact that got my attention, though: In virtually all studies that examined the impact of nuts in our diet, nut consumption has been associated with a reduction in coronary heart disease risk. |
Bottom Line Health
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| Because of the potential for kidney damage, cyclosporine is typically used for only one year. Acitretin, the only oral retinoid approved by the US Food and Drug Administration (FDA) to treat psoriasis, can thin the hair, cause dry skin and lips, cause bone abnormalities and affect liver function. Because of the risk of birth defects, women of childbear-ing years should not take it.
BIOLOGICS
These drugs are a new option for moderate to severe psoriasis.
•TNF inhibitors. |
Joerg Gruenwald, Ph.D.
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| OVERDOSAGE
Overdosages in susceptible patients can lead to liver, cardiac and kidney damage as well as central nervous system disorders such as spasms, more rarely also to psychoses and to permanent injuries such as paralysis and visual disorders, even blindness.
Cases of death, particularly among children, have been observed following administration of Filmaron oil (10% solution of volatile extracts of the rhizomic drag in cooking oil).
DOSAGE
Mode of Administration: Warning: Dosages may be toxic! |
J. Douglas Bremner
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 Vancomycin can cause deafness and kidney damage and therefore should be used with caution. (The exact number of patients affected by these side effects is not known.) It can also cause potentially fatal anaphylactic reactions. For these reasons vancomycin should be taken as a last resort.
Antiviral Agents
THE FLU SHOT
Viruses infect human cells by being absorbed into these cells, having their RNA and proteins replicate, and then bursting out of the cells. |
| These drugs can worsen kidney damage in patients with kidney dysfunction and so should not be taken by those who have kidney problems. Women who are pregnant should consult with their doctor about whether to take antibiotics; some are safer than others.
Antibiotics can also cause liver damage and sun sensitivity. (See Chapter 10 for more about the general uses and risks of antibiotics.) These side effects, however, are not common. In general, these drugs are fairly safe for healthy people, but they aren't as effective in the treatment of acne as medications like Accutane (isotretinoin). |
| Rare side effects include Stevens-Johnson syndrome, which involves a total body rash and peeling that could be fatal, and crystal formation in the urine, which can lead to kidney damage. Sulfisoxazole has an action similar to that of sulfamethoxazole/trimethoprim as well as similar side effects.
NITROFURANTOINS
Like the sulfonamides, nitrofurantoins (Macrodantin, Macrobid, Furadan-tin), which inhibit bacteria locally in the urinary tract by an as-yet-unknown mechanism of action, are also used for urinary infections. Common side effects are anorexia, nausea, and vomiting. |
| It also can rarely cause kidney damage.
Antifungals
Fungal infections include Tinea (ringworm), candidiasis, aspergillosis, cryptococcosis, blastomycosis, histoplasmosis, and coccidioidomycosis. Tinea (ringworm) is not actually a worm but a fungus that causes itching, redness, and a spreading circular patch. Different disorders all caused by tinea include athlete's foot, jock itch, ringworm of the scalp, ringworm of the body, and ringworm of the nails. Candida is usually present in the mouth, intestines, and vagina. Immunocompromise or overuse of antibiotics can cause an outbreak of Candida. |
| These drugs can worsen kidney damage in patients with kidney dysfunction. They can also cause liver damage and sun sensitivity. These side effects, however, are not common, and in general these drugs are safer than drugs like clindamycin and streptomycin.
AMINOGLYCOSIDES
Aminoglycosides are useful against both gram-positive and gram-negative bacteria, and are used mainly to treat severe urinary tract infections. When combined with cephalosporins they constitute the first-line treatment of severe, life-threatening infections caused by gram-negative bacteria. |
Mehmet C. Oz., M.D. and Michael F. Roizen, M.D.
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 Commercial brands of carpet and clothing-spot cleaners have largely moved to glycol ethers, which can be inhaled or absorbed through the skin and may cause blood disorders, as well as liver and kidney damage. They can be avoided with a combination of natural oils, alcohol, and oxygen-based cleaners.
IN CLOSETS If you get your clothes dry-cleaned, remove them from the plastic wrap, which traps in the chemicals used to clean them, and air them out on a porch or another covered area that is open to the outside air. Limit dry cleaning to only what absolutely has to be dry cleaned. |
Bottom Line Health
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| There have been reports of rhabdomyolysis, kidney damage and kidney failure in some patients taking this drug. I recommend it only if no other drug lowers cholesterol adequately.
If you need a significant reduction in cholesterol, particularly if you already have heart disease or risk factors, one of the high-potency statins makes sense.
For a more modest reduction, you may consider an older, less powerful drug. Lovastatin is a particularly attractive choice if cost is a factor—it is the only statin available in generic form and costs up to four times less than the other statins. |
Andreas Moritz
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 Hypertension and the retention of urine in the kidneys may lead to kidney damage. Conventional treatments for this condition consist mostly of diuretic (urine-forming) drugs and restricted salt consumption. Both can have severe drawbacks. Diuretic drugs, which are used to normalize blood pressure, as well as reduced salt intake, strongly undermine the body's emergency measures to save the little water it has left for normal cellular activities. The resulting stress response causes a further increase in dehydration, and the vicious cycle is complete. |
Jonny Bowden, Ph.D., C.N.S.
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 One, urine retention and strain on the bladder can lead to more serious problems, including bladder damage, kidney damage, bladder stones, urinary tract infection, and the inability to control urination. If you catch BPH early, there's a much lower risk of such complications. And fortunately, there are some easy and natural ways to bring relief (more on that in a moment).
Saw palmetto is the "go-to" herb when it comes to taming the urge to pee every few hours. |
Michael Friedman, ND
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 High blood pressure leads to heart and kidney damage. In turn, kidney damage causes further hypertension. At the same time, the hyperglycemia continues to produce free radicals, initiating a cascade of chemical reactions destroying tissues throughout the body.
It was clear that the pharmaceutical drugs she had been taking were not addressing her problems effectively. This was indicated by the fact that her blood pressure was 200/100 mmol/Hg and her blood sugar was 22 mmol/L, despite the fact that she had been taking oral hypoglycemic drugs intermittently for 20 years. |
Jeffrey M. Smith
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| Pollen-sterilizing barnase in GM crops may cause kidney damage......................................................100
3.7 High lysine corn contains increased toxins and may retard growth......................................................102
3.8 Cooking high lysine corn may create disease-promoting toxins...........................................................104
3.9 Disease-resistant crops may promote human viruses and other diseases..............................................106
Section 4: The foreign protein may be different than what is intended................................. |
| William Freese and David Schubert, Nil tun' Biotechnology
1. Corn and canola are engineered to produce a pollen-sterilizing toxin called barnase.
2. Barnase is toxic to human cells and causes kidney damage in rats.
3. Although the GM plants were designed to produce the toxin in a non-food portion of the plant, some of the toxin is likely produced in all parts of the plant. |
| When injected into rats, it causes kidney damage.66
Although the barnase gene is present in all cells of the corn plant, the company hoped that the toxic enzyme was produced only in the anther—the pollen-bearing part of the stamen. They therefore used a promoter to switch on the barnase gene which is "tissue-specific," normally activated in the anther.
According to Freese and Schubert, "It is well-known that so-called tissue-specific promoters drive production of low levels of transgenic protein in non-target tissues. |
| Barnase may damage human health
Because barnase is known to cause kidney damage in rats, degrade RNA, and be toxic to human cells, its presence in food may lead to a wide range of potential problems. "During seed production," says Joe Cummins, "barnase may be present in dust and debris from the crop and surface along with groundwater may be contaminated with the toxin. Humans or animals breathing the plant material may experience severe toxicity. |
Andreas Moritz
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| Other side effects include perforation of the colon, colitis, Crohn's disease, blurred vision, Parkinson's disease, liver and kidney damage, hepatitis and hypertension.
A 20-year-old acne medicine that millions of American teens are, no doubt, taking every day has been linked to a stunning array of negative psychiatric conditions including suicide, depression, psychosis, violent and aggressive behaviors, mood swings, emotional instability, paranoia and changes in personality. This makes one wonder if any drug, no matter how commonly prescribed is even remotely safe. |
Joerg Gruenwald, Ph.D.
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| High dosages of the drug (or the herb) administered over extended periods can bring about chronic gastritis, kidney damage, liver damage and neurotoxic effects. The treatment for poisonings proceeds symptomatically.
DOSAGE
Mode of Administration: Preparations of paprika are exclusively for external indications in antirheumatic ointments and plasters.
Preparation: A liquid extract is prepared by percolating lOOg drug with 60g ethanol. Other formulations include: Capsicum-oleoresin with 90% ethanol and a tincture with 90% ethanol. |
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