James Dowd and Diane Stafford
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 Type 1 Diabetes
Type 1 diabetes—also called juvenile diabetes—stems from antibodies directed to the islet cells in the pancreas. The islet cells make insulin in response to rising glucose levels in the blood. The inflammation these antibodies create eventually destroys the islet cells, causing diabetes. This differs from the insulin resistance of type 2 diabetes.
In the Netherlands thirty years ago, public health officials recommended rickets prevention via 2,000 IU of vitamin D a day (via cod-liver oil) from birth through a child's first birthday. In 1997, Dr. |
| Vitamin D and Diabetes
With type 1 diabetes, an autoimmune disease, early in childhood development your immune system begins to make antibodies to islet cells that manufacture insulin in the pancreas. These antibodies destroy the islet cells, and the production of insulin declines, producing diabetes symptoms.
Type 2 diabetes is characterized by impairment in insulin release as well as insulin resistance in muscles, fat cells, and the liver. Insulin resistance often accompanies obesity, and dietary factors and inactivity can make it worse. |
Donna Jackson Nakazawa
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 Islet cell antibodies are produced when the body's immune system fails to recognize insulin-generating islet cells produced by the pancreas as natural to the body and attacks them as if they were dangerous foreign substances, suddenly decreasing the body's ability to produce the insulin that helps cells absorb glucose. High levels of islet cell antibodies show that the body is destroying the islet cells in the pancreas.
Tests developed in the mid-1990s found that a combination of two newly recognized autoantibodies—GAD65 and IA-2—could also predict type 1 diabetes over time. |
Too Profitable to CureBrent Hoadley, Ph.D.
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| It may be a "partial" cure, such as a daily injection to prevent destruction of beta cells, or monthly injections of new islet cells. It might be a one-time treatment or one requiring an annual "booster." Before it is ever marketed, though, you can depend on its being castigated by the pharmaceutical industry and delayed by the FDA.
Dr. Holcombe, an Eli Lilly executive, admits that diabetics should not be looking for a cure from Lilly. Quite frankly, diabetics cannot even depend on Lilly to supply better insulins. |
Donna Jackson Nakazawa
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| Over the next fifteen years, Faustman struggled, with a dedicated crew of eleven PhDs, to identify the exact group of pathological T cells that were misbehaving in type 1 diabetes and destroying islet cells in the pancreas. These errant T cells, she found, produced completely different proteins within their cells than did normal cells. In fact, these rogue T cells ought not to have been circulating in the body in the first place.
Normally, our bone marrow and thymus produce millions of T cells, which are the foot soldiers that work diligently to serve the immune system. |
| High levels of islet cell antibodies show that the body is destroying the islet cells in the pancreas.
Tests developed in the mid-1990s found that a combination of two newly recognized autoantibodies—GAD65 and IA-2—could also predict type 1 diabetes over time. However, researchers found that—as with prediagnostic lupus biomarkers—there were some patients who were positive for some of these biochemical markers but still did not develop type 1 diabetes. In 2005, Dr. |
Mike Adams
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 Several studies have demonstrated that a protein in cows' milk closely resembles the molecular structure of the cells in the pancreas that produce insulin, called islet cells. Because the immune system confuses the two, it begins to attack the islet cells by mistake, leading to their destruction.
- Russell Blaylock, M.D. |
Connie Bennett, C.H.H.C. with Stephen T. Sinatra, M.D.
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 A high proportion of animals on a high-GI diet had damaged or scarred islet cells in the pancreas," explained Dr. Ludwig, who spearheaded the project. "If the damage had progressed, I'd expect type 2 diabetes would develop."
On the other hand, the group eating the healthier carbs didn't have those problems. "The low-GI group had normal-appearing pancreases," Dr. Ludwig observes.
I hope that you've received ample information so that you'll consider kicking culprit carbs to avoid the chronic big killers. Let's close with thoughts from two experts. |
Donna Jackson Nakazawa
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| The thing that astonished Faustman and her team the most, however, was that when you killed off just the incorrectly functioning T cells, it not only stopped the disease, it allowed the body to regenerate the insulin-producing islet cells, reversing the disease entirely.
The very idea that by killing off the fugitive T cells that cause type 1 diabetes damage you could encourage a healthy pancreas to regenerate was considered so far-fetched that Faustman's team was met with scathing skepticism from most of the scientific community. Scientists throughout the world openly questioned her claims. |
Too Profitable to CureBrent Hoadley, Ph.D.
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| Type 1 diabetes,
• Effect of BCG vaccination on the reversal of new-onset insulin-dependent diabetes mellitus,
• Nanotechnology — targeting disease cells,
• UCSF scientists identify protein on t-cell that triggers Type 1 diabetes,
• Infusion of insulin producing islet cells produces insulin independence in Type 1 patients,
• Xenografts may be less susceptible to autoimmune attack,
• Iacocca Foundation funds breakthrough T-cell studies searching for a cure to diabetes,
• NovoNordisk licenses T-cell therapy - islet neogenesis therapy. |
Russell L. Blaylock, M.D.
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 Several studies have demonstrated that a protein in cow's milk closely resembles the molecular structure of the cells in the pancreas that produce insulin, called islet cells. Because the immune system confuses the two, it begins to attack the islet cells by mistake, leading to their destruction.
Although proof of this connection appeared in one of the most prestigious diabetes journals, the general public is still not aware of the risk. Why? Because of the power of the milk producers. |
James Dowd and Diane Stafford
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| These antibodies destroy the islet cells, and the production of insulin declines, producing diabetes symptoms.
Type 2 diabetes is characterized by impairment in insulin release as well as insulin resistance in muscles, fat cells, and the liver. Insulin resistance often accompanies obesity, and dietary factors and inactivity can make it worse.
You may need extra insulin to overcome insulin resistance. The high insulin levels of type 2 diabetes contribute to diabetes complications, including cholesterol abnormalities, diabetic eye disease, diabetic kidney disease, and vascular disease. |
| The inflammation these antibodies create eventually destroys the islet cells, causing diabetes. This differs from the insulin resistance of type 2 diabetes.
In the Netherlands thirty years ago, public health officials recommended rickets prevention via 2,000 IU of vitamin D a day (via cod-liver oil) from birth through a child's first birthday. In 1997, Dr. Elina Hypponen and her colleagues at the Tampere School of Public Health in Finland analyzed health records of babies who were born in 1966 in Oulu and Lapland, Finland, to check for development of type 1 diabetes. |
| But lacking sufficient vitamin D to suppress these D-cells or to dumb down this interaction, the T-cells spur B-cells to make antibodies to the islet cells. These antibodies trigger an inflammatory response, which activates more D-cells and M-cells in the pancreas and the lymph system. As more and more islet-cell proteins are presented to more and more T-cells, the process expands—and eventually, this heightened anti-islet-cell response destroys them, which results in declining insulin production and diabetes development. |
Gabriel Cousens
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 What happens is that the activated T-lymphocytes infiltrate the islet cells in the pancreas. Macrophages and T-cells appear to be involved in the destructive cycle as they release cytokines that create free radical damage. This free-radical induced islet beta cell death involves breaks
PATHOGENESIS OF TYPE-1 DIABETES MELLITUS
EVENT
AGENT OR RESPONSE
Genetic susceptibility
HLA-DR3, DR4, DW3, DW4, B8, B15
Environmental Event
Virus, Cow's milk protein ingested by mother or child i
Infiltration of activated T lymphocytes i
Activation of autoimmunity
Self-? |
| Low intracellular NADH levels contribute to the death of islet cells of the pancreas. Niacinamide does seem to help prevent pancreatic beta cell death, but it does not seem to intervene in the inflammatory process, which is why the live-food diet and Vitalzym X play an important role in reducing inflammation. B-3 is good for the functioning of glucose tolerance factor and it decreases lipid buildup. |
Michael Friedman, ND
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 Niacinamide
Protects islet cells of the pancreas
Helps with DM Type I autoimmune process if taken within first 6 months
25 mg per kg
Hyperinsulinemia
Many patients with DM Type II and hyperinsulinemia have low body temperatures and can benefit from WT3 therapy. If the thyroid system appears to need help, WT3 therapy and/or other thyroid support can always be used. The best thing about WT3 therapy is that it doesn't have to be taken for life, unless the patient has Hashimoto's disease. The improvements are often lasting, butWT3 alone won't always normalize insulin levels. |
James A. Howenstine, MD
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 Autoimmune
Many persons have a form of diabetes in which the body develops antibodies against tissues such as the islet cells of the pancreas. As the islet cells are destroyed diabetes appears.
Immunization with vaccines can be promptly followed by the onset of Type 1 diabetes in children. Approximately 80% of children with Type 1 diabetes are believed to have developed the illness from an adverse reaction to a vaccine. The mechanism is believed to be an autoimmune injury to the pancreatic islet cells precipitated by a vaccine. |
Mike Adams
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| Because the immune system confuses the two, it begins to attack the islet cells by mistake, leading to their destruction.
- Russell Blaylock, M.D., Health and Nutrition Secrets That Can Save Your Life
A critical review and analysis of all relevant citations in the medical literature indicated that early cows'milk exposure may, in fact, be an important determinant of subsequent type 1 diabetes and may increase the risk about 1.5 times. |
Michael Friedman, ND
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| They constitute 70% of the islet cells and function to lower blood sugar with the secretion of insulin that is essential for the uptake of glucose from the blood into the majority of the body's cells.
Virtually all cells use insulin in order to absorb glucose, except for the tissues found in the retina, nerves, and kidney. Insulin is the facilitator that allows sugar to enter the cells by increasing the number of proteins that transport glucose across cell membranes into muscle cells, adipocytes, white blood cells, and certain other cells. |
Russell L. Blaylock, M.D.
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| Because the immune system confuses the two, it begins to attack the islet cells by mistake, leading to their destruction.
Although proof of this connection appeared in one of the most prestigious diabetes journals, the general public is still not aware of the risk. Why? Because of the power of the milk producers. It seems the media would rather have tens of thousands of children suffer a life of diabetes than anger one of their biggest financial contributors. I would also point out that cow's milk has significantly higher levels of glutamate than human milk. |
Kaayla T. Daniel, PhD, CCN
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 Recent studies suggest that acinar, ductal and islet cells are all highly plastic and able to transdifferentiate or change their phenotype from one type to another. In terms of determining the origin of any pancreatic cancer, all pancreatic cells could be considered potential facultative stem cells.81
BETTER SAFE THAN SORRY
Clearly, we must be cautious in extrapolating the results from animal studies to humans. Different animals react differently to feeds containing protease inhibitors, and no animal provides a completely appropriate model for humans. |
The Life Extension Editorial Staff
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 In contrast, benign tumors showed weak expression or no expression of COX-2, and only islet cells displayed COX-2 expression in normal pancreatic tissues (Okami et al. 1999).
An article in the journal Anticancer Research evaluated the general COX inhibitor, indomethacin (Indo-cin and Indomethacin capsules), and the COX-2 specific inhibitor NS-398 on four pancreatic cancer cell lines. Both agents inhibited cellular proliferation and growth and induced apoptosis (programmed cell death) (Dmg et al. 2000). |
Gale Maleskey
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 The vitamin is needed for cells in the pancreas, called islet cells, to produce insulin, the hormone that allows cells to take up blood sugar. Without adequate vitamin D, islet cells don't produce insulin.
In animals with an inherited tendency to develop type 1 diabetes, the active vitamin D hormone helps prevent the disease, Dr. DeLuca says. While studies have not yet been done in humans, researchers speculate whether it might prove to have a similar effect.
Help for T-Helpers
Vitamin D also helps to regulate some of the white blood cells that make up the immune system. |
Gary Null, Ph.D.
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 Results of this study found that the resistance of pancreatic islet cells to toxic doses of nitric oxide was improved significantly by their preincubation with alpha-tocopherol.
—V. Burkart, et al., "Suppression of Nitric Oxide Toxicity in islet cells by Alpha-tocopherol,"
FEBS Lett, 364(3), May 15, 1995, p. 259-263.
Results of this study showed that rats fed a vitamin E and selenium supplemented diet experienced strong protection against heme protein oxidation relative to rats fed a diet deficient in antioxidants.
—H. Chen and A.L. |
James A. Howenstine, MD
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| As the islet cells are destroyed diabetes appears.
Immunization with vaccines can be promptly followed by the onset of Type 1 diabetes in children. Approximately 80% of children with Type 1 diabetes are believed to have developed the illness from an adverse reaction to a vaccine. The mechanism is believed to be an autoimmune injury to the pancreatic islet cells precipitated by a vaccine. If my child developed Type 1 diabetes from a vaccine, I would give the child a trial of two to three months of thymic extract. |
Christian B. Allan and Wolfgang Lutz
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 Our idea here is that carbohydrates induce the pancreas, specifically the islet cells, into overstimulation, that is, excess insulin production. This is a known fact. This overstimulation may radiate to the other islet cells, which causes the entera to accelerate the movement of ingested food, so that the intestine cannot digest them properly. This partially undigested food enters the terminal ileum, which is not able to absorb the foodstuffs. |
The Life Extension Editorial Staff
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| Comment: Sulfonylurea drugs stimulate insulin secretion from islet cells; about 30% of patients fail treatment due to beta cell exhaustion.
Refractory hyperglycemia may require insulin therapy to control blood glucose levels, but until the individual has attempted lifestyle modification, insulin appears a poor first choice. Information appearing in the Washington Post (August 9, 2001, page Al) stated that nearly 60% of those who are poised to develop diabetes can avert the disease (and insulin therapy) through lifestyle modification. |
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