T. Colin Campbell, Ph.D. and Thomas M. Campbell II
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 OTHER FACTORS
It has been recently noted that the same risk factors that promote colorectal cancer, a diet low in fruits and vegetables and high in animal foods and refined carbohydrates, can also promote insulin resistance syndrome.77-79 From there, scientists have hypothesized that insulin resistance may be responsible for colon cancer.77-82 insulin resistance was described in chapter six as a diabetic condition. And what's good for keeping insulin resistance under control is also good for colon cancer: a diet of whole, plant-based foods. |
David W. Grotto, RD, LDN
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 DIABETES: Rats who ate white-fleshed sweet potatoes had marked improvement in pancreatic cell function, lipid levels, glucose management, and reduced insulin resistance within eight weeks. A human study also showed improved insulin resistance when sweet potatoes were included in the diet.
MEMORY ENHANCEMENT: Rats who ate purple-fleshed sweet potatoes showed significant improvement in cognitive function, which may be attributed to the anthocyanins present in the potato.
CANCER: A cell study showed that sweet potatoes have unique cancer-fighting properties. |
Mike Adams, the Health Ranger
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 Sure, they can tell you what they think are causes, such as saying that diabetes is caused by insulin resistance. But all they're actually doing is describing another symptom. The cause of diabetes is not insulin resistance, that's just one of the cascading symptoms that leads to the ultimate diagnosis of the disease. The real question is: "What causes insulin resistance? |
T. Colin Campbell, Ph.D. and Thomas M. Campbell II
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| From there, scientists have hypothesized that insulin resistance may be responsible for colon cancer.77-82 insulin resistance was described in chapter six as a diabetic condition. And what's good for keeping insulin resistance under control is also good for colon cancer: a diet of whole, plant-based foods.
This diet happens to be very high in carbohydrates, which have recently been under assault in the marketplace. Because carbohydrate-confusion persists, let me remind you that there are two different types of carbohydrates: refined carbohydrates and complex carbohydrates. |
Dr. Steve Blake
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 A more serious insulin resistance is known as type 2 diabetes. The clinical signs of type 2 diabetes include elevated blood sugar levels and insulin resistance.
Cell membranes have insulin receptors. The sensitivity of this receptor to insulin can be improved by chromium. Insulin binds to the insulin receptor in the cell membrane to activate the receptor, as seen in Figure 13-4. The activation of the insulin receptor enables glucose and chromium to enter the cell. Chromium binds to the insulin receptor and enhances its activity. With available chromium, more glucose enters the cell. |
Marshall Editions
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 Hirsutism has been linked to 9^\ljjf insulin resistance, so follow a low-carbohydrate diet to reduce insulin ^55^ levels, improve insulin resistance, and help you lose weight if needed.
When consuming starches, consume mostly whole grains, such as brown rice as opposed to white rice. Increase your consumption of omega-3 fats, one of the essential fatty acids. Omega-3 fats are found in cod liver oil, and in fatty fish such as salmon, sardines, and mackerel. Eliminate trans-fatty acids from your diet. |
Elaine Magee
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 Obesity influences insulin resistance. Short-term studies have demonstrated that losing 5 percent of body weight (about 10 pounds for someone weighing 200 pounds or 15 for a 250-pound person) helps decrease insulin resistance and improve high blood sugar, high blood lipids, and high blood pressure in people with type 2 diabetes.
Sugar. To eat sugar or not to eat it, that's the big question for people with diabetes. The answer: Go ahead and eat sugar, but follow the ADA's recommendations. Sugar-containing foods can be substituted for other carbohydrates in the individualized meal plan. |
Mike Adams, the Health Ranger
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 If the insulin is not opening up the cells to allow the nutrients in, you will have an insulin resistance.
When that happens, using things like vanadium and bitter melon can be helpful. Frequently, a chromium problem gives you insulin resistance. You do not have the chromium there to unlock the cell to allow the nutrients and the insulin to do their work. We put a lot of chromium in there. Each capsule in the human formula has 200 micrograms.
And this chromium is not a picolinate, because there has been research with chromium picolinate that shows that you can actually get genetic damage. |
Mike Adams, the Health Ranger
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| The cause of diabetes is not insulin resistance, that's just one of the cascading symptoms that leads to the ultimate diagnosis of the disease. The real question is: "What causes insulin resistance?"
So you see, if you backtrack from conventional medicine's explanations about the causes of disease, and you keep seeking deeper and deeper causes for the symptoms, then you fairly quickly get to a point where conventional medicine has no clue, because they can't tell you what causes insulin resistance. |
Tori Hudson, N.D.
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 For those women who have PCOS and are overweight, regular and preferably almost daily aerobic exercise in the range of two and a half to five hours per week is necessary to improve insulin resistance and lose weight.
CONVENTIONAL MEDICINE APPROACH
Successful management of amenorrhea depends on an accurate diagnosis. A careful history and examination and simple laboratory investigations will most likely yield a diagnosis that allows one to offer appropriate treatment in the majority of cases. |
| All of these mechanisms—plus modifying insulin resistance and/or lowering a hypersecretion of insulin, treating the underlying endocrine problem, and inducing ovulation—are the keys to treating PCOS.
Additional Therapies
Recent research also supports the use of manual soft-tissue therapy for pelvic adhesions, which may be implicated in some cases of infertility where there has been a history of surgery, infection, inflammation, or trauma. |
| Hormonal changes in menopausal women are probably associated with an increase in insulin resistance, leading to increased fat storage, increased abdominal fat, and weight gain.
Headaches. Hormonal changes may play a role in headaches, especially in perimenopause and especially in women with migraine headaches. Migraine headaches tend to be worse on one side of the head and worse with light and noise, can be associated with nausea and vomiting, and tend to be moderate to severe. |
Jack Challem
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 Your body secretes still more insulin, and you become even less responsive to it. insulin resistance develops when your body ignores what the insulin is trying to accomplish. Insulin levels continue to increase until your body's ability to make it wears out.
Although many of the complications of prediabetes and diabetes have been attributed to elevated blood sugar, high insulin levels actually seem to do far greater damage. Elevations in insulin precede increases in blood sugar by as much as fifteen years, leading to increases in belly fat, blood pressure, and blood fats. |
Gabriel Cousens, M.D.
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 A high protein intake may also increase insulin resistance. Research by Gene Stiller, Ph.D., found that a protein-enhanced diet may actually increase insulin resistance rather than decrease it.17 Stiller's research team found that when people consumed a protein-rich diet, their insulin output actually was greater than when they consumed an equal amount of carbohydrate-rich foods. Interesting, of course, is the point that has been made in Conscious Eating and Rainbow Green Live-Food Cuisine that everyone has to have an individualized diet that will be optimal for them. |
Jack Challem
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| NAC may have more general benefits in preventing insulin resistance, especially for people who eat a high-fructose diet. Take 1,000 to 2,000 IU daily. Note: Because of its high sulfur content, NAC may smell like rotten eggs.
Magnesium. People with diabetes are commonly deficient in magnesium, a mineral that is directly and indirectly involved in managing blood-sugar levels. In an analysis of nine well-controlled clinical trials, researchers concluded that magnesium supplements could significantly lower fasting blood sugar and raise the "good" high-density lipoprotein form of cholesterol. |
Tori Hudson, N.D.
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| In these cases, a 10 percent weight loss can lead to ovulation and also decrease insulin resistance. A diet lower in starchy carbs and higher in healthy prorein is an important strategy for women with PCOS, whether they are overweight or not.
A holistic approach to treatment requires exploring the mental, spiritual, emotional, and physical aspects of the patient integrated with a meticulous medical approach employing mind-body-oriented perspectives. |
Thomson Healthcare, Inc.
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 Randomized controlled trial for an effect of green tea consumption on insulin resistance and inflammation markers. J Nutr Sci Vitaminol; 51(5); 335-342. 2005.
Gotoh A. Inhibitory effects of Green Tea extract on human prostatic cancer cell lines (abstract 2671). AACR; 39:392. 1998.
Graham B, In: Graham HN. Tea: The Plant and Its Manufacture, Chemistry, and Consumption of the Beverage. In: The Methylxanthine Beverages and Foods: Chemistry, Consumption, and Heath Effects, Alan R. Liss, New York, S.29-74. 1984.
Gupta S, Ahmad N, Nieminen AL et al. |
| Soy protein may improve insulin resistance and glycemic control and may have a use as part of a diabetic regime. Soy is mostly beneficial for use in menopause, but not all clinical trials demonstrate positive results. More studies are needed to further define its role. Soy failed to reduce hot flushes in breast cancer patients. Mild to moderate hypertensive patients supplemented with Soy milk experienced a modest reduction in blood pressure. Soy's role in infant diarrhea is not fully clear. |
Jack Challem
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| The mechanism may be related to elevated blood-sugar levels or insulin resistance in the brain. High levels of blood sugar also generate dangerous molecules called free radicals, which may damage both brain cells and blood vessels in the brain.
Poor concentration. One of the classic signs of diabetes is poor concentration, or feeling fuzzy headed. This appears to be related to abnormally high levels of blood sugar, which suppress orexins, a group of brain chemicals that keeps our minds sharp and alert.
Mood swings. Moods often follow blood-sugar levels. |
| After several years, the insulin resistance becomes so pronounced that glucose levels start to climb. That's why people with type 2 diabetes commonly have elevated levels of both insulin and glucose.
Your doctor may hesitate to measure your insulin levels, and your insurer may be reluctant to pay for it. But getting the test is in your own best interest, so insist on it.
, , , . j . , A high fasting insulin
Your tasting insulin can also be combined with ,. . , level is a sign of preyour fastins glucose to calculate your homeosta- ,. , . |
Michael Pollan
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 It turns out that "a higher intake of trans fat can contribute to increased risk of CHD through multiple mechanisms"; to wit, it raises bad cholesterol and lowers good cholesterol (something not even the evil saturated fats can do); it increases triglycerides, a risk factor for CHD; it promotes inflammation and possibly thrombogenesis (clotting) , and it may promote insulin resistance. Trans fat is really bad stuff, apparently, fully twice as bad as saturated fat in its impact on cholesterol ratios. |
| Since leaving the bush some years before, all ten had developed type 2 diabetes; they also showed signs of insulin resistance (when the body's cells lose their sensitivity to insulin) and elevated levels of triglycerides in the blood—a risk factor for heart disease. |
| Adding omega-3 s to the diet of rats has been shown to protect them against insulin resistance. (The same effect has not been duplicated in humans, however.) The theory is that omega-3s increase the permeability of the cell's membranes and its rate of metabolism. (Hummingbirds have tons of omega-3s in their cell membranes; big mammals much less.) A cell with a rapid metabolism and permeable membrane should respond particularly well to insulin, absorbing more glucose from the blood to meet its higher energy requirements. |
Hyla Cass, M.D.
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 Deficiency is especially common in diabetics; chromium lack can create insulin resistance and poor blood sugar balance.
Chromium supplements can improve blood sugar levels. Of fifteen studies, twelve found at least some positive effect of chromium supplementation on various aspects of diabetes. In my own clinical experience, I have found chromium to be very helpful in fighting sugar cravings.
Dose: Take 200 meg per day. Vanadium
This trace mineral is, like chromium, essential for insulins actions on lowering blood sugar. |
| This "super antioxidant" has been found to have healing effects on neuropathy in diabetics, as well as to control insulin resistance. Food sources include spinach, broccoli, beef, yeast (particularly Brewer's yeast), and certain organ meats (such as the kidney and heart). It is made in small amounts in the body. ALA works together with vitamins E and C, enhancing the body's overall ability to neutralize free radicals. ALA has also been found to help insulin work better, and to promote production of glutathione, a powerful antioxidant made in the liver. |
| FlBRATES: bezafibrate (Bezalip), ciprofibrate (Modalim), clofibrate (Atromid-S), fenofibrate (TriCor), and gemfibrozil (Lopid)
These drugs work well to lower triglycerides and "bad" LDL and raise "good" HDL (high-density lipoproteins); they may be used with statins in diabetics because fibrates help to reduce insulin resistance.
Actions: These drugs work through a mechanism similar to those of some blood sugar-lowering (hypoglycemic) drugs. |
Mike Adams, the Health Ranger
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| You are giving chromium that helps reverse the blocking, the insulin resistance.
Now, the consequential factors lipoic acid, vitamin B1 and biotin are in the pathway of conversion of pyruvic acid to acetyl coenzyme A, which is the Kreb's cycle feedstock. If you do not have those three nutrients in sufficient amounts, you are not going to be able to convert those sugars that the body has into the Kreb's cycle to make energy.
We put in lipoic acid -- and lipoic acid is a classic nutrient they use for treating diabetics at higher doses -- and that is one of the ways. |
| Frequently, a chromium problem gives you insulin resistance. You do not have the chromium there to unlock the cell to allow the nutrients and the insulin to do their work. We put a lot of chromium in there. Each capsule in the human formula has 200 micrograms.
And this chromium is not a picolinate, because there has been research with chromium picolinate that shows that you can actually get genetic damage. It actually goes to the DNA, drops the chromium off and it can damage the gene. I do not use chromium picolinate. |
Mike Adams, the Health Ranger
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| The real question is: "What causes insulin resistance?"
So you see, if you backtrack from conventional medicine's explanations about the causes of disease, and you keep seeking deeper and deeper causes for the symptoms, then you fairly quickly get to a point where conventional medicine has no clue, because they can't tell you what causes insulin resistance. Yes, they can describe the biochemical mechanisms, but they can't tell you what causes that biochemistry to take place. |
Jack Challem
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| Jack, you have absolutely no signs of insulin resistance or prediabetes," he said. "You're in incredibly good health."
In my latest round of tests, in April 2007, my numbers continued to improve. My blood sugar and insulin remained low, and my HbAlc had finally decreased from 5.2 percent to 4.9 percent (the equivalent of a 77 mg/dl blood-sugar level). My iron levels were a quarter of what they were ten years before; this is important because high iron levels are a risk factor for diabetes and heart disease. My cholesterol level was down to 185 mg/dl. |
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