Joerg Gruenwald, Ph.D.
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 There are indications that Horse Chestnut seed extract reduces the activity of lysosomal enzymes which is increased in chronic pathological conditions of the veins, so that the breakdown of glycoacalyx (mucopolysaccharides) in the region of the capillary walls is inhibited. The filtration of low-molecular proteins, electrolytes and water into the interstitium is inhibited through a reduction of vascular permeability. |
Jeffrey M. Smith
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 This supports the notion above that RNA accumulates within the PG because its transport out of the nucleus is inhibited.
Finally, components involved in either gene expression (RNA Polymerase II) or RNA processing (Sm antigen, hnRNPs, and SC35) were "decreased in two- and five-month-old GM-fed mice, and ... restored to normal at eight months."83 This implies that components in the GM soy diet resulted in lower metabolic activity in Sertoli cells and spermatocytes during the early stages of adulthood of the mice. |
Thomson Healthcare, Inc.
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| John's Wort (900 mg) significantly inhibited p-glycoprotein while long term use of St. John's Wort nonsignificantly induced p-glycoprotein in an open-label study of 12 healthy subjects. Fexofenadine (60 mg) was studied as a marker p-glycoprotein substrate. Fexofenadine Cmax increased 45% and oral clearance decreased 20% (both p<0.05 compared to pretreatment) (Wang et al, 2002).
St. John's Wort significantly increased P-glycoprotein expression and associated drug efflux in a randomized, single-blinded, placebo-controlled trial of 22 healthy subjects (13 female, 9 male). Subjects received St. |
Dr. Abram Hoffer, MD, FRCP (C) and Dr. Harold D. Foster, PhD
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 If this process is not inhibited in time, it will lead to increased levels of triglycerides in the blood, higher levels of cholesterol, and eventually serious cardiovascular risk. It is known that rats subjected to stress experience increased levels of blood cholesterol and triglycerides. A Californian study showed that in accountants, the levels of these lipids rose before tax deadlines, showing the extreme sensitivity of lipid level to stress.
Clinical Evidence
Dr E. |
| Hoffer reviewed the early literature that showed niacin, thiamin, and liver extract inhibited senility from developing and described senile patients from his practice who were treated with niacin. Their mean age was 69. Five senile psychotics recovered. Two were markedly improved by niacin, and two were not helped by it. Six were depressed, not senile, and of these, five recovered and remained well.
The best results were seen when the niacin was given before definite senile changes occurred. |
Joerg Gruenwald, Ph.D.
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| The filtration of low-molecular proteins, electrolytes and water into the interstitium is inhibited through a reduction of vascular permeability.
INDICATIONS AND USAGE
HIPPOCASTANI FOLIUM
Eczema, superficial and deep varicose veins, leg pains, phlebitis and thrombophlebitis, hemorrhoids, spastic pains before and during menstruation. In folk medicine, the leaves are used as a cough remedy as well as arthritis and rheumatism. |
| The antimicrobial effect has been demonstrated against bacillus, pseudomonas, and Candida; dermatomyces are also inhibited. The choleretic effect has been described in a study which is not accessible.
INDICATIONS AND USAGE
¦ Common cold
¦ Cough/bronchitis
¦ Fevers and colds
¦ Inflammation of the mouth and pharynx
¦ Liver and gallbladder complaints
¦ Loss of appetite
¦ Tendency to infection
Caraway is used for dyspeptic complaints, meteorism, gastrointestinal cramps, flatulence, and feelings of fullness as well as nervous cardiac-gastric complaints. |
| Gorkow C, Wuttke W, (1994) In vftro prolactin but not LH and FSH release is inhibited by compounds in extracts of Agnus castus, direct evidence for a dopaminergic principle by the dopamine receptor assay. Exp Clin Endocrinol 102:448-454.
Jarry H, Leonhardt S, Wuttke W, Behr B, Gorkow C, (1991) Agnus castus als dopaminerges Wirkprinzip in Mastodynon N. Z Phytother 12:77-82.
Kustrac D et al., The composition of the essential oil of Vitex agnus-castus. In: PM 58(7):A681. 1992. |
| The forming of melanin from DOPA using tyrosinase as well as from DOPA-CHROM through auto-oxidation is also said to be inhibited by the drug. The maximum antibacterial effect is expected 3 to 4 hours after administration.
INDICATIONS AND USAGE
¦ Infections of the urinary tract
Uva-Ursi is used for inflammatory disorders of the efferent urinary tract. The drug should not be taken over a long period of time without consulting a doctor.
CONTRAINDICATIONS
The drug is contraindicated in pregnant women, nursing mothers and children under 12 years of age. |
| Spasmolytic effect: The bronchial spasms, which are induced in a guinea pig by histamine, are inhibited in vivo, depending on the dose, by trans-isoasaron. The survival rate is determined subsequent to the addition of a histamine-con-taining aerosol 30 minutes after trans-isoasarin has been administered. The control substance here is clemizole hydrochloride, which has a similarly inhibiting effect.
Local anesthetic effect: The action of trans-isoasaron and of isomethyleugenol was tested on 10 volunteer subjects, in order to compare it with benzocaine (anesthetic index Al = 1). |
Brigitte Mars, A.H.G.
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 The effect of this compound in dissolving the outer lining of pathogenic microbes is so potent that it must be removed before olive fruits can be fermented or the process will be inhibited.
The leaf increases the number and activity of phagocytes and interferes with viral infection by inactivating the virus, preventing the virus from shedding its coat, budding, or assembling at the cell membrane. It can also directly penetrate an infected host and inhibit viral replication. The leaf relaxes and dilates peripheral blood vessels and protects the body against hardening of the arteries. |
Tori Hudson, N.D.
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 One study found tea tree effectively inhibited both fluconazole-susceptible and fluconazole-resistant cases of candidiasis in vitro and in animals.55-56 Perhaps the most impressive study used an emulsified 40 percent solution of Australian tea tree oil with 13 percent isopropyl alcohol. In the 96 cases of trichomonal vaginitis, clinical cures were seen with the application of six treatments applied once weekly with a solution-saturated tampon left in place for 24 hours (see "Sample Treatment Plan for Trichomonas Vaginalis" sidebar later in this chapter for specifics). |
| Researchers also noted that coumestrol actually inhibited the uptake of estradiol by the uterus over the long term, and they postulated that there was actually an inhibitory effect at the estradiol receptor sites. Other researchers have noted that coumestans and isoflavones compete with estradiol for uterine receptor sites but have less affinity for them than estradiol.42
Coumestrol has been found to increase uterine weight at a 100 meg dose when given to rats at a certain time in the development of glands. |
Lester A. Mitscher and Victoria Toews
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 Investigators from the Cancer Research Center at the University of Chicago discovered that EGCG from green tea inhibited the growth of prostate tumors and also reduced the size of existing tumors. "It is possible that there is a relationship between the high consumption of green tea and the low incidence of prostate and breast cancers in some Asian countries," the researchers concluded.15
LIVER CANCER
Most tumors that form in the liver are malignant and are usually the result of cancers from other sites of the body that metastasize to the liver. |
Jeffrey M. Smith
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| If protein digestion is inhibited, (which may occur with reduced zymogens), it may increase the chance of allergic reactions to protein fragments. The pancreas may also be forced to produce and excrete more protein digesting enzymes, which might put undue pressure on the organ.
CC T n the testes of young and JL adult mice fed on GM soybeans, both spermatocytes (precursors of sperm cells) and Sertoli cells (their nurse cells) show reduced nuclear activity, especially RNA production. Structures involved in lipid metabolism and detoxification are also enlarged in Sertoli cells. |
Thomson Healthcare, Inc.
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| At high concentrations, Cimicifuga racemosa inhibited the proliferation of human breast adenocarcinoma cells (MCF-7). In addition, estrogen-induced proliferation of MCF-
7 was reduced in the presence of Cimicifuga racemosa extract, an effect that was reversible with increased concentrations of estradiol. Another in vitro study failed to demonstrate any significant binding to estrogen or progesterone receptors as well as estrogenic effect of Black Cohosh (Zava et al, 1998). |
Donna Jackson Nakazawa
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 NIH researchers found that curcumin completely inhibited the onset of rheumatoid arthritis in animals by working to keep inflammatory proteins from being released and preventing destruction in the joints. The daily dose of curcumin administered was roughly equivalent to 120 curry dinners—so future uses of curcumin in humans will revolve around supplementation rather than dietary intake. Meanwhile, clinical trials are currently planned to test turmeric supplements in suppressing rheumatoid arthritis in humans. |
Jeffrey M. Smith
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| Gene expression in early mice embryos was temporarily inhibited in the group whose mothers were fed GM soy. (See section 1.12.)
• Increased herbicide residues associated with GM crops might cause endocrine disruption or toxic effects in fetal development. (See section 6.)
• One of the few intergenerational studies reported more than a sixfold increase (55.6% vs 9%) in offspring mortality within three weeks. (See section 1.14. |
Tori Hudson, N.D.
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| The addition of soy inhibited bone loss, although not to the same extent as was achieved with estrogen treatment.45 Another study of ovariectomized rats also reported a positive effect of the soy phytoestrogen genistein in maintaining bone.46 These authors also reported that genistein suppresses the bone resorption cells (osteoclasts) both in the test tube and in vivo.
Several human studies have provided further insight into the possible role of soy in bone health. |
| With less estrogen in the body, bone resorption is no longer inhibited. This decline in estrogen is the most significant factor in the increased bone loss associated with menopause.19 In the spine, bone loss of 2 percent per year begins about two to three years before the last menstrual period, and this accelerated rate of loss ends three to four years after menopause. At the hip, bone loss has an age-related rate of decline of about 0.5 percent per year. Over these five to seven years, it totals approximately 10.5 percent loss for the spine and 5.3 percent for the hip. |
| Pseudomonas aeruginosa, and Staphylococcus saprophyticus were significantly inhibited.20 These results provide a good ration-Vitamin C
Acute infections: 500-2,000 mg every 2 hours for 2 days, then 500-2,000 mg 3 times daily for 5-10 days
Chronic, recurring infections: 1,000-3,000 mg daily Prevention: 500-1,000 mg daily ale for the beneficial effects of vitamin C for both prevention and treatment of UTIs.
Vitamin C is likely safe for pregnant and lactat-ing women in controlled amounts: up to 2,000 mg per day in women over age 19 and up to 1,800 mg per day for women 14 to 18.
D-Mannose. |
Herbert Ross, DC with Keri Brenner, L.Ac.
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 Several studies have shown that melatonin production significantly drops or is completely inhibited by inadequate exposure to natural bright light during the day and also by excessive exposure to artificial bright light at night. Both factors can cause sleep onset insomnia as well as seasonal affective disorder.
Americans spend the vast majority of their time indoors, usually in win-dowless cubicles and energy-efficient homes under low-intensity artificial lights. |
John E. Sarno, M.D.
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 Alexander makes this statement: "The general psychodynamic background in all cases is a chronic inhibited aggressive state, a rebellion against any form of outside or inside pressure, against being controlled by other persons or against the inhibitory influence of their own hypersensitive consciences."
This observation closely parallels my own findings, and with one change is an excellent description of many people suffering from TMS. For "chronic inhibited aggressive state" I would substitute "chronic unconscious rage. |
Jack Challem
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 It can help us relax, cope with stress, be less inhibited, and reduce physical pain from injuries or disease. For many people, drinking alcohol becomes a central part of their social activities.
Peer pressure often factors in with the use of cocaine, meth, and other street drugs. It's cool and daring to use drugs for the first time, but the initial mental alertness and decreased appetite attract people as well. In a world that values multitasking and increased productivity, the short-term effects of cocaine can be exhilarating. |
David W. Grotto, RD, LDN
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 LEUKEMIA: Two human cell line studies showed that persimmon extract strongly inhibited the growth and induced apoptosis (programmed cell death) of leukemia cells.
CHOLESTEROL: Rats who had a persimmon-supplemented diet had significantly less total cholesterol, LDL cholesterol, triglycerides, and lipid peroxides compared to rats who didn't eat persimmons.
Tips on Using Persimmons
SELECTION AND STORAGE:
• Look for persimmons that are round and plump, and have smooth, glossy skin and deep red undertones. Avoid fruits that are missing the green leaves at the top. |
| A cell study using advanced human prostate cancer cells found that treatment with grape seed extract inhibited cell growth and caused them to die. Another study showed that drinking four or more glasses of red wine per week cut the risk of prostate cancer in half.
COGNITIVE FUNCTION: Concord grape juice significantly improved laboratory animals' short-term memory in a water maze test, as well as coordination, balance, and strength.
WEIGHT CONTROL: A study found that grape seed extract may be helpful in limiting absorption and accumulation of dietary fat in cells observed under a microscope. |
| CANCER: A cell study using human breast cancer cells found that treatment with pomegranate extract significantly inhibited cancer cell growth and increased cell apoptosis (cell death). Another cell study found that pomegranate juice reduced inflammatory cell signaling in colon cancer cells. Men with rising prostate-specific antigen (PSA) scores after receiving radiation therapy who consumed pomegranate juice daily had an increase in cell apoptosis (cell death) and a decrease in cell proliferation. And other research points to pomegranate's ability to inhibit protaste tumor growth. |
| Another cell study showed that goji inhibited leukemia cancer cells, and a mouse study showed that goji enhanced the killing effect of radiation therapy.
Tips on Using Goji Berries
SELECTION AND STORAGE:
• Goji can be purchased at Chinese supermarkets and herb shops and health food stores.
• Goji berries are processed into a variety of other forms including juice, powdered, and dried.
• Store in a cool, dry place.
PREPARATION AND SERVING SUGGESTIONS:
• Goji berries can be eaten right off of the vine!
• Wash and then soak dried goji berries for fifteen minutes before eating. |
Jeffrey M. Smith
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| Or it may be that (pre)messenger RNAs are no longer being adequately processed or their normal export from the nucleus into the cytoplasm is being inhibited. Such interference with normal gene expression may result in unhealthy Sertoli cells or spermatocytes, either of which might interfere with sperm health or quantity.
As in the case of pancreatic cells in the previous study, "A decrease in the number of nuclear pores (NP) was also detected in GM soy fed mice." 82 Pores are the gateway through which RNA and proteins move in and out of the cell nucleus. |
Andreas Moritz
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 Side effects include high blood pressure, stomach ulcers with possible perforation of the stomach wall (this is how my father died), cramps and dizziness, inhibited growth in children within six weeks of taken the drugs, irregular menstruation, weakening of muscular strength, slowed healing of wounds, vision problems, skin atrophy, allergic shock, loss of libido, decrease in bone density, manic depression, and the emergence of latent diabetes. Steroids are now handed out, even for babies, at the first sign of inflammation of any kind. |
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