David Steinman
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 Based on the data accumulated by the registry, the estimated annual average incidence rate of premature thelarche in Puerto Rican girls ages six to twenty-four months of age is eight cases per one thousand live female births from 1984 to 1993. This incidence is perhaps the highest ever reported in North America, if not the world. Compared with a study conducted in Minnesota, the incidence of premature thelarche in the Puerto Rican female population is 18.5 times higher. |
Mike Adams, the Health Ranger
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 Also, several beneficial effects from aloe ingestion on age-related disease were found: Group 2 and 3 showed a lower incidence of atrial thrombosis than Group 1. Furthermore, Group 2 showed a significantly lower incidence of fatal chronic nephropathy and occurrence of multiple causes of death compared to the control group. All groups ingesting aloe showed a slightly lower incidence of fatal leukemia. Moreover, no adverse, toxic effects were found with the ingestion of aloe vera.
"Nephropathy" simply means kidney disorders, by the way. |
Mike Adams, the Health Ranger
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 Specifically, the study shows (reprinted from the abstract): a) a significant dose-related increase of malignant tumor-bearing animals in males, in particular in the group treated at 2000 ppm; b) a significant increase of the incidence in lymphomas/leukemias in males treated at 2000 ppm and a significant dose-related increase of the incidence of lymphomas/leukemias in females, in particular in the group treated at 2000 ppm; c) a significant dose-related increase of the incidence of mammary cancer in females, in particular in the group treated at 2000 ppm. Conclusions. |
David Steinman
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| Based on the data accumulated by the registry, the estimated annual average incidence rate of premature thelarche in Puerto Rican girls ages six to twenty-four months of age is eight cases per one thousand live female births from 1984 to 1993. This incidence is perhaps the highest ever reported in North America, if not the world. Compared with a study conducted in Minnesota, the incidence of premature thelarche in the Puerto Rican female population is 18.5 times higher. |
Dan Buettner
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 She did a study comparing people living in the area with the highest incidence of stomach cancer (near San Jose) and the lowest rate of stomach cancer (Nicoya) to try to identify the cause. "I found that school kids in both places were equally infected with
Hp," she said. "So we knew that it wasn't just the bacteria. The cancer comes from how people react to it, and there are many things that mix."
When I asked her to venture a guess as to why the incidence of cancer is so much lower in Nicoya, she hedged. |
J. Douglas Bremner
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 Although the prevalence of depression (meaning that it has occurred at some time in your life) is
16%, the actual incidence (developing new-onset depression) during any given year is only 1.6%.
Therefore, in the four-month period of an isotretinoin trial, about 0.5% of patients would spontaneously develop depression. Estimates of the incidence of depression following treatment with isotretinoin range from 1% to 4% to 6%. More than 6 million patients have been treated with Accutane. |
David Winston, RH(AHG), and Steven Maimes
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 Results: incidence of cases during an influenza epidemic dropped by two-thirds.
Subjects: Twelve hundred long-distance truck drivers.
Results: Improved productivity, incidence of cases during an influenza epidemic was reduced by 30 percent.
Subjects: Fourteen thousand auto factory workers. Results: 30 percent decrease in total reported symptoms such as fatigue, insomnia, and anxiety; 40 percent reduction in high blood pressure and heart disease symptoms.
Subjects: One hundred and seven patients receiving drugs for gastric cancer. |
Shannon Brownlee
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 Men in Seattle were also five times more likely to undergo surgical removal of the prostate, the
* That's assuming no increase in incidence. There has been an increase in incidence since the introduction of PSA testing, but according to most experts, it does not appear to be due to more cancers, just more detection. most common method of treating the disease. A prostatectomy is a delicate surgical procedure that often renders patients impotent, incontinent, or both, even in the hands of the most accomplished surgeon. |
Mike Adams, the Health Ranger
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| Furthermore, Group 2 showed a significantly lower incidence of fatal chronic nephropathy and occurrence of multiple causes of death compared to the control group. All groups ingesting aloe showed a slightly lower incidence of fatal leukemia. Moreover, no adverse, toxic effects were found with the ingestion of aloe vera.
"Nephropathy" simply means kidney disorders, by the way. So this is explaining that aloe vera reduces kidney disease and other causes of death. |
Ron Garner
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 This is why people who consume large amounts of animal and dairy products suffer from an increased incidence of cardiovascular disease.
Unsaturated efas, like those found in seed oils and fish, prevent saturated fats from aggregating by keeping them dispersed. This may explain why Eskimos who consumed traditional diets had a very low incidence of heart disease. The fat of land animals does not contain omega-3 efas, whereas the fat of sea mammals and fish does.
Trans Fats
Trans fats are a major contributing risk factor for developing cardiovascular disease. |
Mehmet C. Oz., M.D. and Michael F. Roizen, M.D.
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 Research shows that an elevated level of the E4 protein is correlated with a higher incidence of Alzheimer's. Fortunately, there are things you can do to turn down the activity of the E4 gene and allow the rest of the Apo E team to clear your power lines. Eating turmeric, which is found in Indian foods, seems to reduce expression of the E4 gene (India, by the way, has a relatively low incidence of Alzheimer's). Exercise has a similar effect. |
Michael T. Murray and Michael R. Lyon
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 These lean and wiry people developed an astronomical incidence of obesity. At one time, 100 percent of adult Pima Indians were grossly obese and the incidence of type 2 diabetes was a staggering 65 percent. The numbers have come down a bit (70 percent and 22 percent, respectively), but are still among the highest in the world.
In 1962, anthropologist James V Neel suggested that tribal hunter-gathers like the Pimas had body processes well adapted to feast-or-famine cycles. This genetic adaptation was termed the "thrifty genotype" to signify the ability to withstand famines. |
Caldwell B. Esselstyn, Jr., M.D.
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 What's more, in recent years, researchers have observed that as residents of areas with a low incidence of cardiovascular disease begin to adopt a more Western style of life and diet, the incidence of disease—especially coronary disease—rises dramatically.
It may be years before we understand each step and every nuance of the process by which dietary fat and cholesterol destroy coronary arteries. But we are well aware of the general outlines. |
Mark Lynas
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 One of the most wide-ranging analyses was undertaken by Eleanor Burke and colleagues from the Hadley Centre at Britain's Meteorological Office, who used a measure known as the 'Palmer Drought Severity Index' to forecast the likely incidence of drought over the century to come. The results were deeply troubling. The incidence of moderate drought doubled by 2100 - but worst of all, the figure for extreme drought (currentiy 3 per cent of the planet's land surface) rose to 30 per cent. |
Caldwell B. Esselstyn, Jr., M.D.
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| What's more, in recent years, researchers have observed that as residents of areas with a low incidence of cardiovascular disease begin to adopt a more Western style of life and diet, the incidence of disease—especially coronary disease—rises dramatically.
It may be years before we understand each step and every nuance of the process by which dietary fat and cholesterol destroy coronary arteries. But we are well aware of the general outlines. |
Erich Grotewold
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 Treatment of TRAMP mice with 100-500 mg genistein/kg diet reduced the incidence of advanced-stage prostate tumors, in a dose-dependent manner (Mentor-Marcel et al., 2001). A high-isoflavone diet also was shown to inhibit methylnitrosourea-induced prostate tumor in Lobund-Wistar rats (J. Wang et al., 2002). Topically applied genistein reduces the incidence and multiplicity of skin tumors in the DMBA-initiated and TPA-promoted multiplicity of skin mouse model by 20% and 50%, respectively (J. Wang et al., 2002). |
Ray D. Strand
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 The study showed no reduction in the incidence of lung cancer in any of the groups receiving the supplements. But even more of a concern was the fact that those individuals who were taking the beta-carotene supplementation actually showed an increase in the incidence of lung cancer. This came as a shock to the investigators because several earlier studies had shown a reduced risk in those patients who had high levels of vitamin E and beta carotene in their diets or blood streams.
The CARET Study
This study involved eighteen thousand smokers and asbestos workers who lived in Washington State. |
Donna Jackson Nakazawa
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 But what is especially striking is that South Asian immigrants who move to Western countries soon show an increased incidence of autoimmune inflammatory bowel diseases like Crohn's disease and ulcerative colitis.
Clearly, the diet most Americans favor is a far cry from the whole-foods diet that Gerry Mullin and other complementary and alternative-minded physicians believe might help to rebalance an overreactive immune system. |
| Likewise, a heightened incidence of lupus in a small African-American community in Georgia has been attributed to environmental pollutants from industrial sources. In a four-year study of Choctaw Native Americans in southeastern Oklahoma, researchers found a higher than average occurrence of scleroderma. Although genetics in the closely related Choctaw population was likely a contributing factor, relatives who moved away did not have as high a rate of scleroderma. |
| THE STORY INTHE NUMBERS
If you were to look today at a chart detailing incidence rates of autoimmune disease versus heart disease and cancer, you would see that while cancer and heart disease rates are, more or less, flatlin-ing, autoimmune diseases are continuing in a steady upward climb. This raises some interesting questions. If an estimated 25 percent of people around the globe carry genes that make them susceptible to autoimmune disease, and if 8. |
Craig Pepin-Donat
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 The reality is that if no one used tobacco and everyone ate a balanced, healthy diet of natural organic foods coupled with moderate exercise, the incidence of these types of diseases and the number of prescription drugs that people take would be a fraction of what it is today. Despite the fact that it is obviously smarter and better to take these preventive measures, many people continue to eat poorly and refuse to perform even a minimal amount of physical activity. Instead, we look to our doctors and their prescription pads to cure our ills. It's an avoidable tragedy. |
Anne Harrington
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 By the early twentieth century, the incidence of neurasthenia had reached what appeared to be epidemic proportions. A writer for the North American Review, H. Adding-ton Bruce, observed in 1908, "On every street, at every corner, we meet the neurasthenics."8 A new group of elite, private-practice neurologists— so-called nerve doctors—emerged to treat the growing numbers of the infirm and the distressed in the wealthier classes, while people of more modest means tended to favor the tonics and pills that were sold by the patent-medicine industry as ways to calm and strengthen "bad nerves. |
Tom Bohager
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 According to a recent study in 10 healthy adults, cellular immune response to intestinal microorganisms was enhanced following intake of L. rhamnosus GG for 5 weeks. This increased the response of peripheral T lymphocytes to intestinal bacteria and enhanced an inflammatory response by increasing the secretion of suppressive cytokines and decreasing secretion of pro-inflammatory cytokines."11 ž"Administration of L. rhamnosus GG to pregnant mother weeks prior to delivery and to their newborn babies through 6 months of age led to a 50% decrease in the infants' incidence of recurring atopic eczema. |
Anne Harrington
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| The reason had to do with a skewing of the epidemiological data; while heart disease was on the rise in general, its incidence was particularly high among males who self-identified as white-collar managerial types—so much so that some cardiologists had taken to calling coronary heart disease the executive disease.
Why might white-collar executives be more at risk than others? In the mid-1950s, San Francisco cardiologists Meyer Friedman and Ray Rosen-man began to make the link to stress. |
Jonny Bowden, Ph.D., C.N.S.
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 On the other hand, it's also associated with a higher incidence of nausea, vomiting, and other gastrointestinal disturbance. That said, it might be helpful.
Biotin and Fenugreek
Yet many experts consider it something of a Band-Aid on the problem, which doesn't get to the cause of PCOS. Remember that the main thing metformin does is help the body use insulin better. Chromium picolinate (see page 46) does the same thing and is a great supplement to use together with a low-carb diet to help manage both blood sugar and insulin. |
| Jj
A Weapon against Cancer
Low dietary intake of selenium is associated with increased incidence of several types of cancers, including lung, colorectal, skin, and prostate. Animal and human research shows that supplemental selenium can protect against certain cancers.
"Nearly 200 animal studies have been conducted to evaluate the effects of (supplemental) levels of selenium on experimental carcinogenesis. Of these, two-thirds have found that high levels of selenium reduced the development of tumors at least moderately and in most cases very significantly," writes P.D. Whanger, Ph.D. |
Donna Jackson Nakazawa
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| However, this increase in lupus "is so enormous," says Petri, part of it can only be explained by an increase in the incidence of lupus itself.
Petri's emphatic tone reveals her concern for her patients' well-being as well as her frustration over how little physicians understand about why so many people's immune systems are attacking their own healthy tissue. |
Too Profitable to CureBrent Hoadley, Ph.D.
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| Then we note in a press release the occurrence of rashes, worsening of diabetic retinopathy, allergic reactions, sodium retention, and that the improved glycemic control with soluble human insulin is associated with increased incidence of hypoglycemia.
• In the 1995 patent #5,422,33910 awarded to the JoslinDiabetes Center, it is stated that immune systems of the patient produce antibodies, which interfere with insulin-related function. Human insulin and animal insulin antibodies are an immunological response to insulin treatment. |
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