J. Douglas Bremner See book keywords and concepts |
The use of B vitamins has also been advocated as a way to improve cognition because high levels of the amino acid homocysteine have been seen in patients with Alzheimer's disease. Since homocysteine is involved in vitamin B pathways, it was felt that lowering homocysteine with vitamin B therapy would lead to an improvement in cognition. In one study, 276 healthy people over age sixty-five with elevated homocysteine concentrations were given folate and vitamins B12 and B6 or a placebo. Neither folate nor vitamin B supplementation resulted in an improvement in scores of cognition after two years. |
Mike Adams, the Health Ranger See article keywords and concepts |
Kunin: And it's frustrating because right now there's been a lot of talk, for example, in the arena of homocysteine. They're now saying that the theory of homocysteine in its relationship with cardiovascular disease may be in question -- when, in fact, we know that homocysteine is a pro-clotting factor. For your audience who may not know what homocysteine is -- every time you eat animal protein, you're ingesting homocysteine. |
Bruce Fife and Jon J. Kabara See book keywords and concepts |
Blood levels of homocysteine is one of the most accurate of the risk factors. homocysteine is an amino acid derived from protein found in meat, milk, and other foods. Recent research has shown that homocysteine levels in the blood are much more strongly associated with heart disease than cholesterol.2 In fact, homocysteine may help raise blood cholesterol. The association of high blood cholesterol with heart disease may be due more from homocysteine (derived primarily from protein found in meat and dairy products) than from cholesterol (or saturated fat). |
J. Douglas Bremner See book keywords and concepts |
Since homocysteine is involved in vitamin B pathways, it was felt that lowering homocysteine with vitamin B therapy would lead to an improvement in cognition. In one study, 276 healthy people over age sixty-five with elevated homocysteine concentrations were given folate and vitamins B12 and B6 or a placebo. Neither folate nor vitamin B supplementation resulted in an improvement in scores of cognition after two years.21
GINKGO BILOBA
Ginkgo biloba, a supplement derived from the ancient ginkgo tree of China, has long been believed to increase memory, energy, and concentration. |
Mike Adams, the Health Ranger See article keywords and concepts |
For your audience who may not know what homocysteine is -- every time you eat animal protein, you're ingesting homocysteine. And for those people who cannot manage their homocysteine through the normal pathways -- if they've got a problem with their folic acid and their B12 -- the only other way they can manage their homocysteine is through remethylation. And that's what this product is all about. It's really opening the doors to your methyl pathways, which affect every single organ of your body. |
Bruce Fife and Jon J. Kabara See book keywords and concepts |
Blood levels of homocysteine is one of the most accurate of the risk factors. homocysteine is an amino acid derived from protein found in meat, milk, and other foods. Recent research has shown that homocysteine levels in the blood are much more strongly associated with heart disease than cholesterol.2 In fact, homocysteine may help raise blood cholesterol. The association of high blood cholesterol with heart disease may be due more from homocysteine (derived primarily from protein found in meat and dairy products) than from cholesterol (or saturated fat). |
Dr. Abram Hoffer, MD, FRCP (C) and Dr. Harold D. Foster, PhD See book keywords and concepts |
For example, the enzyme cystathionine P-synthase catalyzes homocysteine and serine to form cystathionine. Individuals with a defective form of this enzyme develop very high blood and urine homocysteine levels that can cause a variety of symptoms, including mental retardation, vascular and skeletal problems, and optic lens dislocation. It has been found that roughly one half of cystathionine |3-synthase deficient patients respond well to very high doses of vitamin B-6, the coenzyme for cystathionine (3-synthase, which can lower their homocysteine and serine concentrations to normal levels. |
Mike Adams, the Health Ranger See article keywords and concepts |
For your audience who may not know what homocysteine is -- every time you eat animal protein, you're ingesting homocysteine. And for those people who cannot manage their homocysteine through the normal pathways -- if they've got a problem with their folic acid and their B12 -- the only other way they can manage their homocysteine is through remethylation. And that's what this product is all about. It's really opening the doors to your methyl pathways, which affect every single organ of your body. |
T. Colin Campbell, Ph.D. and Thomas M. Campbell II See book keywords and concepts |
What are folic acid and homocysteine? Folic acid is a compound derived exclusively from plant-based foods such as green and leafy vegetables. homocysteine is an amino acid that is derived primarily from animal protein.77 This study found that it was desirable to maintain low blood homocysteine and high blood folic acid. In other words, the combination of a diet high in animal-based foods and low in plant-based foods raises the risk of Alzheimer's disease. |
The Editors of FC&A See book keywords and concepts |
| People with low amounts of B12 and folate had higher homocysteine levels. This is particularly important because one study found that people with high levels of homocysteine were at an almost three times greater risk for Alzheimer's disease than those with low levels.
A regular 12-ounce cafe latte supplies 400 mg of calcium. You can get even more calcium, and less fat and calories, by using low-fat or fat-free milk.
Other researchers have found B6 also helps lower homocysteine. |
Bottom Line Health See book keywords and concepts |
| Kaare Harald Bonaa, MD, PhD
"Combination vitamin therapies, which do lower homocysteine, have no effect on cardiovascular events, even though the homocysteine level is lowered," says Dr. Joseph Loscalzo, head of the department of medicine at Brigham and Women's Hospital in Boston.
THE FIRST STUDY
In the first study, called the Norwegian Vitamin (NORVIT) trial, Norwegian researchers randomly assigned 3,749 men and women who had had heart attacks to receive either folic acid along with vitamins B-6 and B-12, or a placebo. |
Jack Challem See book keywords and concepts |
For example, a low intake of vitamins B6, B12, and folic acid raises high blood concentrations of homocysteine, a substance that damages blood vessel walls. This blood vessel damage invites cholesterol deposits as the body makes a misguided attempt to heal itself. Taking these B vitamins lowers homocysteine levels and protects blood vessels.
Endothelial dysfunction is another risk factor for diabetes and coronary heart disease, although it is not routinely measured. The endothelium is a thin layer of cells lining the inside of blood vessels. |
Kaayla T. Daniel, PhD, CCN See book keywords and concepts |
Back in the 1950s, studies with Cebus monkeys showed that diets containing soy protein isolates were atherogenic, but feeding of methionine to the monkeys prevented atherogenesis, probably because of reduced plasma levels of homocysteine resulting from increased SAM synthesis.3233 Recently, a study of retired school teachers in Baltimore found that increased dietary protein led to decreased plasma homocysteine and decreased dietary protein led to increased plasma homocysteine.34 This suggests that a diet rich in soy protein is highly unlikely to be good for preventing heart disease. |
Mehmet C. Oz., M.D. and Michael F. Roizen, M.D. See book keywords and concepts |
To compound matters, without B vitamins, your homocysteine levels rise, and that doubles the risk of developing Alzheimer's. homocysteine is an amino acid associated with stroke, heart disease, and Alzheimer's. Although no study has demonstrated a benefit of supplementation to your thinking process, the products are generally safe, and anecdotal evidence is enticing. We recommend a supplement with 400 micrograms of folic acid, 800 micrograms of B,2, and 40 milligrams of B6 a day. |
Andreas Moritz See book keywords and concepts |
Normally, your body has a built-in defense mechanism against homocysteine buildup; it transforms it into a harmless substance called cystathionine, which is flushed from the body in the urine. However, regularly overeating proteins greatly undermines this ability. Foods that are high in folic acid (see chapter 7) have been shown to drastically lower homocysteine levels and thereby reduce the risk of cardiovascular disease. |
T. Colin Campbell, Ph.D. and Thomas M. Campbell II See book keywords and concepts |
What are folic acid and homocysteine? Folic acid is a compound derived exclusively from plant-based foods such as green and leafy vegetables. homocysteine is an amino acid that is derived primarily from animal protein.77 This study found that it was desirable to maintain low blood homocysteine and high blood folic acid. In other words, the combination of a diet high in animal-based foods and low in plant-based foods raises the risk of Alzheimer's disease. |
Bottom Line Health See book keywords and concepts |
| Beware: Few doctors routinely test for homocysteine. Insist on the test. An average reading is approximately 10—but lower is better.
People who have elevated homocysteine are two to three times more likely to have a stroke than those who have lower levels.
•Take aspirin daily. People who have had a stroke or who are at high risk of having one should consider taking a daily aspirin to inhibit blood clots in the arteries. An 81-milligram (mg) baby aspirin and a 325-mg adult aspirin appear to be equally effective, but the smaller dose is less likely to cause intestinal bleeding. |
Elaine Magee See book keywords and concepts |
At high levels, homocysteine is thought to damage artery linings, leading to heart attack and stroke, as well as contribute to blood clots.) In other words, they each work independently to help lower homocysteine
B Vitamins: How Much Do I Need Each Day?
The 1998 Dietary Reference Intakes recommend the following: FOLIC ACID
/ 400 meg (dietary folate/folic acid equivalents)/day for men ages 19+ / 400 meg (dietary folate equivalents)/day for women ages 19+
VITAMIN B6*
/ 1.3 mg/day for men ages 14-50 / 1.7 mg/day for men ages 51 + 1.2 mg/day for women ages 14-18 y 1. |
Mehmet C. Oz., M.D. and Michael F. Roizen, M.D. See book keywords and concepts |
To compound matters, without B vitamins, your homocysteine levels rise, and that doubles the risk of developing Alzheimer's. homocysteine is an amino acid associated with stroke, heart disease, and Alzheimer's. Although no study has demonstrated a benefit of supplementation to your thinking process, the products are generally safe, and anecdotal evidence is enticing. We recommend a supplement with 400 micrograms of folic acid, 800 micrograms of B,2, and 40 milligrams of B6 a day. |
Gary Null and Amy McDonald See book keywords and concepts |
Homocysteine causes behavioral deficits, and melatonin may protect against homocysteine toxicity.
The Effect of Vitamin-Mineral Supplementation on the Intelligence of American Schoolchildren: A Randomized, Double-Blind Placebo-Controlled Trial. Schoenthaler SJ; Bier ID; et al. Journal of Alternative and Complementary Medicine, 2000 February, 6(l):19-29.
Vitamin-mineral supplementation significantly increased the nonverbal intelligence of a minority of American schoolchildren. Parents of children with low academic performance should obtain a full nutritional assessment. |
Michael T. Murray See book keywords and concepts |
Elevated homocysteine levels are an independeni: risk factor for heart attack, stroke, and peripheral vascular disease. In addition, recent research has implicated elevations of homocysteine in the development of the long-term complications of diabetes, especially diabetic retinopathy.7
Although folic acid has received the most attention as a nutritional supplement to lower homocysteine levels, several studies have shown quite clearly that the best reductions are seen when vitamin Bfi and B12 are supplemented along with folic acid. |
Elaine Magee See book keywords and concepts |
Alcoholics have highly elevated homocysteine concentrations. Wine and hard liquor have been shown to raise concentrations—but there seems to be a loophole for beer, which seems to have no effect. Some researchers have suggested that the folate (folic acid) and B6 in beer might help counteract the homocysteine-raising effects of the alcohol.
-
IS THERE REALLY "GOOD" CHOLESTEROL? |
Peter J. Whitehouse and Daniel George See book keywords and concepts |
Some studies have demonstrated that eleva-
12 O tions in the level of an amino acid called homocysteine are associated with increased risk for stroke and a loss of cognitive performance characteristic of Alzheimer's disease. Folic acid and vitamins B]2 and B6 are co-factors in homocysteine's metabolic pathways, and their presence in the body may potentially lower levels of this substance. This has prompted some physicians to recommend the three vitamins as supplements. |
Stephen T. Sinatra, M.D. See book keywords and concepts |
I believe that the bias currently shown in the medical community against coenzyme Qio is very similar to medicine's twenty-five-year-long rejection of the homocysteine theory of Kilmer McCully the brilliant pioneer in homocysteine research. It took a very long time, but mainstream medicine now embraces Dr. McCully's revolutionary findings.
BACKGROUND AND STUDIES OF COENZYME Q10
Anyone can purchase any number of brands of coenzyme Qi0 in health food stores today. |
James Dowd and Diane Stafford See book keywords and concepts |
Folic acid is important in fighting cardiovascular disease and reducing levels of homocysteine, an amino acid responsible for inflaming and damaging blood vessels and associated with osteoporosis. Folic acid, vitamin B6, and vitamin B12 all can reduce levels of homocysteine.
Pregnant women have a special need for folic acid because it's key to fetal development and nervous system functioning. The same goes for women who are planning pregnancies. |
Dr. Abram Hoffer, MD, FRCP (C) and Dr. Harold D. Foster, PhD See book keywords and concepts |
Individuals with a defective form of this enzyme develop very high blood and urine homocysteine levels that can cause a variety of symptoms, including mental retardation, vascular and skeletal problems, and optic lens dislocation. It has been found that roughly one half of cystathionine |3-synthase deficient patients respond well to very high doses of vitamin B-6, the coenzyme for cystathionine (3-synthase, which can lower their homocysteine and serine concentrations to normal levels. |
Michael T. Murray See book keywords and concepts |
If a person is relatively deficient in folic acid, vitamin B6, or vitamin B12, there will be an increase in the level of homocysteine. This compound has been implicated in a variety of conditions, including atherosclerosis. homocysteine is thought to promote atherosclerosis by directly damaging the artery and by reducing the integrity of the vessel wall, as well as by interfering with the formation of collagen (the main ptotein in connective tissue and bone).
Elevated homocysteine levels are an independeni: risk factor for heart attack, stroke, and peripheral vascular disease. |