Paula Begoun and Bryan Barron
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 Blue Green Algae with grape seed extract Moisturizer SPF 15, for Combination/ Oily Skin ($16.28 for 4 ounces) is nearly identical to the Green Tea & Ginkgo Moisturizer SPF 15, for Normal Skin, above and the same review applies.
© Blue Green Algae with grape seed extract Soothing Mask, for Combination/Oily Skin ($8.98 for 4 ounces) is similar to the Green Tea & Green Clay Rejuvenating Mask, for Normal Skin, above except this adds lavender oil, which makes it too irritating.
AUBREY ORGANICS OILY SKIN 5
© Natural Herbal Facial Cleanser, for Oily Skin ($12. |
David W. Grotto, RD, LDN
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 A cell study using advanced human prostate cancer cells found that treatment with grape seed extract inhibited cell growth and caused them to die. Another study showed that drinking four or more glasses of red wine per week cut the risk of prostate cancer in half.
COGNITIVE FUNCTION: Concord grape juice significantly improved laboratory animals' short-term memory in a water maze test, as well as coordination, balance, and strength.
WEIGHT CONTROL: A study found that grape seed extract may be helpful in limiting absorption and accumulation of dietary fat in cells observed under a microscope. |
Jonny Bowden, Ph.D., C.N.S.
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 Flavonoids, grape seed extract, and Pycnogenol. Plant compounds called flavonoids, proanthocyanidins, and antho-cyanidins are all helpful in the treatment of varicose veins. All seem to help strengthen the delicate walls of the veins and capillaries. Foods richest in these substances include berries (blueberries and blackberries) as well as cherries, grapes, and tea. Add these foods to your diet and take a supplement of grape seed extract, which is rich in these compounds.
4. Vitamin C. |
David W. Grotto, RD, LDN
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| Inhibitory effects of grape seed extract on lipases. Nutrition. 11(10), 876—879.
Shukitt-Hale B et al. Effects of Concord grape juice on cognitive and motor deficits in aging. Nutrition. 2006 Mar;22(3):295-302.
Guava www.hort.purdue.edu/newcrop/morton/guava.html
Abdelrahim, S. I., et al. Antimicrobial activity of Psidium guajava L. Fitoterapia. 2002; 73(7-8): 713-715.
Arima H et al. Isolation of antimicrobial compounds from guava (Psidium guajava L.) and their structural elucidation. Biosci Biotechnol Biochem. 2002; 66(8): 1727-1730. Cheng JT et al. |
Jonny Bowden, Ph.D., C.N.S.
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| Other ingredients you may see on the ingredients list in a glucosamine-chondroitin formula may include sea cucumber (Cucumaria frondosa), grape seed extract, boswellia, and turmeric, all of which have varying degrees of anti-inflammatory action.
Exercise for Arthritis
You may feel like exercise is out of the question if you have arthritis. Not so. Moderate exercise can be your best friend—building strong muscles around the joints can go a long way toward relieving joint pain, not to mention the benefits exercise provides to overall endurance, well-being, and mood. |
Thomson Healthcare, Inc.
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 Radiation protection with grape seed extract (abstract P.31). Health Phys; 74(6 suppl):S12. 1998.
Maffei Facino R, Carini M, Aldini G, et al. Free radicals scavenging action and anti-enzyme activities of procyanidines from Vitis vinifera. A mechanism for their capillary protective action. Arzneimittelforschung May;44(5):592-601. 1994.
Maffei Facino R, Carini M, Aldini G, et al. Procyanidines from Vitis vinifera seeds protect rabbit heart from ischemia/reperfusion injury: antioxidant intervention and/or iron and copper sequestering ability. Planta Med Dec;62(6):495-502. 1996. |
| Energy Intake
A randomized, double-blind, placebo-controlled crossover study of 51 normal to overweight subjects found grape seed extract effective in reducing 24-hour energy intake (EI) in certain individuals. For 3 days, subjects ate an ad libitum lunch and dinner. Standard breakfast and snacks were provided. Supplements were taken 30-60 minutes prior to each meal. In the total study population, no differences in 24-hour energy intake were found between the two treatment groups. However, in the subgroup of 23 subjects with an energy requirement greater than or equal to the median of 7. |
| Cytoprotective Effects: Various abstracts reported that grape seed extract has in vitro effects that may ameliorate the toxic effects of chemotherapeutic agents (Joshi et al, 1998); that it provides some protection against radiation damage to spermatogonia! cells in the testes (Lanka et al, 1998); and that it may attenuate acetaminophen induced hepatic DNA damage, apoptopic cell death, and influence gene expression (Ray et al, 1998). |
| Prophylactic decrease in postoperative facial edema was the main efficacy criteria. The grape seed extract cohort scored significantly better than placebo against postoperative facial swelling (Baruch, 1984).
Three patients with chronic pancreatitis (2 with history of alcohol excess and 1 idiopathic) experienced a decrease in frequency and intensity of abdominal pain and resolution of vomiting (in 1 patient) when taking Grape Seed proantho-cyanidin extract ActiVin®, a potent antioxidant. |
Mike Adams, the Health Ranger
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 It has green tea extract, grape seed extract, lipoic acid, and buffered vitamin C. We designed our red line to provide a solid foundation for pets' health.
We also offer a blue label line of supplements, which focuses on helping with specific conditions, like allergies. Allergies are a major problem in animals. Allergy Defense for pets is the same as our Allergy Support Plus for humans. Within hours you can stop the itching if you keep an animal on it. Many of them scratch away all their hair, and they are itchy and miserable. You can stop that with Allergy Defense. |
Erich Grotewold
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 Matrix assisted laser desorption/ionization time of flight mass spectrometry of polygalloyl polyflavan-3-ols in grape seed extract, J Agric Food Chem 48: 1663-1667. Krueger, C. G., Vestling, M. M. and Reed, J. D., 2003, Matrix-assisted laser desorption/ionization timeof-flight mass spectrometry of heteropolyflavan-3-ols and glucosylated heteropolyflavans in sorghum
[Sorghum bicolor (L.) Moench], J Agric Food Chem 51: 538-543. Le Gall, G., DuPont, M. S., Mellon, F. A., Davis, A. L., Collins, G. J., Verhoyen, M. E. and Colquhoun, I.
J. |
James F. Balch, M.D. and Mark Stengler, N.D.
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 Grape Seed Extract
Description: grape seed extract is, as the name implies, the extract of grape seeds. This supplement contains a class of flavonoids known as proanthocyanidins. Grape seed is mainly used as an antioxidant and to improve the stability of collagen and elastin, two substances that are important for healthy skin, joints, ligaments, tendons, and blood vessels. It is also used to improve microcirculation throughout the body.
Indications: Antioxidant support Bruising
Macular degeneration
Retinopathy
Varicose veins Precautions: No side effects have been reported. |
Hyla Cass, M.D.
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 Other Antioxidants
A broad spectrum of antioxidants—vitamins C, E, mixed carotenes (found in colorful vegetables and fruit), proanthocyanidins (found in grape seed extract), curcumin (from the herb turmeric), and catechins (found in tea, particularly the green variety)—is useful to round out any diabetic's supplement program. The various antioxidants work together, like instruments in an orchestra; taking one or two isn't enough. For best results, take a combination of antioxidants. |
Marshall Editions
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 Grape seed: Studies on grape seed extract have shown its ability to increase blood vessel integrity and to prevent damage by toxins and chemical and environmental irritants. Take 300 mg daily for three weeks, then decrease the dosage to 75 mg a day to prevent future nosebleeds.
Blueberries, bilberry, and huckleberries: These all contain high levels of antioxidant flavanoids and phenolic acids, which promote and ensure vessel strength. Eat one cup of the mixed berries a day. |
Bottom Line Health
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| Also helpful: The herbs grape seed extract (200 mg daily) and green tea extract (200 mg daily), both of which help prevent eye damage.
HEARTBURN
This fiery pain behind the breastbone is caused by stomach acid backing up into the esophagus. There are drugs that shut down stomach acid production, but a natural approach aims to improve digestion.
Natural approach: The probiotic acidophilus (one to three capsules before each meal) adds "friendly" bacteria that fight heartburn by aiding digestion.. . |
David W. Grotto, RD, LDN
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| November). grape seed extract induces apop-totic death of human prostate carcinoma DU145 cells via caspases activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release. Carcinogenesis. 23(11), 1869-1876.
Albers AR et al. The antiinflammatory effects of purple grape juice consumption in subjects with stable coronary artery disease. Arterioscler Thromb Vase Biol. 2004 Nov;24(ll):el79-180.
Falchi M et al. Comparison of cardioprotective abilities between the flesh and skin of grapes. J Agric Food Chem. 2006 Sep 6;54(18):6613-6622. |
Thomson Healthcare, Inc.
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| Lanka et al, 1998); and that it may attenuate acetaminophen induced hepatic DNA damage, apoptopic cell death, and influence gene expression (Ray et al, 1998). grape seed extract inhibited stomach mucosal injury in mice induced by 60 percent ethanol (EtOH) containing 150 millimolar hydrochloric acid (HC1) (Saito et al, 1998). r
Hair Growth: Proanthocyanidins extracted from Grape Seeds promote proliferation of hair follicle cells, and possess hair-cycle converting activity from the telogen phase to the anagen phase. |
Paula Begoun and Bryan Barron
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| AUBREY ORGANICS COMBINATION/OlLY SKIN 4 © Blue Green Algae with grape seed extract Facial Cleansing Lotion, for Combination/Oily Skin ($15.48 for 8 ounces) has a cleansing base consisting of castile soap, and although this version uses olive oil instead of animal fat it can still be drying for skin. The lavender oil also contributes to making this cleanser problematic for any skin type.
© Blue Green Algae with Grape Seed Fixtract Facial Toner, for Combination/Oily Skin ($9.28 for 8 ounces) lists alcohol and witch hazel as its main ingredients, making this not recommended for any skin type. |
| Blue Green Algae with grape seed extract Soothing Mask, for Combination/Oily Skin ($8.98 for 4 ounces) is similar to the Green Tea & Green Clay Rejuvenating Mask, for Normal Skin, above except this adds lavender oil, which makes it too irritating.
AUBREY ORGANICS OILY SKIN 5
© Natural Herbal Facial Cleanser, for Oily Skin ($12.98 for 8 ounces) is painful to even write about! This very irritating cleanser exposes skin to soap, witch hazel, alcohol, eucalyptus, camphor, and menthol, among other problematic ingredients. Ouch!
© Natural Herbal Facial Astringent, for Oily Skin ($9. |
Gary Null and Amy McDonald
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 Naturally occurring in grape seed extract and pine bark extract.
10 mg two times daily with meals
VITAMINS AND NUTRIENTS vitamin C vitamin E
DAILY DOSE
1-3 grams
?400 IU
?200 mg (gamma-tocopherol)
?65 mg (palm oil-derived tocotrienols)
COMMENTS
Mixed tocopherols with an emphasis on gamma.
Additional Supplements for Impacting Depression
The following chart summarizes additional supplements I recommend for individuals who suffer from, or are specifically concerned about, depression. |
Mike Adams, the Health Ranger
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 I won't say the name of the manufacturer, but somebody in this industry created a grape seed extract. They had it manufactured at a specific contract manufacturer, and, accidentally, fish fills made it into their entire lot. One of their customers said, "I'm taking this grape seed extract and I feel great, but I keep burping fish."
So, it's just funny. A lot of people experience that. It becomes something that continues to deter them from taking the fish oil. Omega-3s, DHA and EPA are so involved with every level of our health because they are used in every cell of our body. |
Mike Adams, the Health Ranger
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 Have you ever heard of the nutritional supplement called grape seed extract? Guess where it comes from? ... Grape seeds, of course. It's some of the best cardiovascular medicine known to modern science, far more potent than any prescription drug, yet with zero negative side effects. Yet food companies have removed it from the food supply and promoted "seedless grapes" as a benefit to consumers! |
Mike Adams, the Health Ranger
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| I mean, that has turmeric, grape seed extract; what is the thinking behind this product?
Dr. Liers: Joint Health Formula for Pets is the same as Joint Health Formula for people, except for desiccated liver as flavoring for the pets. It is a multi-dimensional product, just like Diabetes Defense. That is, I designed it so that you are not just going after joint health in one direction only. Obviously, the glucosamine hydrochloride is in there because glucosamine helps to rebuild those connective tissues. It has actually been shown in clinical studies to reduce inflammation and pain. |
| Then there is the kind of grape seed extract containing longer-chain proanthocyanidins that tends to be a better collagen cross-linker. Japanese researchers have actually used those to cure ulcers. They will give rabbits ulcers and give them longer-chain proanthocyanidins, and they will actually heal up that ulcer. Well, I put those in here because you want to strengthen the connective tissues and you want to get that cross-linking. They have shown that enzymes cannot break down those connective tissues that are cross-linked with those longer-chain proanthocyanidins. |
Ralph Moss, PhD
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 Grape Seed Extract
A compound very similar in composition to Pycnogenol is grape seed extract. It also contains a high proportion of anthocyanins. Although Pycnogenol was the first anthocyanin supplement to appear in the United States, grape seed extract (depending on the brand) is usually more potent, containing between 92 to 95 percent bioflavonoids, compared to 85 percent for Pycnogenol.
Cost
Grape seed extract is considerably less expensive than Pycnogenol. It is available for about 20c per tablet. |
Mike Adams, the Health Ranger
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| Then we have the grape seed extract in there. So we put quercetin chalcone in Pet-C Plus because it was a more recent design than Pro-C, and that makes this formula even more potent.
Back to the issue of vitamin C with an animal -- any animal that has an illness is going to need more vitamin C. These other factors in there are going to strengthen their bodies and trap free radicals and detoxify. As you may know, glutathione is responsible for 60 percent of liver detoxification. You need to get glutathione into the liver. It is crucial. |
| I have it in my Pro-C, which is my super duper antioxidant formula that is like the Pet-C Plus for animals, where we put in green tea extract, grape seed extract, glutathione, n-acetyl-l-cysteine, lipoic acid, selenium, and vitamins B2 and B6 because those are in the pathways that make glutathione work.
These antioxidants operate in the redox cycles that the body uses and they all work together. They protect each other. One might free up another one to do the job that only it can do. Pro-C and Pet-C Plus are super duper products. |
| The reason is that grape seed extract is one of the best collagen cross-linkers known. You get weakened blood vessels when you get glycation of the proteins because you have high blood sugar all the time. If you can cross-link those proteins and collagen, you are going to prevent the blood vessels from just deteriorating. That is some of the design logic that goes into a product like Diabetes Defense.
The cost of pet nutrition vs. sick pets
Mike: Many pet owners say, "Well that is going to get very expensive for me to keep buying these vitamins. |
David W. Grotto, RD, LDN
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| WEIGHT CONTROL: A study found that grape seed extract may be helpful in limiting absorption and accumulation of dietary fat in cells observed under a microscope.
Tips on Using Grapes
SELECTION AND STORAGE:
• Look for grapes that are intact, plump, and free of wrinkles.
• Red grapes should be mostly red, green grapes should have a slight yellowish hue, and blue-black and purple grapes should be deep in color.
• Wrap unwashed grapes in a paper towel, place in a plastic bag, and put in the refrigerator for longer storage.
• Grapes will keep fresh for several days at room temperature. |
Dr. Steven R. Gundry
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 Supplementation with cranberry extract, grape skin extract, and grape seed extract seems to me prudent and inexpensive insurance. Want more antioxidant protection? Pycnogenols-combinations of polyphenols from tree bark and alpha lipoic acid-are superb antioxidants, as are mushroom extracts, especially reishi, cordyceps, or maitake. All enhance immune-system function, elevate the level of natural killer cells (another type of white blood cell that protect us), and improve athletic performance. |
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