Tori Hudson, N.D.
See book keywords and concepts |  A GAG in the form of N-acetyl glucosamine or glucosamine sulfate can be used as part of a multifactorial approach to repair the bladder epithelium.
Glucosamine Sulfate
750 mg twice daily
N-Acetyl Glucosamine
500 mg twice daily
Vitamin A. Vitamin A has been shown to inhibit mast cell growth and proliferation, and deficiency may aggravate the clinical manifestations of inflammatory reactions due to mastocytosis.23-26 Vitamin A also helps to elevate urinary nitric oxide levels. (See the section on L-arginine and inflammation for more information on the role of nitric oxide in IC. |
by Michael Murray, N.D. and Joseph Pizzorno, N.D.
See book keywords and concepts | | By treating the root of the problem through the promotion of cartilage synthesis, glucosamine sulfate not only improves the symptoms, including pain, but also helps the body to repair damaged joints.
The double-blind studies indicate that with glucosamine sulfate supplementation, most people with OA will experience significant improvement within four weeks. However, the longer it is used the better the results, because the effects are cumulative and long-lasting.
The typical dosage of glucosamine sulfate is 1,500 milligrams per day. |
Jonny Bowden, Ph.D., C.N.S.
See book keywords and concepts |  Most studies have used glucosamine sulfate, so unless you're allergic to sulfates, that's probably your safest bet. The best studies used 1,500 mg of glucosamine sulfate a day, though I've heard some health practitioners swear by the idea of "loading up" with 3,000 mg a day for the first month and then dropping down to the recommended 1,500 mg. Some evidence suggests the dose has to be adjusted for obesity. Chondrotin seems to work well at around 800 to 1,500 mg daily. |
David Hoffman, FNIMH, AHG
See book keywords and concepts |  A number of studies have compared glucosamine sulfate with ibuprofen for the treatment of osteoarthritis.1 A recent randomized, double-blind, controlled clinical trial compared the use of glucosamine sulfate and ibuprofen in patients diagnosed with temporomandibular joint (TMJ) osteoarthritis. The researchers concluded that both glucosamine sulfate and ibuprofen reduced pain levels in these patients. However, glucosamine sulfate had a significandy greater influence in reducing pain produced during function and pain caused by daily activities. |
Mike Adams, the Health Ranger
See article keywords and concepts |  And what was happening, I was noticing that after we played basketball -- and you know, we played for two hours full court, so it was pretty intense -- they'd be popping ibuprofen and aspirin and other anti-inflammatories, and I would be taking glucosamine sulfate and my vitamin C, and my lipoic acid and such.
What was happening was that by taking those anti-inflammatory agents they were decreasing their pain and stiffness afterwards, but they were also blocking the body's ability to repair the damaged tissue, whereas glucosamine sulfate supports the body's own healing process. |
Jonny Bowden, Ph.D., C.N.S.
See book keywords and concepts | | In animal and human studies, MSM has been shown to help arthritis, either alone or in combination with another popular nutrient, glucosamine sulfate. In one randomized, double-blind, placebo-controlled study published in the journal Clinical Drug Investigation, the addition of only 500 mg of MSM to 500 mg of glucosamine resulted in greater reduction of pain and swelling, improvement of functional ability of joints, and better and more rapid improvement, all without major adverse effects. (And in my opinion, the results are way better with higher doses—as happened with my hiking buddy. |
Mike Adams, the Health Ranger
See article keywords and concepts | | What was happening was that by taking those anti-inflammatory agents they were decreasing their pain and stiffness afterwards, but they were also blocking the body's ability to repair the damaged tissue, whereas glucosamine sulfate supports the body's own healing process. And so, it's kind of funny, the younger guys are now starting to ask me what I've been taking, because I'm by a sizable margin the oldest person playing with this group of guys.
Mike: And this is glucosamine sulfate, you said, vitamin C, lipoic acid?
Dr. Pizzorno: Right.
Mike: Those are the big three, huh?
Dr. |
Marshall Editions
See book keywords and concepts |  Take 1,500 mg of glucosamine sulfate a day to reduce joint pain and rebuild cartilage. This is especially helpful if the pain is related to TMJ disease. Methylsulfonylmethane (MSM) is a natural anti-inflammatory and helps with pain; take 4,000-8,000 mg daily. Take 4-6 g of fish oil a day to reduce inflammation and provide joint lubrication. It may take two to three months for significant effects to be seen. Also take one to two capsules of protease enzyme on an empty stomach to reduce inflammation. |
Jonny Bowden, Ph.D., C.N.S.
See book keywords and concepts | | Not only that, the glucosamine sulfate group showed a significant improvement in their WOMAC Index (a standardized measure of pain) while there was a trend for worsening of pain in the placebo group.
Let's face it: Joint pain is uncomfortable and frustrating, especially for those who are used to living an active life. For relief from the pain, many reach for remedies like the prescription drugs in the category known as COX-2 inhibitors (Celebrex and Vioxx are famous examples), or pain relievers such as acetaminophen (Tylenol) and nonsteroidal anti-inflammatory drugs (Aleve). | | Those who are allergic to sulfates may take glucosamine hydrochloride and not glucosamine sulfate, and they should avoid chondroitin sulfate. Glucosamine is derived from shrimp, oyster, and crab shells, and chondroitin is derived from cartilage of cows, pigs, and sharks. There is no synthetically made glucosamine on the market.
Glucosamine and chondroitin help regrow cartilage. However, if you have no cartilage left, these nutrients will not do any good to o artificial knees. They may help, though, with 2 your other joints. | | Adding to the Arsenal
In addition to glucosamine sulfate and chon-droitin sulfate, other nutrients have been shown to have benefit and may work synergistically with glucosamine and chondroitin.
Methyl sulfonylmethane (MSM) (see page 66) is terrific for joint pain, largely because of its high sulfur content. (There's a reason people all over the world flock to hot sulfur baths for pain relief.) MSM blocks the transmission of impulses in nerve fibers that carry pain signals. |
by Michael Murray, N.D. and Joseph Pizzorno, N.D.
See book keywords and concepts | | Glucosamine sulfate has been used by millions of people worldwide and is registered as a drug in the treatment of OA in more than seventy countries.
The more than twenty published clinical trials with glucosamine sulfate have demonstrated an overall success rate of 72 to 95 percent in various forms of OA. In OA of the knee, the success rate is more than 80 percent. |
James F. Balch, M.D. and Mark Stengler, N.D.
See book keywords and concepts |  The two forms of supplemental glucosamine are glucosamine sulfate and glucosamine hydrochloride. Most of the research to date has been done with the sulfate form.
Indications: Osteoarthritis Sprains/strains
Precautions: Digestive upset, including diarrhea. Persons who are allergic to shellfish don't normally have a problem, as this reaction is usually to the protein found in the meat of shrimps and in crabmeat. People who are allergic to sulfa drugs do not need to be concerned as the source of the drugs is different from the mineral sulfur that is part of glucosamine sulfate. |
by Michael Murray, N.D. and Joseph Pizzorno, N.D.
See book keywords and concepts | | The double-blind studies indicate that with glucosamine sulfate supplementation, most people with OA will experience significant improvement within four weeks. However, the longer it is used the better the results, because the effects are cumulative and long-lasting.
The typical dosage of glucosamine sulfate is 1,500 milligrams per day.
Capsaicin-containing creams and gels applied topically are showing impressive results when applied to the skin in cases of osteoarthritis. Capsaicin works by depleting the pain neurotransmitter substance P. |
Thomson Healthcare, Inc.
See book keywords and concepts |  Reichelt A, Forster KK, Fischer M et al: Efficacy and safety of intramuscular glucosamine sulfate in osteoarthritis of the knee: a randomised, placebo-controlled, double-blind study. Arzneimittelforschung; 44(l):75-80. 1994
Reuser AJJ, Wisselaar HA: An evaluation of the potential side-effects of alpha-glucosidase inhibitors used for the management of diabetes mellitus. Eur J Clin Invest; 24(suppl 3): 19-24. 1994
Richy F, Bruyere O, Ethgen O et al: Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis. Arch Intern Med; 163(13): 1514-1522. | | Intramuscular: 400 mg of glucosamine sulfate once daily (Reichelt et al 1994; D'Ambrosio et al 1981; Crolle et al 1980). A regimen of 400 mg twice weekly for 6 weeks has also been given (Reichelt et al 1994). literature
Balkan B, Dunning BE: Glucosamine inhibits glucokinase in vitro and produces a glucose-specific impairment of in vivo insulin secretion in rats. Diabetes; 43(10):1173-1179. 1994
Braham R, Dawson B, Goodman C et al: The effect of glucosamine supplementation on people experiencing knee pain. Br J Sports Med; 37(l):45-49. | | Subjects (n=160) with symptomatic cervical and/ or lumbar spine osteoarthritis of at least 6 months' duration received 1,500 mg of glucosamine sulfate daily or placebo for 6 weeks. Outcome measures included visual analog scales and/or clinical measurements for pain, morning stiffness, tenderness, and mobility. Analysis of variance found significant improvement compared to placebo at both locations for pain at rest and at night, tenderness and lateral flexion, and at tie lumbar level for pain on active movement, flexion, otation, and morning stiffness. | | Sixty-three patients were randomized to receive a water-soluble cream (30 mg/g of glucosamine sulfate; 50 mg/g of chondroitin sulfate, 140 mg/g of shark cartilage, 32 mg/g of camphor, and 9 mg/g of peppermint oil) or placebo for 8 weeks. Both groups reported improvement on the visual analog scale pain scores, with the treatment group improving a further 1.2 points (p=0.03) at 4 weeks and 1.8 points (p=0.002) at 8 weeks compared to the placebo group. |
Earl L. Mindell, RPh, PhD with Virginia Hopkins, MA
See book keywords and concepts | | In one recent study that compared the effects of glucosamine sulfate and a placebo on the progression of knee osteoarthritis, it was found that three years of treatment with 1,500 mg a day of glucosamine sulfate halted the progression of cartilage deterioration and joint space narrowing. Those who took the placebo showed progressive joint space narrowing, to the tune of 0.19 mm over three years. Symptoms improved 20 to 25 percent with glucosamine sulfate and only mod-esdy with the placebo. |
Thomson Healthcare, Inc.
See book keywords and concepts | | In the 6-month evaluation, patients with varying degrees of pain were randomized to receive 500 mg of glucosamine sulfate three times daily (n=38) or placebo (n=37). There were no differences between the groups in any assessment marker at any time during the trial. The authors suggested that their results differ from previous glucosamine studies because the patients in this trial were more symptomatic and had more structural damage than patients in trials with positive glucosamine results. |
Earl L. Mindell, RPh, PhD with Virginia Hopkins, MA
See book keywords and concepts | | In one recent study that compared the effects of glucosamine sulfate and a placebo on the progression of knee osteoarthritis, it was found that three years of treatment with 1,500 mg a day of glucosamine sulfate halted the progression of cartilage deterioration and joint space narrowing. Those who took the placebo showed progressive joint space narrowing, to the tune of 0.19 mm over three years. Symptoms improved 20 to 25 percent with glucosamine sulfate and only mod-esdy with the placebo. |
Marshall Editions
See book keywords and concepts | | Take 250 mg of magnesium twice a day as it also' alleviates muscle spasm. glucosamine sulfate is helpful for sciatica caused by a herniated disc. Take 1,500 mg a day.
Herbs: Take 500 mg of bromelain three times a day for its anti-inflammatory effects. White willow relieves pain in the lower back and throughout the body. Products should be standardized to contain 240 mg of salicin or take 5 ml of a tincture three times a day. Ginger has anti-inflammatory benefits and relieves pain. Take 1-2 g or 1-2 ml of a tincture three times a day. | | Follow the instructions on the container. glucosamine sulfate, which is usually combined with chondroitin sulfate, reduces leg pain and rebuilds cartilage. Take 1,500 mg of glucosamine daily with 1,200 mg of chondroitin. Take 4,000-8,000 mg of methylsulfonylmethane (MSM) a day for its natural anti-inflammatory benefits. Taking 4-6 g of fish oil a day also reduces inflammation, but allow two to three months to see significant effects. Niacinamide has been clinically reported to help arthritis, which can present as leg pain. Take 500 mg three times a day. | | Herbs work best when combined with physical therapy and other nutritive support such as glucosamine sulfate.
652
Compresses: You can quickly relieve swelling and pain in acute injuries by applying ice to the knee for three to five minutes, as often as can be tolerated, in the first 24-48 hours.
Anti-inflammatory tincture: Alfalfa is very nutritious, and contains high amounts of vitamins, minerals, and protein, all of which are necessary for healing tissue. Alfalfa is also a mild anti-inflammatory and diuretic, relieving excess fluid from around the knee. | | Follow the instructions on the container. glucosamine sulfate, which is usually combined with chondroitin sulfate, reduces knee pain and rebuilds cartilage. Take 1,500 mg of glucosamine daily with 1,200 mg of chondroitin. Take 4,000-8,000 mg of methylsulfonylmethane (MSM) a day for its I natural anti-inflammatory benefits. Niacinamide has been clinically reported to help arthritis, which can present as knee pain. Take 500 mg three times a day. Higher doses should be supervised by a doctor. | | Also take 1-3 g of vitamin C a day to strengthen connective tissue and build the immune system, and one to two capsules of protease enzyme (to be taken on an empty stomach) to reduce inflammation. glucosamine sulfate, which is usually combined with chondroitin sulfate, reduces joint pain and rebuilds cartilage. Take 1,500 mg daily of glucosamine with 1,200 mg of chondroitin. Methylsulfonylmethane (MSM) has natural anti-inflammatory benefits and contains the mineral sulfur, which is an important component of cartilage. Take 4,000-8,000 mg daily. |
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