Tori Hudson, N.D.
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 No studies have been published on over-the-counter preparations of chondroitin sulfates and glucosamine preparations; however, a link has been established between chondroitin and IC.22 A GAG in the form of N-acetyl glucosamine or glucosamine sulfate can be used as part of a multifactorial approach to repair the bladder epithelium.
Glucosamine Sulfate
750 mg twice daily
N-Acetyl Glucosamine
500 mg twice daily
Vitamin A. |
Mike Adams, the Health Ranger
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 When Celebrex turned out to produce faster pain-reducing results, the mainstream media essentially declared glucosamine supplements to be useless.
It's nonsense, of course. All smoke and mirrors. Or, in this case, a comparison of apples and oranges. Masking pain with a painkiller is always fast. But if you really want to solve the underlying problem, you need good nutrition, not just dangerous chemicals that also cause heart attacks and strokes as side effects, by the way.
By the way, the study also used a low-dose, cheap version of glucosamine known to have poor assimilation. |
Tori Hudson, N.D.
See book keywords and concepts |
| A GAG in the form of N-acetyl glucosamine or glucosamine sulfate can be used as part of a multifactorial approach to repair the bladder epithelium.
Glucosamine Sulfate
750 mg twice daily
N-Acetyl Glucosamine
500 mg twice daily
Vitamin A. Vitamin A has been shown to inhibit mast cell growth and proliferation, and deficiency may aggravate the clinical manifestations of inflammatory reactions due to mastocytosis.23-26 Vitamin A also helps to elevate urinary nitric oxide levels. (See the section on L-arginine and inflammation for more information on the role of nitric oxide in IC. |
Mike Adams, the Health Ranger
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| By the way, the study also used a low-dose, cheap version of glucosamine known to have poor assimilation. That's how the majority of so-called "alternative" studies are conducted: Researchers just happen to coincidentally use synthetic, low-dose vitamins or supplements, all the while acting like they're conducting real science.
This isn't real science. It's a charade. And once again, the mainstream media bought the whole thing hook, line and sinker.
If you're going to compare glucosamine with Celebrix, why not run another trial and compare calcium with crack? |
| Researchers now try to discredit glucosamine chondroitin sulfate supplements
Always working hard on new ways to discredit nutritional supplements, conventional medical researchers have now found a clever way to attack nutritional supplements used to treat joint pain. In what can only be called a fraudulently designed study, the Glucosamine-chondroitin Arthritis Intervention Trial (GAIT) compared these nutritional supplements with Celebrex, a prescription drug that only treats joint pain symptomatically and does nothing to rebuild cartilage or other tissue. |
by Michael Murray, N.D. and Joseph Pizzorno, N.D.
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| The main function of glucosamine in joints is to stimulate the manufacture of molecules known as glycosamino-glycans (GAGs), which are the key structural components of cartilage. It appears that as some people age, they lose the ability to manufacture sufficient levels of glucosamine. The result is that cartilage loses its ability to act as a shock absorber. The inability to manufacture glucosamine has been suggested to be the major factor leading to OA.
Glucosamine sulfate has been the subject of more than three hundred scientific investigations and more than twenty double-blind studies. |
Mike Adams, the Health Ranger
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 It really addresses the underlying cause, that glucosamine is utilized by the body to manufacture cartilage components. Studies have shown that as people get older they lose the ability to manufacture sufficient quantities of glucosamine. So it's a virtual deficiency state. Giving them the glucosamine leads to growth and regeneration of the cartilage. That's good medicine. This addresses the cause with the solution.
In addition to glucosamine sulfate, there are a number of other products that can be used and have documentation. |
Mike Adams, the Health Ranger
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| If you're going to compare glucosamine with Celebrix, why not run another trial and compare calcium with crack? I can see the results now: "100% of the patients reported feeling better on crack. Therefore, calcium is useless." It's exactly the same stupid logic. I'm convinced many researchers are actually ON crack. |
James F. Balch, M.D. and Mark Stengler, N.D.
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 The two forms of supplemental glucosamine are glucosamine sulfate and glucosamine hydrochloride. Most of the research to date has been done with the sulfate form.
Indications: Osteoarthritis Sprains/strains
Precautions: Digestive upset, including diarrhea. Persons who are allergic to shellfish don't normally have a problem, as this reaction is usually to the protein found in the meat of shrimps and in crabmeat. People who are allergic to sulfa drugs do not need to be concerned as the source of the drugs is different from the mineral sulfur that is part of glucosamine sulfate. |
Donna Jackson Nakazawa
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 More familiar to many of us, glucosamine, the over-the-counter natural product that has been touted to help with joint and cartilage problems associated with arthritis, may also provide some relief to individuals with multiple sclerosis. Using a mouse model of MS, neurologists recently found that doses of glucosamine similar to those commonly taken as supplements dramatically delayed the onset of MS symptoms and improved the ability of lab animals to walk and move. Researchers believe that glucosamine may prove useful in human trials for those suffering from MS.
PROBIOTICS. |
by Michael Murray, N.D. and Joseph Pizzorno, N.D.
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| It appears that as some people age, they lose the ability to manufacture sufficient levels of glucosamine. The result is that cartilage loses its ability to act as a shock absorber. The inability to manufacture glucosamine has been suggested to be the major factor leading to OA.
Glucosamine sulfate has been the subject of more than three hundred scientific investigations and more than twenty double-blind studies. glucosamine sulfate has been used by millions of people worldwide and is registered as a drug in the treatment of OA in more than seventy countries. |
| Glucosamine is a simple molecule that can be manufactured in the body. The main function of glucosamine in joints is to stimulate the manufacture of molecules known as glycosamino-glycans (GAGs), which are the key structural components of cartilage. It appears that as some people age, they lose the ability to manufacture sufficient levels of glucosamine. The result is that cartilage loses its ability to act as a shock absorber. The inability to manufacture glucosamine has been suggested to be the major factor leading to OA. |
J. Douglas Bremner
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 Most of the earlier studies of glucosamine and chondroitin were performed by manufacturers and were not well controlled.16 In 2000 a metaanalysis of studies of glucosamine and chondroitin found that the studies that were funded by supplement manufacturers resulted in more favorable results for the supplement combo than did independent studies; few of the manufacturers' studies were properly controlled. Overall there was a moderate effect for both, and the authors concluded that some degree of efficacy was probable. |
| Glucosamine is derived from the shells of crabs and oysters and is widely promoted as a natural substance for the treatment of arthritis and joint pain. glucosamine is considered a precursor of proteoglycans, which are thought to be instrumental in helping cartilage retain water and in promoting formation of an elastic layer that may improve the functional characteristics of cartilage.
Chondroitin is a product derived from the cartilage of sharks and cows that is promoted for use in the prevention of arthritis and the treatment of joint pain. |
Ray D. Strand
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 Many of my orthopedic friends support the use of glucosamine too, since they realize that being able to delay a joint replacement is ultimately in the patient's best interest.
Chondroitin Sulfate
Chondroitin sulfate is often combined with glucosamine sulfate to create a one-two punch. Chondroitin makes up part of the proteoglycans and is responsible for attracting water into the cartilage. This makes the cartilage more pliable and spongy. Without this important nutrient the cartilage becomes drier and more fragile. |
Donna Jackson Nakazawa
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| Using a mouse model of MS, neurologists recently found that doses of glucosamine similar to those commonly taken as supplements dramatically delayed the onset of MS symptoms and improved the ability of lab animals to walk and move. Researchers believe that glucosamine may prove useful in human trials for those suffering from MS.
PROBIOTICS. One area in which a great deal of research has been done in autoimmune-disease patients is that of probiotic supplementation. |
Paula Begoun and Bryan Barron
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 The only ingredient it contains that comes close to matching that description is glucosamine, and the amount of it in this producr is minuscule, not to mention that glucosamine does not exfoliate the skin (though it is often positioned as a gentle alternative to AHA or BHA products). Dior's naming this product Ultimate Wrinkle Creme can only mean they are completely out of the loop when it comes to what ingredients it takes to create a good moistutizef with significant amounts of antioxidants and othet skin-beneficial substances. |
Mike Adams, the Health Ranger
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 This is really the whole gamut of bone joint support -- glucosamine, carnitine, taurine, ginger, gotu kola, vanadium, calcium, magnesium, myoinositol -- so we got things in there.
Mike: Oh, I love it.
Kunin: To get these 30 ingredients you would normally have to get about five different products. These all work synergistically. To give you another perspective about the concept behind Ola Loa and the thought process that goes into it -- glucosamine is a sugar. People can take glucosamine in high doses and wind up getting into a pre-diabetic state.
Mike: Wow. I didn't know that. |
Mike Adams, the Health Ranger
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 Obviously, the glucosamine hydrochloride is in there because glucosamine helps to rebuild those connective tissues. It has actually been shown in clinical studies to reduce inflammation and pain. Everybody knows that.
Some people will use chondroitin sulfate and they have these big arguments saying this is better, and that is better. Dr. Jonathan Wright, a doctor who educates other doctors about nutrition, wrote that men who are prone to prostate cancer should not take bovine sources of chondroitin sulfate. They can actually cause some problems. |
Hyla Cass, M.D.
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 Dose: Start with 1,500 mg of glucosamine plus 1,200 mg of chondroitin, or start out with glucosamine only, adding chondroitin only if you don't feel benefits within about three months' time.
Boswellia serrata
Boswellia is a traditional Ayurvedic medicinal herb. It has been used to relieve arthritic symptoms for thousands of years. Modern research has pitted Boswellia against NSAIDs and found that it may be a more effective anti-inflammatory than the drugs. |
J. Douglas Bremner
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| Although glucosamine and chondroitin (alone or in combination) did not result in a statistically significant reduction in pain, combination therapy was superior to placebo (but not to Celebrex) in a subset of patients with moderate to severe arthritis pain.
Overall the studies of glucosamine and chondroitin show some evidence for efficacy of the combination, although the results are not definitive. These supplements do not have potentially dangerous side effects, unlike other medications for arthritis, like Celebrex. |
Joe Graedon, M.S. and Teresa Graedon, Ph.D.
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 Sales of glucosamine and chondroitin have been spectacular, exceeding $700 million annually. Can it last?
GLUCOSAMINE AND CHONDROITIN
Ever since Jason Theodosakis, MD, wrote his giant bestseller, The Arthritis Cure, glucosamine and chondroitin (G&C) have been the most popular alternative treatments for osteoarthritis. The promise was that these dietary supplements would relieve pain and inflammation and repair damaged cartilage. How good is the evidence that G&C live up to this reputation?
Over the years there have been numerous studies published in medical journals. |
Mike Adams, the Health Ranger
See article keywords and concepts |
| Obviously, the glucosamine hydrochloride is in there because glucosamine helps to rebuild those connective tissues. It has actually been shown in clinical studies to reduce inflammation and pain. Everybody knows that.
Some people will use chondroitin sulfate and they have these big arguments saying this is better, and that is better. Dr. Jonathan Wright, a doctor who educates other doctors about nutrition, wrote that men who are prone to prostate cancer should not take bovine sources of chondroitin sulfate. They can actually cause some problems. |
Mike Adams, the Health Ranger
See article keywords and concepts |
| Giving them the glucosamine leads to growth and regeneration of the cartilage. That's good medicine. This addresses the cause with the solution.
In addition to glucosamine sulfate, there are a number of other products that can be used and have documentation. For example, MSM is a physiological form of sulfur that has been shown to enhance the effectiveness of glucosamine. Sulfur is most likely utilized in the manufacture of these cartilage components as well.
Mike: What about Celadrin?
Dr. Murray: Celadrin is a new product that has just hit the market. |
Hyla Cass, M.D.
See book keywords and concepts |
| Dose: Start with 1,500 mg of glucosamine plus 1,200 mg of chondroitin, or start out with glucosamine only, adding chondroitin only if you don't feel benefits within about three months' time.
Boswellia serrata
Boswellia is a traditional Ayurvedic medicinal herb. It has been used to relieve arthritic symptoms for thousands of years. Modern research has pitted Boswellia against NSAIDs and found that it may be a more effective anti-inflammatory than the drugs. |
Paula Begoun and Bryan Barron
See book keywords and concepts |
| The only ingredient it contains that comes close to matching that description is glucosamine, and the amount of it in this producr is minuscule, not to mention that glucosamine does not exfoliate the skin (though it is often positioned as a gentle alternative to AHA or BHA products). Dior's naming this product Ultimate Wrinkle Creme can only mean they are completely out of the loop when it comes to what ingredients it takes to create a good moistutizef with significant amounts of antioxidants and othet skin-beneficial substances. |
Hyla Cass
See book keywords and concepts |
| Dose: Start with 1,500 mg of glucosamine plus 1,200 mg of chondroitin, or start out with glucosamine only, adding chondroitin only if you don't feel benefits within about three months' time.
Boswellia serrata
Boswellia is a traditional Ayurvedic medicinal herb. It has been used to relieve arthritic symptoms for thousands of years. Modern research has pitted Boswellia against NSAIDs and found that it may be a more effective anti-inflammatory than the drugs. |
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