Fibrates

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Nutrition in the Prevention and Treatment of Disease Ann M. Coulston and Carol J. Boushey See book keywords and concepts

Fibrates: What have we learned in the past 40 years? Pharmacotherapy 27, 412-424. 9. Brown, W. V. (2007). Expert commentary: The safety of fibrates in lipid-lowering therapy. Am. J. Cardiol. 99, 19C-21C. 10. Wierzbicki, A. S. (2006). fibrates after the FIELD study: Some answers, more questions. Diabetes Vase. Dis. Res. 3, 166-171. 11. Bots, M. L., Visseren, F. L., Evans, G. W., et al. (2007). Torcetrapib and carotid intima-media thickness in mixed dys-lipidaemia (RADIANCE 2 study): A randomised, double-blind trial. Lancet 370, 153-160. 12. Schmitz, G., Schmitz-Madry, A., and Ugocsai, P.

Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health J. Douglas Bremner See book keywords and concepts

Eai ly rrea I merits Introduced in the late 1960s, the first generation of the lipid-lowering drugs came in the form of resins and fibrates, which included gemfibrozil (Lopid) and fenofibrate (Tricor). fibrates were found to lower LDL cholesterol and prevent heart disease, but they were also found to actually increase overall mortality by as much as 47%) Animal studies showed that these drugs caused cancer; in some cases the cancer risk was seen at blood levels only three- to fourfold higher than those seen in the normal treatment of high cholesterol.

Nutrition in the Prevention and Treatment of Disease Ann M. Coulston and Carol J. Boushey See book keywords and concepts

Expert commentary: The safety of fibrates in lipid-lowering therapy. Am. J. Cardiol. 99, 19C-21C. 10. Wierzbicki, A. S. (2006). fibrates after the FIELD study: Some answers, more questions. Diabetes Vase. Dis. Res. 3, 166-171. 11. Bots, M. L., Visseren, F. L., Evans, G. W., et al. (2007). Torcetrapib and carotid intima-media thickness in mixed dys-lipidaemia (RADIANCE 2 study): A randomised, double-blind trial. Lancet 370, 153-160. 12. Schmitz, G., Schmitz-Madry, A., and Ugocsai, P. (2007). Pharmacogenetics and pharmacogenomics of cholesterol-lowering therapy. Curr. Opin. Lipidol.

Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health J. Douglas Bremner See book keywords and concepts

Eai ly rrea I merits Introduced in the late 1960s, the first generation of the lipid-lowering drugs came in the form of resins and fibrates, which included gemfibrozil (Lopid) and fenofibrate (Tricor). fibrates were found to lower LDL cholesterol and prevent heart disease, but they were also found to actually increase overall mortality by as much as 47%) Animal studies showed that these drugs caused cancer; in some cases the cancer risk was seen at blood levels only three- to fourfold higher than those seen in the normal treatment of high cholesterol.

Supplement Your Prescription: What Your Doctor Doesn't Know About Nutrition Hyla Cass, M.D. See book keywords and concepts

Less frequently used drugs for high cholesterol include the bile acid sequestrants and fibrates. DRUGS FOR HEART DISEASE RISK FACTORS AND THE NUTRIENTS THEY DEPLETE attack. CLASSES OF CHOLESTEROL-LOWERING DRUGS BILE ACID SEQUESTRANTS: cholestyramine (Questran), colesevelan (Welchol), and colestipol (Colestid) Bile acid sequestrants are sometimes used in combination with statins, and may be used alone in women who are pregnant or breastfeeding. Actions: Bile acid sequestrants work by preventing cholesterol from being absorbed, and increasing the amount that's flushed out of the body.

FlBRATES: bezafibrate (Bezalip), ciprofibrate (Modalim), clofibrate (Atromid-S), fenofibrate (TriCor), and gemfibrozil (Lopid) These drugs work well to lower triglycerides and "bad" LDL and raise "good" HDL (high-density lipoproteins); they may be used with statins in diabetics because fibrates help to reduce insulin resistance. Actions: These drugs work through a mechanism similar to those of some blood sugar-lowering (hypoglycemic) drugs.

Side effects: fibrates have potential for serious side effects when combined with statins: they increase risk of rhabdomyolysis, a life-threatening breakdown of muscle tissue, and of myopathy, muscle pain and damage. As you'll see, both of these side effects are of concern with statins alone. Nutrients depleted: Gemfibrozil depletes CoQi0 and vitamin E. Clofi-brate has been found to deplete vitamin B12. Needed supplements: Take CoQ10 (100-300 mg), vitamin E (100 mg in tocotrienol form), and vitamin B12 (200 meg).

Timeless Secrets of Health & Rejuvenation: Unleash The Natural Healing Power That Lies Dormant Within You Andreas Moritz See book keywords and concepts

Both animal and human trials have demonstrated increases in cancers when cholesterol was lowered through fibrates and statins. In the CARE trial, for example, breast cancer increased a whooping 1,400 percent! An important connection also exists between low cholesterol and strokes. On Christmas Eve, 1997, a very important study made the headlines in the press. Researchers heading the famous Framingham study (still continuing) said that "Serum cholesterol level is not related to incidence of stroke...

Supplement Your Prescription: What Your Doctor Doesn't Know About Nutrition Hyla Cass See book keywords and concepts

Side effects: fibrates have potential for serious side effects when combined with statins: they increase risk of rhabdomyolysis, a life-threatening breakdown of muscle tissue, and of myopathy, muscle pain and damage. As you'll see, both of these side effects are of concern with statins alone. Nutrients depleted: Gemfibrozil depletes CoQ10 and vitamin E. Clofi-brate has been found to deplete vitamin B]2. Needed supplements: Take CoQI0 (100-300 mg), vitamin E (100 mg in tocotrienol form), and vitamin B12 (200 meg).

Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health J. Douglas Bremner See book keywords and concepts

Since the fibrates (e.g., gemfibrozil) can cause cancer and may actually increase mortality, I recommend that these medications should not be taken. Another class of older drugs, called bile acid sequestrants [e.g., cholestyramine (Locholest, Questran)], binds cholesterol in the gut and decreases its absorption. It lowers cholesterol, including "good" HDL levels. This drug can cause nutritional deficiencies through interference with absorption, as well as bloating and constipation, and should be avoided.

Nutrition in the Prevention and Treatment of Disease Ann M. Coulston and Carol J. Boushey See book keywords and concepts

The most commonly used drugs to lower TG concentrations are the fibrates. These drugs also raise HDL-C and improve small dense LDL, so would be expected to have large beneficial effects. Their use in the management of lipoprotein disorders has a history dating back to the mid-1960s. However, their prominence has lessened over the years because of unimpressive results in major clinical trials, safety concerns, and the emergence of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statin drugs).

Fibrates after the FIELD study: Some answers, more questions. Diabetes Vase. Dis. Res. 3, 166-171. 11. Bots, M. L., Visseren, F. L., Evans, G. W., et al. (2007). Torcetrapib and carotid intima-media thickness in mixed dys-lipidaemia (RADIANCE 2 study): A randomised, double-blind trial. Lancet 370, 153-160. 12. Schmitz, G., Schmitz-Madry, A., and Ugocsai, P. (2007). Pharmacogenetics and pharmacogenomics of cholesterol-lowering therapy. Curr. Opin. Lipidol. 18, 164-173. 13. Anderson, J. T., Grande, F., and Keys, A. (1957).

Supplement Your Prescription: What Your Doctor Doesn't Know About Nutrition Hyla Cass See book keywords and concepts

Less frequently used drugs for high cholesterol include the bile acid sequestrants and fibrates. BILE ACID SEQUESTRANTS: cholestyramine (Questran), colesevelan (Welchol), and colestipol (Colestid) Bile acid sequestrants are sometimes used in combination with statins, and may be used alone in women who are pregnant or breastfeeding. Actions: Bile acid sequestrants work by preventing cholesterol from being absorbed, and increasing the amount that's flushed out of the body.

FlBRATES: bezafibrate (Bezalip), ciprofibrate (Modalim), clofibrate (Atromid-S), fenofibrate (TriCor), and gemfibrozil (Lopid) These drugs work well to lower triglycerides and "bad" LDL and raise "good" HDL (high-density lipoproteins); they may be used with statins in diabetics because fibrates help to reduce insulin resistance. Actions: These drugs work through a mechanism similar to those of some blood sugar-lowering (hypoglycemic) drugs.

Best Choices From the People's Pharmacy Joe Graedon, M.S. and Teresa Graedon, Ph.D. See book keywords and concepts

As a bonus, fibrates raise good HDL cholesterol better than some other cholesterol-lowering drugs. There is one other category of cholesterol medication. Although these drugs are not prescribed very often, they can lower cholesterol when other medicines are not appropriate. These drugs bind to bile acids, precursors to cholesterol. By preventing the reabsorption of cholesterol from the digestive tract, the body eliminates it more effectively. These drugs include cholestyramine (LoCholest, Questran), colestipol (Cholestid), and cole-sevelam (WelChol).

Unleash the Inner Healing Power of Foods The Editors of FC&A See book keywords and concepts

These include statins, niacin therapy, fibrates, and bile acid binding resins. In the future, there might even be a cholesterol vaccine. It's still in the works, but keep your eyes open. Maximize the power of statins Your doctor may have prescribed a statin to help lower your cholesterol. Statins, like Zocor or Upitor, do wonders for your cholesterol, but you can help them work even better. Here are effective strategies to help you maximize the power of statins. Try the Mediterranean approach.

Best Choices From the People's Pharmacy Joe Graedon, M.S. and Teresa Graedon, Ph.D. See book keywords and concepts

Another category of medications that lowers cholesterol reasonably well is the fibrates. Gemfibrozil (Lopid) has been on the market for more than 25 years and is now available generically at $15 to $20 for a month's supply. That makes it one of the more cost-effective cholesterol-lowering drugs in the pharmacy. A newer compound called fenofibrate (TriCor) is also available. Both drugs are quite effective at lowering triglycerides, total cholesterol, and LDL cholesterol. They are also very good at turning small, dense particles of bad cholesterol into larger, less dangerous particles.

Combining fibrates with statins may increase the risk of severe muscle problems (rhabdomyolysis). Cost: Highly variable, ranging from $15 for generic gemfibrozil to $80 to $110 for a month's supply of TriCor. Conclusions Cholesterol is only one of more than 240 risk factors for heart disease. Focusing on this one element without addressing others is a little like trying to play a song with only one note. If we have learned anything about healthy lifestyles, it is that moderation in all things is the key to success. You will find a wonderful story in our appendix (page 467) from Laura Effel.

Complete Guide to Prescription and Nonprescription Drugs 2005 H. Winter Griffith, M.D. See book keywords and concepts

WARNINGS & PRECAUTIONS Don't take if: • You are allergic to any fibrates. • You have had serious liver disease. Before you start, consult your doctor: • If you have had liver or kidney disease. • If you have had peptic ulcer disease. • If you have had gallbladder disease or gallstones. • If you have diabetes. Over age 60: Adverse reactions and side effects may be more frequent and severe than in younger persons. May develop flu-like symptoms. Pregnancy: Decide with your doctor if drug benefits justify risk to unborn child. Risk category C (see page xviii).

Gary Null's Power Aging Gary Null See book keywords and concepts

All members of the two most popular classes of lipid-lowering drugs (the fibrates and the statins) cause cancer in rodents, in some cases at levels of animal exposure close to those prescribed to humans."22 It is through animal testing that scientists find out whether a drug is safe enough to investigate as a medication for humans. In spite of the fact that these lipid-lowering drugs were causing cancer in animals, they were tested and released to the public as if they were safe. The researchers waffled when they reported on the possibility that lipid-lowering drugs could cause cancer.

Principles and Practice of Phytotherapy: Modern Herbal Medicine Simon Mills and Kerry Bone See book keywords and concepts

High doses of fibrates generally led to a reduction of between 10% and 15%.50 In a conference report which has not been published, Cynara leaf extract or placebo were administered to 44 healthy volunteers under double-blind conditions. Total cholesterol was significantly decreased and HDL-cholesterol tended to rise. There were no significant differences between the two treatment groups with respect to side effects.

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