Caldwell B. Esselstyn, Jr., M.D.
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 Follow-up angiograms had showed reversal of coronary artery disease among the experimental group, and that benefit continued at the five-year follow-up study. Additional PET-scan imaging of his experimental patients at five years confirmed that 99 percent were able to halt or reverse disease. There was a direct correlation between adherence to the program after one year and after five years.
Dr. Ornish reported twenty-five new coronary events in his experimental patients at five years, which were 2. |
| During those first twelve months, his experimental patients had suffered less severe and less frequent attacks of angina than the members of the control group. Follow-up angiograms had showed reversal of coronary artery disease among the experimental group, and that benefit continued at the five-year follow-up study. Additional PET-scan imaging of his experimental patients at five years confirmed that 99 percent were able to halt or reverse disease. There was a direct correlation between adherence to the program after one year and after five years.
Dr. |
Craig Pepin-Donat
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 Here is the typical path a drug travels: After three years of pre-clinical testing, experimental drugs enter a three-stage clinical trial process with human subjects. Approximately five in every 5,000 compounds that enter the preclinical process proceed to clinical trials.
Phase 1 includes the initial introduction of an experimental drug into humans. The total number of subjects included in Phase 1 studies varies with the drug, but it usually ranges from 20 to 80 people. This stage takes a year. |
Caldwell B. Esselstyn, Jr., M.D.
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| Additional PET-scan imaging of his experimental patients at five years confirmed that 99 percent were able to halt or reverse disease. There was a direct correlation between adherence to the program after one year and after five years.
Dr. Ornish reported twenty-five new coronary events in his experimental patients at five years, which were 2.5 times fewer events than were identified in his control patients receiving traditional cardiac care. I have personally met some of Dr. Ornish's original patients, who like mine were doing well nineteen years later. |
Mark Schapiro
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 Shipments of American rice found to be contaminated with an experimental variety of a genetically engineered rice called Liberty Link had been sent to Europe and Japan, where they were not authorized for sale or consumption. Further shipments of all American long-grain rice were stopped by the national authorities. Genetically engineered rice is not yet in widespread cultivation in the United States; the contaminant was an experimental variety made by Bayer Crop Sciences. "We got a panicked call from some of our growers," Kimbale recalled, "who wanted a test for rice. |
Paula Begoun and Bryan Barron
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 Because of arbutin's hydroquinone content it can have melanin-inhibiting properties (Source: The Journal of Pharmacology and experimental Therapeutics, February 1996, pages 765-769). Although the research describing arbutin's effectiveness is persuasive (even if most of the research was done in vitro), concentration protocols have not been established. That means we don't know how much arbutin it takes to lighten skin when it is added to a cosmetic formulation. Moreover, most cosmetics companies don't use arbutin because of its cost. |
Paul D. Blanc, M.D.
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 To this day, carbon disulfide is still one of the solvents of choice in experimental chemistry; it was certainly there under the workbench fume hood during my one-semestet stint as an organic chemistry student.
Ether had not yet been introduced as an anesthetic by 1812, but those who worked with it were well aware of its marked propensity to vaporize. Along with its solvent properties, this, too, was a characteristic that carbon disulfide seemed to share with ether. |
Connie Bennett, C.H.H.C. with Stephen T. Sinatra, M.D.
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 The Role of Low Progesterone and Tension as Triggers of Premenstrual Chocolate and Sweets Craving: Some Negative experimental Evidence." Physiology and Behavior 67, no. 3 (1999): 417-20.
National Institute of Allergy and Infectious Diseases. "Chronic Fatigue Syndrome," May 2004. http:Wwww.niaid.nih.gov/factsheets/cfs.htm.
National Women's Health Information Center. "Vaginal Yeast Infections," July 2002. http://www .4woman.gov/faq/yeastinfect.htm.
Prevention's Ultimate Guide to Women's Health and Wellness. Emmaus, PA: Rodale Books, 2002.
Shaw, G., et al. |
| Clinical Sciences Research Institute and a professor of experimental diabetes at Warwick Medical School in Coventry, Great Britain, sums it up well: "For too long, we've been concerned about the risks of a diet high in bad fats when one high in sugars can be just as dangerous."
"A diet very high in sugars, not complex carbs, ends up making your liver secrete more triglycerides," continues Dr. Zammit, former head of cell biochemistry at the internationally known Hannah Research Institute in Ayr, Scotland. |
| Zammit, speaking by phone from Great Britain, where he is director of the Clinical Sciences Research Institute and a professor of experimental diabetes at Warwick Medical School in Coventry.
"If excess insulin is present for long periods as a result of eating all those refined carbs, the liver is prompted to pump out even more dangerous triglycerides. This process can then snowball to the point where excess triglycerides cause insulin resistance in the muscle cells, which stops them from removing glucose from the blood. As time goes by, more insulin is secreted. |
Lester A. Mitscher and Victoria Toews
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 Since the addition of cholesterol to their diet was the only significant experimental change in the lives of these animals, Anitschkow concluded that cholesterol was the cause of their cardiovascular disease.
Researchers subsequentiy hypothesized that more cholesterol in the diet translated into more cholesterol in the blood. This extra cholesterol settles onto the blood vessel walls to form deposits of fatty plaque that may build up until they eventually block the normal flow of blood. |
| Then, for each of two four-day periods, the volunteers followed experimental oral hygiene procedures. In the first period, they ate a normal diet but refrained from all oral hygiene other than rinsing their mouths with a solution containing tea polyphenols after each meal and before bed. In the second period, they followed the same regimen, but the mouth rinse did not contain any active ingredients. At the end of each study period, bacteria counts were taken again and another dental examination was conducted. |
Connie Bennett, C.H.H.C. with Stephen T. Sinatra, M.D.
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| Advances in experimental Medicine and Biology 461 (1999): 251-65.
Liu, Jianghong, Adrian Raine, Peter H. Venables, and Sarnoff A. Mednick. "Malnutrition at Age 3 Years and Externalizing Behavior Problems at Ages 8, 11, and 17 Years." American Journal of Psychiatry 161 (November 2004): 2005-13.
Lustman, Patrick, Ryan Anderson, Kenneth B. Freedland, et al. "Depression and Poor Glycemic Control: A Meta-analysis of the Literature." Diabetes Care 23, no. 7 (2000): 934-37.
Matthews, Keith, Alasdair Rooney, and Richard Day. "Depression, Appetite and Eating. |
Michael Pollan
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 However imperfect, it's the sharpest experimental and explanatory tool we have. It also satisfies our hunger for a simple, one-nutrient explanation. Yet it's one thing to entertain such explanations and quite another to mistake them for the whole truth or to let any one of them dictate the way you eat.
You've probably also noticed that many of the scientific theories put forward to account for exactly what in the Western diet is responsible for Western diseases conflict with one another. |
Paula Begoun and Bryan Barron
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| There is also other research that has shown that lactic and glycolic acids can indeed inhibit melanin production apart from their actions as exfoliants on skin (Source: experimental Dermatology, January 2003, Supplemental, pages 43-50).
Either way, there is a good amount of evidence that in combination with other treatments—such as hydroquinone, azelaic acid, laser resurfacing, and, of course, an effective sunscreen—AHAs can be very effective for improving the overall appearance of sun-damaged skin and possibly helping other ingredients better penetrate skin. |
Dr. Arthur Janov
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 There is now experimental evidence for how repressed feelings leak their energy to the orbitofrontal cortex (OBFC), resulting in all sorts of beliefs and strange ideas.2 In an experiment where feelings were stimulated and the subject was then asked to hold down the feeling, the output of the amygdala was diminished almost completely while the activity in the left OBFC increased considerably. In short, suppression of feeling seems to activate the thinking and believing areas as a kind of defensive maneuver. Almost every defensive maneuver is designed to protect consciousness. |
Roberta Bivins
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 But mesmerism had not been targeted for investigation because it was scientifically suspect—many established medical techniques lacked experimental evidence of their mechanism and few had more than anecdotal/empirical evidence of efficacy—Mesmerism was investigated because it existed in an atmosphere of sexual tension and titillation. |
| Germs remained dogmatic as well as experimental entities; indeed, one doctor echoed the catechism in expressing his own allegiance to germ theory:
I hold that every contagious disease is caused by the introduction into the system of a living organism or microzyme, capable of reproducing its kind, and minute beyond all reach of sense. I hold that as all life on our planet is the result of antecedent life, so is all specific disease the result of antecedent specific disease. I hold that as no germ can originate de novo, neither can a scarlet fever come into existence spontaneously. |
| In mesmerism, the hypnotized patients themselves became the experimental instruments. Their self-reports while under the mesmeric influence were taken by the therapy's medical and lay supporters as 'objective' data not merely about the hypnotic state but about the conditions for which they were being treated. Even today, the role of subjective states like optimism and 'will to live' are well recognized within biomedicine as important predictors of patient survival rates in serious illness and trauma. |
| The Government protested that subjects for the trial would be hard to find, and instead handed the samples over to the medical profession for experimental use. In other words, while willing to assess the drug for its potential within a western framework, the Government had no interest in sanctioning the system from which it emerged, the practitioners who used it, or their culturally specific patterns of use. Unsurprisingly, perhaps, the orthodox doctors who eventually performed the trial reported the powders inefficacious. |
| They took to the rapidly expanding medical press, producing both case studies of its therapeutic successes and (even more copiously) experimental reports. Both types of account circulated widely, aided by the then-common practice in European and American medical journals of reprinting 'digests' of each other's more prominent articles. Perhaps even more effective in spreading information about the 'new' technique were the enthusiastic accounts of foreign medical students in Paris. |
J. Douglas Bremner
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 You may have seen Morgan Spurlock wolf down multiple cheeseburgers in supersized portions at McDonald's in the Supersize Me documentary film and then complain about a feeling of depression that could be relieved only by going back to McDonald's. experimental studies have shown that a large intake of fats leads to feelings of sleepiness that are not related to the food alone. Diets deficient in folate and vitamins B6 and B12 are also associated with depression.
Part of living a happy, healthy life is eating the right food. |
Paula Begoun and Bryan Barron
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| Hormone levels and the stress of illness add more factors (Sources: Climacteric Journal of the International Menopause Society, August 2007, pages 289-297; and experimental Dermatology, February 2005, page 156).
• Genetics. This speaks for itself. The genes you inherit may hinder or help a great deal, but they too are only part of the picture given environmental influences and the other factors listed here (Sources: Current Problems in Dermatology, 2007, volume 35, pages 28-38; and Journal of Investigative Dermatology, February 2006, pages 277-282).
• Bone loss. |
| The good news is that, theoretically, this new horizon in skin care is incredibly exciting (Sources: Microscopy Research and Technique, January 2003, pages 107-114; Nature Medicine, February 2003, pages 225-229; Journal of Investigative Dermatology, March 2002, pages 402^08; International Journal of Biochemistry and Cell Biology, July 2004, pages 1141-1146; experimental Cell Research, March 2002, pages 130-137; Skin Pharmacology and Applied Skin Physiology, September-October 2002, pages 316-320; and www.signaling-gateway.org). |
Dr. Arthur Janov
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| We have an experimental laboratory in our work where we see the unconscious every day with patients. We do not need statistical truths. We have biologic ones.
Those in cognitive therapy are able to "feel better," but confuse that with getting better because they can use language and words to suffocate pain. They use thoughts to anesthetize feelings and imagine and think that all is well.
There is a world of the deep unconscious that needs to be explored; an unconscious from our animal legacy. That unconscious can never be understood in verbal language. |
Paul D. Blanc, M.D.
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| Amazingly, this strain of medical writing did not die out with the ascendance of experimental over empiric medicine in the nineteenth century. S. Weir Mitchell, a leading American physician-writer, published an 1871 best seller entitled Wear and Tear, which is essentially a popularized monograph on work burnout, even though that specific term, of course, is never used. Mitchell approaches the problem as a novel and emerging manifestation of post-Civil War American work mores. |
Thomson Healthcare, Inc.
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 Protective effect of boldine in experimental colitis. Planta Med 63(4): 311-315. 1997.
Hue B, Corronc Hie Kuballa B, Anton R. Effects of the natural alkaloid boldine on cholinergic receptors of the insect central nervous system. Pharm Pharmacol Lett 3: 169-172. 1994
Kern W, List PH, Horhammer L (Eds.), Hagers Handbuch der Pharmazeutischen Praxis, 4. Aufl., Bde. 1-8, Springer Verlag Berlin, Heidelberg, New York, 1969.
Kreitmar H, (1952) Pharmazie 7:507.
Leung AY, Encyclopedia of Common Natural Ingredients Used in Food Drugs and Cosmetics, John Wiley & Sons Inc., New York 1980. |
| Animal experiments revealed embryotoxic and teratogenic effects of maytansine (no detailed description of dosage or experimental procedure available). Should not be used during pregnancy. contraindications
Congorosa preparations are contraindicated during pregnancy. dosage
Mode of Administration: Preparations are available for internal and external use.
How Supplied:
Capsules
Daily Dosage:
Infusion/decoction (2 to 5%) - 100 to 400 mL internally. Externally as required. |
Shannon Brownlee
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 Defibrillators were just experimental," he says. All of these tools would soon revolutionize the treatment of heart attacks, but balloon angioplasty was especially gratifying for cardiologists, because they could actually see the effects of their handiwork. They could inflate the balloon in an occluded blood vessel, where it crushed the blockage against the sides of the artery, extract the ballon, and then watch the flow of blood. "Angioplasty seemed to be incredibly successful in certain patients," says Lange. "Over the last twenty years we've refined our efforts. |
| Now a fellow at the world-renowned Dana-Farber Cancer Institute, in Boston, he was about to administer the experimental breast cancer therapy that would be linked with his name and would come to be considered one of the most controversial treatments in all of medicine.
His patient's name was Diane. A truck driver who was only a year older than Peters, Diane had an enormous breast tumor. It was erupting from the skin of the upper right quadrant of her right breast and simultaneously penetrating deep between her ribs and into her right lung. |
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