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Bottom Line's Health Breakthroughs 2007

Bottom Line Health
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During the next 10 years, the men whose exercise endurance (as measured on a treadmill) was in the lowest 20% of the group were at a much higher risk of dying than those who had high total cholesterol levels (above 240)—confirming that exercise is even more important than cholesterol control. •But many patients prefer pills because they're easier. There is no question that many of us would rather take a pill than change our lifestyle. If the pills worked, it would simply be a question of how we want to spend our money.

The Most Effective Natural Cures on Earth: The Surprising, Unbiased Truth about What Treatments Work and Why

Jonny Bowden, Ph.D., C.N.S.
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Congestive heart failure patients have experienced an increase in exercise endurance on only 900 mg of carnitine per day. It also appears to help alleviate the symptoms of angina. The Perfect Quartet Vegetarians often lack L-carnitine in their diets (and most certainly lack D-ribose, which is primarily found in red meat and veal). Carnitine (carnis means "meat" or "flesh") is found in mutton, lamb, beef, red meat, and pork and in only tiny amounts in plant foods.

Nutrition in the Prevention and Treatment of Disease

Ann M. Coulston and Carol J. Boushey
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Theoretically, inadequate carbohydrate intake during repeated days of exercise leads to a gradual depletion of muscle glycogen stores and impairment of exercise endurance. More recently, investigators have suggested that training in a low glycogen state may have some beneficial effects on the adaptation of the muscle. This is further discussed in Section VII on nutrition and training adaptations. Dietary guidelines for the general population make recommendations for carbohydrate intake as a percentage of dietary energy (for e.g.

The Natural Pharmacy: Complete A-Z Reference to Natural Treatments for Common Health Conditions

Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D.
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A few clinical trials also indicated that pyruvate supplements may improve exercise endurance (page 43) ,7'8 though weight-lifting capacity did not improve.9 Preliminary research indicates that pyruvate functions as an antioxidant (page 467), inhibiting the production of harmful free radicals.10' u' 12 Preliminary research with animals suggests that, due to its antioxidant function, pyruvate may inhibit the growth of cancerous (page 87) tumors.13 However, this effect has not been confirmed in human studies. Where is it found?

Prescription for Natural Cures: A Self-Care Guide for Treating Health Problems with Natural Remedies Including Diet and Nutrition, Nutritional Supplements, Bodywork, and More

James F. Balch, M.D. and Mark Stengler, N.D.
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It has also been shown to have antioxidant effects and may improve one's exercise endurance. Indications: Antioxidant support Athletic support Weight loss Precautions: High dosages may cause digestive upset. Dosage: Take 5 to 30 grams daily for weight loss. Red Yeast Rice Description: Red yeast rice, the fermented product of rice on which red yeast (Monascus purpureus) is grown, is a supplement that's used to lower cholesterol. Historically, red yeast rice was described in ancient Chinese texts as an aid to improve circulation.

PDR for Nutritional Supplements

Sheldon Saul Hendler and David Rorvik
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Pymvate has also shown some ability to enhance exercise endurance capacity. Used in combination with dihydroxyacetone (DHA), pymvate (100 grams for seven days ) significantly enhanced submaximal arm endurance capacity in untrained males (20 to 26 years old). This placebo-controlled study demonstrated a pymvate ability to significantly increase arm muscle glucose extraction before and during exercise. A follow-up study demonstrated similar positive effects in enhancing leg exercise endurance.

The Natural Pharmacy: Complete Home Reference to Natural Medicine

Schuyler W. Lininger, Jr. DC
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Enhanced leg exercise endurance with a high-carbohydrate diet and dihyroxyacetone and pyruvate. / Appl Phys 1990; 69(5): 1651-56. 5. Stanko RT, Robertson RJ, Spina RJ, et al. Enhancement of arm exercise endurance capacity with dihy-droxyacetone and pyruvate. / Appl Phys 1990; 68(1): 119-24. 6. Deboer LWV, Bekx PA, Han L, et al. Pyruvate enhances recovery of rat hearts after ischemia and reperfu-sion by preventing free radical generation. Am J Physiol 1993; 265: H1571-76. 7. Cicalese L, Subbotin V, Rastellini C, et al.

Textbook of Natural Medicine 2nd Edition Volume 1

Michael T. Murray, ND
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Enhancement of arm exercise endurance capacity with dihydroxyacetone and pyruvate. J Appl Physiol 1990; 68: 119-124 136. Stanko RT, Robertson RJ, Galbreath RW et al. Enhanced leg exercise endurance with a high-carbohydrate diet and dihydroxyacetone and pyruvate. J Appl Physiol 1990; 69: 1651-1656 137. Robertson RJ, Stanko RT, Goss FL et al. Blood glucose extraction as a mediator of perceived exertion during prolonged exercise. Eur J Appl Phys 1990; 61: 100-105 138. Terrados N, Maughan RJ. Exercise in the heat, strategies to miriimize the adverse effects on performance.

PDR for Nutritional Supplements

Sheldon Saul Hendler and David Rorvik
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INDICATIONS AND USAGE Glycerol may be useful for improving hydration and, thus, exercise endurance in some, but research results related to this putative benefit are mixed. There is no evidence that glycerol helps with weight loss. Intravenous glycerol is helpful in some with acute ischemic cerebral infarct. Oral glycerol has been useful in preventing some of the neurologic and audiologic sequellae of childhood bacterial meningitis. RESEARCH SUMMARY Pre-exercise administration of glycerol significantly improved cycling endurance time in two double-blind, randomized, cross-over trials.
A follow-up study demonstrated similar positive effects in enhancing leg exercise endurance. On the other hand, a recent study showed no pymvate effect on anaerobic performance and body composition in football players except when it was combined with creatine. More research in needed. There is evidence from in vitro, animal and preliminary human research that pyruvate, in doses and modes of administration not relevant to supplementation, may be effective in some with cardiac ischemia through its inhibition of free-radical generation, among other things.

Staying Healthy with Nutrition: The Complete Guide to Diet and Nutritional Medicine

Elson M. Haas, M.D.
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It is a good amino The combination of L-arginine exercise endurance and strength, Vitamin Power (Harmony Books, Nev\j and one gram of lysine taken togi building. (Other authors, such as an arginine-ornithine combination positive nitrogen balance, meaning thatr is being broken down and eliminated, about 1,000 mg. each at night after week, when the other amino acids are The branched-chain amino acids which are essential. In our bodies, these For people working on muscle buildin one.

Textbook of Natural Medicine 2nd Edition Volume 1

Michael T. Murray, ND
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Enhanced leg exercise endurance with a high-carbohydrate diet and dihydroxyacetone and pyruvate. J Appl Physiol 1990; 69: 1651-1656 137. Robertson RJ, Stanko RT, Goss FL et al. Blood glucose extraction as a mediator of perceived exertion during prolonged exercise. Eur J Appl Phys 1990; 61: 100-105 138. Terrados N, Maughan RJ. Exercise in the heat, strategies to miriimize the adverse effects on performance. J Sports Sci 1995; 13: S55-62 139. Burke LM, Read RS. Dietary supplements in sport. Sports Med 1993; 15: 43-65 140. Lamb DR, Brodowicz GR.

The Natural Pharmacy: Complete Home Reference to Natural Medicine

Schuyler W. Lininger, Jr. DC
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A few clinical trials also indicate that pyruvate supplements may improve exercise endurance.45 Preliminary research indicates that pyruvate functions as an antioxidant (p. 267), inhibiting the production of harmful free radicals.*"8 Preliminary research with animals suggests that due to its potential antioxidant function, pyruvate may inhibit the growth of cancer tumors;9 however, this effect has not been confirmed in human studies. Where Is It Found?
Metabolic and exercise endurance effects of coffee and caffeine ingestion. / Appl Physiol 1998; 85: 883-89. 183. Pasman WJ, van Baak MA, Jeukendrup AE, et al. The effect of different dosages of caffeine on endurance performance time. Int J Sports Med 1995; 16: 225-30. 184. Mahesh VB, Greenblatt RB. The in vivo conversion of dehy-droepiandrosterone and androstene-dione to testosterone in the human. Acta Endocrinologica 1962; 41: 400-6. 185. German patent number DE 42 14953 Al. 186. Kelly GS. Sports nutrition: A review of selected nutritional supplements for endurance athletes.
Effect of caffeine on metabolism, exercise endurance, and catecholamine responses after withdrawal. J Appl Physiol 1998; 85: 1493-501. 177. Kovacs EMR, Stegen JHCH, Brouns E Effect of caffeinated drinks on substrate metabolism, caffeine excretion, and performance. / Appl Physiol 1998; 85: 709-15. 178. Macintosh BR, Wright BM. Caffeine ingestion and performance of a 1,500-metre swim. Can ] Appl Physiol 1995; 20: 168-77. 179. Pasman WJ, van Baak MA, Jeukendrup AE, et al. The effect of different dosages of caffeine on endurance performance time. Int J Sports Med 1995; 16: 225-30. 180.
Enhancement of arm exercise endurance capacity with dihy-droxyacetone and pyruvate. / Appl Phys 1990; 68(1): 119-24. 121. Bucci LR. Nutrients as ergogenic aids for sports and exercise. Boca Raton, FL: CRC Press, 1993, 45-47 [review]. 122. Wesson M, McNaughton L, Davies P, et al. Effects of oral administration of aspartic acid salts on the endurance capacity of trained subjects. Res Quart Exer Sport 1988; 59: 234-36. 123. Maughan RJ, Sadler DJ. The effects of oral administration of salts of aspartic acid on the metabolic response to prolonged exhausting exercise in man.
Enhancement of arm exercise endurance capacity with dihy-droxyacetone and pyruvate. / Appl Phys 1990; 68(1): 119-24. 6. Deboer LWV, Bekx PA, Han L, et al. Pyruvate enhances recovery of rat hearts after ischemia and reperfu-sion by preventing free radical generation. Am J Physiol 1993; 265: H1571-76. 7. Cicalese L, Subbotin V, Rastellini C, et al. Acute rejection of small bowel allografts in rats: Protection afforded by pyruvate. Trans Proc 1996; 28(5): 2474. 8. Cicalese L, Lee K, Schraut W, et al. Pyruvate prevents ischemia-reperfusion mucosal injury of rat small intestine.

The Food Pharmacy: Dramatic New Evidence That Food Is Your Best Medicine

Jean Carper
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Coffee also relaxes the bronchial muscles, boosts your exercise endurance, and has some hazards, but not nearly all those that have been attributed to it. MENTAL BOOSTER "Caffeine is a mind-accelerating mood booster. This isn't just sales hype brewed up by the coffee industry; it is scientific fact," declares Judith Wurtman, a distinguished mood-food research scientist at MIT. How much ordinary doses of caffeine increase mental performance was defined by Dr. Harris Lieberman, a psychologist in the Department of Brain and Cognitive Sciences at MIT.

Dangerous Grains: Why Gluten Cereal Grains May Be Hazardous To Your Health

James Braly M.D. and Ron Hoggan M.A.
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Common symptoms of iron deficiency may include pale complexion, pale fingernail beds, rapid heartbeat, chronic fatigue, easy bruising, excessive nose bleeds (this may also indicate a vitamin K deficiency, commonly found in celiacs), diminished exercise endurance or tolerance, indigestion, difficulty swallowing, loss of taste, symptoms of "restless leg syndrome" (creepy, crawly sensations in legs, relieved by movement of the legs—magnesium is helpful here, too), heartburn, chest pain, anxiety or depression, and attention and/or learning deficits in children.

PDR for Nutritional Supplements

Sheldon Saul Hendler and David Rorvik
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It also appears to enhance exercise endurance in some and may be protective in others with cardiac ischemia. There is a suggestion in animal work that it might have an ability to reduce insulin resistance. RESEARCH SUMMARY Obese women were given a 1000-calorie liquid diet that included 30 grams of pymvate daily or placebo in the form of matching liquid diet without pyruvate for 21 days. The pyruvate-supplemented women lost significantly more weight, including weight in the form of fat, than did the controls.



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