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Spark: The Revolutionary New Science of Exercise and the Brain

John J. Ratey, MD
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It makes sense that during evolution, organisms had to compete intellectually to figure out how to find food." Mattson's latest work will change the way we look at some of our healthiest foods. An enormous industry has sprung up to promote the cancer-fighting properties of foods and products that contain antioxidants. Eat more antioxidant-rich broccoli, the logic goes, and you'll live a longer and healthier life. True, perhaps, but not for the reasons the marketing folks would have you believe.

Dr. Gundry's Diet Evolution: Turn Off the Genes That Are Killing You - And Your Waistline - And Drop the Weight for Good

Dr. Steven R. Gundry
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Don't attempt this technique early in Diet evolution, or you may find yourself flat on the floor with a very low glucose level. In the next chapter, the last before the Meal Plans and Recipes section, I'll introduce you to more ways-in addition to your diet—that you can employ to induce that funny-sounding but life-lengthening state called hormesis in Phase 3, aka, the rest of your long, healthful life.
As I've alluded to earlier, the fewer concentrated sources of protein you consume as you move through the phases of Diet evolution, the "cooler" your metabolism runs. The fewer calories you give your system to work with, the more efficient your cells become. If you follow the phases I've outlined for you, I feel confident that you can achieve what most of us want: to die "young," at a very old age. Or as Mr. Spock would say, "Live long and prosper.
I assured the couple that if they both went on Diet evolution, we could turn things around, and they agreed. An examination of their eating habits revealed the typical Western diet, helped along by huge amounts of "healthy" rice, since Pansy is Asian. Out it went! In went my dietary program and a host of supplements. In three months, Mark was down 25 pounds, his insulin levels had fallen, and his blood sugar—once 111—was now 95. His HDL had skyrocketed and his blood pressure had returned to normal.
One of my coronary bypass patients also suffered from diabetes and hypertension, until I convinced him to practice Diet evolution, which he has now done for the past two years. He recently returned from his 55th high school reunion and reported that his female classmates kept touching his face and asking him what kind of skin-care products he used. They told him that his skin looked like it did when he was a teenager, whereas the other men looked like they were dying.
Once you try some of these ingredients and realize how they increase your options and ability to follow Diet evolution, I think you will find them as essential as I do. Here are some of my favorites: Agave Ayrup Also called agave nectar, this low-glycemic sweetener made from the cactus of the same name is available in natural foods stores and increasingly in grocery stores. The syrup is usually fermented to produce tequila. Almond meal Ground almonds, available in natural foods stores. (Almond flour is even more finely ground.) Almond milk Use only unsweetened products.
In the first phase of Diet evolution, you followed a way of eating that was as close as possible to the way people ate roughly a century ago, before modern farming methods changed the diet of cattle and other animals from grasses to grains and the introduction of new manufacturing processes that produced grain-based oils and ground grains. During the next six or more weeks, you'll evolve your eating patterns to mimic the diet of our ancestors before the onset of agriculture and the domestication of animals roughly 10,000 years ago.

Spark: The Revolutionary New Science of Exercise and the Brain

John J. Ratey, MD
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It adjusts all of them, to levels that, we can only presume, have been optimally programmed by evolution. The same goes for exercise's effect on BDNF, IGF-1, VEGF, and FGF-2, which provide the building material and oversight for the construction of new connections and neurons. In short, exercise affects so many variables in the brain that its nigh impossible to isolate its effect as we'd like — in the name of hard science. But the evidence is there, from the action of microscopic molecules to massive surveys of tens of thousands of people over the years. Yes, exercise is an antidepressant.
Most of our evolution took place when we were hunter-gatherers, and while there's nothing we can do about that, there is something we can do with that knowledge. As McEwen writes in The End of Stress as We Know It, "It's not inevitable or normal for the very system designed to protect us to become a threat in itself." THE SCIENCE OF BURNING IT OFF You know by now that the function of the brain is to transmit information, from one synapse to the other, and that this requires energy.
Which makes perfect sense in light of evolution. If we strip everything else away, the reason we need an ability to learn is to help us find and obtain and store food. We need fuel to learn, and we need learning to find a source of fuel — and all these messengers from the body keep this process going and keep us adapting and surviving. To pipe fuel to new cells, we need new blood vessels. When our body's cells run short of oxygen, as they can when our muscles contract during exercise, VEGF gets to work building more capillaries in the body and the brain.
THE ALARM SYSTEM Triggered by a primitive call to survive, the body's stress response is a built-in gift of evolution without which we wouldn't be here today. The response ranges from mild to intense depending on the cause. Severe stress activates the emergency phase, commonly known as the fight-or-flight response. It's a complex physiological reaction that marshals resources to mobilize body and brain, and engraves a memory of what happened, so we can avoid it next time. Where was that lion, exactly?
Today there is an ever-widening gap between the evolution of our biology and our society. We don't have to run from lions, but we're stuck with the instinct, and the fight-or-flight response doesn't exactly fly in the boardroom. If you get stressed at work, would you slap your boss? Or turn and run? The trick is how you respond. The way you choose to cope with stress can change not only how you feel, but also how it transforms the brain. If you react passively or if there is simply no way out, stress can become damaging.

Feel Better, Live Longer with Vitamin B-3

Dr. Abram Hoffer, MD, FRCP (C) and Dr. Harold D. Foster, PhD
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Throughout hundreds of thousands of years of evolution, humans became genetically adapted to their diets, lifestyles, and environments. However, since the advent of the Agricultural Revolution 9000 years ago and the Industrial Revolution a few centuries ago, the human diet has changed radically, but during this relatively short time period, virtually no new genetic adaptations have occurred.

The Spontaneous Healing of Belief: Shattering the Paradigm of False Limits

Gregg Braden
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This is clearly a huge question with implications that rattle everything from the ideas of life and evolution to the basis of religion itself. Also, it spawned the hugely popular 1999 film The Matrix. Zuse was obviously a man ahead of his time. Thirty years later, he elaborated on these ideas in his book Calculating Space and set into motion the events that led to the revolution in our view of reality and everyday life.8 Commenting on how his mind-blowing insights took shape, Zuse described how he made the connection between the machines that he was building and the machinery of the universe.

The Genie in Your Genes: Epigenetic Medicine and the New Biology of Intention

Dawson Church
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Scholar Jean Houston, in her book Jump Time, points out that social evolution does not happen in a gradual upward curve.23 It is marked by long plateaus, followed by rapid jumps. She identifies the Renaissance as one such jump. Within 25 years, all the assumptions of society had changed—assumptions about politics and governance, about money and economics, about gender roles, about religion and science, and about health and medicine. This revolution was brought about by a tiny number of people—perhaps a thousand in all.
While the process of genetic evolution can take thousands of years, as genes throw off mutations that are sometimes successful, and often not, evolution through experience and imitation can occur within minutes—and then be passed on to the next generation. The DNA spiral has become a defining icon of our civilization Edward O.

Natural Cures

Michael Castleman
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Evolving Away from Fats There are two ways to reduce the amount of fat in your diet—by evolution or revolution. If you already have a fat-related medical condition or major risk factors for one, consider the more revolutionary approach discussed under "Revolution to the Rescue" on page 271. If not, the evolutionary path can reduce your fat consumption enough to add years to your life and life to your years. Evolving one's diet away from fats begins with reading food labels.

The Genie in Your Genes: Epigenetic Medicine and the New Biology of Intention

Dawson Church
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While the process of genetic evolution can take thousands of years, as genes throw off mutations that are sometimes successful, and often not, evolution through experience and imitation can occur within minutes—and then be passed on to the next generation. The DNA spiral has become a defining icon of our civilization Edward O.

Food Revolution: How your diet can help save your life and our world

John Robbins
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Atkins' New Diet Revolution, the Beverly Hills Diet, Protein Power, the Carbohydrate Addict's Diet, the Scarsdale Diet, Charles Hunt's Diet evolution, and the Quick Weight-Loss Diet. These diets have several things in common. None is advertised as a low-calorie diet, and yet that is what all of them turn out to be. They all prescribe a daily caloric intake that is well below average requirements. As a result, they may seem to work in the short run, but they do not sustain long-term health.

The Cure Within: A History of Mind-Body Medicine

Anne Harrington
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As historian Misia Landau noted: "The growth of a plant, the progress of a disease, the formation of a beach, the evolution of an organism—any set of events that can be arranged in a sequence and related can also be narrated."21 The stories of mind-body medicine, however, are much more than just a sequential arrangement of observed events.

The Autoimmune Epidemic

Donna Jackson Nakazawa
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I ask her what she thinks about the hygiene hypothesis as the primary explanation for rising rates of autoimmunity, at a time in our evolution when we're living in the most chemically polluted environment ever. To elucidate her answer, Fairweather, her warm blue eyes animated behind tortoiseshell glasses, lines up three eight-and-a-half by eleven sheets of paper, turns them horizontally, and lays them side by side in one thirty-three-inch stretch. As she talks she diagrams for me why, in her estimation, the too-clean theory is too flimsy to explain today's autoimmune epidemic.

Food Revolution: How your diet can help save your life and our world

John Robbins
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It places in human hands the capacity to redesign living organisms, the products of some three billion years of evolution.... Up to now, living organisms have evolved very slowly, and new forms have had plenty of time to settle in. Now whole proteins will be transposed overnight into wholly new associations, with consequences no one can foretell____Going ahead in this direction may be not only unwise, but dangerous. Potentially, it could breed new animal and plant diseases, new sources of cancer, and novel epidemics." —George Wald, M.D.
National Cattlemen's Beef Association15 "Nothing will benefit human health and increase the chances for survival of life on earth as much as the evolution to a vegetarian diet." —Albert Einstein The meat industry comes up with some amazing material. Dan Murphy is the editor of Meat Marketing and Technology, a magazine dedicated to the U.S./Canadian meat processing industry. In 2000, coaching the industry in how to be more persuasive, he wrote, "When it comes to . . . the nutritional impact of meat-eating . . . I'm here to tell you that. . .
Not according to paleontologist Richard Leakey, who is widely acknowledged as one of the world's foremost experts on the evolution of the human diet. Leakey points out, "You can't tear flesh by hand, you can't tear hide by hand. Our anterior teeth are not suited for tearing flesh or hide. We don't (and Cro-Magnons didn't) have large canine teeth, and we wouldn't have been able to deal with food sources that required those large canines."81 In fact, says Leakey, even if Cro-Magnons had large canine teeth, the}" still almost certainly would only rarely have eaten meat.

Feel Better, Live Longer with Vitamin B-3

Dr. Abram Hoffer, MD, FRCP (C) and Dr. Harold D. Foster, PhD
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Pauling L. evolution and the need for ascorbic acid. Proceedings of the National Academy of Sciences 1970;67:1643-48. 3 Stone I. The Healing Factor: "Vitamin C" Against Disease. New York NY: Grosset & Dunlap, 1977. 4 Niacin, http://pune.sancharnet.1n/spr_keshri/b3.htm 5 Pearson HA. Sickle cell anaemia: Clinical management during the early years of life. In: Abramson H, Bertles JF, Wethers DL (eds.). Sickle Cell Disease. St. Louis, MO: CV Mosby, 1973:244-51. 6 McElroy A, and Townsend PK. Medical Anthropology in Ecological Perspectives. Boulder, CO: Westview Press, 1989.

The Science of Flavonoids

Erich Grotewold
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Divergent evolution of flavonoid 2-oxoglutarate-dependent dioxygenases in parsley, FEBS Lett 544: 93-98. Martens, S., Forkmann, G, Matern, U., and Lukacin, R., 2001, Cloning of parsley flavone synthase 1, Phytochem 58: 43-46. McKillop, A., Swann, B. P., and Taylor, E. C, 1973, Thallium in organic synthesis. XXXIII. One-step synthesis of methyl arylacetates from acetophenones using thallium(III) nitrate (TTN), J Am Chem Soc 95: 3340-3343. Min, T., Kasahara, FL, Bedgar, D. L., Youn, B., Lawrence, P. K„ Gang, D. R., Halls, S. C, Park, H., Hilsenbeck, J. L., Davin L. B., Lewis, N. G.
The flavonoid biosynthetic pathway in plants: function and evolution, BioEssays 16: 123-132. Kolukisaoglu, H. U., Bovet, L., Klein, M., Eggmann, T., Geisler, M., Wanke, D., Martinoia, E., and Schulz, B., 2002, Family business: the multidrug-resistance related protein (MRP) ABC transporter genes in Arabidopsis thaliana, Planta 216: 107-119. Koornneef, M., 1990, Mutations affecting the testa colour in Arabidopsis, Arabidopsis InfServ 27: 1-4. Krueger, J. H., Elledge, S. J., and Walker, G.
Flavonoids: a colorful model for the regulation and evolution of biochemical pathways, Trends Plant Sci, 10: 236-242. Kolkman, J. M., Conrad, L. J., Farmer, P. R., Hardeman, K., Ahern, K. R., Lewis, P. E., Sawers, R. J. H., Lebejko, S., Chomet, P. and Brutnell, T. P., 2005, Distribution of Activator (Ac) throughout the maize genome for use in regional mutagenesis, Genetics 169: 981-995. Kreuzaler, F., Ragg, H., Fautz, E., Kuhn, D. N. and Hahlbrock, K, 1983, UV-Induction of chalcone synthase mRNA in cell suspension cultures of Petroselinum hortense, Proc Natl Acad Sci USA 80: 2591-2593.

Anxiety: Orthomolecular Diagnosis and Treatment

Dr. Jonathan Prousky, BPHE, BSc, ND, FRSH
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In some of us, anxiety, therefore, might be built into our genes. evolution might favor those who have anxiety, for it makes sense to have a built-in system that ensures survivals Better to have a system that gives more false positives then false negatives. The advantage might be survival, but at a tremendous cost if the sufferer faces a lifetime of discomfort. Thus, it might be said that evolution favors anxious genes. Incidence Most patients with anxiety disorders seek help from a primary care physician rather than a psychiatrist.

Timeless Secrets of Health & Rejuvenation: Unleash The Natural Healing Power That Lies Dormant Within You

Andreas Moritz
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A century of using quinine-based drugs as a prophylactic in people who did not even have malaria has fostered the evolution of new strains of quinine-resistant malaria that defy conventional treatment. The only substance that has shown to cure this type of malaria (within 4 to 8 hours) as well as other similar infections is chlorine dioxide (see Miracle Mineral Supplement (MMS) in chapter 7). Hemorrhagic dengue, another mosquito fever, has recently struck in India, Africa, and parts of Latin America after an absence of at least half a century.

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