Dr. Steve Blake
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 It is made in the liver and is transported to the muscles and the brain. creatine phosphate can pump ADP up to ATP by donating a phosphate group, as seen in Figure 10-4. This happens in just two to seven seconds after an intense effort. After donating a phosphate group, creatine phosphate becomes creatine. This creatine can be recharged back into creatine phosphate.
Phosphorus is the Backbone of DNA
Nucleic acids store and transmit genetic information. The two types of nucleic acids are DNA and RNA. They are both made of long chains of phosphate-containing molecules. |
James F. Balch, M.D. and Mark Stengler, N.D.
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 Creatine
Description: creatine is a naturally occurring substance in the body and in foods, which is made up of three amino acids—arginine, glycine, and methionine. creatine is used by the body's muscle cells to create energy and maintain muscle mass.
Indications: Athletic support
Congestive heart failure Maintaining muscle mass in seniors
Precautions: Diarrhea and muscle cramping are the most common side effects. People with liver or kidney disease should check with their doctors before using creatine.
Dosage: Take 2 to 5 grams daily. |
Michael T. Murray and Michael R. Lyon
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 When combined with weight training, creatine supplementation has been shown to increase muscle mass and improve leg strength, endurance, and power in both elderly and younger subjects. creatine supplementation augments the muscle growth stimulation of weight training, but without the weight training it has little, if any, benefit. Our dosage recommendation is based upon body weight. Take 1 gram of creatine for every 50 pounds of body weight before you work out. If you weigh 150 pounds your dosage would be 3 grams. |
Bottom Line Health
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| MINOCYCLINE AND CREATINE
New finding: In an NIH-sponsored clinical trial, 200 Parkinson's patients who did not yet require medication were randomly assigned to receive 200 mg daily of the antibiotic minocycline, 10 grams (g) daily of creatine (a nutritional supplement used to increase lean body mass and strength) or a placebo for 12 months.
Minocycline was chosen because of its antiinflammatory effects. Inflammation has been detected in the brains of Parkinson's patients. creatine is an energy booster, and decreased energy utilization is a problem in Parkinson's disease. |
Dr. Steve Blake
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| This creatine can be recharged back into creatine phosphate.
Phosphorus is the Backbone of DNA
Nucleic acids store and transmit genetic information. The two types of nucleic acids are DNA and RNA. They are both made of long chains of phosphate-containing molecules. Phosphates are needed for growth as they form the backbone of both DNA and RNA.
H,N
One Phosphate
P H,C \/ —^
OH OH
N
Adenosine MONOphosphate AMP
H,N
Two Phosphates a / 1 j
P P H,C \ /
/\/v^
OH OH
Three Phosphates
Adenosine Diphosphate ADP
H.N ov p ov p o. |
Bottom Line Health
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| Minocycline and creatine were found to be potentially beneficial.
Implication: More study is needed before minocycline or creatine can be prescribed as a treatment for Parkinson's disease.
DEEP BRAIN STIMULATION
New finding: An advanced surgical technique known as deep brain stimulation (DBS) has been shown to provide significant benefit to moderate and advanced Parkinson's patients for up to four years after the onset of treatment.
With DBS, a surgeon implants an electrode inside the brain to stimulate specific brain sites that control movement. |
Paula Begoun
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 AVON ADVANCE TECHNIQUES
All of the Advance Techniques products below contain creatine, which Avon claims strengthens the hair shaft from the inside. creatine is a compound found naturally in our muscles, and the body uses it to form the adenosine triphosphate (ATP) molecule. ATP serves as a burst of fuel for our muscles when they are subjected to intense or strenuous use. In essence, creatine stimulates production of a molecule that makes our muscles perform more efficiently under stress. |
Jack Challem
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 Mark Tanopolsky of the McMaster University Medical School in Hamilton, Ontario, tested the effects of creatine supplements on 102 patients with muscular dystrophies, mitochondrial myopathies, and other disorders affecting bioenergetics. The patients were given 10 grams of creatine daily for five days, followed by 5 grams daily for an average of six days. People receiving the creatine had significant improvements in strength, enabling them to better perform high-intensity exercises. |
Michael T. Murray and Michael R. Lyon
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| Take 1 gram of creatine for every 50 pounds of body weight before you work out. If you weigh 150 pounds your dosage would be 3 grams. If you suffer from any kidney or liver disease, please consult a physician before supplementing with creatine.
A Comprehensive Nutritional Approach to Prevent Sarcopenia žReduce the amount of saturated fat, trans fatty acids, cholesterol, and total fat in your diet by eating only lean sources of protein and more plant foods. žIncrease your intake of omega-3 oils by eating flaxseed oil, walnuts, and cold-water fish such as salmon. |
Covert Bailey
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 The wooden part of the match is creatine; when its phosphorus is in place, it's called creatine-phosphate or creatine-P. If you want to do a super-hard, fast sprint, creatine-P is waiting right in the cell. It doesn't need enzymes to produce energy; it explodes as needed, releasing energy fast enough to rebuild ATP no matter how fast you run. As the phosphorus explodes on a creatine-match, the energy released is used to put fresh phosphorus on the ATP-match. Then the ATP-match explodes, making the muscle contract. This long explanation may make you think that it's a slow, cumbersome system. |
Jack Challem
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| People receiving the creatine had significant improvements in strength, enabling them to better perform high-intensity exercises.
Creatine might also prove helpful in the treatment of amyotrophic lateral sclerosis (ALS), known also as Lou Gehrig's disease. Dr. M. Flint Beal of the Harvard Medical School fed either normal or creatine-supplemented diets to mice bred to develop ALS. During the course of the experiment, nonsupplemented mice had 49 to 95 percent declines in the number of their brain cells. |
Paula Begoun
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| AVON ADVANCE TECHNIQUES
All of the Advance Techniques products below contain creatine, which Avon claims strengthens the hair shaft from the inside. creatine is a compound found naturally in our muscles, and the body uses it to form the adenosine triphosphate (ATP) molecule. ATP serves as a burst of fuel for our muscles when they are subjected to intense or strenuous use. In essence, creatine stimulates production of a molecule that makes our muscles perform more efficiently under stress. |
Jack Challem
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| How to Take creatine Supplements
Start creatine supplementation by taking a "loading" dose of 10 grams daily for one week to saturate tissues. After the first week, decrease the dosage to 5 grams daily.
B-Complex Vitamins and NADH
Several B-complex vitamins play central roles in the Krebs cycle, literally functioning as the hub for all the other nutritional spokes. In particular, vitamins B2 (riboflavin) and B3 (niacinamide) sit at the center of energy production, enabling cells to perform various tasks, including the making of new DNA. |
Jeffrey M. Smith
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 In a chicken feeding study, the addition of lysine resulted "in a growth rate defect and a reduction in breast muscle creatine."74'75 High amounts of lysine in the diet of rabbits increased serum cholesterol and phospholipids in the liver.76 Elevated levels of lysine may be a health consideration, particularly in cultures where corn is a staple.
Lysine normally increases the weight of chickens. During tests of high-lysine corn, however, their increased growth rate during the first 21 days was significantly less than that obtained from regular corn with lysine supplements. |
Paula Begoun
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| There is no substantiated research pertaining to creatine's benefits for hair, though there is anecdotal information that creatine supplements (meaning their consumption in the diet) causes hair loss!
© Advance Techniques Color-Protection Shampoo ($3.49 for 11 ounces) is a standard, but good, shampoo for all hair types that poses minimal risk of buildup. Avon claims this shampoo protects hair color and keeps it vibrant twice as long as regular shampoos—but this product is just regular, ordinary shampoo! |
Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D.
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 Animal proteins, including fish, are the main source of the 1-2 grams per day of dietary creatine most people consume. Supplements in the form of creatine monohydrate are well absorbed and tolerated by the stomach. |
Benjamin H. Natelson, M.D.
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 The only other test I order in my initial evaluation of a patient with severe fatigue or widespread bodily pain is one that measures creatine phosphokinase (CPK). CPK is an enzyme involved in the normal functioning of your muscles, brain, and heart. Your CPK levels can increase when you exercise vigorously, because vigorous exercise produces some muscle damage, and this damage releases CPK. This mild muscle damage explains why your muscles ache after the first day of skiing, for example. |
Jack Challem
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| How to Take creatine Supplements
Start creatine supplementation by taking a "loading" dose of 10 grams daily for one week to saturate tissues. After the first week, decrease the dosage to 5 grams daily.
B-Complex Vitamins and NADH
Several B-complex vitamins play central roles in the Krebs cycle, literally functioning as the hub for all the other nutritional spokes. In particular, vitamins B2 (riboflavin) and B3 (niacinamide) sit at the center of energy production, enabling cells to perform various tasks, including the making of new DNA. |
Dr. Steve Blake
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| ATP.
(d) creatine phosphate.
74. Magnesium in the body is found mostly in the bones and:
(a) Skin.
(b) Blood.
(c) Muscle.
(d) Extracellular fluid.
75. Magnesium:
(a) Relaxes muscles.
(b) Reduces high blood pressure.
(c) Increases calcium absorption into bones.
(d) All of the above.
76. The chemical symbol for iron is:
(a) Hg.
(b) Mn.
(c) Fe.
(d) Zn.
77. Iron is in the center of:
(a) Heme.
(b) Chlorophyll.
(c) White blood cells.
(d) Pyruvic acid.
78. Myoglobin:
(a) Is found in blood.
(b) Is found in muscle.
(c) Acquires oxygen from the lungs.
(d) All of the above.
79. |
Michael T. Murray and Michael R. Lyon
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| When combined with weight training, creatine supplementation has been shown to increase muscle mass and improve leg strength, endurance, and power in both elderly and young subjects. Physical inactivity is a major reason why so many Americans are overweight.
Exercise has been shown to compensate for a reduced basal metabolic rate (BMR) due to calorie restriction.
We recommend a combination of aerobic, strength training, and flexibility exercises to see the full benefits of exercise. The time you spend exercising is a valuable investment toward good health.
8
Rev Up Your Metabolism
H 3. |
Patrick Holford
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 Many competitive sports people supplement creatine. creatine is a substance in the body made of three amino acids—arginine, methionine, and glycine. Not surprisingly, meat is naturally rich in it. creatine is also sold as a supplement, and it's a top seller among athletes because it promotes muscle regeneration and recovery after exercise, as well as improves energy during intensive exercise.
Normally, muscle cells derive energy by breaking down ATP (adenosine triphosphate) to ADP (adenosine diphosphate). |
David Winston, RH(AHG), and Steven Maimes
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 According to Russian research, some adaptogens, such as rhodiola, have been shown to significantly increase the levels of ATP and creatine phosphate in the muscles by increasing the levels of fatty acids. The body uses ATP as a source of energy. During intense physical activity when the body needs energy, more ATP is converted into more fuel for the muscles. Adaptogens also increase both strength and muscle mass by affecting the amount of oxygen available for prolonged physical exertion. |
| Rhodiola increases mitochondrial activity and muscular ATP and creatine levels—resulting in enhanced physical strength and endurance. It also increases blood supply to the brain and muscles. Rhodiola is used to reduce fatigue associated with Lyme disease.
• Shilajit provides energy and, translated from Sanskrit, means "conqueror of mountains and destroyer of weakness."
BRAIN FUNCTION
The brain is part of the nervous system, along with the spinal cord, nerves, and sensory organs. It is responsible for basic body functions and movement, the senses, intelligence, learning, and memory. |
Patrick Holford
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| Many competitive sports people supplement creatine. creatine is a substance in the body made of three amino acids—arginine, methionine, and glycine. Not surprisingly, meat is naturally rich in it. creatine is also sold as a supplement, and it's a top seller among athletes because it promotes muscle regeneration and recovery after exercise, as well as improves energy during intensive exercise.
Normally, muscle cells derive energy by breaking down ATP (adenosine triphosphate) to ADP (adenosine diphosphate). |
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