Mike Adams, the Health Ranger
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 The B6 is a coenzyme. Methylcobalamin is a B12 coenzyme. Folinic acid is a folate coenzyme. Coenzymes are the way these things are used in the body.
The body has to do more work to get the benefit if you are taking something that is not a coenzyme vitamin, typically most of the stuff found in the vitamins out there. For example, the body cannot use pyridoxine hydrochloride (synthetic vitamin B6). It has to grab an ATP and be phosphorylated before becoming a coenzyme that can be used. I went into supplement design because my wife was chemically sensitive. |
Gabriel Cousens, M.D.
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 Bracts as a coenzyme whose job is primarily connected to the methy-lation process needed for the production of phosphatidylcholine, myelin, melatonin, catecholamines, DNA, RNA, cysteine, and normal red blood cells. Several forms of active B[2 work as coenzymes in the body: adeno-sylcobalamin, methylcobalamin, cyancobalamin (found in supplements and fortified foods because it is the most stable form of B12), and hydrox-ocobalamin. There are many natural Bu analogues in food, but they do not work as active coenzymes in the body and may actually block the active B[2 coenzyme function. |
Mike Adams, the Health Ranger
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| It has to grab an ATP and be phosphorylated before becoming a coenzyme that can be used. I went into supplement design because my wife was chemically sensitive. I became her "doctor" in 1984 and ever since then, I have been finding nutrients, such as coenzyme vitamins and other nutrients that are consistent with human body function -- that work with the body.
Coenzymes are not a drag on the human body. The body can just go, "Boom! Used it! It is great. I feel good. It works." That is our thing; we give you something that works to make you healthy. |
J. Douglas Bremner
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 Studies of coenzyme Q10, however, have shown only modest changes in measures of cardiovascular function that were not directly related to clinical function.33 No studies have shown clinical improvement related to heart-disease treatment or prevention with coenzyme Q10. See Chapter 4.
GLUCOSAMINE AND CHONDROITIN
Glucosamine, a product derived from the shells of crabs and oysters, is widely promoted for the treatment of arthritis and joint pain. |
Ray D. Strand
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 What Is coenzyme Q10?
Coenzyme QlO (CoQlO), or ubiquinone, is a fat-soluble vitamin or vitaminlike substance that is also a potent antioxidant. Trace amounts of CoQlO exist in a variety of foods, such as organ meats, beef, soy oil, sardines, mackerel, and peanuts. The body also has the ability to make CoQlO from the amino acid tyrosine, but this is a complicated process that requires at least eight vitamins and several trace minerals to complete. A deficiency in any one of these nutrients can hinder the body's natural production of CoQlO. |
Jack Challem
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 They include
• Antibiotics, which interfere with the B vitamins
• Beta-blockers, which interfere with coenzyme Q10
• Metformin, which interferes with vitamins B6, B12, folic acid, and coenzyme Q10
• Oral contraceptives, which interfere with the B vitamins
• Proton-pump inhibitors, which interfere with vitamins B12 and C
• Thiazides, which interfere with magnesium, potassium, and zinc Metformin, one of the most commonly prescribed drugs for prediabetes and diabetes, interferes with the body's absorption and use of folic acid (a B vitamin) and vitamin B12. |
Tori Hudson, N.D.
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 Food sources: fish high in omega-3 fatty acids include tuna, salmon, sardines, mackerel, and herring (see precautions in text); other sources include flaxseed, hemp seeds, sunflower seeds, walnuts, almonds, and filberts
Coenzyme Q10. coenzyme Q10 is a fat-soluble quinone occurring in the mitochondria of every cell that is a cofactor in the electron transport chain on which most cellular functions rely, making it essential for the health of virtually all human tissues. Plasma levels of this enzyme rise during normal pregnancy, reaching highs of 50 percent above normal by the 36th week. |
Bottom Line Health
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| Research reported at the Congress... coenzyme Q10
New finding: A small trial funded by the National Institutes of Health (NIH) found that taking 1,200 milligrams (mg) of coenzyme Q10 (a natural nutrient that is present in all human cells) daily may slow the progression of early-stage Parkinson's disease.
More study is needed to confirm that CoQIO does indeed slow the progression of the disease. In addition, because the dosage of CoQIO that was studied was found to be only mildly effective, additional research is also needed to determine whether a higher dose (2,400 mg daily) works better. |
J. Douglas Bremner
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| Studies of coenzyme Q10 supplementation, however, have shown only modest changes in heart function, with no effect on what we care most about, which is prevention of heart attacks.
CHOLESTIN
Cholestin is an ancient remedy that has been used in Chinese medicine for centuries for the treatment of heart problems. Derived from yeast on red rice, it is called red rice yeast extract. It has eight statin compounds that are HMG coenzymeA reductase inhibitors, just like statins, that have been shown to reduce cholesterol. |
| The natural next step was to try to use supplements of coenzyme Q10 to prevent heart disease. Studies of coenzyme Q10 supplementation, however, have shown only modest changes in heart function, with no effect on what we care most about, which is prevention of heart attacks.
CHOLESTIN
Cholestin is an ancient remedy that has been used in Chinese medicine for centuries for the treatment of heart problems. Derived from yeast on red rice, it is called red rice yeast extract. |
Mark Sircus
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 It is also found in the phosphoamide bond of phosphocreatine, the phosphoenol bond of phosphoenolpyruvic acid, the mixed anhydride bond of 1,3-diphosphoglyceric acid and in the bond between an acid and a thiol group as in acyl coenzyme A or succinyl coenzyme A.
4 A Machoy-Mokrzynska. Fluoride_Magnesium Interaction. Fluoride (J. of the International Society for Fluoride Research), Vol. 28 No. 4; November, 1995, pp 175-177 see www.magwater.com/fl2.shtml Institute of Pharmacology and Toxicology, Pomeranian Medical Academy, Szczecin, Poland.
5 Bernard Rimland. |
Mike Adams, the Health Ranger
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| The body has to do more work to get the benefit if you are taking something that is not a coenzyme vitamin, typically most of the stuff found in the vitamins out there. For example, the body cannot use pyridoxine hydrochloride (synthetic vitamin B6). It has to grab an ATP and be phosphorylated before becoming a coenzyme that can be used. I went into supplement design because my wife was chemically sensitive. |
Mark Sircus
See book keywords and concepts |
| It is also found in the phosphoamide bond of phosphocreatine, the phosphoenol bond of phosphoenolpyruvic acid, the mixed anhydride bond of 1,3-diphosphoglyceric acid and in the bond between an acid and a thiol group as in acyl coenzyme A or succinyl coenzyme A.
4 A Machoy-Mokrzynska. Fluoride_Magnesium Interaction. Fluoride (J. of the International Society for Fluoride Research), Vol. 28 No. 4; November, 1995, pp 175-177 see www.magwater.com/fl2.shtml Institute of Pharmacology and Toxicology, Pomeranian Medical Academy, Szczecin, Poland.
5 Bernard Rimland. |
Mike Adams, the Health Ranger
See article keywords and concepts |
| I became her "doctor" in 1984 and ever since then, I have been finding nutrients, such as coenzyme vitamins and other nutrients that are consistent with human body function -- that work with the body.
Coenzymes are not a drag on the human body. The body can just go, "Boom! Used it! It is great. I feel good. It works." That is our thing; we give you something that works to make you healthy. That is why I am in the business; for no other reason than that.
About Integrated Health
Dr. Hank Liers is the chief formulator of nutritional supplements sold at Integrated Health (www.IntegratedHealth. |
Steven V. Joyal
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 Effects of coenzyme Ql 0 in early Parkinson disease: Evidence of slowing of the functional decline. Arch Neurol 2002 Oct; 59(10):154l-50.
Shults CW et al. Pilot trial of high dosages of coenzyme Ql 0 in patients with Parkinson's disease. Exp Neurol2004 Aug; 188(2):491-94.
Sima AF et al. Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: An analysis of two randomized placebo-controlled trials. Diabetes Care 2005 Jan; 28(l):89-94.
Singer GM, Geohas J. |
Abram Hoffer, PhD, MD, FRCP(C) and Dr. Jonathan Prousjy, DPHE, DSC, ND, FRSH
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 Vitamin B-12 (Cobalamin)
Vitamin B-12 is involved in numerous biochemical reactions as a cofactor and coenzyme. Its main functions involve DNA synthesis, methionine synthesis from homocysteine, and conversion of propionyl into succinyl coenzyme A from methylmalonate. The psychiatric manifestations of a vitamin B-12 deficiency include agitation or restlessness, dementia, depression, fatigue, irritability, panic and phobic disorders, personality change, psychosis, mild memory impairment, and negativism. |
Thomson Healthcare, Inc.
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 Watts GF, Castelluccio C, Rice-Evans C et al: Plasma coenzyme Q (Ubiquinone) concentrations in patients treated with simvastatin. J Clin Pathol; 46:1055-1057. 1993
Zimmerman JJ: Therapeutic application of oxygen radical scavengers. Chest; 100:189-192. 1991
Folic Acid description
Folic acid is a water-soluble B vitamin found in a variety of foods, especially green leafy vegetables. Folium, the Latin word for leaf, is the source of the term folic acid. This vitamin is required for DNA synthesis and a variety of other key reactions in normal metabolism. |
| The mechanism was thought to be inhibition of macrophage 3-hydroxy-3-methyl glutaryl coenzyme A (HMG CoA) reductase. This enzyme is used in the rate-limiting step of cholesterol synthesis (Fuhrman et al, 1997).
The susceptibility of low-density lipoproteins to oxidation was not changed by increased lycopene plasma concentrations caused by supplementation with Tomato juice. Fifteen renal transplant patients were given either a synthetic orange drink or Tomato juice for 4 weeks in a crossover study. Plasma lycopene levels increased significantly (p<0.015). |
| Other Names: 2-dithiolane-3 penatanoic acid, 1,2-dithiolane-3 valeric acid, 6,8-thioctic acid, Acidum thiocticum, Alpha liponacid, Alpha-Liponsaeure, Lipoaminsaeure, Lipoate, Pyruvate oxidation factor, Thioctic acid, Thioctsaeure actions and pharmacology
EFFECTS
ALA is an important coenzyme and has antioxidant and antidiabetic properties. It is a biologically occurring substance that acts as a cofactor in the pyruvate-dehydrogenase complex, the alpha-ketoglutarate-dehydrogenase complex, and the amino acid hydrogenase complex. |
Dr. Abram Hoffer, MD, FRCP (C) and Dr. Harold D. Foster, PhD
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 Ames and coworkers have methodically provided details of a wide variety of such coenzyme decreased binding affinity diseases and the nutrients most likely to ameliorate them. For example, the enzyme cystathionine P-synthase catalyzes homocysteine and serine to form cystathionine. Individuals with a defective form of this enzyme develop very high blood and urine homocysteine levels that can cause a variety of symptoms, including mental retardation, vascular and skeletal problems, and optic lens dislocation. |
Ray D. Strand
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| She started with some strong antioxidant and mineral tablets along with grape-seed extract and a natural nutrient called coenzyme Q10. Within weeks Evelyn began to feel better.
"For the first time in years, I slept through the night and woke up feeling rested," she reports. "I no longer needed a nap during the day, and I didn't have bladder or bowel problems. I experienced an increase in my endurance level. My strength began returning in my legs and my arms. I could even run up the stairs to answer the phone, which stunned my children. |
Jonny Bowden, Ph.D., C.N.S.
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 In another study, 3 g of taurine outperformed even coenzyme Q10, another superb nutrient with documented results in congestive heart failure.
In 1928, the New York Heart Association published a classification of cardiac patients into four functional classes (I through IV) based on their prognosis and their clinical severity (that publication is now in its ninth edition and still going strong). |
Dr. Abram Hoffer, MD, FRCP (C) and Dr. Harold D. Foster, PhD
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| NAD, the coenzyme, is hydrolyzed or split into niacinamide and adenosine dinucleotide phosphate (ADP-ribose). Niacinamide is converted into niacin, which in turn is once more built into NAD. The enzyme that splits ADP is known as poly (ADP-ribose) polymerase, poly (ADP) synthetase, or poly (ADP-ribose) transferase.
Poly (ADP-ribose) polymerase is activated when strands of deoxyribonucleic acid (DNA) are broken. The enzyme transfers NAD to the ADP-ribose polymer, binding it onto a number of proteins. |
Jonny Bowden, Ph.D., C.N.S.
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| I immediately asked that, in addition to whatever treatment the doctors prescribed, she be put on a high dose of coenzyme Q10 (CoQIO). The first doctor told me he didn't know what that was. The second doctor said he had heard of it but it couldn't do any good and wasn't on their hospital pharmacy list. And the head nurse said, "Oh, that's some kind of enzyme that the heart makes when it's in trouble, right?" I knew right there we were in for trouble. n o ro O n c 73 m
It didn't matter that I faxed them fifty pages of peer-reviewed literature from the National Institute of Medicine. |
Dr. Abram Hoffer, MD, FRCP (C) and Dr. Harold D. Foster, PhD
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| Shultz and coworkers have found that 1200 mg per day of coenzyme Qio is more therapeutic than lower doses.10 However, they were not treating their patients with niacin and other antioxidants. If these anti-oxidants had been given long before the first significant symptoms of Parkinson's disease occurred, they might have been prevented in the majority of cases.
References
1 Foley P. The L-DOPA story revisited. Further surprises to be expected. J Neural Transm Suppl 2000;60:1-20.
2 Cotzias GC, Van Woert MH, Schiffer LM. Aromatic amino acids and modification of Parkinsonism. |
Ray D. Strand
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| About this same time my wife, Liz, and I were flying to the great Northwest when she showed me an article she was reading about a study on a natural nutrient, coenzyme Q10. Liz handed me the article written by Dr. Peter Langsjoen, a cardiologist and biochemist practicing in Tyler, Texas. Dr. Langsjoen had been able to significandy improve the health of his cardiomyopathy patients by simply adding supplements of the nutrient called CoQlO to their daily medications. |
Thomson Healthcare, Inc.
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| Cardiovascular Effects: The most extensive studies of coenzyme Q10 have been in cardiovascular disease, most specifically for its purported benefit in preventing cellular damage during myocardial ischemia and reperfusion (Mortensen 1993; Rengo et al 1993; Greenberg et al 1990). Numerous potential therapeutic mechanisms have been considered. |
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