Andreas Moritz
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 However, to balance this increase, your body will automatically reduce its own cholesterol production. This self-regulating mechanism ensures that cholesterol remains at the exact level that your body requires to sustain optimal functions and equilibrium.
If eating fatty foods does not significantly increase cholesterol levels to meet the body's demands for this vital substance, the body must take other more drastic measures. One of them is the stress response. If your body runs low on cholesterol, you are likely going to feel stressed. |
Thomson Healthcare, Inc.
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 Differential effect of genistein on the stimulation of cholesterol production by basic protein II in normal and hyperapoB fibroblasts. Arterioscler Thromb Vase Biol 18(l):57-64. 1998.
Lamartiniere CA, Murrill WB, Manzolillo PA, et al: Genistein alters the ontogeny of mammary gland development and protects against chemically-induced mammary cancer in rats. PSEBM 217(3):358-364. 1998.
LeCoz CJ, Lefebvre C: Contact dermatitis from maleated Soybean oil: last gasps of an expiring cosmetic allergen. Contact Dermatitis 43(2): 118-119. 2000. |
Hyla Cass, M.D.
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 The drugs lower cholesterol by inhibiting the action of the enzyme, called HMG-CoA, that is responsible for cholesterol production in the body. It just so happens that HMG-CoA is also needed to make CoQ10. When you replenish CoQi0 with a supplement, you can diminish symptoms related to its lack.
What is CoQ10, and what is its role in the body? It is a compound made within the cells of all animals. CoQ]0 is fat-soluble, meaning that it is stored in fats. |
Andreas Moritz
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 It would be much wiser to find out what keeps HDL levels normal than to inhibit cholesterol production in the liver and thereby destroy this precious organ. Elevated LDL cholesterol is not a cause of heart disease; rather, it is a consequence of an unbalanced liver, of a congested, dehydrated circulatory system, and of a poor diet and lifestyle.
If your doctor has told you that lowering your cholesterol with statins will protect you against heart attacks, you have been grossly misled. The number-one prescribed cholesterol-lowering medicine is Lipitor. |
Bottom Line Health
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| Cholesterol is manufactured in the liver, and statins inhibit an enzyme that is needed for cholesterol production. These drugs also prevent the inflammation that lodges cholesterol deposits inside arteries.
Although statins have fewer side effects than other cholesterol-lowering drugs, an estimated 15% to 30% of the people taking them experience abdominal discomfort, muscle or joint pain, muscle weakness and/or memory problems.
More serious side effects occur in 1% to 2% of statin users, whose liver enzymes rise—a warning of possible liver damage if uncorrected. |
Jack Challem
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 In addition, glucagon lowers cholesterol production, which insulin increases. It's also a mild diuretic, signaling the kidneys to release water from the body and combating water weight.
Why Fiber Is Good for You
High-protein diets have frequently been criticized for their lack of vegetables and fruits. Our protein-rich eating plan corrects this problem by recommending that you eat high-fiber, nonstarchy vegetables and fruits. Fiber reduces blood-sugar and insulin levels, and people who eat more fiber are generally thinner than those who don't. |
Andreas Moritz
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| Stress is a powerful trigger for cholesterol production in the body. Since cholesterol is the basic constituent of all stress hormones, any unsettling situation will use up large quantities of cholesterol. To make up for the loss or increased demand of cholesterol, the liver starts making more of it.
Take the example of the cholesterol-increasing effect of television. Research has shown that watching television for several hours at a time can drive up blood cholesterol more dramatically than any other so-called risk factors, including diet, sedentary lifestyle or genetic disposition. |
Andreas Moritz
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| This perceived "shortage" stimulates the liver cells to raise cholesterol production to abnormally high levels (some of the cholesterol is needed to heal and protect injured parts of the arteries). This extra cholesterol enters the liver bile ducts with the intention of being taken to the small intestines for absorption. However, because the membranes and openings of the sinusoids are clogged with accumulated protein fiber (collagen), most of the extra cholesterol never makes it there and, instead, is caught in the bile ducts. |
| Once enough of these degenerate proteins are deposited in the blood vessel walls, adequate quantities of cholesterol can no longer reach the body's cells, and the liver cells automatically raise cholesterol production. The side effect of this response is gallstone formation.
If you are not a vegetarian, it is best to cut out meat,3 eggs, and cheese first, and keep other types of animal protein, such poultry and fish, to a minimum. |
Hyla Cass
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| The drugs lower cholesterol by inhibiting the action of the enzyme, called HMG-CoA, that is responsible for cholesterol production in the body. It just so happens that HMG-CoA is also needed to make CoQ10. When you replenish CoQ10 with a supplement, you can diminish symptoms related to its lack.
What is CoQ10, and what is its role in the body? It is a compound made within the cells of all animals. CoQ10 is fat-soluble, meaning that it is stored in fats. |
Andreas Moritz
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| Both these stressful situations cause a reduction in bile salts (poor digestion of food decreases the reabsorption of bile salts) and an increase of cholesterol production by the liver in response to poor digestion of fats. Both these situations leave the body with no other choice but to produce gallstones.
To escape this vicious cycle, allow yourself to go through the initial phases of food cravings with more awareness. Feel what your body is "telling you" when it signals discomfort. Ask yourself what your body really wants. If you crave something sweet, try eating a piece of fruit instead. |
| Miscellaneous Causes
Watching Television for Several Hours
Scientific research has shown that watching television can dramatically increase cholesterol production in the body. Besides being a necessary component of most tissues and hormones in the body, cholesterol also serves as a stress hormone that increases during physical or mental strain. In fact, cholesterol is one of the first hormones transported to the site of an injury to help heal it. |
| This prompts the liver to increase cholesterol production, causing yet more gallstones to be formed.
The less fat the body receives with the food, the worse the situation becomes. However, since fats cannot be digested properly anymore, the body enters a vicious cycle, which in most cases can only be stopped by removing all gallstones from the liver and gallbladder and then gradually increasing fat intake to normal levels.
Lowfat milk, for example, may be one of the culprits that could start such a vicious cycle. |
Byron J. Richards
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 Unfit fat cells, in a state of panic, send a distress signal to the liver to raise cholesterol production. The liver then sends cholesterol to white adipose tissue in order to stabilize the unfit cells.
Unfortunately, the cholesterol that is made and sent to the fat cells is not able to fix them. Thus, unfit fat cells send a chronic signal to the liver to raise cholesterol. Medications to lower cholesterol do not solve the source of this problem. This problem only goes away when the fat cells shrink in size. High Blood Pressure
High blood pressure is often caused by unfit fat cells. |
Mike Adams, the Health Ranger
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 Statin drugs block cholesterol production, impairing your sex hormones, causing muscle wasting disorders and producing severe nervous system problems. COX-2 inhibitors cause heart attacks that can kill you. NSAIDs (over-the-counter painkillers) kill 16,500 Americans every year due to intestinal bleeding. In all, prescription drugs kill 100,000+ Americans each year and injure another 2 million. You don't see any of these people getting their money back, do you?
The point I'm trying to make here is that in the fields of health and medicine, promises to customers are only selectively enforced. |
Mike Adams
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 High cholesterol is a symptom of an underlying health problem (usually dietary, by the way), but cholesterol drugs merely try to block cholesterol production by the liver, thereby "controlling" one measurable number at the expense of all the other harm being caused by the drug. Sure, your cholesterol might be artificially manipulated and appear to be in a healthy range while you're on the drug, but in truth you're no healthier than before because the root cause of the cholesterol problem (your diet and lack of exercise, probably), is still present. |
Greg Critser
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 Slowly but surely, large epidemiologic studies have proven statins' worth in slowing that process by cutting cholesterol production and reducing inflammation. Three such reports have shown that statins, when taken on a daily basis, decrease the risk of second heart attacks by 30 percent and the risk of death from second heart attacks by 40 percent. Perhaps just as important, in a society geared toward reducing risk, are so-called primary prevention studies involving statins. |
Joseph E. Mario
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 Stop eating refined Carbohydrates, simple sugars; andhydrogenated, fried, saturatedFats (Fats stimulate liver cholesterol production), especially fried animal foods, and the 15-40% trans-fatty acids impairing the liver's ability to turn HDL-cholesterol into Bile salts for intestinal excretion. Eliminate alcohol, tobacco; obesity. Avoid coffee and chlorinated water to lower LDLs. Deficiencies of Fiber and certain Vitamins and Minerals allows cholesterol to settle out of solution and deposit on artery walls. Range 100-180 mg./liter blood; toxicity 200-300. If cholesterol measures over400-600 mg. |
Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D.
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 Fenugreek (page 676) seeds contain compounds known as steroidal saponins that inhibit both cholesterol absorption in the intestines and cholesterol production by the liver.328 Dietary fiber may also contribute to fenugreek's activity. Multiple human trials (some double-blind) have found that fenugreek may help lower total cholesterol in people with moderate atherosclerosis (page 38) or those having insulin-dependent or non-insulin-dependent diabetes (page 152).329,330,331 One human double-blind trial has also shown that defatted fenugreek seeds may raise levels of beneficial HDL cholesterol. |
Amarjit S. Basra
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 A number of in vitro and animal studies of globe artichoke (Cynara scolymus) have been carried out confirming reduced hepatic cholesterol production. Several small clinical studies have also confirmed this response with falling total cholesterol and an increase in HDL.29 Anecdotal reports suggest rhubarb (Rheum palmatum), devil's claw (Harpagophytum procumbens), gulgul (Commiphora mukul), and turmeric (Curcuma longa) also may have some effect. Many herbs may have lipid-lowering potential, but adequate studies have not as yet been carried out to confirm their effectiveness in humans. |
Mike Adams
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| For starters, they interfere with normal, healthy cholesterol production by the liver. This inhibits the creation of CoQIO (a crucial nutrient for cell energy) as well as hormones such as vitamin D. |
Byron J. Richards, CCN
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 Excess carbohydrates lead to elevated NPY in the brain, a condition inducing excessive cholesterol production - regardless of the cholesterol content of food.
Unfortunately, because this plan makes leptin resistance worse, it increases the rate of the onset of major diseases in our society, including obesity. This is not good public-health policy.
THE FIVE RULES - Rule 5
Reduce the amount of carbohydrates eaten.
Carbohydrates are easy-to-use fuels. |
| HIGH CHOLESTEROL, LOW THYROID, AND LEPTIN
The liver is recognized as the primary metabolic factory of cholesterol production in the human body. The liver will make cholesterol even if little is consumed in the diet. As it turns out, snacking between meals is like punching the liver in the nose, the liver responds by making extra cholesterol.
This is fully explained in The Leptin Diet™ section of the book, and is a primary dietary mistake leading to improper cholesterol elevation. |
Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D.
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| Test tube and animal studies indicate that poli-cosanol (page 571) is capable of inhibiting cholesterol production by the liver. |
Earl L. Mindell, RPh, PhD with Virginia Hopkins, MA
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| But perhaps even more serious than the above side effects is the fact that the same mechanism that blocks cholesterol production also blocks the production of coenzyme Q10, a substance essential to a healthy heart and muscles. Your physician may tell you that you'll never have a shortage of CoQIO, but this is not borne out by the facts. The truth is that heart disease patients are consistently found to have low levels of coenzyme Q10. |
The Life Extension Editorial Staff
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 HMG-CoA reductase, the rate-limiting enzyme involved in hepatic cholesterol production, appears to be simulated in both diabetic and nondiabetic animal studies amidst high levels of insulin (Dietschy et al. 1974).
Syndrome X interferes with glucose delivery, a consequence initiated by insulin's nonresponsiveness at the receptor site on the cell. Normally, ordinary levels of insulin will escort glucose into the cell, leaving a bloodstream favoring neither hyper- or hypoglycemia. |
| Artichoke extract intercepts this signal, and the liver complies with less cholesterol production (Murray 1998b).
The flavonoid luteolin appears to be pivotal in the hypocholesterolemic effects of artichoke. Statin drugs reduce cholesterol by competitively inhibiting the binding of HMG-CoA reductase. Tocotrienols also degrade this enzyme. Artichoke research has found no direct inhibition of HMG-CoA reductase. Other enzymatic steps occurring later in the biosynthesis of cholesterol appear unaffected. |
Earl L. Mindell, RPh, PhD with Virginia Hopkins, MA
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| In one study, ingesting this amount daily caused a 26 percent reduction in LDL or "bad" cholesterol production.
Psyllium: 1 to 2 teaspoons a day. Be sure to drink eight glasses of water a day, too.
N-acetyl cysteine (NAC): 500 mg three times a day. This will help raise your glutathione levels, which will support your liver so it can more efficiently excrete cholesterol. |
Laurie Deutsch Mozian, M.S., R.D.
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 Impeding Cholesterol Production
Some phytochemicals have the potential to suppress tumor growth and modestly decrease cholesterol levels by interfering with the pathway that leads to cholesterol production. HMG-COA reductase is a raw material needed by cells to synthesize cholesterol and encourage tumor growth. Some phytochemicals interfere with the HMG-COA reductase pathway and therefore suppress tumor cell reproduction and the accumulation of cholesterol. |
Patrick Holford
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 Vitamin C also inhibits excessive cholesterol production and helps convert cholesterol to bile. All this would lead to a decrease in unnecessary atherosclerotic deposits. In one study, it was shown that a daily 500 mg of vitamin C can lead to a reduction in atherosclerotic deposits within two to six months. "This concept also explains why heart attacks and strokes occur today with a much higher frequency in winter than during spring and summer, the seasons with increased ascorbate intake," said Pauling. |
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