Melody Petersen See book keywords and concepts | In 2000 Pfizer bullied its way into becoming the world's largest pharmaceutical company through a hostile takeover of Warner-Lambert, a firm that had been its partner in the marketing of Lipitor, the cholesterol drug. Warner-Lambert scientists had discovered Lipitor, but Pfizer wanted to sell it.
The takeover also made Pfizer the most profitable drug company in the world. In 2001 Pfizer rang up sales at a rate of almost $4 million an hour and, by the end of the year, had turned $7.8 billion of those sales into profit. | Craig Pepin-Donat See book keywords and concepts | End of Drug Trial Is a Big Loss for Pfizer" (New cholesterol drug Trials Fail)
Alex Berenson
New York Times Health Section (December 4, 2006)
"Risks of Drug-Coated Stents Divide Federal Review Panel"
BarnabyJ. Feder
New York Times Health Section (December 8, 2006)
"Many Prescription Drugs Have Unexpected Harmful Effects"
Maryann Napoli Health/acts (May 2002)
"David J. Graham, MD, MPH, Senate Testimony"
ConsumersUnion.Org (November 18, 2004) Non-profit publisher of Consumer Reports
"Death by Medicine"
Gary Null, Ph.D. et al.
Life Extension (www.lef. | Mike Adams, the Health Ranger See article keywords and concepts | Most drugs actually cause damage to patients, either through liver damage, kidney damage, weight gain or interference with normal physiological function (such as statin drugs blocking the creation of cholesterol -- a nutrient that's extremely important for your health, despite the medical myths promoted by cholesterol drug companies).
We all know this to be true by simple observation. Think of the last person you saw admitted to the hospital for chemotherapy, for example. How are they doing two or three years later? | Mike Adams, the Health Ranger See article keywords and concepts | One person I spoke with had been given a prescription for a high cholesterol drug by his doctor, and was told that changing his diet alone could only lower his cholesterol 10 points. He was told he would need to be on statin drugs for the rest of his life. Refusing to believe that information, he did not fill the prescription and instead started altering his diet, removing animal products, cheese and fried foods, and boosting his consumption of blueberries and other nutrient-dense superfoods. | Mike Adams, the Health Ranger See article keywords and concepts | Most of it is regulated by your liver, so you need to get the liver in line, which I always find interesting, because the major side effect of the cholesterol drug is that it destroys the liver. The back end issue that's more important -- really, really fundamental -- is that cholesterol is not necessarily the criminal it is made out to be. It is primarily guilty by being found at the scene of the crime.
If you really want to drive your doctor crazy when they are recommending cholesterol drugs, ask the doctor, "If cholesterol is clogging my arteries, why don't my veins ever clog? | Joe Graedon, M.S. and Teresa Graedon, Ph.D. See book keywords and concepts | I have been taking this cholesterol drug for 2 years.
Could Lipitor be responsible for my neuropathy? My doctor says that you can't trust anything you find on the Internet.
A. An article in the journal Neurology (May 14,2002) suggests that long-term use of statin-type cholesterol-lowering drugs may be associated with nerve damage.
Can cholesterol-lowering drugs affect memory? That is a question we have wrestled with for nearly 6 years. It started when we received a letter from a woman who complained that Lipitor affected her ability to verbalize thoughts and remember things. | Mark Hyman, M.D. See book keywords and concepts | When you take a drug to lower your cholesterol, it doesn't change the insulin resistance that raised your cholesterol in the first place, it doesn't change your blood sugar problem, it doesn't lower your blood pressure or your homocysteine level or the amount of iron in the bloodstream—all of which are known risks that need to be addressed in order to reverse or control so-called heart disease. The cholesterol drug lowers cholesterol, making you think you are fine because your cholesterol is lower. | Joe Graedon and Teresa Graedon See book keywords and concepts | ERYC Ery-Tab llosone
PG d 13 201G
Cholesterol Drugs
Lopid niacin
Transplant Drug
Sandimmune
Anticoagulant
Coumadin
Not every cholesterol drug listed above interacts with each medicine on this overview tree. See individual summaries for details. Drugs shown here have the most serious known reactions with this type of cholesterol-lowering drug, but check with a health professional before taking any other medicine with one of these agents. | Donald L. Barlett and James B. Steele See book keywords and concepts | In March 2001 and again in December that year, the FDA sent warning letters to Bristol-Myers Squibb Company objecting to the drug makers "unsubstantiated efficacy claims" for Pravachol, a cholesterol drug. Nothing happened. So on August 7, 2003, the FDA sent a third letter complaining about the company's "false or misleading" promotional materials for its big-selling drug. More months went by. Finally, on February 20, 2004, Bristol-Myers published full-page advertisements in newspapers that carried this headline: "Important Correction of Information about Pravachol (pravastatin sodium) tablets. | Earl L. Mindell, RPh, PhD with Virginia Hopkins, MA See book keywords and concepts | | It can increase or prolong the effects of the cholesterol drug pravastatin.
What Are the Interactions with Food?
Orlistat should be taken with meals.
What Nutrients Does It Throw Out of Balance or Interact With?
In patients with normal baseline vitamin levels before using orlistat, after using Orlistat vitamin A levels were low in 2.2 percent; vitamin D levels were low in 12 percent; vitamin E levels were low in 5.8 percent; and beta-carotene levels were low in 6.1 percent. When fats are flushed through the system without being broken down, fat soluble vitamins go along with them. | Thomas J. Moore See book keywords and concepts | A sore tongue can result from the cholesterol drug Questran and the migraine drug Imitrex. The sleep-aid Halcion is linked to a burning tongue. The heart drub Tambocor may cause a swollen tongue. Four other drugs cause "smoker's tongue." Perhaps the most unpleasant, most serious, and most common effect on the tongue is produced in many patients who take neuroleptic drugs for severe mental illness. Damage to the brain's ability to control muscles causes the tongue to protrude from the mouth, making speech difficult and the patient's appearance bizarre. | | When the best-selling cholesterol drug Mevacor was approved for lifetime therapy, fewer than two hundred people had taken it for as long as two years.10 Thus, initial drug testing is essential but incomplete. The only systematic study in the scientific literature found that 51 percent of drugs approved over a decade's time had important risks not detectable in initial testing.11
This deliberate gamble with the safety of the public requires an excellent system to monitor the safety of drugs once they enter the marketplace. | | More usual is this statement about the cancer risks of Pravachol (or pravastatin) the best-selling cholesterol drug:
In a 2-year study in rats fed pravastatin at doses of 10, 30, or 100 mg/kg body weight, there was an increased incidence of hepatocellular carcinomas in males at the highest dose (p<0.01). Although rats were given up to 125 times the human dose (HD) on a mg/kg body weight basis, serum drug levels were only 6 to 10 times higher than those measured in humans given 40 mg pravastatin as measured by AUC. | Joe Graedon and Teresa Graedon See book keywords and concepts | It is certainly logical that such a person might end up taking both DiaBeta (or another brand of glyburide) and Lopid. The cholesterol drug can increase the blood-sugar-lowering power of DiaBeta, and the result may be hypoglycemia. This interaction could be troublesome.
If you must take both medications, monitor your blood sugar carefully and notify your doctor if it is low. The dose of DiaBeta may need to be adjusted. | Thomas J. Moore See book keywords and concepts | Zocor had prevented seventy-eight serious coronary events.21 While costs are high, so are the rewards. Zocor might have cost $30 million or more to test. But in 1996, Zocor produced more than $1 billion in revenue for Merck.22 The necessary long-term testing of drugs could be assured through several kinds of mechanisms. The long-term testing could be performed as a public or private enterprise. It could be paid for with tax dollars, with a 1 percent tax on drugs that required such testing, or with a tax levied directly on the companies that market these highly profitable products. |
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