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Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness

Tori Hudson, N.D.
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Considerable scientific research exists that demonstrates the effect of these natural therapies and interventions in lowering cholesterol, improving blood lipid ratios, lowering blood pressure, preventing clots and strokes, inhibiting fibrinogen, lowering homocysteine levels, strengthening the cardiac muscle, and preventing the oxidative damage to vessel walls, all of which are implicated in cardiovascular disease risk.

Sugar Shock!: How Sweets and Simple Carbs Can Derail Your Life-- and How YouCan Get Back on Track

Connie Bennett, C.H.H.C. with Stephen T. Sinatra, M.D.
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Ludwig, "Effects of an Ad Libitum Low-Glycemic Load Diet on cardiovascular disease risk Factors in Obese Young Adults." American Journal of Clinical Nutrition 81, no. 5 (2005): 976-82. Engeland, Anders, Tone Bjorge, Anne Johanne Sogaard, and Aage Tverdal. "Body Mass Index in Adolescence in Relation to Total Mortality: 32-Year Follow-Up of 227,000 Norwegian Boys and Girls." American Journal of Epidemiology 157 (2003): 517-23. http://aje.oupjournals.org/ cgi/content/full/157/6/517-FNI. Favero A., M. Parpinel, and M. Montella.

101 Foods That Could Save Your Life!

David W. Grotto, RD, LDN
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Balance of unsaturated fatty acids is important to a cholesterol-lowering diet: comparison of mid-oleic sunflower oil and olive oil on cardiovascular disease risk factors. ] Am Diet Assoc. 2005 Tul;105(7):1080-1086. Kapadia, GJ et al. Chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the Epstein-Barr virus early antigen activation assay and the mouse skin two-stage carcinogenesis. Pharmacol Res. 2002 Jun;45(6): 499-505. Sweet potatoes www.sweetpotato.org; www.cayam.com; www.ncsweetpotato.org Bohle K, Spiegelman D, Trichopoulou A, Katsouyanni K, Trichopoulos D.

PDR for Herbal Medicines, Fourth Edition

Thomson Healthcare, Inc.
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The findings suggest that soy protein supplements may offer an uncomplicated method for lowering cardiovascular disease risk (Hoie, 2005). An earlier, randomized, crossover study found that plasma and urinary isoflavone levels markedly increased with regular consumption of whole Soybean extracts in adults (23 men and 10 post-menopausal women). However, no overall differences in plasma lipids, blood pressure, or arterial compliance were identified as compared to the group consuming a control (dairy) diet.
CLINICAL TRIALS Cholesterol A Cochrane Database review identified 10 randomized placebo-controlled trials of apparent quality that examined the effect of consumption of wholegrain foods on cardiovascular disease risk factors and related illness and death in adults. A meta-analysis of these 10 trials showed lower total cholesterol (-0.20 mmol/L; p= 0.0001) and LDL cholesterol (0.18 mmol/ L, p<0.0001) resulting from consumption of oatmeal foods.

Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness

Tori Hudson, N.D.
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A more recent study showed that dietary fiber intake is inversely correlated with several cardiovascular disease risk factors. The highest total dietary fiber and nonsoluble dietary fiber (more than soluble) intakes from fruit, vegetables, and cereals were significantly associated with a decrease in a number of cardiovascular risk factors including overweight, hypertension, lipid markers, and homocysteine.87 Part of fiber's effect on lipids is because these higher fiber diets are in fact diets low in cholesterol intake.
And more recently, consumption of 15 grams (one drink) to 30 grams (two drinks) of alcohol per day by postmenopausal women was shown to improve lipid profiles and therefore decreased their cardiovascular disease risk.144 Alcohol tends to raise HDL cholesterol, which likely contributes to its cardio-protectiveness. Alcohol also has a beneficial effect on decreasing blood clotting. It is not clear whether there are any significant differences between red wine, white wine, liquor, and beer.

Sugar Shock!: How Sweets and Simple Carbs Can Derail Your Life-- and How YouCan Get Back on Track

Connie Bennett, C.H.H.C. with Stephen T. Sinatra, M.D.
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Prevalence of Impaired Fasting Glucose and Its Relationship with cardiovascular disease risk Factors in U.S. Adolescents." 1999-2000 Pediatrics 116, no. 5 (2005): 1122-26. http://pediatrics.aappublications.Org/cgi/content/abstract/116/5/1122. International Diabetes Federation. "Did You Know?" http://www.idf.org/home/index.cfm?node=37. Jacobson, Michael. "CSPI Applauds Agreement to Get High-Calorie Drinks Out of Schools; Drops Planned Litigation." http://cspinet.org/new/200605031.html. Johnson, Rachel K, and Carol Frary.

Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness

Tori Hudson, N.D.
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Lipoprotein(a) levels, an independent biomarker of cardiovascular disease risk, have also been reduced with 2 grams per day of L-carnitine, even in those with type 2 diabetes.253 In addition, some preliminary evidence suggests carnitine may be able to attenuate the muscular side effects of statin therapy.

The Science of Flavonoids

Erich Grotewold
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Soy protein, isoflavones and cardiovascular disease risk, J Nutr, 128: 1589- 1592. Lin, A, and Karin, M, 2003, NF-kappaB in cancer: a marked target, Semin Cancer Biol, 13: 107-114. Lin, J. K, 2002, Cancer chemoprevention by tea polyphenols through modulating signal transduction pathways, Arch Pharm Res 25: 561-571. Lin, J. K., Chen, P. C, Ho, C. T., and Lin-Shiau, S. Y., 2000, Inhibition of xanthine oxidase and suppression of intracellular reactive oxygen species in HL-60 cells by theaflavin-3,3'-digallate, (-)-epigallocatechin-3-gallate, and propyl gallate, J Agric Food Chem, 48: 2736-2743.

The Green Tea Book

Lester A. Mitscher and Victoria Toews
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Antioxidants show a great deal of promise in preventing the oxidation of LDL-cholesterol and thus reducing this cardiovascular disease risk factor.2 THE FRENCH PARADOX AND THE GREEN TEA CONNECTION The story of green tea and a healthy heart actually begins, not in Asia, but in France, with the French Paradox, the medical oddity that we discussed in Chapter 3.

Food Synergy: Unleash Hundreds of Powerful Healing Food Combinations to Fight Disease and Live Well

Elaine Magee
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ApoB levels are a marker for cardiovascular disease risk because ApoB measures small dense LDL particles, which are considered more harmful than normal LDL particles. It's possible that a low-saturated-fat diet also improves bone mineral density. A high-saturated-fat diet was associated with lower hip-bone mineral density in a recent Pennsylvania State University study that analyzed data from NHANES III (the Third National Health and Nutrition Examination Survey), including more than 14,000 men and women. The greatest difference was seen in men under 50 years old. Bone mineral density was 4.

Nutrition in the Prevention and Treatment of Disease

Ann M. Coulston and Carol J. Boushey
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The OEI Expert Panel identified many obesity-related comorbidities, including coronary heart disease and major cardiovascular disease risk factors, e.g., type 2 diabetes, hypertension, and dyslipoproteinemias (in particular, low high-density lipoprotein [HDL] cholesterol and elevated plasma triglycerides), as well as gallbladder disease, respiratory disease, certain cancers (colorectal and prostate, endometrial, cervical, and breast), and osteoarthritis [3].

What Your Doctor May Not Tell You About Diabetes: An Innovative Program to Prevent, Treat, and Beat This Controllable Disease

Steven V. Joyal
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Fiber and cardiovascular disease risk: How strong is the evidence? / Cardiovasc Nurs 2006 Jan-Feb; 21(l):3-8. Fatty fish consumption and ischemic heart disease mortality in older adults: The cardiovascular heart study. Presented at the American Heart Association's 41st annual conference on cardiovascular disease epidemiology and prevention. AHA 2001. Finot PA, Magnenat E. Metabolic transit of early and advanced Maillard products. Prog Food Nutr Sci 1981; 5 (1 -6): 193-207. Foster-Powell K et al. International table of glycemic index and glycemic load values: 2002. Am J Clin Nutr 76:5-56.
Given that insulin resistance is a major cardiovascular disease risk factor, should all patients with insulin resistance and type 2 diabetes be taking a cholesterol-lowering statin drug regardless of their cholesterol level? To get an answer to this question, read on.

There Is a Cure for Diabetes: The Tree of Life 21-Day+ Program

Gabriel Cousens
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C-REACTIVE PROTEIN (CRP) CRP is a pro-inflammatory cytokine that is a cardiovascular disease risk factor. The C-reactive protein reading indicates a degree of inflammation; it is determined by measuring the amount of a specific protein in the blood. Recent research suggests that patients with elevated levels of CRP are at increased risk for diabetes,17 hypertension, and cardiovascular disease. A study of more than 700 nurses showed that those in the highest quartile of trans fat consumption had blood levels of C-reactive protein that were 73 percent higher than those in the lowest quartile.
Diabetics with renal disease have a cardiovascular disease risk that is sevenfold higher than diabetics without renal disease. Mainly, it is our Culture of Death diet and lifestyle that create cardiovascular disease. This has been proven by Dr. Caldwell B. Esselstyn of the Cleveland Clinic. Dr. Esselstyn's study, published in the Journal of Family Practiced showed the reversal of cardiovascular disease with a 100 percent success rate among eighteen patients who followed a vegan diet with no cooked o*7.

Nutrition in the Prevention and Treatment of Disease

Ann M. Coulston and Carol J. Boushey
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Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the Look AHEAD trial. Diab. Care 30, 1374-1383. 52. Appel, L. J., Champagne, C. M., Harsha, D. W., Cooper, L. S., Obarzanek, E., Elmer, P. J., Stevens, V. J., Vollmer, W. M., Lin, P. H., Svetkey, L. P., Stedman, S. W., and Young, D. R. Writing Group of the PREMIER Collaborative Research Group (2003). Effects of the comprehensive lifestyle modification on blood pressure control: main results of the PREMIER clinical trial. JAMA 289, 2083-2093. 53. Bell, E. A., Castellanos, V. A.
Cardiovascular disease, selected cardiovascular disease risk factors, and age-related cataracts: the Beaver Dam Eye Study. Am. J. Ophthalmol. 123, 338-346. 19. Klein, B. E., Klein, R., Lee, K. E., and Meuer, S. M. (2003). Socioeconomic and lifestyle factors and the 10-year incidence of age-related cataracts. Am. J. Ophthalmol. 136, 506-512. 20. Christen, W. G, Glynn, R. J., Manson, J. E., Ajani, U. A., and Buring, J. E. (1996). A prospective study of cigarette smoking and risk of age-related macular degeneration in men. JAMA 276, 1147-1151. 21. Weintraub, J. M., Willett, W. C, Rosner, B.
For example, dietary modulation of enzymes involved in carcinogen metabolism may be important in reducing cancer risk, and dietary intervention that reduces expression of rate-limiting enzymes in cholesterol synthesis may alter cardiovascular disease risk. Enzymes that require micronutrients as cofactors are also used as biomarkers of nutritional status (Table 1). Components of diet have the capacity to modulate protein synthesis and function.

The Liver and Gallbladder Miracle Cleanse: An All-Natural, At-Home Flush to Purify and Rejuvenate Your Body

Andreas Moritz
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Be aware that HC is up to forty times more predictive than cholesterol in assessing cardiovascular disease risk. HC results from the normal metabolism of the amino acid methionine—which is abundant in red meat, milk, and dairy products. High concentrations of protein in the blood hinder the continuously required distribution of important nutrients, especially water, glucose, and oxygen, to the cells. Excessive amounts of proteins in the blood are also responsible for blood dehydration, that is blood thickening—one of the leading causes of high blood pressure and heart disease.

Nutrition in the Prevention and Treatment of Disease

Ann M. Coulston and Carol J. Boushey
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Effects of the National Cholesterol Education Program's Step I and Step II dietary intervention programs on cardiovascular disease risk factors: a meta-analysis. Am. J. Clin. Nutr. 69, 632-646. 34. Heini, A. F., and Weinsier, R. L. (1997). Divergent trends in obesity and fat intake patterns: The American paradox. Am. J. Med. 102, 259-264. 35. Ogden, C. L., Carroll, M. D., Curtin, L. R., McDowell, M. A., Tabak, C. J., and Flegal, K. M. (2006). Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 295, 1549-1555. 36. Wing, R. R., and Hill, J. O. (2001).

Prescription for Nutritional Healing, 4th Edition: A Practical A-to-Z Reference to Drug-Free Remedies Using Vitamins, Minerals, Herbs & Food Supplements

Phyllis A. Balch, CNC
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The mechanisms responsible for omega-3 fatty acids' reduction of cardiovascular disease risk are still being studied. However, it appears that benefits include decreases in triglyceride levels and blood clots, lower risk of sudden death, improved arterial health, and lower blood pressure. Q The largest women's health study ever done, the Women's Health Initiative, had 162,000 participants.

Fundamentals of Naturopathic Endocrinology

Michael Friedman, ND
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Because of the relationship between central adiposity and insulin resistance and because of the correlation between insulin resistance and increased cardiovascular disease risk, it has been suggested that health care providers should begin using waist measurements as a public health tool in screening for high-risk candidates for cardiovascular disease.22 Table 1: Some Metabolic Associations with Insulin Resistance þ Leptin resistance23.

Health and Nutrition Secrets

Russell L. Blaylock, M.D.
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They offer a series of tests that measures markers for cardiovascular disease risk. Each of these tests indicates either an independent risk or a combined risk. For example, if both your LDL cholesterol and C-reactive protein are increased, you have a much greater risk of heart disease than if either one was elevated alone. All of these tests are available with the Comprehensive Cardiovascular Assessment. Blood Lipids This test measures the circulating levels of the major lipid (fats) in the blood stream.

What Your Doctor May Not Tell You About Diabetes: An Innovative Program to Prevent, Treat, and Beat This Controllable Disease

Steven V. Joyal
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Inuit of Nunavik. Am J Clin Nutr 2001 Oct; 74(4):464-73. Dewailly E. Fish consumption and blood lipids in three ethnic groups of Quebec (Canada). Lipids 2003 Apr; 38(4):359-65. Dincer Y et al. Effect of oxidative stress on glutathione pathway in red blood cells from patients with insulin-dependent diabetes mellitus. Metabolism 2002 Oct; 51(10):1360-62. Doggrell SA. Alpha-lipoic acid, an anti-obesity agent? Expert Opin InvestigDrugs 2004 Dec; 13(12):l64l-43. Dulloo AG et al.

Nutrition in the Prevention and Treatment of Disease

Ann M. Coulston and Carol J. Boushey
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SU.VI.MAX. study [57-60]. Dietary intakes were estimated using six 24-hour dietary records collected during the course of 1 year. In women, flavonoid-rich food consumption was associated with decreased systolic blood pressure and a decreased risk for CVD; this relationship was not observed in men. The lack of an effect in men could be attributed to the men's higher risk for CVD; inconsistencies in dietary reporting and measuring of flavonoid consumption also could contribute to this discrepancy. However, this study found that, after 7.

Fundamentals of Naturopathic Endocrinology

Michael Friedman, ND
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Effect of chromium nicotinic acid supplementation on selected cardiovascular disease risk factors. Biol Trace Elem Res 1996;55:297-305. 125. Offenbacher EG, Pi-Sunyer FX. Beneficial effect of chromium-rich yeast on glucose tolerance and blood lipids in elderly subjects. Diabetes 1980;29:919-25. 126. Riales R, Albrink MJ. Effect of chromium chloride supplementation on glucose tolerance and serum lipids including high-density lipoprotein of adult men. AmJ Clin Nutr 1981;34:2670-78. 127. Anderson RA, Polansky MM. Bryden NA, CanaryJJ.

The Natural Pharmacy: Complete A-Z Reference to Natural Treatments for Common Health Conditions

Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D.
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Lifestyle changes that may be helpful Both smoking20 and exposure to secondhand smoke21 increase cardiovascular disease risk. Moderate exercise protects both lean and obese (page 446) individuals from cardiovascular disease.22 CARPAL TUNNEL SYNDROME Carpal tunnel syndrome (CTS) is a condition characterized by pain, tingling, and numbness into the areas of the fingers, hand, and sometimes radiating up into the elbow. The painful sensations of CTS are caused by compression of the median nerve in the tunnel of bones in the wrist.
A double-blind trial showed that a diet high in monounsatutated fatty acids from olive oil, lowers cardiovascular disease risk by 25%, as compared with a 12% decrease from a low-fat (25% fat) diet.93 The trial also found that low-fat diets decrease HDL cholesterol by 4%, which is undesirable, since HDL cholesterol is protective against heart disease. Diets high in monounsaturated fatty acids from olive oil do not adversely affect HDL levels.

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