Gabriel Cousens
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 Microwaving prepared meats sufficiently to ensure sanitary ingestion caused formation of d-Nitrosodienthanolamines, a well-known carcinogen.
?Microwaving milk and cereal grains converted some of their amino acids into carcinogens. Thawing frozen fruits converted their glucoside and galactoside containing fractions into carcinogenic substances.
?Extremely short exposure of raw, cooked, or frozen vegetables converted their plant alkaloids into carcinogens.
?Carcinogenic free radicals were formed in microwaved plants, especially root vegetables. |
David Steinman
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 The evidence that incriminates 1,4-dioxane as a carcinogen is substantial. According to National Toxicology Program studies, the chemical has induced cancer in both sexes of rats and both sexes of mice.27 "There is sufficient evidence for the carcinogenicity of 1,4-dioxane in experimental animals," notes the most recent Eleventh Annual Report on Carcinogens, published by the U.S. Department of Health and Human Services, National Toxicology Program.28 The report notes that the U.S. |
Ray D. Strand
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 Cigarette smoke is the most potent carcinogen to which many of us are exposed. Though nicotine is terribly addictive, we must struggle to rid the body of it and all the carcinogens contained in cigarette smoke. Smokers show a tremendous increase in the number of free radicals in their bodies.' And though to a lesser extent, secondary smoke is also an important factor in oxidative stress.10
2. Reduce Your Exposure to Sunlight. UVA and UVB ultraviolet light is a well-known carcinogen. I strongly recommend using sunscreen that protects against both. It's a discipline you can't live without. |
Joerg Gruenwald, Ph.D.
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 TPA is a carcinogen, affecting prostaglandin metabolism.
INDICATIONS AND USAGE
At present, it is used only in Chinese medicine and in very small doses as a remedy for gallbladder colic, obstruction of the bowels and malaria.
PRECAUTIONS AND ADVERSE REACTIONS
The phorbol esters of the oils are severe cocarcinogenics. Therapeutic uses as well as skin or mucous membrane contacts with the drug are to be strictly avoided. The drug possesses acute toxicity. When applied to the skin, it brings about itching, burning, and after a time blisters. |
Gary Null
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 What most of us may not realize is that exposure to several so-called weak carcinogens may be more dangerous than exposure to one very strong carcinogen.
For example, let's say that each day you eat bacon or luncheon meats preserved and colored with sodium nitrite, a possible carcinogenic agent. And you also have several cups of coffee throughout the day, all sweetened with an artificial sweetener containing saccharin, another known carcinogen. At the same time, you are taking a prescription drug twice daily that is on the government's list of "suspected" carcinogens. |
Gary Null
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| The more of a carcinogen present in the human environment, hence the greater the exposure to it, the greater is the chance of developing cancer from it.
3. Although environmental carcinogens are the predominant causes of human cancer, the incidence of cancer in any population of animals or humans exposed to a carcinogen may be influenced by a variety of factors.
4. There is no known method for measuring or predicting a "safe" level of exposure to any carcinogen below which cancer will not result in an individual or population group.3
CANCER IS CAUSED BY CHEMICALS
Even though Dr. |
Mike Adams, the Health Ranger
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 Propylene oxide is a genotoxic chemical and is listed as a possible carcinogen by the International Agency on Cancer Research. In lab experiments, the chemical leads to gene mutation, DNA strand breaks, and neoplastic cell transformation. It is listed as a "possible" carcinogen because no long-term studies have been done with humans. Its use for treating food for human consumption is banned in the European Union, Canada, Mexico, and most other countries. |
David W. Grotto, RD, LDN
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 Mechanisms by which garlic and allyl sulfur compounds suppress carcinogen bioactivation. Garlic and carcinogenesis. Adv Exp Med Biol 492: 69-81.
Milner, JA. A historical perspective on garlic and cancer. /. Nutrition. 2001. 131: 1027S-1031S.
Steiner M, Lin RS. Changes in platelet function and susceptibility of lipoproteins to oxidation associated with administration of aged garlic extract. / Cardiovasc Pharmacol. 1998;31:904-908.
Ginger www.mayoclinic.com/heaIth/ginger/NS_patient-ginger; www.umm.edu/altmed/consherbs/gingerch.html#overview
Altman RD and Marcussen KC. |
Muhammed Majeed, Ph.D. Vladimir Badmaev, M.D., Ph.D. Uma Shivakumar, Ph.D. R. Rajendran, M.S.
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| Their possible modes of action are outlined below:
Known Sites of Action of Curcumin in Prevention of Chemically-Induced Carcinogenesis in Experimental Animals
Procarcinogen
Inhibition of Cytochrome 450 Increase GSH transferase and Detoxification Process Excretion of Procarcinogen
Direct-acting Carcinogen
Direct binding to carcinogen and inactivation
Replication of cells with changed genetic material
Fixation of mutation
Inhibition of tumor promotion
Cancer
—? |
Bill Sardi
See book keywords and concepts |
 International Journal Cancer 78: 720, 1998]
Growth Years
Years of Fertility
Change of Life
Males
High iron needs
Markedly lower iron needs
Lower iron needs
Females
High iron needs
High iron needs (unless hysterectomy)
Markedly lower iron needs
Iron and breast cancer
The injection of iron into breast tissue exposed to a toxic carcinogen doubles the frequency of tumors observed in rats. Tumors in iron-injected rats were also larger. [Carcinogenesis 18: 1757, 1997]
Japanese researchers have found that progesterone increases the serum iron levels among breast cancer patients. |
Stacy Malkan
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 Now we know: the chemical poisons that run through rivers, fish and polar bears are running through the umbilical cord to our children. The carcinogen in the baby shampoo can't be separated from the carcinogens in the food and the air, just as the polluting chemical plants aren't separate from the leaching trash dumps at the end of the line; they aren't separate from the skyrocketing asthma rates or the chemo parties in the brand-new children's cancer ward.
The story of chemistry also brings us to the threshold of new possibilities. |
Ann M. Coulston and Carol J. Boushey
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 This overview is provided to give some sense of the developing understanding.
A. carcinogen Metabolism
There is quite consistent epidemiologic evidence that alcohol consumption is associated with a moderate increase in breast cancer risk [42]. While there are several possible mechanisms to explain these observations, there is also some evidence that the mechanism of this association involves gene-environment interactions in carcinogen metabolism. |
Devra Davis
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 They aren't the only ones suggesting that electromagnetic fields be considered a possible human carcinogen. The World Health Organization officially recommends that power line siting decisions should consider ways to lower exposures and keep people out of the line of high voltage electricity and has classified EMF as a possible human carcinogen as has the U.S. National Institute of Environmental Health Sciences.15
The debate over electromagnetic fields and cell phones takes place on a playing field that is not at all level. |
Jonny Bowden, Ph.D., C.N.S.
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 They do this by reducing their poisonous effects and stimulating the release of "carcinogen killers," speeding up their removal from the body. Studies have shown that isothiocyanates help prevent lung and esophageal cancer and can lower the risk of other cancers, including gastrointestinal cancer. Several isothiocyanates have been shown to inhibit tumors induced by chemical carcinogens. Broccoli in particular contains a potent isothio-cyanate that is an inhibitor of mammary tumors.
Why Women Should Eat More Broccoli
The anticancer properties of broccoli are well established. |
Thomson Healthcare, Inc.
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| Chemoprotective Effects: Biochanin A, a major active compound isolated from Red Clover extract, inhibited carcinogen benzo(a)pyrene activation in cell cultures. Chemoprotective action is attributed to the ability of biochanin A to inhibit the metabolism of the carcinogen and the extent of its binding to DNA (Cassady et al, 1988).
Estrogenic Effects: Red Clover extract stimulated cell proliferation of estrogen receptor-positive breast cancer cells in vitro. Red Clover extract acts as an estrogen agonist by binding to intracellular estradiol receptors. |
Lester A. Mitscher and Victoria Toews
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 Cancer researchers have concluded that the cytochrome P450 enzymes in the liver "potentiate" NNK by oxidizing it, making it an activated carcinogen. The fact that lung cancer mortality rates are lower in Japan than in the United States, even though Japanese men are twice as likely to smoke as American men, is consistent with the view that lifestyle factors or diet inhibit the activation of tobacco carcinogens.
Experiments on animals indicate that the polyphenols in green tea ameliorate the damage caused by NNK. When mice are treated with NNK they develop an average of 22. |
Mark Schapiro
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 In 1989, the EPA declared a ban on what amounted to more than 90 percent of all uses of asbestos, which it classified as a "known carcinogen." But industry challenged the agency and in 1991 a federal court vacated the ban, asserting that the EPA had not met TSCA's requirements for proof of harm balanced against the benefits of asbestos, and had not demonstrated that the ban was the "least burdensome alternative" for eliminating the "unreasonable risk" of exposure to the carcinogenic substance. |
Committee on Comparative Toxicity of Naturally Occurring Carcinogens
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 Population carcinogen Average High Consumers'1
Synthetic
Pesticide residues DDD, DDE, and DDD
1954 (DDE and
DDT) 1965
Early 1980's Ethylene thiourea Unsymmetrical dimethyl hydrazine
Packaging migrants Diethylhexyl-phthalate 1982 report 1991 report
0.1
0.02
0.001
0.0009; 0.003 0.014
0.07 0.003
Environmental contaminants
TCDD equivalents 0.01-0.04 Polychlorinated biphenyls 0.2
Intentional food additives Butylated hydroxyanisole 0.002-0.007 Potassium bromate
Saccharin 0.002
1
0.1 (average intake, non-nursing infant)
0.02
0.9 (nursing infant) 3
0.005-0.015
0.004 0.008-0. |
Paula Begoun
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 Hazardous Substances Data Bank, National Library of Medicine, "Lead Acetate," June 12, 2000; and National Toxicology Program, "10th Report on Carcinogens, Reasonably Anticipated to be a Human carcinogen," http://ntp-server.niehs.nih.gov/ NewHomeRoc/AboutRoC.html.)
Aside from the health issues, when it comes to creating a desirable hair color, far better options are available in traditional demi or permanent dye products than in shampoo-in type products aimed at men. |
| Regrettably, coal tar is a controversial ingredient for dandruff control because there is evidence that in large concentrations it can be a carcinogen, particularly for causing skin, lung, and scrotum cancer. However, there is no research showing that the use of coal tar in dandruff shampoos has this effect. The research showing coal tar to be a possible carcinogen was from studies carried out in industrial settings where workers were exposed to concentrated solutions over long periods of time (20 to 25 years) and from studies on animals. |
Michael T. Murray, N.D., Joseph E. Pizzorno, N.D.
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 Curcumin has been found to inhibit carcinogens, such as benzopyrene (the carcinogen found in charcoal-broiled meat), from inducing cancer in several animal studies. It appears that the curcumin exerts its anticarcinogenic activity by lowering the activation of carcinogens while increasing the detoxification of those that are activated. Curcumin has also been shown to directly inhibit the growth of cancer cells.37
We recommend eating a lot of curries (turmeric is the key component of curry) to smokers and people exposed to a lot of secondhand smoke. |
Mark Schapiro
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| He cited one example: that of dibutyl phthalate (DBP), a plastic additive in the company's Cover Girl nail polish that the European Commission put on the negative list as a potential carcinogen. In 2006, the company removed the substance from its nail polishes in Europe but not in the United States. Just as it reconfigured the strength of detergent to satisfy different consumer desires, cosmetic products were being formulated differently to meet the needs, said Long, "of different national regulations. |
Committee on Comparative Toxicity of Naturally Occurring Carcinogens
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| Note that the TDS0 is inversely related to potency, in the sense that the more potent the carcinogen, the lower the TDS0. Thus, once the dose-
Table 5-4 Predicted Daily Intake Levels of Selected Naturally Occurring Car-cinogens in the Diet_
Daily Intake (ug/kg-bw/day)
U.S. Population
Average High Consumers
Constitutive
Caffeic acid Food
Coffee"
Derived PhIPb
Urethane Food0 Alcohold
20-200 200-2,000
8-methoxypsoralen(xantho- 0.5 toxin)
0.017
(0.003-0.085) <0.02
0.001-0.003
N-nitrosodimethylamine
Foodc 0.001-0.003
Beer' 1990 0.00005-0.0001
1980 0. |
Mike Adams, the Health Ranger
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 It is either acting as a co-carcinogen or a primary carcinogen. Most likely, it's the formaldehyde breakdown product.
What the Italian study found is that if you take these same animals and expose them to formaldehyde in the same doses, they developed the same leukemias and lymphomas. If you look back at the Troker Study conducted in Spain a couple of years ago, what they found was when they radiolabeled the aspartame, they could actually see formaldehyde binding to the DNA, and it produced both single and double strand DNA breakage. |
Committee on Comparative Toxicity of Naturally Occurring Carcinogens
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| They demonstrated that uncertainty surrounding the values of the model parameters implied considerable uncertainty in tissue doses of the proximate carcinogen. Similar analyses have been conducted by Farrar et al. (1989), Bois et al. (1990), and Hetrick et al. (1991). Methods for uncertainty analysis are described in a recent text by Morgan and Henrion (1990).
Krewski et al. (1995) proposed a general methodology for analyzing uncertainty, variability, and sensitivity in physiologically based pharmacokinetic models. |
Mike Adams
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 Here's what it has to say about nitrosamines: (I bold the important sections):
N-nitrosodimethylamine has been identified by IARC (1978) and NTP (1994) as an animal carcinogen. There is sufficient evidence to indicate the carcinogenicity of N-nitrosodimethylamine in several experimental animal species (IARC 1978). When administered orally, it induced liver hemangiosarcomas, hepatocellular carcinomas, and kidney and lung tumors in mice (Takayama and Oota 1963, 1965; Terracini et al. 1966; Toth etal. 1964; Clapp etal. 1968, 1971; Den Engelse etal. |
Mark Schapiro
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| Formaldehyde is a "known carcinogen," according to the International Agency for Research on Cancer, and a contributor to asthma in young children and respiratory problems in adults, according to the Harvard School of Public Health and other research centers. In the spring of 2006 a timber company in Oregon, Columbia Forest Products, conducted tests of imported Chinese birch planks that it had purchased at a Home
Depot (such tests are not done by the U.S. government, thus our primary information on such matters comes from the private sector or NGOs). |
Committee on Comparative Toxicity of Naturally Occurring Carcinogens
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| Guidelines for carcinogen risk assessment. Fed. Reg. 51:33992-34003
EPA (U.S. Environmental Protection Agency). 1986b. Guidelines for the Health Risk Assessment for Chemical Mixtures. Federal Register 51(185):34014-34025.
EPA (U.S. Environmental Protection Agency). 1989a. Ethylene bisdithiocarbamates; Notice of Preliminary Determination to Cancel Certain Registrations, Notice of Availability of Technical Support Document and Draft Notice of Intent to Cancel. Federal Register 54(243):52158-52185.
EPA (U.S. Environmental Protection Agency). 1989b. |
| N-Nitrosodimethylamine
N-nitrosodimethylamine is a derived naturally occurring carcinogen present in a variety of foods, including cheese, soybean oil, canned fruit, various meat products and cured meats, bacon, frankfurters, ham (cooked), fish and fish products, apple brandy, other alcoholic beverages, and beer. Concentrations in these foodstuffs have been measured to be between 0 and 85 ng/kg. Levels of N-nitrosodimethylamine in various foods from several countries, including the United States, have been reported by IARC (1978). |
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