Cancer genes

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You Don't Have to be Afraid of Cancer Anymore Bill Sardi See book keywords and concepts

A report written by the Council for Responsible Genetics states: "Until we have effective prevention strategies, tests for variants of so-called 'cancer genes' benefit mainly the companies that market them, who stand to make huge profits by exploiting women's justifiable fear of cancer." [Council for Responsible Genetics] Furthermore, is the test always accurate? The widely used genetic test can miss mutations that provoke breast cancer. The test, which detects mutations in genes called BRCA1 and BRCA2, will fail to detect the mutation in about 12% of women tested.

101 Foods That Could Save Your Life! David W. Grotto, RD, LDN See book keywords and concepts

PROSTATE: In vivo and in vitro studies have shown that curcumin reduces the expression of prostate cancer genes, tumor volume and quantity of nodules in treated groups. COLON CANCER: In a small study, patients who had precancerous polyps were treated with curcumin for six months. The average number of polyps dropped sixty percent, and the average size dropped by fifty percent. HEART HEALTH: Rats who were fed higher doses of curcumin in their diet had significantly lower liver triacylglycerols and very-low-density lipoprotein (VLDL) cholesterol.

This study showed that what we eat can influence cancer genes. Several other studies support this direction for further investigation into breast cancer. Researchers have seen that the chemical sulforaphane, found in cruciferous vegetables like cauliflower, stopped lung cancer cells in an animal trial, and helped kill off and stop the growth of prostate cancer cells in a test tube study on human cells. RHEUMATOID ARTHRITIS: Researchers who followed a group of older women for over ten years found that those who consumed more cruciferous vegetables had a decreased risk of rheumatoid arthritis.

You Don't Have to be Afraid of Cancer Anymore Bill Sardi See book keywords and concepts

Resveratrol can put cancer genes to sleep. Hundreds of genes that are required for tumor cells to divide and replicate can be shut off. One cancer researcher described the ability of resveratrol to influence gene-controlled tumor growth as a "biologically specific tsunami."[Cancer Biology Therapy 3:889-90, 2004] Natural compounds from plants like resveratrol address whole mechanisms and sets of pathways that interfere with tumors rather than single enzyme inhibition accomplished through the use of synthetic drugs. "Natural compounds (like resveratrol) .........

Breast cancer genes, Myths & Facts] All women have BRCA1 and BRCA2 genes. Mutations in these genes increase the risk for breast cancer. It is misleading to say that there is about an 80% lifetime risk for breast cancer if there are mutations in the BRCA genes. This misstatement is used to sell women on the idea of mastectomy (breast removal). [Journal of the National Cancer Institute, November 7, 93:1585, 2001 ] Mutations in the BRCA gene do not necessarily result in breast cancer. Colin B.

That is, the gene-controlled mutations that lead to cancer do not become evident for decades. cancer genes simply increase the likelihood of developing this disease. [Seminars Cancer Biology 7: 49-53, 1996] For instance, the genes linked to ovarian cancer (BRCA1), colon cancer (hMSH2 and hMLHl), and melanoma (MLM) confer a higher lifetime risk for cancer, but represent less than 5% of these types of cancer.

Though often relegated to preventing weight loss (wasting) during the progression of cancer, it has now been found that certain foods, spices and herbs can switch cancer genes off. Readers of this book may not initially be ready to go where this book leads. But it may at least alter their thinking and cause cancer patients to adopt a plan that has more chance of success than conventional cancer treatment does today. This book signals a new day in cancer care, one where patients will play a more prominent role, if given proper guidance.

While a revolution is underway in natural cancer remedies, backed by solid science, alternative medicine clings to archaic cancer treatments of the past, seemingly oblivious to the fact we now live in an era of genetic medicine where foods and dietary supplements can switch cancer genes off better than any prescription medicine. For the first time in history, cancer patients have more powerful molecules at their direct disposal than any therapies pharmaceutical companies could even think of developing.

Grocery Warning: How to recognize and avoid the groceries that cause cancer, diabetes, heart disease, high cholesterol, high blood pressure, and other common diseases Mike Adams See book keywords and concepts

It interieres with enzymes that "breed" cancer genes, cuts off the blood vessels that act as supply lines to developing cancers, stunts the growth of cancer cells. At the same time that genistein is stopping cancer cells, it also stops the growth of cells that can clog arteries, scavenging the free radicals that oxidize LDL cholesterol, the bad cholesterol. That makes soy an antidote to artery deterioration; some documented studies even conclude that it helps rejuvenate old arteries. - Stephanie Beling, M.D.

The Biology Of Belief: Unleashing The Power Of Consciousness, Matter And Miracles Bruce H. Lipton See book keywords and concepts

Willett 2002] While the media made a big hoopla over the discovery of the BRCA1 and BRCA2 breast cancer genes, they failed to emphasize that ninety-five percent of breast cancers are not due to inherited genes. The malignancies in a significant number of cancer patients are derived from environmentally-induced epigenetic alterations and not defective genes.

Health and Nutrition Secrets Russell L. Blaylock, M.D. See book keywords and concepts

We know that constant bombardment of the DNA by free radicals leads to the eventual activation of cancer genes (oncogenes). Once these genes are activated, cancer is inevitable. As with nervous system disease, cancer risk in the face of high MSG and aspartame consumption would be highest in persons possessing a genetic propensity for cancer. For example, a women with a strong family history of breast cancer or ovarian cancer would be at a much higher risk than a women with no such history. (Interestingly, the ovaries also contain glutamate receptors.

The reason for this delay is that the switching on of cancer genes (oncogenes) has to occur in a certain sequence and involves numerous genes. This polyge-netic basis of disease occurs in many diseases including hypertension, diabetes, lipid disorders, gout, arthritis, osteoporosis, and polycystic ovaries. Each gene contributes a small part of the puzzle that eventually results in the disease. If a piece is missing, the disease may not fully develop.

Anti-Aging Manual: The Encyclopedia of Natural Health Joseph E. Mario See book keywords and concepts

Protease-Inhibitors in Chickpeas (most effective), Soybeans, Beans, Rice, Sweet Potato, and Seeds may allow cells to dedifferentiate to normal in colon and other cancer s ites, inhibit cancer genes, block or reverse DNA mutations, protect from radiation and pollution damage, protect from protein-splitting protease enzymes; inhibit early- and late-stage cancers of the mouth, esophagus, breast, lung, pancreas, and colon (one 8 oz. bottle Haelen fermented Soybean concentrate daily for 60 days).

Prescription for Nutritional Healing, 4th Edition: A Practical A-to-Z Reference to Drug-Free Remedies Using Vitamins, Minerals, Herbs & Food Supplements Phyllis A. Balch, CNC See book keywords and concepts

With the discovery of two "breast cancer genes" (BRCA1 and BRCA2), gene therapy is receiving more attention. This research is still in its infancy and much more investigation in this area needs to be done. Q Biopsies that are less invasive now can be done using a fine needle aspiration (removing cells from a breast lump) and stereotactic core biopsies (which uses a bigger needle that a computer guides to remove suspicious tissue seen on a mammogram).

Health and Nutrition Secrets Russell L. Blaylock, M.D. See book keywords and concepts

Certain vitamins and plant chemicals, called phytochemicals, can inhibit the activation of these cancer genes, and prevent a gene's instruction from reaching its destination in the cell's mechanism. This is how genes influence the function of cells, by ordering the secretion of special signaling molecules that instruct enzymes, for instance, to build a special protein that will promote the growth and spread of the cancer. Or in another instance, it will turn off a gene's instructions, preventing the information transcription.

The New Optimum Nutrition Bible Patrick Holford See book keywords and concepts

Even people with "cancer genes," such as the BCRA1 gene for breast cancer, won't develop cancer without the environmental insults that tip the scales from healthy into abnormal cell growth. Other risk factors include hormonal imbalance, often induced by exposure to hormone-disrupting chemicals such as HRT, exposure to radiation or ultraviolet light, pollution, food additives, drugs, and infections. However, of all risk factors diet is the greatest, a fact that is backed up by the great progress being made in both the treatment and the prevention of cancer with nutritional therapy.

Disease Prevention and Treatment The Life Extension Editorial Staff See book keywords and concepts

Its connection to cancer is now under intense scrutiny because methylation acts as a switch to activate or deactivate cancer genes (Momparlier et al. 2001; Sasaki et al. 2001). Cancer is fundamentally cellular growth gone wild. It can involve any organ of the body, but the one factor cancers have in common is that they are made of wildly proliferating cells. Normal cells replicate themselves, then stop. Cancer cells race through all normal checkpoints of cellular growth without stopping, and they cease to communicate with other cells.

Herbal Medicine, Healing and Cancer: A Comprehensive Program for Prevention and Treatment Donald R. Yance, j r.,C.N., M.H., A.H.G., with Arlene Valentine See book keywords and concepts

Folic Acid and Vitamin B12 Folic acid and vitamin B12 appear to aid in a process that turns cancer genes off by helping transfer methyl groups and their metabolism. When the process, called methylation, doesn't work, as is the case in alcohol abuse, or if the person is on the chemo drug methotrexate, cancer genes produce proteins that may cause cells to proliferate. A methyl-group-deficient diet leading to hypomethylation of DNA and RNA can promote cancer in the liver. A significant body of information suggests that a deficiency of vitamin Bi2 can enhance the activity of various carcinogens.

Disease Prevention and Treatment The Life Extension Editorial Staff See book keywords and concepts

The study suggests that arsenic-induced malignant transformation is linked to DNA hypomethylation subsequent to depletion of SAMe, potentially resulting in abereant gene activation, including cancer genes. Note: In methylation, a compound is derived from ethanol in which hydroxyl hydrogen is replaced by a metal. Gubrelay et al. (2001) conducted a study in mice to determine the role of SAMe to increase removal of cadmium from target organs by diethylenetriamine penta acetic acid (DTPA).

Herbal Medicine, Healing and Cancer: A Comprehensive Program for Prevention and Treatment Donald R. Yance, j r.,C.N., M.H., A.H.G., with Arlene Valentine See book keywords and concepts

Tumor-Suppressor Genes Another class of cancer genes are the previously mentioned tumor-suppressor genes. Mutations that knock out tumor-suppressor genes are more threatening than the activation of oncogenes, previously thought to be the most important genetic cause of cancer. Mutations in tumor-suppressor genes should be viewed as markers for tumor susceptibility. The most common genetic mutation that occurs in human cancers is in the tumor-suppressor gene p53.

Alternative Cures: The Most Effective Natural Home Remedies for 160 Health Problems Bill Gottlieb See book keywords and concepts

The protective factor in pizza may be a pigment in tomatoes called lycopene, which blocks free radicals, strengthens the immune system, and may help regulate cancer genes. Lycopene is a type of phytochemical, an anti-disease compound in food. It is also found in red grapefruit. Robert Rountree, M.D., cofounder of the Helios Health Center in Boulder, Colorado, "prescribes" a teaspoon a day of tomato paste for his patients with prostate cancer. "Lycopene has more potent antioxidant properties than beta-carotene, and it has anti-cancer properties," he says.

PowerFoods: Good Food, Good Health with Phytochemicals, Nature's Own Energy Boosters Stephanie Beling See book keywords and concepts

It interferes with enzymes that "breed" cancer genes, cuts off the blood vessels that act as supply lines to developing cancers, stunts the growth of cancer cells. At the same time that genistein is stopping cancer cells, it also stops the growth of cells that can clog arteries, scavenging the free radicals that oxidize LDL cholesterol, the bad cholesterol.That makes soy an antidote to artery deterioration; some documented studies even conclude that it helps rejuvenate old arteries.

Health in the 21st Century: Will Doctors Survive? Francisco, M.D. Contreras See book keywords and concepts

Researcher Edward Giovannucci, Harvard Medical School, thinks folic acid may help turn off cancer genes. Giovannucci's team discovered that a high intake of folic acid, from fresh vegetables and fruit and vitamin supplements, lowered the risk of tumor development. Other research shows folic acid directs the growth of new cells in the body. A shortage or lack of this nutrient may contribute to improper or abnormal cell formation. We now know that a lack of folic acid in early stages of pregnancy increases the chances of birth defects. Who are we going to believe?

Living Downstream Sandra Steingraber See book keywords and concepts

Finding "cancer genes" is not going to prevent the vast majority of cancers that develop. Moreover, even when rare, inherited mutations play a role in the development of a particular cancer, environmental influences are inescapably involved as well. Genetic risks are not exclusive of environmental risks. Indeed, the direct consequence of some of these damaging mutations is that people become even more sensitive to environmental carcinogens. In the case of hereditary colon cancer, for example, what is passed down the generations is a faulty DNA repair gene.

Somehow, Jeannie has managed to finish writing two articles, one about the search for cancer genes and another on breast cancer prevention for a British medical text. Feeling triumphant, she is in the mood to talk about cancer—but not her own. "You remind me of Rachel Carson," I laugh. We talk all the way to the ocean and back. Silent Spring is remembered for the birds. When I ask people to name words, phrases, or images that Rachel Carson's book evokes for them, "thin eggshells" is among the most frequent responses.

Permanent Remissions Robert Hass, M.S. See book keywords and concepts

The known breast cancer genes, including the recently discovered BRACl and BRAC2 genes, account for perhaps only 5%-10% of all cases. What, then, accounts for the steady rise in the number of women with breast cancer over the years? A number of cancer researchers believe that environmental toxins (xenoestrogens) mimic the action of estrogen produced in the body or at least alter the hormone's activity.

The Truth About Hormone Replacement Therapy: How to Break fee from the Medical Myths of Menopause National Women's Health Network See book keywords and concepts

The risk of ovarian cancer for women with a mutation in breast cancer genes is not yet known, but estimates range from 16 to 44 percent.20 For these women, several respected researchers recommend preventative removal of the ovaries by age thirty-five, although this procedure isn't completely effective because some ovarian cells remain.21'22'23'24 ormone Replacement Is Necessary We support the use of estrogen by women whose ovaries are removed before age forty-five.

Living Downstream Sandra Steingraber See book keywords and concepts

Cancer incidence rates are not rising because we are suddenly sprouting new cancer genes. Rare, heritable genes that predispose their hosts to cancer by creating special susceptibilities to the effects of carcinogens have undoubtedly been with us for a long time. The ill effects of some of these genes might well be diminished by lowering the burden of environmental carcinogens to which we are all exposed. In a world free of aromatic amines, for example, being born a slow acety-lator would be a trivial issue, not a matter of grave consequence.

Herbal Medicine, Healing and Cancer: A Comprehensive Program for Prevention and Treatment Donald R. Yance, j r.,C.N., M.H., A.H.G., with Arlene Valentine See book keywords and concepts

When the process, called methylation, doesn't work, as is the case in alcohol abuse, or if the person is on the chemo drug methotrexate, cancer genes produce proteins that may cause cells to proliferate. A methyl-group-deficient diet leading to hypomethylation of DNA and RNA can promote cancer in the liver. A significant body of information suggests that a deficiency of vitamin Bi2 can enhance the activity of various carcinogens. Other studies also indicate a link between alterations of the intracellular metabolism of cobalamin (B12) and the increased growth of melanoma.

When Healing Becomes A Crime: The Amazing Story of the Hoxsey Cancer Clinics and the Return of Alternative Therapies Kenny Ausubel See book keywords and concepts

Both factors produce cancer genes called oncogenes, from the Greek onkos, meaning a lump or mass. Although organized medicine rejected any viral theory of cancer for the better part of this century, there is now credible data to indicate viral involvement in certain cancers. Some scientists go so far as to suggest that cancer may turn out to be a virally transmitted infectious disease like smallpox, bubonic plague, and others that were the primary cause of death in 1900.

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