Andreas Moritz See book keywords and concepts | All this is changing now since recent disclosure of flawed and bad research in medical journals, such as omitting crucial data concerning the arthritis drug Vioxx, or publishing two papers by the South Korean researcher Dr. Hwang Woo Suk, who fabricated evidence that he had cloned human cells.
"Journals have devolved into information-laundering operations for the pharmaceutical industry, say Dr. Richard Smith, the former editor of BMJ, the British medical journal, and Dr. Richard Horton, the editor of The Lancet, also based in Britain. | Dr. Timothy Scott See book keywords and concepts | In 1988 the top-selling arthritis drug in the world was Voltaren (diclofenac), a name most of you probably don't remember any more. It became the top-selling arthritis drug in the U.S. as well, thanks in part to the drug's promotion by the famous but retired baseball star, Mickey Mantle. Mantle made numerous television appearances during the year and casually mentioned that growing older brought some additional aches and pains, but, fortunately, Voltaren was available. | Donna Jackson Nakazawa See book keywords and concepts | These include Oren-cia, a rheumatoid arthritis drug new to the market that researchers hope will help lupus patients; LymphoStat-B, which has had some success in reducing lupus disease activity; and CellCept, a drug in use for organ-transplant recipients, now being tested in lupus patients with severe kidney disease—but which also carries an increased risk of lymphoma because of the way it suppresses the entire immune system.
I FELT LIKE A TICKING TIME BOMB
For many patients, that horse race is regrettably late out of the gate. | Mike Adams, the Health Ranger See article keywords and concepts | In this drug trial, which tested an experimental arthritis drug on volunteer patients, things went terribly wrong: After being injected with the anti-inflammatory drug TGN1412, patients began tearing their shirts off, screaming that their heads were going to explode. One patient's head swelled to triple its normal size, and patients were passing out, vomiting, or screaming in sheer terror.
Within minutes after the injections, patients were suffering from severe breathing attacks, convulsions and excruciating pain. As reported in The Sun, a U.K. | Andreas Moritz See book keywords and concepts | VIOXX, a leading arthritis drug, was withdrawn by its producer, Merck & Co, after evidence leaked out that its use doubled the risk of heart attack and stroke. [As per the end of 2007, Merck was faced with 4,200 state and federal Vioxx-related lawsuits pending across the U.S.] According to documentation, both the drug producer and the FDA knew of this risk since the mid-nineties. The result of this well-kept secret was that a minimum of 27,000 people suffered a heart attack or died because of it. | | Another arthritis drug, infliximab (Remicade), is on alert for causing cancer.
Amazingly, many people have been so blinded by clever advertising campaigns and brainwashing that they have no clue they are being methodically poisoned in order to support and sustain the most lucrative business in the world besides oil, the pharma-medical industry. An investigation made public by CNN on 26 September 2007 discovered that 56 million prescriptions each year are handed out by doctors for drugs that are not even approved by the FDA. Two percent of all prescription drugs in the U.S. | | According to a January 2005 report, the dangerous arthritis drug Vioxx apparently has killed over 135,000 people. Then consider the hundreds of OTCs, such as aspirin. This "harmless" drug increases the risk of potentially lethal internal bleeding; it also makes blood more likely to clot, not less!
And did you know that taking ibuprofen (Advil, Motrin) in combination with aspirin actually doubles your risk of death from heart-related causes! | | Take the example of the arthritis drug VIOXX, or other painkillers, including CLELEBREX, ALEVE, and BEXTRA. Isn't it astounding that these poisonous, expensive drugs could have passed all the supposedly rigorous, scientific safety tests and been sold to millions of unsuspecting arthritis sufferers, just to find out years later that they sharply increase the risk of heart attack and stroke? Could there be double standards for "rigorous testing" in the field of medical research, one for before and one for after introducing these drugs to the market? | Greg Critser See book keywords and concepts | The medical caveat came via Eli Lilly, which in the early 1980s introduced a novel arthritis drug named Oraflex. To distinguish it from others in a deeply competitive category, young executives in Lilly's marketing department decided on a new tack. In the past, companies might send out information kits to medical journals, trying to drum up some free trade coverage. But only physicians who actually flipped through their weekly periodicals saw those. | Leslie Taylor, ND See book keywords and concepts | If the constituents in chuchuhuasi responsible for inhibiting PKC can be synthesized, it is possible that a new arthritis drug will be developed. In the meantime, the natural bark of this important Amazon rainforest tree will continue to be an effective natural herbal remedy for arthritis, for adrenal support, and as an immune tonic—as it has been for centuries. It is best prepared as it has been traditionally: as an alcohol tincture or a decoction. | Joe Graedon and Teresa Graedon See book keywords and concepts | The arthritis drug Clinoril (sulindac) may be less likely to interact with beta-blockers, but no matter which arthritis drug is used, people taking an arthritis drug in combination with a beta-blocker will need to have blood pressure monitored frequently. If hypertension becomes a problem, the physician should adjust the dose of beta-blocker or reconsider treatment options. Symptoms of Beta-Blocker Undertreatment
Blood pressure may climb and heart symptoms might appear. Be alert for chest pain or palpitations and notify your doctor immediately. Monitor blood pressure carefully. | | Experts warn doctors to avoid this combination if possible. The arthritis drug Clinoril (sulindac) may be less likely to interact with beta-blockers, but no matter which arthritis drug is used, people taking an arthritis drug in combination with a beta-blocker will need to have blood pressure monitored frequently. If hypertension becomes a problem, the physician should adjust the dose of beta-blocker or reconsider treatment options. Symptoms of Beta-Blocker Undertreatment
Blood pressure may climb and heart symptoms might appear. | Mike Adams See book keywords and concepts | UT Southwestern Medical Center at Dallas
Rheumatoid arthritis drug raises cancer risk. Johnson 8c Johnson
Angiogenesis heart drugs may worsen heart conditions. Dartmouth Medical School
Antipsychotic drugs increase diabetes and heart disease risk for kids. Johns Hopkins Children's Center
Anti-psychotic medications may cause diabetes. Yale researchers, American Journal of Psychiatry
Vioxx blamed for 140,000 Americans' heart problems. U.S, Food and Drug Administration
Prozac doubles suicide risk. British Medical Journal
HRT increases stroke risk by 30%. | Joe Graedon and Teresa Graedon See book keywords and concepts | Experts warn doctors to avoid this combination if possible. The arthritis drug Clinoril (sulindac) may be less likely to interact with beta-blockers, but no matter which arthritis drug is used, people taking an arthritis drug in combination with a beta-blocker will need to have blood pressure monitored frequently. If hypertension becomes a problem, the physician should adjust the dose of beta-blocker or reconsider treatment options. Symptoms of Beta-Blocker Undertreatment
Blood pressure may climb and heart symptoms might appear. | Peter Rost See book keywords and concepts | The deal gave him Celebrex, a pain and arthritis drug for which Monsanto had signed a co-promotion deal with Pfizer, which meant that both companies would jointly sell this new drug.
The deal may also have sealed Pharmacia's fate, since Pfizer has a penchant for devouring companies when the products they co-promote start selling too well. This was a major factor in Pfizer's take-over of Warner-Lambert, which gave them Lipitor, a cholesterol-lowering agent that eventually created sales of $ 11 billion per year.
As I listened to Fred's voicemail, his stern message startled me. | Dr. Timothy Scott See book keywords and concepts | It became the top-selling arthritis drug in the U.S. as well, thanks in part to the drug's promotion by the famous but retired baseball star, Mickey Mantle. Mantle made numerous television appearances during the year and casually mentioned that growing older brought some additional aches and pains, but, fortunately, Voltaren was available. No one knew at the time that these appearances were bringing Mickey Mantle a substantial amount of money from CIBA-Geigy, the drug's manufacturer. | | Money Influences Drug Research and Drug Approval
Merck's arthritis drug Vioxx made front page news in 2004 when Merck announced it was going to remove the drug from the market because of concerns over increased cardiovascular risks. Most of the public still believes that the Vioxx-heart problem link was only discovered in 2004. The 2004 edition of the Physicians' Desk Reference24 (PDR), the compilation of
FDA-approved drug package inserts, makes it plain that the danger was known years before the drug was pulled from the market. | | During the clinical trials comparing Vioxx with its logical competitor, the previously top-selling arthritis drug Naproxen, Vioxx came out looking terrible with more than twice as many serious cardiovascular events (45) during 10/4 months of testing.25 Those 45 "events" in 10V4 months of use by 4,047 patients are just a little over a 1% chance of having a stroke or heart attack during less than one year of use. In small but legible print the PDR has been warning patients of this risk for years. | Jacky Law See book keywords and concepts | What they couldn't have known was the funding both she and the website took was from Immunex, the maker of the arthritis drug Enbrel. And when Lauren Bacall chatted about a friend who had gone blind from macular degeneration and been helped by Visudyne, she didn't think to mention that Novartis, the drug's manufacturer, had paid her a fee.
The extent of the fees is closely guarded information, but they are thought to be in the millions. The money spent has a global reach. | Marcia Angell, M.D. See book keywords and concepts | That happened in a clinical trial of the arthritis drug Celebrex. A study sponsored by the drug company that makes it, Pharmacia (since acquired by Pfizer), ostensibly showed that Celebrex caused fewer side effects than two older arthritis drugs. These results were published, along with a favorable editorial, in The Journal of the American Medical Association. Not until after publication did the editors learn that the results were based on only the first six months of a yearlong trial. When the entire trial was analyzed, there was no advantage to Celebrex. | Katharine Greider See book keywords and concepts | Makers of the new arthritis drug Vioxx spent $160 million pushing it to consumers in 2000, more advertising dollars than were dropped on Pepsi Cola, Budweiser beer, Nike shoes, or Campbell's soups. Vioxx sales shot up 360 percent.
The way industry spokespeople tell it, Americans should count themselves lucky—drug ads are educational, informing us about health conditions so we can seek appropriate treatment. "The bottom line is that direct-to-consumer advertising is good for patients and good for public health," says a PhRMA spokesman. | The Life Extension Editorial Staff See book keywords and concepts | Lodine XL (extended release form) is an arthritis drug approved by the FDA that interferes with COX-2 metabolic processes. The maximum dosage for Lodine is 1000 mg daily. The most convenient dosing schedule for the patient involves prescribing 2 Lodine XL 500-mg tablets in a single daily dose. As with any NSAID, extreme caution and physician supervision are necessary. The most common complaints associated with Lodine XL use relate to the gastrointestinal tract (PDR 2002). | Dharma Singh Khalsa, M.D. See book keywords and concepts | Gradually, however, it was replaced as an arthritis drug by synthetic anti-inflammatory steroids.
Pregnenolone also improves the transmission of impulses among neurons, and therefore has a positive effect upon memory and cognitive processing.
Many researchers believe that pregnenolone is the most powerful memory-enhancing hormone. Although only a limited number of studies and experiments have been done on its cognitive-enhancement properties, those that have been done support the efficacy of the substance. | Earl Mindell, R.Ph., Ph.D. See book keywords and concepts | The bark of this plant is being investigated as a potential arthritis drug by a leading pharmaceutical company. Chucuhuasi is included in formulas designed to enhance sports performance (it reduces muscle pain after a hard workout) and to treat arthritis.
Hercampure
This rainforest herb is being promoted as a cure for high cholesterol and obesity. It is reputed to speed up metabolism and to help the body burn fat more efficiendy, as well as to control appetite. Look for this herb in weight-loss formulas. | The Editors of Prevention Magazine Health Books See book keywords and concepts | These abnormalities have also been noted in people taking penicillamine, a rheumatoid arthritis drug. Dr. Prasad also believes that vegetarians and older people who don't eat much food, including meats, are often shortchanged on zinc. "Mild deficiency is much more common than most people realize," he says.
Tinnitus
Silencing the Ring
Susan J. Seidel, an otologist (hearing specialist) at the Greater Baltimore Medical Center, knows exactly how she developed the cicada-like chirp in her left ear. | Jean Carper See book keywords and concepts | Glucosamine also proved more effective than piroxi-cam, a popular European arthritis drug, in a 1994 study. Dr. Luigi Rovati at the Rotta Research Laboratories in Italy, who discovered the glucosamine sulfate molecule in the early 1960s, found glucosamine more effective in dampening disease activity in 329 patients with osteoarthritis than either a placebo or piroxicam alone or in combination with glucosamine.
What also makes glucosamine vastly superior is the lack of side effects. For example, in Dr. | | The mainstay of arthritis drug treatment in the United States is a family of medicines known as nonsteroidal anti-inflammatory drugs (NSAIDS), including aspirin and ibuprofen. Sadly, they can be quite harmful. Their use to treat arthritis has created an epidemic of bleeding ulcers, says Dr. James F. Fries, Stanford University medical professor and arthritis expert. NSAIDS account for 10,000 to 20,000 deaths and 100,000 to 200,000 hospitalizations each year, he says. About one-fourth of those who use NSAIDS to relieve chronic pain develop ulcers. | Joe Graedon and Teresa Graedon See book keywords and concepts | That's cause for concern by itself, but add an arthritis drug to the mix and you are playing with fire. Anti-inflammatory drugs often cause stomach irritation and ulceration. When someone taking one of these pain relievers also takes an anticoagulant such as Coumadin, the risk of a bleeding ulcer becomes much greater. This could be a deadly complication, especially in older people.
Methotrexate
NSAIDs create extra problems when they are mixed with certain other medications. Some of these interactions may be fatal. One in particular concerns us. |
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