Gabriel Cousens
See book keywords and concepts |  Scientists and FDA officials have known about this connection for years. alloxan causes diabetes by creating free radical damage to the DNA in the beta cells of the pancreas. The Textbook of Natural Medicine calls alloxan a "potent beta cell toxin." It is unfortunate that the FDA still allows companies to use it to process foods we eat. Research also shows that we are able to reverse the effects of alloxan with vitamin E. According to Dr. Gary Null's Clinicians' Handbook of Natural Healing, vitamin E effectively protected lab rats from the harmful effects of administered alloxan. |
Mark Sircus
See book keywords and concepts |  Another example is alloxan. Studies show that alloxan, the chemical that makes white flour look "clean and beautiful" destroys the beta cells of the pancreas.26 Scientists have known of the alloxan-diabetes connection for years yet there seems to be a conspiracy in efforts to maintain the appearance of integrity in the
FDA, which allows dangerous chemicals that can cause diabetes to be used in drugs and food. |
Gabriel Cousens
See book keywords and concepts | | A remarkable discovery that a single injection of alloxan can produce diabetes mellitus in laboratory animals was made in 1942, in Glasgow, by John Shaw Dunn and Norman McLetchie.19 Scientists and FDA officials have known about this connection for years. alloxan causes diabetes by creating free radical damage to the DNA in the beta cells of the pancreas. The Textbook of Natural Medicine calls alloxan a "potent beta cell toxin." It is unfortunate that the FDA still allows companies to use it to process foods we eat. |
Mark Sircus
See book keywords and concepts | | Studies show that alloxan, the chemical that makes white flour look "clean and beautiful" destroys the beta cells of the pancreas.26 Scientists have known of the alloxan-diabetes connection for years yet there seems to be a conspiracy in efforts to maintain the appearance of integrity in the
FDA, which allows dangerous chemicals that can cause diabetes to be used in drugs and food. | | Unfortunately, most consumers are unaware of alloxan and its potentially fatal link to diabetes because these facts are not well publicized, are hidden by FDA approval, and certainly doctors and the food industry are not informing parents that they and their children are being poisoned by white flour containing alloxan. Diabetes and Chemical Poisoning. Source: (http://imva.info/)
27 Consumer Reports (Feb. 2006):
28 Genetically Engineered Food Biotech, Biotechnology, GMO, Genetically Modified (www.organicconsumers.org/gelink.html)
29 Health Hazards of Genetically Manipulated Foods; www. |
Gabriel Cousens
See book keywords and concepts | | Research also shows that we are able to reverse the effects of alloxan with vitamin E. According to Dr. Gary Null's Clinicians' Handbook of Natural Healing, vitamin E effectively protected lab rats from the harmful effects of administered alloxan.
In support of that, researchers have found that among rats that are genetically susceptible to IDDM, feeding wheat gluten will cause 40 percent of the subjects to develop IDDM. Several other groups of rats with the same genetic inclination to develop IDDM were fed gluten-free diets, and only 10-15 percent developed IDDM. |
Mark Sircus
See book keywords and concepts | | Unfortunately, most consumers are unaware of alloxan and its potentially fatal link to diabetes because these facts are not well publicized, are hidden by FDA approval, and certainly doctors and the food industry are not informing parents that they and their children are being poisoned by white flour containing alloxan. Diabetes and Chemical Poisoning. Source: (http://imva.info/)
27 Consumer Reports (Feb. 2006):
28 Genetically Engineered Food Biotech, Biotechnology, GMO, Genetically Modified (www.organicconsumers.org/gelink.html)
29 Health Hazards of Genetically Manipulated Foods; www. |
Gabriel Cousens
See book keywords and concepts | | There is a food environment characterized by heavy marketing of excitotoxin-rich processed junk foods, refined carbohydrates such as white sugar and white flour with alloxan, heavy use of animal fats and trans fats, agrochemical-laden foods, and heavy-metal toxicity. These characteristics combine to result in a negative synergy that has precipitated diabetes at pandemic levels, when it was relatively rare before 1940. This is not an accident—the Culture of Death is an active and thoughtless Crime Against Wisdom. |
Thomson Healthcare, Inc.
See book keywords and concepts |  Pharmacological sequential trials for the fractionation of components with hypoglycemic activity in alloxan diabetic mice from Ginseng radix. J Pharm Dyn; 4:402-409. 1981.
Kitigawa I, Yaligali Zasshi 103:612. 1983.
Kobayashi S et al. Inhibitory actions of phospholipase A(2) and saponins including ginsenoside R(bl) and glycyrrhizin on the formation of nicotinic acetylcholine receptor clusters on cultured mouse myotubes. Phytother Res; 4:106-111. 1990.
Konno C, Murakami M, Oshima Y et al. Isolation and hypoglycemic activity of panaxans Q, R, S, T, and U, glycans of Panax ginseng roots. | | Kumari K, Augusti KT, Antidiabetic effects of S-methylcystein sulphoxide on alloxan diabetes. In: PM 61(l):72-74. 1995.
Kupidlowska E, Bieniak B, Ruchirawat A, Zobel AM. Influence of methyl derivatives of coumarin on mitotic activity and ultrastructure of meristemic cells of Allium cepa root tips. Phytomedicine 2 (3); 275-281. 1996
Lancaster JE, Shaw ML. Gamma-Glutamyl Peptides in the Biosynthesis of S-Alk(en)yl-L-Cysteine Sulphoxides (Flavour Precursors) in Allium. Phytochemistry 28; 455-460. 1989
Paradiz J. Assessement of damage to irridated onion (Allium cepa L.) by cytogenic analyses. |
Joerg Gruenwald, Ph.D.
See book keywords and concepts | | Kumari K, Augusti KT, Antidiabetic effects of S-methylcystein sulphoxide on alloxan diabetes. In: PM 61(l):72-74. 1995.
Liakopoulou-Kyriakides M et al., (1985) Phytochemistry 24: 600 and 1593.
Maugh TH, (1979) Science 204:293.
Spare CG, Virtanen Al, (1963) Acta Chem Scand 17:641.
Tverskoy L, Dmetriev A, Kozlovsky A, Grodzinsky D, Two phytoalexins from Allium-cepa bulbs. In: PH 30:799. 1991.
Vollhardt BR, Zwiebelolmazerat (z.B. Alligerol). In: Intern Praxis 32(1):201. 1992.
Wagner H, Bayer Th, Dorsch W, Das antiasthmatische Wirkprfnzip der Zwiebel (Allium cepa L.). In: ZPT 9(6): 165. 1988. |
Michael T. Murray
See book keywords and concepts |  In animal models of type 1 diabetes, beta cells are destroyed by administering compounds that generate free radicals (such as nitrosamines and alloxan, a drug often used to create diabetes in experimental animals because of its free-radical-damaging effects on beta cells). Recently, researchers decided to see what would happen if they gave the animals fish oil before receiving the diabetes-inducing drug alloxan. They discovered that the fish oils prevented chemically induced type 1 diabetes. |
Thomson Healthcare, Inc.
See book keywords and concepts | | Hypoglycemic Effects: Oral administration of an infusion or decoction of olive leaf exerted a hypoglycemic effect in normoglycemic rats and in animals made diabetic with alloxan (Gonzalez et al. 1992). In another experimental model of diabetes, induced by streptozotocin, olive leaf failed to lower blood glucose levels or prevent glucosuria and ketonu-ria, but it did reduce circulating levels of liver enzymes and minimized histopathologic abnormalities in both the kidneys and liver (Onderoglu et al, 1999). |
Gabriel Cousens
See book keywords and concepts | | Gary Null's Clinicians' Handbook of Natural Healing, vitamin E effectively protected lab rats from the harmful effects of administered alloxan.
In support of that, researchers have found that among rats that are genetically susceptible to IDDM, feeding wheat gluten will cause 40 percent of the subjects to develop IDDM. Several other groups of rats with the same genetic inclination to develop IDDM were fed gluten-free diets, and only 10-15 percent developed IDDM. Further, the rate and severity of diabetes could be manipulated by varying the amount of gluten in the diet. |
Michael Friedman, ND
See book keywords and concepts |  In another study utilizing alloxan diabetic rabbits and one human patient, gymnema brought down the fasting blood glucose levels, together with serum cholesterol and triglyceride levels, while improving serum protein levels. The hypoglycemic action took several weeks to develop. Oral administration in normal rats apparently has no significant effect, but only in rats made hyperglycemic experimentally (alloxan, anterior pituitary-treated, tolbutamide, adrenaline). |
Mark Sircus
See book keywords and concepts | | Alloxan induces irreversible diabetes mellitus after 24 hours following its administration and the condition proves to be chronic by laboratory tests after seven days. Experimental Model of Induction of Diabetes Mellitus in Rats; Acta Cir. Bras, vol.18 no.spe S o Paulo 2003 (www.scielo.br/ scielo.php?pid=S0102-86502003001100009&script=sci_arttext&tlng=en)
26 Researchers who are studying diabetes commonly use the chemical to induce the disorder in lab animals. |
Amarjit S. Basra
See book keywords and concepts |  HYPOGLYCEMIC ACTIVITY
Many natural drugs are used in traditional medicine as antidiabetics, and several active compounds have been identified by in vivo bioassay using experimental diabetic animals induced by alloxan or streptozotocin (STZ) or by using the oral sucrose tolerance test (an animal model of insulin-dependent diabetes mellitus) and by in vitro bioassay testing glucose transport activity.
Prevention of hyperglycemia and hyperinsulinemia by retardation of glucose uptake by the small intestine is one successful approach to improving insulin resistance in diabetes mellitus. |
David Hoffman, FNIMH, AHG
See book keywords and concepts |  Momordica charantia (bitter gourd or melon)
Nelumbo nucifera (sacred lotus)
Opuntia ficus-indica (prickly pear)
Panax ginseng (ginseng)
Psidium gujava (guava)
Syzygium cumini (jambul)
Trigonella foenum-graecum (fenugreek)
Vernonia amygdalina (bitter leaf)
Testing of plants for hypoglycemic properties is based on inducing diabetes in animals with toxins (such as alloxan) and evaluating the hypoglycemia or glucose tolerance produced by a plant extract compared with that of a standard, such as tolbutamide. alloxan causes selective necrosis of the pancreatic islet P cells. | | The experimental severity of the disease can be increased or decreased by varying the dose of alloxan.
Glycans from the mushroom Ganoderma lucidum produce significant hypoglycemia in alloxan-induced diabetes in animals. They appear to operate through a unique mechanism, probably affecting glycogen or glucose metabolism.141 Ganoderan B, one of these glycans, has been shown to elevate plasma insulin levels and increase the activities of hepatic glucokinase, phosphofruc-tokinase, and glucose-6 phosphate dehydrogenase. |
Amarjit S. Basra
See book keywords and concepts | | Hypoglycaemic and anti-hyperglycaemic effects of Trigonella foenum-graecum leaf in normal and alloxan induced diabetic rats, Journal of Ethnopharmacology, 58: 149-155.
9. Okabayashi, Y., Taui, S., Fijisaiwa, T, Koide, M., Hasegawa, H., Nakamusa, T, Fujii, M., and Otsuki, M., 1990, Effect of Gymnema sylvestre on glucose homeostasis in rats, Diabetes Research Clinic Practice, 9: 143.
10. Chandalia, M., Garg, A., Lutjohan, D., el al., 2000. Beneficial effects of high dietary fibre in patients with type 2 diabetes niellitus, New England Journal of Medicine, 342: 1392-1398.
11. Yongchaiyuda, S. |
Michael T. Murray
See book keywords and concepts | | Recently, researchers decided to see what would happen if they gave the animals fish oil before receiving the diabetes-inducing drug alloxan. They discovered that the fish oils prevented chemically induced type 1 diabetes. The mechanisms responsible for this effect are related to improved cell membrane function leading to enhanced antioxidant status and suppression of the formation of inflammatory compounds known as cytokines.24
Nitrates
Clear links between increased levels of nitrate from dietary sources and water and an increased risk for type 1 diabetes has been established. |
Leslie Taylor, ND
See book keywords and concepts |  Their study determined that pata de vaca was found to "elicit remarkable hypoglycemic effects," and brought about a "decrease of glycemia in alloxan diabetic rats by 39%."9 In 2002, two in vivo studies on the blood sugar-lowering effects of pata de vaca were conducted by two separate research groups in Brazil. The first study reported "a significant blood glucose-lowering effect in normal and diabetic rats."10 In the second study, 150 g of the leaf (per liter of water) was given to diabetic rats as their drinking water. |
Michael Friedman, ND
See book keywords and concepts | | Hypoglycaemic activity of Syzigium cumini seeds: Effect on lipid peroxidation in alloxan diabetic rats. J Ethnopharmacol. 1998 May;61(l):l-7.
65. Tager M, Dietzmann J, Thiel U, Hinrich Neumann K, Ansorge S. Restoration of the cellular thiol status of peritoneal macrophages from CAPD patients by the flavonoids silib-inin and silymarin. Free Radic Res. 2001 Feb;34(2):137-51.
66. Greenway, F. Frome, B. Engels, T. McLellan, A. Temporary relief of post herpetic neuralgia with topical geranium oil: American Journal of Medicine Nov 2003;115:586-87.
67. Schnaubelt Medical Aromatherapy. |
Joseph E. Mario
See book keywords and concepts |  Lipid membrane peroxidation turns Lipids into aldehydes, lipofusc in, andperoxidesto T-cell failure,herpes,cancer,atherosclerosis, emphysema, infectious disease, osteoporosis, and diabetes (from oxy-radical damage in pancreas Beta-cells from chemicals alloxan, paraquat, and chemotherapy chemicals). Free radicalscauseprogeria/extremelyrapidaging before puberty, from lack of free radical-scavenging Enzymes (controlled with Horseradish enzyme Peroxidase). The Major Histocompatibility Complex (MHC) regulates the SOD and Glutathione-Peroxidase radical response team. |
Michael Friedman, ND
See book keywords and concepts | | Antidiabetic and antihyperlipidaemic effect of alcoholic Syzigium cumini seeds in alloxan induced diabetic albino rats.
J Ethnopharmacol. 2004 Apr;91 (2-3):209-13.
58. Lupattelli G, Marchesi S, Lombardini R, Roscini AR, Trinca F, Gemelli F, Vaudo G, Mannarino E. Artichoke juice improves endothelial function in hyperlipemia. Life Sci. 2004 Dec 31;76(7):775-82.
59. Saenz Rodriguez T, Garcia Gimenez D, de la Puerta Vazquez R. Choleretic activity and biliary elimination of lipids and bile acids induced by an artichoke leaf extract in rats. Phytomedicine. 2002 Dec;9(8):687-93.
60. |
Dianne Onstad
See book keywords and concepts |  One of the substances added during the bleaching process is alloxan, which destroys the beta cells of the insulin-producing pancreas. After bleaching, white flour often has dough conditioners added that reduce the need for kneading. White flour can remain in the grocery store at room temperature almost indefinitely without becoming rancid, a boon for retailers but not for consumers. This fake food, with little or negative nutritional value, is an integral part of more than 90 percent of the baked products sold. |
C. P. Khare
See book keywords and concepts |  Pongamia pinnata exhibited significant hypoglycaemic effect in normal and alloxan diabetic rabbits.
The oil of Pongamia pinnata showed antibacterial activity against Mic. pyogenes var. aureus, Mic. pyogenes var. citreus, B. subtilis, C. diphtheriae, Sal. typhosa, Sal. paratyphi A, Sal. paratyphi B and E. coli; being most active against Sal. paratyphi A. The oil was found to be more active than neem oil. The oil was, however, inactive against P. vulgaris and Ps. pyocyana.
The essential oil from Pongamia pinnata showed mild antifungal activity against kerati-nophillic fungi, viz. |
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