Jonny Bowden, Ph.D., C.N.S. See book keywords and concepts | The Anticancer Properties of Fresh Garlic Extracts, aged garlic, and Garlic Oil
Then there's cancer. Compounds in garlic have been shown in many laboratory studies to be chemoprotective. Epidemiological evidence shows a decreased risk of stomach and colon cancer in areas where the consumption of garlic (and other vegetables in the allium family) is high. A recent article in the prestigious Journal of Nutrition stated that "evidence continues to point to the anticancer properties of fresh garlic extracts, aged garlic, garlic oil and a number of ... compounds generated by processing garlic. | Joerg Gruenwald, Ph.D. See book keywords and concepts | Ide N et al., aged garlic extract and its constituents inhibit Cu++-induced oxidative modification of low density lipoproteins. In: PM 63(3):263-264. 1997.
Imai J et al., Antioxidant and radical scavenging effects of aged garlic extracts and its constituents. In: PM 60(5):417. 1994.
Jain AK, Can garlic reduce levels of serum lipids? In: JAMA 94:632-635. 1993.
Jain RC, Vyas CR, (1974) Brit Med J 2:730.
Jung F, Kiesewetter H, Mrowietz C, Pindur G, Heiden M, Miyashita C, Wenzel E, Akutwirkungen eines zusammengesetzten Knoblauchpraparates auf die Fliepfahigkeit des Blutes. In: ZPT 10(3):87. | Phyllis A. Balch, CNC See book keywords and concepts | Study volunteers (both smokers and nonsmokers) were given aged garlic extract once daily for fourteen days, and researchers concluded that supplementation with aged garlic may help prevent atherosclerosis and other diseases associated with oxidative stress. aged garlic extract is odorless and tasteless for those worried about putting a strain on their social lives. Other garlic supplements include garlic oil and garlic powder in capsules or tablets. | Thomson Healthcare, Inc. See book keywords and concepts | The authors concluded that more in-depth and appropriate studies are needed before definitive conclusions or recommendations about garlic's cardio-protective powers in humans can be made (Rahman, 2006)
A small trial examining the effects of aged garlic Extract (AGE) on endothelial dysfunction in people with cardiovascular risk factors or established vascular disease generated mixed results. | Bill Sardi See book keywords and concepts | Current Cancer Drug Targets 3: 67-81, 2003] aged garlic extract (AGE) has been shown to inhibit both the growth and migration of tumor cells in a laboratory dish. [International J Molecular Medicine 9:641-3, 2002]
In order to confirm the effects of AGE on colon/rectal adenomas (benign epithelial tumors having a glandular origin and structure), researchers provided 2.4 and 0.16 milliliters of AGE per day to patients diagnosed with adenomas. The number and size of these precancerous tumors were determined before and 12 months after intake by direct observation with a colonoscopy. | | Aged garlic ... 471 Garlic and H. pylori... 471
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Herbs p 432-492
Drug resistance ... 472
Garlic, blood clotting and cancer... 472
Telomeres, garlic and cancer... 472
Garlic and medications ... 472
Garlic tolerability... 473
Garlic pills... 473
Mistletoe (Iscador)... 474
Licorice... 475
Milk thistle... 475
Resveratrol... 476
The professor finds a cure for his leukemia ... 476
Small molecules rule ... 477
Resveratrol tackles lymphoma ... 478
Who spread the falsehoods? ... 478
Many pathways blocked by resveratrol... 478
Resveratrol: the nine ways it fights cancer ... | | Various garlic preparations exhibit anti-cancer properties, including fresh crushed garlic cloves, fresh garlic extract, aged garlic, garlic oil, and other sulfur compounds derived from garlic.
The question is, which is the best way to consume garlic: fresh, cooked or aged? [Critical Review Food Science Nutrition 44:479-88, 2004]
Garlic processing
A study was designed to compare several garlic powders with various levels of alii in, a precursor of active sulfur compounds, for their ability to prevent cancer. Rodents were fed diets with three garlic powders with various alliin contents. | Thomson Healthcare, Inc. See book keywords and concepts | Three varieties of fresh Garlic (common, Chinese, and elephant) and 10 commercial Garlic products (including aged garlic, odorless Garlic, Garlic oil, and freeze-dried Garlic) were tested. All types of Garlic inhibited CYP3A4. Fresh Garlic (phosphate buffer extracts) inhibited CYP3A4 by 44% to 59% depending on the variety tested, with common Garlic the most inhibitory. Fresh Garlic (phosphate buffer extracts) had little effect on 2C19 and 2D6 and strongly stimulated 2C9(2) (Foster et al, 2001). | | More recent results of a preliminary, double-blind, randomized clinical trial of aged garlic Extract (AGE) in individuals with precancerous lesions of the large bowels—colorectal adenomas—found that after 12 months of treatment, subjects administered high-dose AGE (2.4mL/d) as an active treatment significantly suppressed both the size and number of colon adenomas after 12 months of treatment (P=0(P=0.04).04) as compared to subjects given low-dose AGE (0.16mL/d) or placebo. | | Two types of commercial supplements (powdered Garlic and aged garlic Extract) were tested against each other and placebo. The Garlic failed to reduce LDL-C more than 10 mg/dL (0.26 mmol/L) when used for 6 months. In addition, no statistically significant effects were seen with Garlic in terms of HDL-C, triglyceride levels, or the ratio of total cholesterol to HDL-C. Based on various observations made, the authors conclude that Garlic in "reasonable" doses in any form is unlikely to generate lipid benefits (Gardner 2007). | | A review of a series of animal and in vitro studies evaluating the antitumor and immune-enhancing effects of aged garlic extract suggests potential use in the treatment of bladder cancer. Animal and in vitro studies provided evidence that Garlic may inhibit carcinogenesis, inhibit cancer cell growth, and promote chemical carcinogen detoxification. Documented immunological effects of Garlic include increased interleu-kin-2, TNF-alpha, and interferon-gamma production and stimulation of macrophage infiltration, natural killer cells, and lymphokine-activated killer cells. | Marshall Editions See book keywords and concepts | Take 600 mg of an aged garlic extract twice a day. Passionflower, which can be taken at 250 mg in capsule form or 1 ml in tincture form, helps to decrease blood pressure associated with stress. Dandelion leaf, when taken at 300 mg or 2 ml three times a day, acts as a gentle, natural diuretic to lower blood pressure.
HOMEOPATHY
Due to its chronic nature, high blood pressure is best treated by a combination of complementary and conventional therapies. If mild symptoms have recently developed, consult a homeopathic practitioner as a first resort to bring blood pressure down to a desirable level. | Jonny Bowden, Ph.D., C.N.S. See book keywords and concepts | Green tea was one of the eight (the other seven were aged garlic, curcumin, melatonin, resveratrol, Gingko biloba, vitamin C, and vitamin E). And a paper published recently in the Journal of Nutritional Biochemistry (September 2004) examined the neuroprotective mechanisms of green tea polyphenols— especially EGCG—on both Alzheimer's and Parkinson's disease.
Everyone Benefits from Tea
I've spent this much time on tea because it is one of the few foods (or drinks) about which I can say that virtually everyone would benefit from drinking it. | | Two of the best are Kyolic aged garlic, widely available in better health food stores, and Allicidin by Designs for Health, available on my Web site (www.jonnybow-den.com).
In Ayurvedic (Indian) medicine, ginger is known as the "universal remedy" No wonder. J This little plant contains a whole pharmacy of ingredients with multiple health benefits.
Many people are already aware of ginger's awesome ability to soothe an upset stomach and end nausea
By stimulating saliva, it may also help digestion. And ginger ale has long been a favorite for upset stomach for a very good reason: It works. | | One recent research article demonstrated the ability of aged garlic extract to inhibit the proliferation of colorectal cancer cells. And yet another study demonstrated the ability of another compound from garlic—diallyl disulfide—to inhibit leukemia cells in a test tube.
Garlic can even help fight the common cold. In one study published in Advances in Natural Therapy, a group of seventy patients was given a high-quality standardized garlic supplement for twelve weeks while another group of seventy-two patients was given a placebo. | Thomson Healthcare, Inc. See book keywords and concepts | Although additional studies are needed, the authors elucidate these possible links and suggest a possible anti-dementia benefit in tandem with heart disease benefits identified with aged garlic Extract (AGE) particularly (Borek 2006).
Hyperlipidemia
Note: There are contradicting results regarding the lipid-lowering effect of Garlic, which may be attributed to lack of manufacturing standardization of the products used in the studies. The fresh Garlic may contain higher amounts of the active ingredient, allicin, which is inactivated upon cooking. | David W. Grotto, RD, LDN See book keywords and concepts | The effect of the aged garlic extract, "Kyolic," on the development of experimental atherosclerosis. Arterosclerosis. 1997;132:37-42.
Fleischauer, AT, Arab L. Garlic and cancer: a critical review of the epidemiologic literature. / Nutrition. 2001; 131:1032S-1040S.
Gonzalez C et al. Fruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European Prospective Investigation into Cancer and
Nutrition (EPIC-EURGAST). Int J Cancer. 2006 May 15;118( 10):2559-2566.
Hsing AW, Chokkalingam AP, Gao YT, et al. | Gary Null and Amy McDonald See book keywords and concepts | Results of this study showed that the chronic dietary administration of aged garlic extract improved spatial learning in senescence-accelerated mice.
Ginseng Root Prevents Learning Disability and Neuronal Loss in Gerbils with 5-minute Forebrain Ischemia. Wen TC; et al. Acta Neuropathologica, 1996, 91(l):15-22.
This study examined the neuroprotective effects of ginseng roots in 5-minute ischemic gerbils. Red ginseng powder, crude ginseng saponin, crude ginseng non-saponin, and pure ginsenosides Rbl, Rgl and Ro were administered 7 days prior to ischemia. | | The researchers found beneficial effects of aged garlic extract (AGE) and S-allyl cysteine (SAC) on Abeta-induced apoptosis and reactive oxygen species (ROS) generation in a rat cell line.
The Green Tea Polyphenol (-)-Epigallocatechin Gallate Attenuates Beta-Amy-loid-Induced Neurotoxicity in Cultured Hippocampal Neurons. Choi YT; Jung CH. Life Sciences, 2001 December, 21:70(5):603-614.
Green tea polyphenols have protective effects against betaA-induced neuronal apoptosis, which may be beneficial for the prevention of Alzheimer's disease.
Oxidative Stress and Alzheimer Disease. | David W. Grotto, RD, LDN See book keywords and concepts | A ten-month study evaluated the effect of aged garlic extract (AGE) on the lipid profiles of men with moderately high cholesterol. Platelet adhesion and fibrinogen (makes blood sticky, increasing risk of clotting) was reduced by approximately thirty percent in subjects taking AGE.
REDUCED RISK OF PREECLAMPSIA DURING PREGNANCY: Researchers in London found that garlic may help to boost the birth weight of babies and decrease preeclampsia complications at birth.
CANCER: Nearly thirty studies have shown that garlic has some cancer-preventive effect. | | Changes in platelet function and susceptibility of lipoproteins to oxidation associated with administration of aged garlic extract. / Cardiovasc Pharmacol. 1998;31:904-908.
Ginger www.mayoclinic.com/heaIth/ginger/NS_patient-ginger; www.umm.edu/altmed/consherbs/gingerch.html#overview
Altman RD and Marcussen KC. Effects of ginger extract on knee pain in patients with osteoarthritis. Arthritis Rheum. 2001 ;44( 11) :2461-2462.
American Association for Cancer Research 97th annual meeting, April 1-5, 2006, Washington, D.C. Study author J. Rebecca Liu, M.D. | Phyllis A. Balch, CNC See book keywords and concepts | Most studies have focused on the healing powers of fresh, raw, or cooked garlic, and aged garlic extract (AGE), while only a relative few have tested dried or powdered garlic supplements. Kyolic aged garlic Extract from Wakunaga of America is a garlic extract that is standardized to contain a certain level of both SAC and SAMC. Unlike other aged garlic products, Kyolic contains the compound fructosyl arginine, which, in laboratory tests, proved to be as effective as vitamin C in its antioxidant activity. | Joerg Gruenwald, Ph.D. See book keywords and concepts | Antioxidant and radical scavenging effects of aged garlic extracts and its constituents. In: PM 60(5):417. 1994.
Jain AK, Can garlic reduce levels of serum lipids? In: JAMA 94:632-635. 1993.
Jain RC, Vyas CR, (1974) Brit Med J 2:730.
Jung F, Kiesewetter H, Mrowietz C, Pindur G, Heiden M, Miyashita C, Wenzel E, Akutwirkungen eines zusammengesetzten Knoblauchpraparates auf die Fliepfahigkeit des Blutes. In: ZPT 10(3):87. 1989.
Kabelik J, (1970) Pharmazie 25:266.
Koch HP, Der lange Weg zum "geruchlosen Knoblauch". In: PUZ 25(4):186-191. 1996.
Koch HP, Epidemiologic der Knoblauchforschung. | Amarjit S. Basra See book keywords and concepts | Attenuation of cell migration and induction of cell death by aged garlic extract in rat sarcoma cells, International Journal of Molecular Medicine, 9(6): 641-643.
94. Yamasaki, T. and Lau, B.H., 1997, Garlic compounds protect vascular endothelial cells from oxidant injury, Nippon YakurigakuZasshi, 110(Suppl. 1): 138P-141P (in Japanese); Ide, N., Nelson, A.B., and Lau, B.H., 1997, aged garlic extract and its constituents inhibit Cu(2+)-induced oxidative modification of low density lipoprotein, Planta Medica, 63(3): 263-264.
95. Li, Y, Yang, L., Cui, J.T., Li, W.M., Guo, R.F., and Lu, Y. | | Itakura, Y, 2001, Immunomodulatory effects of aged garlic extract, Journal of Nutrition, 131 (3s): 1075S-1079S.
133. Horie, T, Awazu, S., Itakura, Y, and Fuwa, T.. 2001, Alleviation by garlic of antitumor drug-induced damage to the intestine, Journal of Nutrition, 131 (3s): 1071S-1074S.
134. Key, T.J., Silcocks, P.B., Davey, G.K., Appleby, P.N., and Bishop, D.T., 1997, A case-control study of diet and prostate cancer, British Journal of Cancer, 76(5): 678-687.
135. Challier, B., Perarnau, J.M., and Viel, J. | Kevin Trudeau See book keywords and concepts | Garlic capsules, Kyolic aged garlic Extract www.kyolic.com (800) 421-2998
Grapefruit seed extract, NutriBiotic www.nutribiotic.com (800) 225-4345
Probiotics, Jarrowdophilus + FOS www.jarrow.com (800) 726-0886
Vitamin C, Truly Natural Vitamin C www.healthforce.com (760) 747-8822
B-Complex, Max Stress B Nano-Plex www.vpnutrition.com (877)335-1509
Panothenic Acid www.organicpharmacy.org (800) 819-6742
42. GAS
For more information go to Find A Cure at www.naturalcures.com.
Down on all fours, butt in the air, self-massage, breathe and release.
Digestive enzymes, Dr.Fred Bisci www. | Amarjit S. Basra See book keywords and concepts | S-allylmercaptocysteine (SAMC), a stable-water-soluble organosulphur compound present in aged garlic extract, has antiproliferative activity against hormone-dependent breast (MCF-7) and prostate (CRC-1740) cancer cell lines and two erythroleukemia (HEL and OCIM-1) cell lines, but not against normal cultured human umbilical vein endothelial cells.104 The dose-dependent inhibition of the growth of HEL and OCIM-1 cells (IC50 46-93 urn) was characterized by blockage of cell cycle progression at the G2/M phase and induction of reduced protein synthesis/apoptosis.105 SAMC (50 mg-L~! | Jack Challem See book keywords and concepts | A cell study at the Philadelphia Biomedical Research Institute tested the effects of green tea extract and aged garlic extract on sickle-cell dehydration, which exacerbates blood-cell damage and may increase clotting. Epigallocatechin gallate, a major antioxidant component of green tea extract, almost completely inhibited sickle-cell dehydration. The garlic extract reduced dehydration by 30 percent.
Taken together, these studies show that people suffering from sickle-cell anemia risk multiple nutrient deficiencies and often have extremely high vitamin requirements. | | Over six months Ohnishi asked 10 patients to take 6 grams of vitamin C, 1,200 IU of vitamin E, 1,000 meg of folic acid, and 6 grams of aged garlic extract daily. Meanwhile the subjects' twin siblings took only folic acid. People taking the high-potency vitamins had one-third the number of painful sickle-cell episodes, compared with those taking only folic acid.
Red blood cells from people with sickle-cell anemia are more susceptible to free-radical damage, and low intake of vitamin E may increase the risk of sickle-cell symptoms. |
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