Dr. Arthur Janov See book keywords and concepts | Finally I was prescribed 0.6 mg zyprexa daily—an extremely low dose. I had specifically asked for it because a Primal friend with symptoms like mine had been helped. After the first intake I slept through the entire night, which had not happened for more than 15 months. I continued taking zyprexa.
Taking zyprexa continued to help me sleep, something which my doctor didn't want to believe. Zyprexa's indication is not sleepiness, but schizophrenia. |
Too Profitable to CureBrent Hoadley, Ph.D. See book keywords and concepts | | Zyprexa, at $8 per pill, is Lilly's new antipsychotic drug, and its leading money-maker.8 Seventy percent of the $2.63 billion in sales comes from U.S. government Medicaid spending. But since this obviously isn't adequate profit for Lilly, the company managed to keep hidden for a considerable time the link that shows zyprexa is causing Type 2 diabetes. Can you guess what Lilly's second-leading money maker is...? Surprise! Drugs for treating diabetes. Talk about CREATING a market! | Dr. Arthur Janov See book keywords and concepts | What he did not understand was that zyprexa calmed down my first-line brainstem, which is why I slept through the nights and got the rest I badly needed. I started doing a little better, but still I remained being constantly overwhelmed in my life and not being able to experience anything good.
After another four months I found myself again sleepless most nights and in a constant struggle with my therapist, whom I perceived as doing everything wrong all the time. I was stuck in another depression. Then 4.25 mg Prozac were prescribed to me in addition to 0.6 mg zyprexa daily. | Charles Barber See book keywords and concepts | All five of the studies paid for by Lilly showed the superiority of their drug zyprexa to Risperdal, while three of the four Johnson & Johnson studies favored Risperdal over zyprexa. "The comparative studies are a joke. They are comical. A lot of the scientific literature these days is worthless," says Jack E. Rosenblatt, a psychiatrist.76 Furthermore, clinical trials that do not favor a company's interest simply do not have to be reported to the FDA. |
Too Profitable to CureBrent Hoadley, Ph.D. See book keywords and concepts | | Lilly
• zyprexa is an expensive antipsychotic drug, and Lilly's current leading moneymaker; 70% of sales are to the U.S. government.
• George Herbert Walker Bush served on the Board of Directors of Eli Lilly Corporation.
• Ken Lay, former CEO of Enron, also was a member of the Lilly Board of Directors.
• Sidney Taurel, current CEO of Eli Lilly, serves on your Homeland Security board.
• Mitch Daniels, a former Lilly vice-president, served as Director of Management and Budget.
• The National Alliance for the Mentally 111 received significant funding from Lilly. | | But since this obviously isn't adequate profit for Lilly, the company managed to keep hidden for a considerable time the link that shows zyprexa is causing Type 2 diabetes. Can you guess what Lilly's second-leading money maker is...? Surprise! Drugs for treating diabetes. Talk about CREATING a market! Of course, none of this would be possible without unknowing or unscrupulous doctors, their handy little prescription pads, and a willingness to sacrifice patient well-being for pharmaceutical profiteering. | Jack Challem See book keywords and concepts | Early in 2007, Eli Lilly, the maker of zyprexa (noted previously) agreed to pay a total of $1.2 billion to 28,500 people who took the drug for bipolar disease or schizophrenia. The drug had gained a reputation for promoting both obesity and diabetes.
Likewise, in early 2007, researchers at the Cleveland Clinic published an analysis of forty-two studies involving the antidiabetes drug rosigli-tazone (Avandia). They reported that the drug increased the risk of heart attack by 43 percent. | Dr. Timothy Scott See book keywords and concepts | If we once again use zyprexa as an example (we should assume that, as the nation's most popular antipsychotic, it has fewer side effects than would other drugs in this group), we learn that 11% of those on zyprexa (10 mg/day) experienced "akathisia events" in a six-week trial developed by the drug's manufacturer.19 To understand the nature of akathisia, consider the experiment conducted by the drug authority and researcher David Healy.
Using normal, healthy volunteers from among the students, nurses and other medical staff at a British university, Dr. | Shannon Brownlee See book keywords and concepts | When the authors of the
Journal of Psychiatry survey looked at the trials, they found a curious thing: In five trials that were paid for by Eli Lilly, its drug, zyprexa, came out looking superior to Risperdal, a drug made by the company Janssen. But when Janssen sponsored its own trials, Risperdal was the winner three out of four times. When it was Pfizer funding the studies, its drug, Geodon, was best. In fact, this tendency for the sponsor's drug to come out on top held true for 90 percent of the more than thirty trials in the survey. | Kelly Patricia O'Meara See book keywords and concepts | The patented mental health drugs embedded within this model program include: Risperdal, zyprexa, Seroquel, Geodone, Depakote, Paxil, Zoloft, Celexa, Wellbutrin, Zyban, Remeron, Serzone, Effexor, BuSpar, Adderall and Prozac, all manufactured by the above companies.
8. TMAP concluded that the atypical antipsychotic medications Risperdal, produced by Janssen Pharmaceutica, zyprexa produced by Eli Lilly, and Seroquel, produced by AstraZeneca, are the drugs of choice for all first, second and third-line treatments for Schizophrenia.
9. | Mark Sircus See book keywords and concepts | Many of these children are being treated with psychiatric medications zyprexa, Risperdal, Geodon, Seroquel, Clozaril, and Abilify. All of these drugs carry black box warnings to alert MD's about the dangers of diabetes. All these drugs would in all likelihood push down magnesium serum levels.
Do not, and I scream, do not trust psychologists, psychiatrists and the current drug-pushing culture of education.
Dr. | Dr. Arthur Janov See book keywords and concepts | Prozac were prescribed to me in addition to 0.6 mg zyprexa daily. The indication was depression— this combined treatment was a newly discovered approach to treat depression.
And it did wonders. After about a month I began to feel differently, more energetic, less negative. My sessions began to change. I would experience one feeling at a time and not any longer have 10 feelings popping up at once. After a feeling it would take me five, 10, sometimes 30 minutes, and then I felt that I actually was out of the feeling. I had closed down! That had never happened to me before. | Shannon Brownlee See book keywords and concepts | Zyprexa." The documents rocketed around the Internet and were subsequently published on several Web sites. Lilly sought and obtained a court injunction, ordering anybody who had a copy of its documents to return them prompdy or risk being sued. But trying to get all of them back was a little like trying to stuff toothpaste back into the tube. As of January 1 c, 2007, the documents sat defiantly available on Swedish servers, under a domain registered on Christmas Island, a tiny, coconut-tree-studded chunk of volcanic rock in the Indian Ocean. | Mark Sircus See book keywords and concepts | Consider the antipsychotic drugs used to treat children with autism for behavior control. zyprexa, Risperdal, and others can cause hyperglycemia, which causes increased excretion of orally administered magnesium.
While drugs bind with magnesium, diminishing its availability in the body, the threat of depletion doesn't end there. Two cans of soda per day (all of which contain phosphates) can also bind up significant amounts of magnesium. The phosphorus contained in these "harmless" beverages prevents the absorption of magnesium ions in the GI tract. | Gabriel Cousens See book keywords and concepts | The anti-psychotic zyprexa, for example, has been implicated in causing weight gain and diabetes. With increased weight, there is increased diabetes. Little research has been done on the long-term impact of Type-2 diabetes on children, over their life span. The chronic complications that follow tend to happen ten to fifteen years after the onset. This means that life-limiting complications such as kidney disease, heart disease, stroke, and blindness are now hitting people in the prime of their lives, in the middle of their most productive years. | Dr. Timothy Scott See book keywords and concepts | The FDA's approved statement for zyprexa, America's best-selling antipsychotic drug, in discussing one type of movement disorder known as tardive dyskinesia reads, "Whether antipsychotic drug products differ in their potential to cause tardive dyskinesia is unknown."10
Isn't it amazing that the FDA has routinely approved new antipsychotics though they claim to have no idea if one is any safer than another? It is even more amazing that this same statement has been included in the drug insert sheet for zyprexa and several other antipsychotics for many years. | Charles Barber See book keywords and concepts | The company has been under federal and state investigation for its marketing practices for zyprexa.
Lilly is not alone. Almost every major drug company is being investigated criminally or civilly for alleged efforts to promote their drugs beyond their approved uses. | | In particular, a class of agents called "atypical antipsychotics"—Risperdal, Clozaril, and zyprexa are the best known—had been shown in early clinical studies to be far superior to the Haldols and the Thorazines. Overnight, it seemed, almost all patients were converted to these new drugs, as well as new-generation antidepressants and mood stabilizers. It was not at all unusual for my clients to be taking three, four, five, or six different types of psychiatric drugs in a given day—a combination not unlike the number of street drugs many of them had once been addicted to. | | Another fun house, "Zyprexa," featured a mirrored room with dozens of telephones hanging from the ceiling. This, the sales reps explained, was an illustration of the communication problems associated with schizophrenia.61
To boost the image of the products they sell, drug representatives are typically vivacious and cute and female. "There's a saying that you'll never meet an ugly drug rep," said Dr. Thomas Carli, of the University of Michigan.62 "Many give off a kind of glow, as if they had just emerged from a spa or salon. | | Any casual attendee simply passing through the exhibit spaces can grab enough Zoloft pens, Viagra calendars, and zyprexa coffee cups to last a decade. Major international conferences, such as the World Congress of Biological Psychiatry, feature bizarre installations to promote the drugs. At the Berlin conference in 2001, Eli Lilly set up what were described as "fun houses" to draw the attention of physicians to their products. In one fun house, called "Prozac," a huge mouselike creature sat in front of a blank TV screen. | | The antipsychotic zyprexa, the seventh best-selling drug in the world in 2005, was responsible for 30 percent of Lilly's revenues that year.12 Effexor accounted for 18 percent of Wyeth's revenues in 2005.13 The antipsychotic Risperdal was Johnson & Johnson's second best-selling drug in 2004. And in 2004, the psychiatric drugs Zoloft, Seroquel, Celexa, and Lexapro were each the number-one or the number-two best-selling products of their respective manufacturers. | Gerald E. Markle and Frances B. McCrea See book keywords and concepts | Their widespread use is well documented; in 2003, zyprexa (chemical name, olanzapine), was sixth in retail sales in the United States. The advantage of second generation drugs is that they have fewer side effects, especially those that produce the dreaded Parkinson-like symptoms. The problem is that 39% of all patients develop agranulocytosis (a decrease in white blood cells)51 which leads to death in about 1.3% of all cases. Other problems include increases in diabetes and significant weight gain.
All this considered: Are they effective in treatment? | Shannon Brownlee See book keywords and concepts | In late 2006, a scandal erupted when a plaintiff's lawyer from Alaska sent internal company documents obtained during a court case against Eli Lilly, the maker of zyprexa, to a reporter at the New York Times. The newspaper reported that the documents, which included e-mail, marketing material, sales projections, and scientific reports, showed that the company had hidden information about the drug's potential to cause severe side effects. | Melody Petersen See book keywords and concepts | He took Zoloft, an antidepressant; zyprexa, an antipsychotic; and two one-milligram tablets of Xanax, an antianxiety medicine, and then went to bed. A short time later he got into his car and began driving.
Just before 10:00 a.m., Mr. Little ran his car into a vehicle stopped at a stop sign. When he got out of his car to talk to the other driver, his vehicle began rolling forward and nearly hit the other car again. According to the driver of the other car, Mr. Little had trouble climbing out of his car. He hung on to the car door for support.
Minutes after the first accident, Mr. | | Studies have shown these antipsychotic drugs, including zyprexa and Risperdal, do not help patients with Alzheimer's. Instead, the drugs appear to increase their risk of death.
In the late 1980s, doctors began prescribing Tambocor and Enkaid, which were approved to treat irregular heartbeats, to patients who did not have these symptoms but had suffered heart attacks. Years later a government study showed that the drugs almost tripled the death rate among such patients. In his 1995 book Deadly Medicine, Thomas J. | Gary Null and Amy McDonald See book keywords and concepts | Unfortunately, as we are becoming all too aware by the growing number of lawsuits, governmental warnings, and media attention, these medications often end up causing more harm than good. zyprexa is just one case in point. Approved in 1996 by the FDA to treat bipolar disorder and schizophrenia, it has been associated with increased risk of hyperglycemia and diabetes to such an extent that its manufacturer Eli Lilly agreed in 2005 to pay nearly $700 million to settle thousands of claims.
When treating patients with bipolar disorder, Dr. Vickar recommends tryptophan or lithium. | | Other second-generation drugs that came on the scene after clozapine—including Risperdal, zyprexa, and Seroquel—bypass the already mentioned side effects but pose a whole new dilemma: weight gain and metabolic changes linked to an increased risk of high cholesterol and diabetes.
Beyond the known side effects, there is question about the relative effectiveness of these drugs. According to a 2006 study published in the Archives of General Psychology, there was no reported clinical advantage to the more expensive and highly touted second-generation antipsychotics when compared with the first. |
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