Seroxat

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SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRIS): citalopram (Celexa, Cipramil, Talohexane), escitalopram (Cipralex, Lexapro), fluoxetine (Fluctin, Fontex, Lovan, Prozac, Sarafem), paroxetine (Aropax, Paxil, seroxat), and sertraline (Apo-Sertral, Gladem, Lustral, Stimuloton, Serlift, Zoloft) SSRIs are the most commonly prescribed class of antidepressants. Action: SSRIs work by tricking the brain into thinking there are more serotonin neurotransmitters than there really are.

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Indeed, Richard Brook, chief executive of MIND, had resigned from the MHRA expert committee charged with assessing the SSRIs before this final verdict, saying the regulator had been sitting on evidence that seroxat had been prescribed in unsafe doses for ten years.34 Ushering in changes The train of events that had so battered the reputation of its US counterpart, the FDA, was being replicated on the other side of the Atlantic as measures were instantly taken to restore public confidence in the whole process of medicines regulation.

In June 2004, New York attorney general Eliot Spitzer accused GlaxoSmithKline of 'repeated and persistent fraud' for concealing vital safety information when seroxat, or Paxil as it is known in the US, is used in children. According to the FDA, 2.23 million prescriptions for Paxil had been dispensed to people under the age of 17 in 2002 for a range of conditions that include depression, attention-deficit disorder, anxiety and other mood disorders.29 Spitzer's contention did not concern whether the drug was good or not, only that information had been withheld from the assessment process.

Cardiff solicitor, Mark Harvey, was one of many to start challenging new definitions of 'addiction' as he prepared a case against GlaxoSmith-Kline, the company that makes seroxat. Harvey told Simon Garfield in the Observer Magazine: However you dress it up, they're trying to suggest that it's not a major issue. But I've got people who say they've been trying to get off it for four or five years and say, 'My life is a misery.' I've heard this argument about it not being addictive, but I think it's mischievous.

Her GP recommended a more gradual tapering method and prescribed seroxat liquid. I measured it out with a cup, cutting down 2-3 mg each week. By the time I got near 12mg, I was in physical and emotional turmoil. The nausea had returned, along with flu-feelings, aches, blinding dizziness, exhaustion, rapid and painful successive electric shocks and depression. Most disturbing was the onset of suicidal thoughts and violent nightmares, in which I saw members of my family hurt. For weeks, I was unable to leave my bed. Friends would visit me with food parcels and cook for me.

When I first started taking seroxat I noticed no difference to the wobbly sensation, but felt detached from reality and became lethargic. I would frequently experience 'electric shocks', which caused me to visibly jolt. The tiredness and detachment feeling affected my ability to study and travel to university, leading to the second year of my degree being postponed. After six months, there was a noticeable improvement to the wobbly sensation and Sarah returned to university. By now her weight had started to increase, however, and she needed increasing amounts of sleep.

The makers of this class of drug that now includes seroxat, Cipramil, Lustral, Efexor, Dutonin, Faverin and others, seemed to have no difficulty persuading people that they could benefit from them. Not only are people with eating, sexual, and anxiety disorders, depres-sives, schizophrenics, and post-traumatic stress disorder patients candidates for Prozac ... [wrote psychiatrist Dr William S. Appleton in his guide to the new antidepressants back in 1997].

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But the problem of withdrawal is just one of many challenges to the blockbuster Paxil—also known as seroxat and Aropax. One of the world's top-selling antidepressants, the drug was also one of the biggest money-spinners ever for the giant Anglo-American pharmaceutical company GSK. A large part of Paxil's extraordinary success was because it has been approved to treat more conditions than almost all of its competitor antidepressants.

For example, Paxil is Aropax in Australia and seroxat in the UK. Zoloft is called Lustral in the UK. Doughnuts for the doctors Depression For almost two decades, Oldani and thousands like him have helped instill and reinforce the notion that depression is a widespread psychiatric disease most likely due to a chemical imbalance in the brain, best fixed with a modern group of drugs called selective serotonin reuptake inhibitors, or SSRIs, that includes Prozac, Paxil, and Zoloft.

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August, 2000: In the United Kingdom their version of the FDA called the MCA wrote asking GlaxoSmithKline to include the following warning in the Paxil package insert even though as of July, 2001 that has not yet happened: "Occasionally thoughts of suicide or self harm may occur or may increase in the first few weeks of treatment with seroxat, until the antidepressant effect becomes apparent. Tell your doctor immediately if you have any distressing thoughts or experiences.

The relationship is so strong, Dr Donovan says, that he firmly believes promotional material for SSRIs including seroxat [Paxil] should be changed immediately so doctors no longer prescribe them to potentially suicidal patients thinking, mistakenly, that by doing so they are protecting their lives." When Dr Donovan sent the manuscript of this study to SmithKline Beecham [now GlaxoSmithKline] (who partially financed the study along with Eli Lilly) before it was published asking for comments. They did not reply.

Since then more adverse reaction reports have been filed about seroxat for problems combined." And just before Christmas a crucial article was published in the British Journal of Psychiatry by Dr Stuart Donovan and colleagues. Of 2,776 patients taking SSRIs who were treated at the Derbyshire Royal Infirmary over two years. They found that if you look for a statistically significant relationship between taking SSRIs and suicide by overdosing on them, you won't find much.

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